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Case Report
- Unveiling a hidden hazard: lead poisoning from hobbyist activities and its long-term impact
- Chiara Pucci, Luca Tomassini, Marco dell’Omo, Alessandra Deini, Daniele Lillacci, Cristiana Gambelunghe, Mauro Zampolini, Nicola Murgia, Angela Gambelunghe
- Ann Occup Environ Med 2025;37:e15. Published online May 26, 2025
- DOI: https://doi.org/10.35371/aoem.2025.37.e15
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Abstract
PDF - Background
Lead poisoning is a serious public health issue that can arise from various sources, including nonoccupational exposure. This can make it challenging to manage, as lead poisoning can arise from unexpected sources. This case study examined lead poisoning in a 52-year-old man linked to hobbyist activities involving lead pellets, highlighting the diagnostic and therapeutic challenges associated with this uncommon source of exposure.
Case presentation
A 52-year-old man with a history of sports fishing presented with confusion, balance disorders, and memory loss. The initial medical evaluation revealed anemia and elevated lead levels. Further investigations, including imaging and blood tests, confirmed the presence of ingested lead pellets. The patient underwent chelation therapy, which led to a reduction in blood lead levels and improvement in symptoms. Follow-up over 46 months showed a gradual decrease in lead levels and partial recovery of cognitive function, although a few lead-related effects persisted.
Conclusions
This case underscores the need for awareness of non-traditional sources of lead exposure, such as hobbyist activities. Effective diagnosis and treatment, including chelation therapy, can significantly alleviate the effects of lead poisoning. Ongoing monitoring is essential to manage long-term health outcomes related to chronic lead exposure.
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- 215 Download
Case Report
- Occupational asthma related to indoor air pollution in a worker at an indoor air gun shooting range: a case report
- Kwang Min Lee, Seungho Lee, Yoon-Ji Kim, Seung-eun Lee, Youngki Kim, Dongmug Kang, Se-Yeong Kim
- Ann Occup Environ Med 2023;35:e13. Published online June 19, 2023
- DOI: https://doi.org/10.35371/aoem.2023.35.e13
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Abstract
Abstract in Korean
PDF
Supplementary Material Background Indoor air pollution can cause and exacerbate asthma. We report a previously undescribed case of occupational asthma related to indoor air pollution in a worker at an indoor air gun shooting range and highlight the potential risk of developing occupational asthma in this environment.
Case presentation A 31-year-old man presented with dyspnea, cough, and sputum and was diagnosed with asthma complicated by pneumonia. Objective evidence of asthma was obtained by performing a methacholine bronchial provocation test. It was suspected that the patient had occupational asthma, which began one month after changing jobs to work within the indoor air gun shooting range. The highest peak expiratory flow (PEF) diurnal variability on working days was 15%, but the highest variation was 24%, with 4 days out of 4 weeks having a variation of over 20% related to workplace exposure. Conversely, the diurnal variability on the rest days was 7%, and no day showed a variation exceeding 20%. The difference in the average PEF between working and rest days was 52 L/min. PEF deterioration during working days and improvement on rest days were noted.
Conclusions The results obtained from the in-depth analysis of the PEF were adequate to diagnose the patient with occupational asthma. Exposure to indoor air pollution and lead and the patient’s atopy and allergic rhinitis may have contributed to the development of occupational asthma.
- 실내 공기총 사격장 근로자의 실내공기오염관련 직업성 천식 증례보고
a배경: 실내공기오염은 천식을 유발하고 악화시킬 수 있다. 본 연구는 실내 공기총 사격장에서 일하는 근로자의 실내 공기 오염과 관련된 이전에 기술되지 않은 직업성 천식 사례를 보고하고, 이러한 환경에서 직업성 천식 발병의 잠재적 위험을 강조한다.
증례
31세 남자가 호흡곤란, 기침, 가래 증상이 나타나 내원하였고, 폐렴이 동반된 천식으로 진단되었다. 천식의 객관적인 증거는 메타콜린 기관지유발검사를 시행하여 획득하였다. 환자는 실내공기총 사격장에서 근무하기 위해 이직한지 한달만에 직업성 천식을 앓고 있는 것으로 의심되었다. 근무일의 최고호기유량(PEF) 주간 변동성은 15%였지만, 가장 높은 변동성은 24%였으며, 4주 중 4일은 작업장 노출과 관련하여 20% 이상의 변동성을 보였다. 반대로 쉬는 날의 일교차는 7%로 20%를 넘는 날은 없었다. 근무일과 휴식일 사이의 평균 최고호기유량(PEF) 차이는 52 L/min이었다. 근무일 동안 PEF 악화 및 휴식일의 개선이 주목되었다.
결론
최고호기유량(PEF)의 심층분석결과는 직업성 천식 환자를 진단하기에 적합하였다. 실내공기오염과 납 노출, 환자의 아토피와 알레르기성 비염이 직업성 천식 발병에 기여했을 가능성이 있다. -
Citations
Citations to this article as recorded by
- Assessing physical and mental health impacts of solid cooking fuel emissions
Pradeep Kumar, Era Upadhyay, Anoop Yadav, Krishnamurthi Kannan
Air Quality, Atmosphere & Health.2025; 18(7): 2077. CrossRef - Recent developments in occupational asthma
Claudia Blouin, Catherine Lemière
Current Opinion in Pulmonary Medicine.2024; 30(3): 281. CrossRef - Occupational agents-mediated asthma: From the perspective of autophagy
Xiu He, Dengxiang Yao, Xiaoli Yuan, Jiaqi Ban, Yuxuan Gou, Mingdan You
Science of The Total Environment.2024; 952: 175880. CrossRef
- Assessing physical and mental health impacts of solid cooking fuel emissions
- 2,623 View
- 35 Download
- 3 Web of Science
- 3 Crossref
Original Article
- The health effects of low blood lead level in oxidative stress as a marker, serum gamma-glutamyl transpeptidase level, in male steelworkers
- Su-Yeon Lee, Yong-Jin Lee, Young-Sun Min, Eun-Chul Jang, Soon-Chan Kwon, Inho Lee
- Ann Occup Environ Med 2022;34:e34. Published online November 2, 2022
- DOI: https://doi.org/10.35371/aoem.2022.34.e34
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Abstract
Abstract in Korean
PDF
Background This study aimed to investigate the association between lead exposure and serum gamma-glutamyl transpeptidase (γGT) levels as an oxidative stress marker in male steelworkers.
Methods Data were collected during the annual health examination of workers in 2020. A total of 1,654 steelworkers were selected, and the variables for adjustment included the workers’ general characteristics, lifestyle, and occupational characteristics. The association between the blood lead level (BLL) and serum γGT level was investigated by multiple linear and logistic regression analyses. The BLL and serum γGT values that were transformed into natural logarithms were used in multiple linear regression analysis, and the tertile of BLL was used in logistic regression analysis.
Results The geometric mean of the participants’ BLLs and serum γGT level was 1.36 μg/dL and 27.72 IU/L, respectively. Their BLLs differed depending on age, body mass index (BMI), smoking status, drinking status, shift work, and working period, while their serum γGT levels differed depending on age, BMI, smoking status, drinking status, physical activity, and working period. In multiple linear regression analysis, the difference in models 1, 2, and 3 was significant, obtaining 0.326, 0.176, and 0.172 (all:
p < 0.001), respectively. In the multiple linear regression analysis stratified according to drinking status, BMI, and age, BLLs were positively associated with serum γGT levels. Regarding the logistic regression analysis, the odds ratio of the third BLL tertile in models 1, 2, and 3 (for having an elevated serum γGT level within the first tertile reference) was 2.74, 1.83, and 1.81, respectively.Conclusions BLL was positively associated with serum γGT levels in male steelworkers even at low lead concentrations (< 5 μg/dL).
- 제철소 남성근로자들의 저농도 납노출이 산화스트레스 지표인 혈청 감마지티에 미치는 건강영향
목적
본 연구의 목적은 일개 제철소에 근무하는 남성 근로자들의 납 노출 수준과 산화스트레스 지표로서의 혈청 감마지티와의 연관성을 확인하는 것이다.
방법
본 연구는 2020년 시행된 근로자 건강검진 자료를 이용하였으며, 총 1,654명의 남성 근로자가 최종 연구대상으로 선정되었다. 일반적 특성, 생활양식 및 직업적 특성을 나타내는 변수를 설정하여 보정하였으며, 혈중납수준과 혈청 감마지티의 연관성을 알아보기 위해 다중선형회귀분석 및 로지스틱회귀분석을 실시하였다. 다중선형회귀분석에서는 자연로그로 변환된 혈중납 및 혈청 감마지티값을, 로지스틱회귀분석에서는 혈중납 3분위수를 이용하였다.
결과
연구대상자의 혈중납 및 혈청 감마지티의 기하평균은 각각 1.36 μg/dL, 27.72 IU/L 이었으며, 혈중납수준은 연령, 체질량지수, 흡연, 음주, 교대근무, 근무기간에 따라 차이가 있었고, 혈청 감마지티는 연령, 체질량지수, 흡연, 음주, 신체활동, 근무기간에 따라 차이를 보였다. 다중선형회귀분석에서는 모형 1,2,3 에서 혈중납수준과 혈청감마티지의 유의미한 연관성을 보여주었으며 (Model 1, β : 0.326, p < 0.001 ;Model 2, β: 0.176, p< 0.001;Model 3, β: 0.172 p< 0.001), 음주상태, 연령, 체질량지수, 음주 및 흡연 통합변수로 층화하여 분석하였을 때에도 혈중납수준과 혈청감마지티의 연관성은 유의하였다. 로지스틱회귀분석은 혈중납 3분위수와 혈청 감마지티 상승위험의 연관성을 보여주었다. (Model 1, OR: 2.74, 95% CI: 1.764.28 ;Model 2, OR: 1.83, 95%CI:1.132.95 ; Model 3, OR 1.81, 95%CI:1.122.92)
결론
일개 제철소 남성근로자를 대상으로 실시된 본 연구는 혈중납 5μg/dL 이하의 저농도 노출수준에서도 혈중납 수준과 혈청 감마지티 수치가 연관성이 있음을 보여준다. -
Citations
Citations to this article as recorded by- Occupational Lead Exposure Among Civilian Indoor Shooting Range Workers in Korea: A Report of Blood Lead Levels and Airborne Lead
Sungjin Park, Jaeyoung Park, Bumjoon Lee, Yi-Ryoung Lee, Jiho Kim, Younmo Cho, Hyeongyeong Choi, Kyeongyeon Kim
Journal of Korean Medical Science.2025;[Epub] CrossRef - The Association Between Blood Lead Levels and Urgency Urinary Incontinence Among Adult Females: A Retrospective Study Based on NHANES 2005–2020
Junwei Wang, Cunming Zhang, Aiwei Zhang
Biological Trace Element Research.2024; 203(7): 3630. CrossRef - The Association Between Blood Lead Levels and Coronary Artery Calcium Score Determined by Using Coronary Computed Tomography Angiography
Eunyoung Park, Suwhan Kim, Seunghyeon Cho, Hyeonjun Kim, Inho Jung, Jai-Dong Moon, Won-Ju Park
Journal of Korean Medical Science.2023;[Epub] CrossRef
- Occupational Lead Exposure Among Civilian Indoor Shooting Range Workers in Korea: A Report of Blood Lead Levels and Airborne Lead
- 1,565 View
- 5 Download
- 3 Web of Science
- 3 Crossref
Research Article
- The effects of exposure to lead, cadmium and mercury on follicle-stimulating hormone levels in men and postmenopausal women: data from the Second Korean National Environmental Health Survey (2012–2014)
- Tae-Woo Lee, Dae Hwan Kim, Ji Young Ryu
- Ann Occup Environ Med 2019;31:e21. Published online August 28, 2019
- DOI: https://doi.org/10.35371/aoem.2019.31.e21
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Abstract
PDF
Background Follicle-stimulating hormone (FSH), a gonadotropin secreted by the pituitary gland, is a representative secondary sex hormone and an important indicator of reproductive function. The effects of heavy metals such as lead, cadmium, and mercury on humans have been studied, but reports on their effects on sex hormone levels are lacking. Therefore, we investigated the relationship between heavy metal exposure and FSH levels in Korean men and postmenopausal women.
Methods A total of 4,689 adults (2,763 men and 1,926 postmenopausal women aged 50 years or over) who participated in the Second Korean National Environmental Health Survey (2012–2014) were included. We compared differences in serum FSH levels by demographic characteristics using the t-test and analysis of variance. Multiple linear regression analysis was used to determine the relationship between the blood levels of lead and mercury and the urine cadmium level, and serum FSH levels.
Results On multiple linear regression analysis, lead exposure was positively associated with serum FSH concentrations in postmenopausal women (β = 2.929,
p = 0.019). However, we found no significant association between serum FSH concentration and blood lead and mercury levels, or urine cadmium level, in men.Conclusions This study suggests that lead exposure can affect the FSH level in postmenopausal women. Further studies are needed to evaluate the effects of low-dose long-term exposure to heavy metals on sex hormones.
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Citations
Citations to this article as recorded by- Effects of Lead Exposure on 1573 Male Workers’ Sex Hormones in China
Ping Wang, Zhiling Wu, Ju Li, Yue Li, Xuefeng Wang, Mengya Ma, Wenkai Wei, Yijun Wang, Yi Liu, Yi Sun, Ling Tao, Yanyan Yang, Ziyuan Zhou, Jingchao Ren, Jia Cao, Guanghui Zhang
Toxics.2025; 13(5): 415. CrossRef - ADAPTIVE REARRANGEMENTS OF STRUCTURAL COMPONENTS IN THE ADULT RATS’ ADENOHYPOPHYSIS AFTER LONG-TERM EXPOSURE TO HEAVY METAL SALTS
N. B. Hryntsova, A. M. Romaniuk, V. I. Bumeister, K. O. Sikora
World of Medicine and Biology.2024; 20(87): 192. CrossRef - Hormonal profile changes under the influence of environmental factors in children residing in the Aral environmental disaster region
Valerii O. Erkudov, Kenzhabek Umar ugli Rozumbetov, Azat T. Matchanov, Andrey P. Pugovkin, Symbat N. Nisanova, Madina A. Kalmuratova, Andrey V. Kochubeev, Sergey S. Rogozin
Pediatrician (St. Petersburg).2024; 14(5): 51. CrossRef - Exposure to heavy metals and hormone levels in midlife women: The Study of Women's Health Across the Nation (SWAN)
Xin Wang, Ning Ding, Siobán D. Harlow, John F. Randolph, Bhramar Mukherjee, Ellen B. Gold, Sung Kyun Park
Environmental Pollution.2023; 317: 120740. CrossRef - Association of Blood Mercury Level with Liver Enzymes in Korean Adults: An Analysis of 2015–2017 Korean National Environmental Health Survey
Jin-Wook Chung, Dilaram Acharya, Jitendra Kumar Singh, Joon Sakong
International Journal of Environmental Research and Public Health.2023; 20(4): 3290. CrossRef - Exposure to endocrine-disrupting metals and serum estrogen levels among US women
Anna Corry Gerald, Srividya Ganapathy, Jianmin Zhu, Yudan Wei
Reproductive Toxicology.2023; 118: 108392. CrossRef - A cross-sectional study of the association between heavy metals and pan-cancers associated with sex hormones in NHANES 1999–2018
Hai-ming Cao, Ya-zhu Yang, Bao-yi Huang, Yunzhe Zhang, Yu Wu, Zi Wan, Lin Ma
Environmental Science and Pollution Research.2023; 30(21): 61005. CrossRef - Exposure to mixed chemicals elevated triiodothyronine (T3) and follicle-stimulating hormone (FSH) levels: epidemiology and in silico toxicogenomic involvement
Hai Duc Nguyen
Environmental Science and Pollution Research.2023; 30(38): 88803. CrossRef - The Association Between Heavy Metals Exposure and Sex Hormones: a Systematic Review on Current Evidence
Yasaman Rami, Karim Ebrahimpour, Mahboobeh Maghami, Bahareh Shoshtari-Yeganeh, Roya Kelishadi
Biological Trace Element Research.2022; 200(8): 3491. CrossRef - Follicle-stimulating hormone and blood lead levels with bone mineral density and the risk of fractures in pre- and postmenopausal women
Huixin Tong, Bo Su, Zhize Liu, Yongjie Chen
Frontiers in Endocrinology.2022;[Epub] CrossRef - Adaptive morphofunctional rearrangements in the adult rats adenohypophysis after long-term exposure of heavy metal salts
Hryntsova Nataliia, Hodorova Ingrid, Romanyuk Anatoly, Kravets Alexander, Rybarova Silvia, Lovasova Kvetuse, Mihalik Josef, Pavliuk-Karachevtseva Andriana, Vecanova Janka, Kolesar Dalibor, Bolekova Andriana, Flesarova Slavka
Acta Medica Martiniana.2022; 22(2): 70. CrossRef - Association between blood cadmium and vitamin D levels in the Yangtze Plain of China in the context of rapid urbanization
Chi Chen, Hao-Jie Zhang, Hua-Ling Zhai, Yi Chen, Bing Han, Qin Li, Fang-Zhen Xia, Ning-Jian Wang, Ying-Li Lu
Chinese Medical Journal.2021; 134(1): 53. CrossRef - Indoor particulate matter and blood heavy metals in housewives: A repeated measured study
Dong-Wook Lee, Jongmin Oh, Shinhee Ye, Youngrin Kwag, Wonho Yang, Yangho Kim, Eunhee Ha
Environmental Research.2021; 197: 111013. CrossRef - Prenatal blood levels of some toxic metals and the risk of spontaneous abortion
Mohsen Vigeh, Masud Yunesian, Takehise Matsukawa, Mansour Shamsipour, Maryam Zare Jeddi, Noushin Rastkari, Mohammad Sadegh Hassanvand, Mamak Shariat, Homa Kashani, Reihaneh Pirjani, Mohammad Effatpanah, Mahboobeh Shirazi, Ghazal Shariatpanahi, Katsumi Oht
Journal of Environmental Health Science and Engineering.2021; 19(1): 357. CrossRef - Independent and combined associations of urinary heavy metals exposure and serum sex hormones among adults in NHANES 2013–2016
Chengzhe Tao, Zhi Li, Yun Fan, Xiuzhu Li, Hong Qian, Hao Yu, Qiaoqiao Xu, Chuncheng Lu
Environmental Pollution.2021; 281: 117097. CrossRef - Effects of Cadmium, Lead, and Mercury on the Structure and Function of Reproductive Organs
Peter Massányi, Martin Massányi, Roberto Madeddu, Robert Stawarz, Norbert Lukáč
Toxics.2020; 8(4): 94. CrossRef
- Effects of Lead Exposure on 1573 Male Workers’ Sex Hormones in China
- 2,249 View
- 4 Download
- 16 Web of Science
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Case Report
- Collective exposure to lead from an approved natural product-derived drug in Korea
- Dae-Young Lim, Won-Yang Kang, Ji-Sung Ahn, Seunghyeon Cho, Suwhan Kim, Jai-Dong Moon, Byung-Chan Lee, Won-Ju Park
- Ann Occup Environ Med 2019;31:e20. Published online August 26, 2019
- DOI: https://doi.org/10.35371/aoem.2019.31.e20
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Abstract
PDF
Background In Asian countries, including Korea, lead poisoning caused by traditional herbal medicines is often observed in the clinic. However, there have been no reports thus far of lead poisoning caused by drugs that were approved by the Korea Food and Drug Administration (KFDA). Here, we describe seven patients who ingested a problematic natural product-derived drug (NPD).
Case presentation In July 2018, seven patients visited a university hospital after ingesting an NPD, S. capsules. These patients complained of various symptoms, and their blood lead levels (BLLs) were elevated relative to those of the general population (arithmetic mean: 19.5 ± 11.6 µg/dL, range: 6.28–35.25 µg/dL). The total doses and BLLs were directly proportional to each other among the patients (
r = 0.943,p = 0.001). After the patients discontinued drug intake, their BLLs decreased gradually. The capsule was confirmed to contain lead above the standard value (arithmetic mean: 2,547 ± 1,821.9 ppm).Conclusion This incident highlights the need to strengthen standards for the management of NPD ingredients in Korea. NPDs are more likely to be contaminated than other drugs. Thorough management by the KFDA is essential to prevent a recurrence. Moreover, systematic health care is needed for many patients who have taken problematic NPDs.
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Citations
Citations to this article as recorded by- Lead and arsenic intoxications by traditional and alternative medicine: men are more sensitive than women
Lucia Gerke, Roland Seifert
Naunyn-Schmiedeberg's Archives of Pharmacology.2025; 398(1): 799. CrossRef - Non-clinical safety evaluation of Mangeum-tang
Sung-min Hwang, Sung-young Jo, Su-yeong Kim, Jun-sub Kim, Hyun-woo Cho, Jong-Hyun Nho
Advances in Traditional Medicine.2025;[Epub] CrossRef - A Case of Severe Lead Poisoning with Basophilic Stippling Teardrop Cell
Wonyang Kang, Seunghyeon Cho, Dae-Young Lim, Suwhan Kim, Won-Ju Park
Journal of Korean Medical Science.2019;[Epub] CrossRef
- Lead and arsenic intoxications by traditional and alternative medicine: men are more sensitive than women
- 1,658 View
- 3 Download
- 3 Web of Science
- 3 Crossref
Research Article
- Environmental exposure of heavy metal (lead and cadmium) and hearing loss: data from the Korea National Health and Nutrition Examination Survey (KNHANES 2010–2013)
- Gu Hyeok Kang, Jun Young Uhm, Young Gon Choi, Eun Kye Kang, Soo Young Kim, Won Oh Choo, Seong Sil Chang
- Ann Occup Environ Med 2018;30:22. Published online April 17, 2018
- DOI: https://doi.org/10.1186/s40557-018-0237-9
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Abstract
PDF
Background Lead and cadmium have been identified as risk factors for hearing loss in animal studies, but large-scale studies targeting the general human population are rare. This study was conducted to investigate the link between heavy metal concentrations in blood and hearing impairment, using a national population-based survey.
Methods The study participants comprised 6409 Koreans aged 20 or older, who were included in the Fifth and Sixth Korea National Health and Nutrition Examination Surveys (KNHANES 2010–2013). Hearing impairment was categorized into two types, low- and high-frequency hearing impairment, using pure tone audiometry. Low-frequency hearing impairment was defined as having a binaural average of hearing thresholds for 0.5, 1, and 2 kHz exceeding 25 dB, and high-frequency hearing impairment was defined as having a binaural average of hearing thresholds for 3, 4, and 6 kHz exceeding 25 dB. The blood levels of heavy metals (lead and cadmium) were classified into quartiles. Cross-sectional association between hearing impairment and the level of heavy metals (lead and cadmium) was examined in both sexes. Multivariate logistic regression was used to obtain adjusted odds ratios (ORs) and 95% confidence intervals (CIs).
Results Among men, the prevalence of low- and high- frequency hearing impairment was 13.9% and 46.7%, respectively, which was higher than the prevalence among women (11.8% and 27.0%, respectively). Regarding lead, the adjusted OR of high-frequency hearing impairment for the highest blood level group versus the lowest group was significant in both men (OR = 1.629, 95% CI = 1.161–2.287) and women (OR = 1.502, 95% CI = 1.027–2.196), after adjusting for age, body mass index, education, smoking, alcohol consumption, exercise, diagnosis of diabetes mellitus, hypertension, and noise exposure (occupational, loud, firearm noises). No links were found between blood lead levels and low-frequency hearing impairment, or between blood cadmium levels and low- or high-frequency hearing impairment in either sex.
Conclusions The present study findings suggest that even exposure to low-level lead is a risk factor for high-frequency hearing loss. A prospective epidemiologic study should be conducted to identify the causal relationship between human health and exposure to heavy metals, and efforts to reduce heavy metal exposure in the general population should continue.
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Citations
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Yi Mi, Pin Sun
Hearing Research.2025; 461: 109252. CrossRef - Industrial air pollution and newborn hearing screening failure
Yanhong Huang, Yan Lin, Roberta P. Lavin, Li Luo, Ming Luo, Shuguang Leng, Netanya M. Mullen, Karen Hawley, Xi Gong
Journal of Hazardous Materials.2025; 492: 138241. CrossRef - Occupational Lead Exposure Ototoxicity Evaluated With Distortion-Product Otoacoustic Emissions
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Ear & Hearing.2024; 45(2): 329. CrossRef - Higher exposure to 1,3-butadiene is associated with more severe hearing loss
Sang-Yoon Han, Sang-Yeon Lee, Myung-Whan Suh, Jun Ho Lee, Moo Kyun Park
Scientific Reports.2024;[Epub] CrossRef - Crafting Strategies for Promoting Healthy Ear and Hearing Care: Making It Happen
Saurabh Ram Shrivastava, Prateek Sudhakar Bobhate, Harshal Gajanan Mendhe, Gulshan R Bandre
Noise and Health.2024; 26(122): 354. CrossRef - Hearing Loss and Disorders: The Repercussions of Climate Change
Sue Sherratt
American Journal of Audiology.2023; 32(4): 793. CrossRef - The role of calcium, Akt and ERK signaling in cadmium-induced hair cell death
Jennifer Galdieri, Chloe Adams, María Padilla, Tamara M. Stawicki
Molecular and Cellular Neuroscience.2023; 124: 103815. CrossRef - Combined effects of multiple metals on hearing loss: A Bayesian kernel machine regression approach
Mingming Liang, Xianwei Guo, Xiuxiu Ding, Qiuxia Song, Hao Wang, Ning Li, Wanying Su, Qiwei Liang, Yehuan Sun
Ecotoxicology and Environmental Safety.2022; 247: 114279. CrossRef - Metformin attenuates cadmium-induced degeneration of spiral ganglion neuron via restoring autophagic flux in primary culture
Qian Li, Liuqian Wang, Di Ji, Wei Yu, Yan Zhang, Yanghong Xiang, Chao Zhou, Liting Wang, Ping Deng, Huifeng Pi, Yonghui Lu, Qinlong Ma, Mindi He, Lei Zhang, Zhengping Yu, Anchun Deng
Journal of Inorganic Biochemistry.2022; 234: 111901. CrossRef - Effects of cadmium and high-fat diet on essential metal concentration in the mouse testis
Bin Zhou, Adrienne Gentry, Qian Xu, Jamie L. Young, Xiaofang Yan, Kelly Pagidas, Yu Yang, Walter H. Watson, Maiying Kong, Lu Cai, Jonathan H. Freedman
Toxicology Reports.2021; 8: 718. CrossRef - Metal Exposures, Noise Exposures, and Audiometry from E-Waste Workers in Agbogbloshie, Ghana
Krystin Carlson, Niladri Basu, Julius N. Fobil, Richard L. Neitzel
International Journal of Environmental Research and Public Health.2021; 18(18): 9639. CrossRef - Mechanotransduction Activity Facilitates Hair Cell Toxicity Caused by the Heavy Metal Cadmium
Caleigh Schmid, Isabella Alampi, Jay Briggs, Kelly Tarcza, Tamara M. Stawicki
Frontiers in Cellular Neuroscience.2020;[Epub] CrossRef - Disruption of essential metal homeostasis in the brain by cadmium and high-fat diet
John C. Mazzocco, Rekha Jagadapillai, Evelyne Gozal, Maiying Kong, Qian Xu, Gregory N. Barnes, Jonathan H. Freedman
Toxicology Reports.2020; 7: 1164. CrossRef - Exposure to lead, mercury, styrene, and toluene and hearing impairment: evaluation of dose-response relationships, regulations, and controls
Ehsan Hemmativaghef
Journal of Occupational and Environmental Hygiene.2020; 17(11-12): 574. CrossRef - Association of Blood Cadmium with Cardiovascular Disease in Korea: From the Korea National Health and Nutrition Examination Survey 2008–2013 and 2016
Jihyun Jeong, Sang-moon Yun, Minkyeong Kim, Young Ho Koh
International Journal of Environmental Research and Public Health.2020; 17(17): 6288. CrossRef - Environmental ototoxicants, a potential new class of chemical stressors
Lucia Fábelová, Christopher A. Loffredo, Jana Klánová, Klára Hilscherová, Milena Horvat, Juraj Tihányi, Denisa Richterová, Ľubica Palkovičová Murínová, Soňa Wimmerová, Renata Sisto, Arturo Moleti, Tomáš Trnovec
Environmental Research.2019; 171: 378. CrossRef - Association between cadmium exposure and hearing impairment: a population-based study in Korean adults
Da Jung Jung
Yeungnam University Journal of Medicine.2019; 36(2): 141. CrossRef
- Machine learning-based prediction of hearing loss: Findings of the US NHANES from 2003 to 2018
- 2,046 View
- 3 Download
- 19 Web of Science
- 17 Crossref
Research Article
- The association between cadmium and lead exposure and blood pressure among workers of a smelting industry: a cross-sectional study
- Hyun Chan An, Joo Hyun Sung, Jiho Lee, Chang Sun Sim, Sang Hoon Kim, Yangho Kim
- Ann Occup Environ Med 2017;29:47. Published online October 4, 2017
- DOI: https://doi.org/10.1186/s40557-017-0202-z
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Abstract
PDF
Background Lead and cadmium are harmful heavy metals that are used for a variety of occupational purposes. Considering their potentially hazardous effects on health, studies on the association between exposure to these two heavy metals and health disorders have been actively conducted. This study aimed to determine the association between blood lead and cadmium levels and blood pressure in workers exposed to lead and cadmium in a smelter.
Methods Nine hundred and sixty-three male workers who worked in a smelter, and underwent medical examinations at the Ulsan University Hospital between January 1 and December 31, 2014, were selected as participants. Among them, 310 subjects whose data on height, weight, blood pressure, fasting blood glucose, lipid profile, and blood lead and cadmium levels were available and who answered the questionnaire were selected as the final participants. We investigated the drinking habit, smoking status, exercise adequacy, and family history of hypertension of these workers using formal questionnaires. A statistical analysis was conducted using Student’s
t -test, analysis of variance, and linear or logistic regression.Results The association between blood lead and cadmium levels and blood pressure was analyzed through statistical adjustment of the risk factors of hypertension. Results showed an association between blood cadmium level and blood pressure elevation. However, blood lead level was found to be not correlated with blood pressure elevation.
Conclusions This study shows the association between blood cadmium level and systolic blood pressure (SBP) and diastolic blood pressure (DBP) elevation.
Trial registration IRB No. 2017–03-037. Retrospectively Registered 30 March 2017.
-
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Citations to this article as recorded by- Sensitivity Analysis for Quantiles of Hidden Biases in Matched Observational Studies
Dongxiao Wu, Xinran Li
Journal of the American Statistical Association.2025; 120(551): 1657. CrossRef - The association between occupational lead exposure and serum levels of vitamin D3 and a bone turnover biomarker in smelter workers
Rateba Said Mohammed, Basma Hussein Mourad
International Archives of Occupational and Environmental Health.2025; 98(3): 297. CrossRef - Occupational Risk Factors for Cardiovascular Disease: A Comprehensive Review
Seung Yeon Jeon, Chan Young Lee, Yun-Hee Lee, Hyojeong Kim, Jiwon Kim, Soo Kyung Cho, Han Soo Noh, Mo-Yeol Kang
Current Cardiology Reports.2025;[Epub] CrossRef - Occupational Exposure to Cadmium and Its Compounds: A Review on Health Effects and Monitoring Techniques
Younes Mehrifar, Hamideh Pirami, Somayeh Farhang Dehghan
Journal of Occupational Health and Epidemiology.2025; 14(2): 133. CrossRef - Analysis of serum lead, copper, iron, and zinc and hematological parameters in battery smelting workers: assessing lead toxicity
Maleeha Sikandar Memon, Ikram Udiin Ujjan, Marvi Shaikh, Sadia Qamar Arain, Arshi Naz, Huma Abbasi
BioMetals.2024; 37(6): 1529. CrossRef - Cadmium induces microcytosis and anisocytosis without anaemia in hypertensive rats
Garsha McCalla, Paul D. Brown, Chukwuemeka Nwokocha
BioMetals.2024; 37(2): 519. CrossRef - The dynamic face of cadmium-induced Carcinogenesis: Mechanisms, emerging trends, and future directions
Mohamed Ali Hussein, Abishek Kamalakkannan, Kamyab Valinezhad, Jhishnuraj Kannan, Nikhila Paleati, Rama Saad, André Kajdacsy-Balla, Gnanasekar Munirathinam
Current Research in Toxicology.2024; 6: 100166. CrossRef - Relationships between blood concentrations of cadmium, lead, mercury, selenium, and manganese and the risk of chronic kidney disease: a cross-sectional study based on NHANES 2011–2018
Shenghua Yao, Dan Xu
Archives of Medical Science.2024;[Epub] CrossRef - Hematological, cardiovascular and oxidative DNA damage markers associated with heavy metal exposure in electronic waste (e-waste) workers of Bangladesh
Sarker Masud Parvez, M Mamun Huda, Mahbubur Rahman, Farjana Jahan, Masatake Fujimura, Shaikh Sharif Hasan, Nirupam Aich, Abul Hares, Zahir Islam, Rubhana Raqib, Luke D Knibbs, Peter D Sly
Toxicology.2024; 509: 153978. CrossRef - Development and validation of an ICP-MS method and its application in assessing heavy metals in whole blood samples among occupationally exposed lead smelting plant workers
Kuldip Upadhyay, Ankit Viramgami, Rakesh Balachandar, Ankit Sheth, P. Sivaperumal
JBIC Journal of Biological Inorganic Chemistry.2024; 29(7-8): 763. CrossRef - Total arsenic, dimethylarsinic acid, lead, cadmium, total mercury, methylmercury and hypertension among Asian populations in the United States: NHANES 2011–2018
Jun Tang, Qinheng Zhu, Yang Xu, Yexinyi Zhou, Longtao Zhu, Lanfei Jin, Weiye Wang, Lan Gao, Guangdi Chen, Hao Zhao
Ecotoxicology and Environmental Safety.2022; 241: 113776. CrossRef - Molecular mechanisms of mechanical function changes of the rat myocardium under subchronic lead exposure
Oksana P. Gerzen, Salavat R. Nabiev, Svetlana V. Klinova, Ilzira A. Minigalieva, Marina P. Sutunkova, Boris A. Katsnelson, Larisa V. Nikitina
Food and Chemical Toxicology.2022; 169: 113444. CrossRef - The effect of blood cadmium levels on hypertension in male firefighters in a metropolitan city
Ye-eun Jeon, Min Ji Kim, Insung Chung, Jea Chul Ha
Annals of Occupational and Environmental Medicine.2022;[Epub] CrossRef - Analysis of lead, cadmium, and arsenic in colored cosmetics marketed in Pakistan
Shazia Abrar, Sadia Javed, Shumaila Kiran, Hushmat Awan
Journal of Public Health Policy.2022; 43(1): 54. CrossRef - Effects of Lead and/or Cadmium on the Contractile Function of the Rat Myocardium Following Subchronic Exposure and Its Attenuation with a Complex of Bioprotectors
SV Klinova, IA Minigalieva, MP Sutunkova, LI Privalova, OP Gerzen, YuV Riabova, YuL Protsenko, AA Balakin, ON Lukin, RV Lisin, SR Nabiev, VG Panov, LB Katsnelson, LV Nikitina, BA Katsnelson
ЗДОРОВЬЕ НАСЕЛЕНИЯ И СРЕДА ОБИТАНИЯ - ЗНиСО / PUBLIC HEALTH AND LIFE ENVIRONMENT.2021; : 25. CrossRef - Effect of Heavy Metals caused by E-waste Activities on Soil Samples, PM2.5, Human Fingernails, and Scalp Hair in Moradabad City, India
Anju Chauhan, Ranjana Choudhari, Atul Kumar, Bhopal Singh, Anamika Tripathi
Journal of Ecophysiology and Occupational Health.2021; : 96. CrossRef - Association between heavy metals, high-sensitivity C-reaction protein and 10-year risk of cardiovascular diseases among adult Korean population
Hai Duc Nguyen, Hojin Oh, Ngoc Hong Minh Hoang, Min-Sun Kim
Scientific Reports.2021;[Epub] CrossRef - Does Exposure of Lead and Cadmium Affect the Endometriosis?
Min-Gi Kim, Young-Sun Min, Yeon-Soon Ahn
International Journal of Environmental Research and Public Health.2021; 18(17): 9077. CrossRef - Biomass of the macrophyte remedies and detoxifies Cd(II) and Pb(II) in aqueous solution
Franciele de Freitas, Suzana Junges Vendruscolo, Marcos Antônio Soares, Leandro Dênis Battirola, Ricardo Lopes Tortorela de Andrade
Environmental Monitoring and Assessment.2021;[Epub] CrossRef - A review of potentially harmful chemicals in crumb rubber used in synthetic football pitches
Filipa O. Gomes, M. Rosário Rocha, Arminda Alves, Nuno Ratola
Journal of Hazardous Materials.2021; 409: 124998. CrossRef - The Aging Kidney—As Influenced by Heavy Metal Exposure and Selenium Supplementation
Jan Aaseth, Jan Alexander, Urban Alehagen, Alexey Tinkov, Anatoly Skalny, Anders Larsson, Guido Crisponi, Valeria Marina Nurchi
Biomolecules.2021; 11(8): 1078. CrossRef - Effects of heavy metals on hypertension during menopause: a Korean community-based cross-sectional study
Hai Duc Nguyen, Hojin Oh, Min-Sun Kim
Menopause.2021; 28(12): 1400. CrossRef - Joint Effect of Alcohol Drinking and Environmental Cadmium Exposure on Hypertension in Korean Adults: Analysis of Data from the Korea National Health and Nutrition Examination Survey, 2008 to 2013
Yun‐Hee Choi, Da‐An Huh, Kyong Whan Moon
Alcoholism: Clinical and Experimental Research.2021; 45(3): 548. CrossRef - Prevalence of current and former smoking in industrial workers worldwide: a systematic review and meta-analysis
Sohrab Amiri, Seyed Morteza Hosseini
Journal of Addictive Diseases.2021; 39(3): 288. CrossRef - Assessement of Blood Lead and Cadmium Levels in Occupationally Exposed Workers of Jodhpur, Rajasthan
Taru Goyal, Prasenjit Mitra, Preeti Singh, Shailja Sharma, Praveen Sharma
Indian Journal of Clinical Biochemistry.2021; 36(1): 100. CrossRef - Exposure to multiple metals and the risk of hypertension in adults: A prospective cohort study in a local area on the Yangtze River, China
Qi Zhong, Hua-bing Wu, Qin-shan Niu, Ping-ping Jia, Qi-rong Qin, Xiao-dong Wang, Jia-liu He, Wan-jun Yang, Fen Huang
Environment International.2021; 153: 106538. CrossRef - Acute oral toxicity assessment of ethanolic extracts of Antidesma bunius (L.) Spreng fruits in mice
Maria Nilda M. Muñoz, Urdujah G. Alvarado, Jerica Isabel L. Reyes, Kozo Watanabe
Toxicology Reports.2021; 8: 1289. CrossRef - Late-life Cardiac Injury in Rats following Early Life Exposure to Lead: Reversal Effect of Nutrient Metal Mixture
Chand Basha Davuljigari, Rajarami Reddy Gottipolu
Cardiovascular Toxicology.2020; 20(3): 249. CrossRef - Genotoxic Effect of Lead and Cadmium on Workers at Wastewater Plant in Iraq
Salih Ibrahem, Muna Hassan, Qais Ibraheem, Khalid Arif
Journal of Environmental and Public Health.2020; 2020: 1. CrossRef - Association Between Blood Lead Level and Uncontrolled Hypertension in the US Population (NHANES 1999–2016)
Hui Miao, Yan Liu, Thomas C. Tsai, Joel Schwartz, John S. Ji
Journal of the American Heart Association.2020;[Epub] CrossRef - Cadmium-induced endothelial dysfunction mediated by asymmetric dimethylarginine
Hamda A. Al-Naemi, Sandra Concepcion Das
Environmental Science and Pollution Research.2020; 27(14): 16246. CrossRef - Biomarkers of Exposure among USA Adult Hookah Users: Results from Wave 1 of the Population Assessment of Tobacco and Health (PATH) Study (2013–2014)
Mark J. Travers, Cheryl Rivard, Eva Sharma, Sandra Retzky, Berran Yucesoy, Maciej L. Goniewicz, Cassandra A. Stanton, Jiping Chen, Priscilla Callahan-Lyon, Heather L. Kimmel, Baoyun Xia, Yuesong Wang, Connie S. Sosnoff, Víctor R. De Jesús, Benjamin C. Blo
International Journal of Environmental Research and Public Health.2020; 17(17): 6403. CrossRef - Lead and kidney: Concentrations, variabilities, and associations across the various stages of glomerular function
Ram B. Jain
Journal of Trace Elements in Medicine and Biology.2019; 54: 36. CrossRef - Urinary Metal Concentrations and the Incidence of Hypertension Among Adult Residents Along the Yangtze River, China
Qi Zhong, Chun-xiao Jiang, Chi Zhang, Qian Zhang, Qi-rong Qin, Xiao-dong Wang, Fen Huang
Archives of Environmental Contamination and Toxicology.2019; 77(4): 490. CrossRef - The modifying effect of kidney function on the association of cadmium exposure with blood pressure and cardiovascular mortality: NHANES 1999–2010
Yi Gao, Xiangzhu Zhu, Martha J. Shrubsole, Lei Fan, Zhaolin Xia, Raymond C. Harris, Lifang Hou, Qi Dai
Toxicology and Applied Pharmacology.2018; 353: 15. CrossRef - Reduction in Prevalence of Hypertension and Blood Heavy Metals among Curry-Consumed Korean
Jo-Woong Choi, Chorong Oh, Sun-Yup Shim, Suyoun Jeong, Hyung Sik Kim, Min-Sun Kim
The Tohoku Journal of Experimental Medicine.2018; 244(3): 219. CrossRef
- Sensitivity Analysis for Quantiles of Hidden Biases in Matched Observational Studies
- 2,114 View
- 3 Download
- 34 Web of Science
- 36 Crossref
Research Article
- Levels of blood lead and urinary cadmium in industrial complex residents in Ulsan
- Sang Hoon Kim, Yang Ho Kim, Hyun Chan An, Joo Hyun Sung, Chang Sun Sim
- Ann Occup Environ Med 2017;29:26. Published online June 26, 2017
- DOI: https://doi.org/10.1186/s40557-017-0179-7
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Abstract
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Background Populations neighboring industrial complexes are at an increased health risk, due to constant exposure to various potentially hazardous compounds released during industrial production activity. Although there are many previous studies that focus on occupational exposure to heavy metals, studies that focused on environmental exposure to lead and cadmium are relatively rare. The purpose of this study is to evaluate the extent of the environmental exposure of heavy metals in residents of industrial area.
Methods Four areas in close proximity to the Ulsan petrochemical industrial complex and the Onsan national industrial complex were selected to be included in the exposure group, and an area remotely located from these industrial complexes was selected as the non-exposure group. Among the residents of our study areas, a total of 1573 subjects aged 20 years and older were selected and all study subjects completed a written questionnaire. Blood and urine samples were obtained from about one third of the subjects (465 subjects) who provided informed consent for biological sample collection. Total 429 subjects (320 subjects from exposure area, 109 subjects from non-exposure area) were included in final analysis.
Results The geometric mean blood lead level among the subjects in the exposed group was 2.449 μg/dL, which was significantly higher than the non-exposure group’s level of 2.172 μg/dL. Similarly, the geometric mean urine cadmium levels between the two groups differed significantly, at 1.077 μg/g Cr. for the exposed group, and 0.709 μg/g Cr. for the non-exposure group.
In a multiple linear regression analysis to determine the relationship between blood lead level and related factors, the results showed that blood lead level had a significant positive correlation with age, the male, exposure area, and non-drinkers. In the same way, urine cadmium level was positively correlated with age, the female, exposure area, and smokers.
Conclusions This study found that blood lead levels and urine cadmium levels were significantly higher among the residents of industrial areas than among the non-exposure area residents, which is thought to be due to the difference in environmental exposure of lead and cadmium. Furthermore, it was clear that at a low level of exposure, differences in blood lead or urine cadmium levels based on age, gender, and smoking status were greater than the differences based on area of residence. Therefore, when evaluating heavy metal levels in the body at a low level of exposure, age, gender, and smoking status must be adjusted, as they are significant confounding factors.
-
Citations
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Environmental Research Letters.2024; 19(11): 114020. CrossRef - Environmental pollution by xenobiotics as a risk factor for the development of reproductive complications in the population of the industrial region
T.A. Holovkova
Hygiene of Populated Places.2024; 2024(74): 162. CrossRef - Investigating Blood Lead Levels and Its Health Effects on Employees of a Petroleum Industry and the Surrounding Residents
Luay M. Mohammad, Manoochehr Karami, Yadollah Mehrabi, Seyed Saeed Hashemi Nazari, Somayeh Farhang Dehghan, Hasan A. Baiee, Mohammed Rafiee
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Journal of Radiation Research and Applied Sciences.2023; 16(2): 100553. CrossRef - Urinary concentrations of heavy metals in pregnant women living near a petrochemical area according to the industrial activity
Xiruo Kou, Lucía Iglesias-Vázquez, Martí Nadal, Josep Basora, Victoria Arija
Environmental Research.2023; 235: 116677. CrossRef - The Protection of Zinc against Acute Cadmium Exposure: A Morphological and Molecular Study on a BBB In Vitro Model
Jacopo J. V. Branca, Donatello Carrino, Ferdinando Paternostro, Gabriele Morucci, Claudia Fiorillo, Claudio Nicoletti, Massimo Gulisano, Carla Ghelardini, Lorenzo Di Cesare Mannelli, Matteo Becatti, Alessandra Pacini
Cells.2022; 11(10): 1646. CrossRef - Relationship between renal function and metal exposure of residents living near the No. 6 Naphtha Cracking Complex: A cross-sectional study
Tzu-Hsuen Yuan, Ming-Jie Jhuang, Yen-Po Yeh, Yi-Hsuan Chen, Sasha Lu, Chang-Chuan Chan
Journal of the Formosan Medical Association.2021; 120(10): 1845. CrossRef - Blood lead level and Helicobacter pylori infection in a healthy population: A cross-sectional study
Won-Ju Park, Soo-Hyeon Kim, WonYang Kang, Ji-Sung Ahn, Seunghyeon Cho, Dae-Young Lim, Suwhan Kim, Jai-Dong Moon
Archives of Environmental & Occupational Health.2020; 75(6): 333. CrossRef - Lead and kidney: Concentrations, variabilities, and associations across the various stages of glomerular function
Ram B. Jain
Journal of Trace Elements in Medicine and Biology.2019; 54: 36. CrossRef - Human Blood Lead Levels and the First Evidence of Environmental Exposure to Industrial Pollutants in the Amazon
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International Journal of Environmental Research and Public Health.2019; 16(17): 3047. CrossRef - A study on the concentration of biomarkers for heavy metals and VOCs in the residents living in the vicinity of Gwangyang Industrial Complex in Korea
Kyoungho Lee, Seokwon Lee, Ryoungme Ahn, Jae Hyoun Kim, Bu-Soon Son
Journal of Odor and Indoor Environment.2019; 18(3): 228. CrossRef - Risk assessment of lead and cadmium exposure from electronic waste recycling facilities in Southern Thailand
Peeranart Kiddee, Somsiri Decharat
Environmental Earth Sciences.2018;[Epub] CrossRef - Comparison of a 10-Year Cumulative Age-Standardized Incidence Rate of Lung Cancer among Metropolitan Cities in Korea (During the 2000–2009 Period): Review of Occupational and Environmental Hazards Associated with Lung Cancer
Joo Hyun Sung, Chang Sun Sim, Minsu Ock, Inbo Oh, Kyoung Sook Jeong, Cheolin Yoo
International Journal of Environmental Research and Public Health.2018; 15(6): 1259. CrossRef - Environmental and Body Concentrations of Heavy Metals at Sites Near and Distant from Industrial Complexes in Ulsan, Korea
Joo Hyun Sung, Inbo Oh, Ahra Kim, Jiho Lee, Chang Sun Sim, Cheolin Yoo, Sang Jin Park, Geun-Bae Kim, Yangho Kim
Journal of Korean Medical Science.2018;[Epub] CrossRef
- Heavy metals and ocular toxicity: Breakthroughs in accumulation mechanisms, molecular pathways, and cutting-edge therapeutic strategies
- 1,267 View
- 2 Download
- 18 Web of Science
- 16 Crossref
Review
- Evaluation and management of lead exposure
- Hwan-Cheol Kim, Tae-Won Jang, Hong-Jae Chae, Won-Jun Choi, Mi-Na Ha, Byeong-Jin Ye, Byoung-Gwon Kim, Man-Joong Jeon, Se-Yeong Kim, Young-Seoub Hong
- Ann Occup Environ Med 2015;27:30. Published online December 15, 2015
- DOI: https://doi.org/10.1186/s40557-015-0085-9
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Abstract
PDF
Lead, which is widely used in industry, is a common element found in low concentrations in the Earth’s crust. Implementations to reduce environmental lead concentrations have resulted in a considerable reduction of lead levels in the environment (air) and a sustained reduction in the blood lead levels of the average citizen. However, people are still being exposed to lead through a variety of routes in everyday commodities.
Lead causes health problems such as toxicity of the liver, kidneys, hematopoietic system, and nervous system. Having a carcinogenic risk as well, the IARC classifies inorganic lead compounds as probably carcinogenic to humans (Group 2A). Occupational lead poisonings have decreased due to the efforts to reduce the lead concentrations in the working environment. In contrast, health hazards associated with long-term environmental exposure to low concentrations of lead have been reported steadily. In particular, chronic exposure to low concentrations of lead has been reported to induce cognitive behavioral disturbances in children.
It is almost impossible to remove lead completely from the human body, and it is not easy to treat health hazards due to lead exposure. Therefore, reduction and prevention of lead exposure are very important. We reviewed the toxicity and health hazards, monitoring and evaluation, and management of lead exposure.
-
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Yasar N Kavil, Hassan Alshemmari, Mohammed M Alkasbi, Saeed Saad Alelyani, Mohammed I Orif, Radwan Kh Al-Farawati
Journal of Hazardous Materials Advances.2025; 17: 100610. CrossRef - Heavy Metal Accumulation and Nutrient Composition in Erpetoichthys calabaricus: Environmental and Human Health Implications
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Sungjin Park, Jaeyoung Park, Bumjoon Lee, Yi-Ryoung Lee, Jiho Kim, Younmo Cho, Hyeongyeong Choi, Kyeongyeon Kim
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Khaled A. Osman, Hala H. Elsayed Mohamed, Maher S. Salama
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Science Progress.2025;[Epub] CrossRef - Review on the validity of heavy metal safety standards in children’s activity zones
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Journal of Odor and Indoor Environment.2025; 24(2): 113. CrossRef - TiO2@PLDOPA@Fe3O4 Nanokompozitinin Kurşun Adsorpsiyonunda Kullanımı ve PLDOPA Film Kalınlığının Adsorpsiyon Üzerine Etkisi
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Karadeniz Fen Bilimleri Dergisi.2025; 15(3): 1027. CrossRef - Smoking and the risk of prostate cancer: a review of risk and disease progression
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Deus R. Rutehenda, Christopher Adaku, Timothy Omara, Christopher Angiro, Emmanuel Ntambi
World.2024; 5(1): 136. CrossRef - Efficacy of outer membrane permeabilization in promoting aromatic isothiocyanates-mediated eradication of multidrug resistant Gram-negative bacteria and bacterial persisters
Chung-Cheng Lo, Tzu-Hui Yeh, Ya-Hsuan Jao, Tzu-Hui Wang, Horng-Ren Lo
Folia Microbiologica.2024; 69(5): 993. CrossRef - Allium sativum Essential Oil Supplementation Reverses the Hepatic Inflammation, Genotoxicity and Apoptotic Effects in Swiss Albino Mice Intoxicated with the Lead Nitrate
Kusum Sharma, Veena Sharma
Biological Trace Element Research.2024; 202(7): 3258. CrossRef - Sm2O3 micron plates/B4C/HDPE composites containing high specific surface area fillers for neutron and gamma-ray complex radiation shielding
Zhipeng Huo, Yidong Lu, Hong Zhang, Guoqiang Zhong
Composites Science and Technology.2024; 251: 110567. CrossRef - 5,7-dihydroxy-3′,4′,5′-trimethoxyflavone mitigates lead induced neurotoxicity in rats via its chelating, antioxidant, anti-inflammatory and monoaminergic properties
Varinder Singh, Richa Shri, Parul Sood, Manjinder Singh, Thakur Gurjeet Singh, Ravinder Singh, Amit Kumar, Sheikh F. Ahmad
Food and Chemical Toxicology.2024; 189: 114747. CrossRef - Exposure and Health Risks Posed by Potentially Toxic Elements in Soils of Metal Fabrication Workshops in Mbarara City, Uganda
Eunice Nuwamanya, Denis Byamugisha, Caroline K. Nakiguli, Christopher Angiro, Alice V. Khanakwa, Timothy Omara, Simon Ocakacon, Patrick Onen, Daniel Omoding, Boniface Opio, Daniel Nimusiima, Emmanuel Ntambi
Journal of Xenobiotics.2024; 14(1): 176. CrossRef - 3-hydroxy-3′,4′,5′-trimethoxyflavone protects rats against lead-induced neurotoxicity via chelation and modulating oxidative stress, inflammatory and monoaminergic systems
Varinder Singh, Richa Shri, Parul Sood, Manjinder Singh, Thakur Gurjeet Singh, Ravinder Singh, Amarjot Kaur, Amit Kumar, Tanveer Singh, Sheikh F. Ahmad, Sabry M. Attia
Journal of Functional Foods.2024; 118: 106278. CrossRef - Utilization of magnetite-supported coal fly ash as an efficient adsorbent for Pb metal removal in aqueous environments
Nurmaya Arofah, Annisa Naila Izzati, Yusraini Dian Inayati Siregar, Yulyani Nur Azizah, Agus Rimus Liandi
Case Studies in Chemical and Environmental Engineering.2024; 10: 100883. CrossRef - Biochemical study of the effect of lead exposure in nonobese gasoline station workers and risk of hyperglycemia: A retrospective case-control study
Ahmad Tarik Numan, Nada Kadum Jawad, Hayder Adnan Fawzi
Medicine.2024; 103(32): e39152. CrossRef - Polydatin as a potential candidate that alleviates lead poisoning: insights from biochemical and oxidative damage in lead-induced Wistar rats
Salisu M. Highab, Jamilu Ya’u, Muhammad G. Magaji, Dalhatu M. Shehu
Advances in Traditional Medicine.2024; 24(1): 211. CrossRef - Comprehensive review on toxic heavy metals in the aquatic system: sources, identification, treatment strategies, and health risk assessment
Panchamoorthy Saravanan, V. Saravanan, R. Rajeshkannan, G. Arnica, M. Rajasimman, Gurunathan Baskar, Arivalagan Pugazhendhi
Environmental Research.2024; 258: 119440. CrossRef - Halide Perovskites’ Multifunctional Properties: Coordination Engineering, Coordination Chemistry, Electronic Interactions and Energy Applications beyond Photovoltaics
Taame Abraha Berhe, Wei-Nien Su, Bing Joe Hwang
Inorganics.2024; 12(7): 182. CrossRef - Awareness Level About Lead Poisoning Among the Saudi Population in Arar City, Saudi Arabia: A Cross-Sectional Study
Ekramy Elmorsy, Rawwabi Satam R Alshammari, Rashed Satam B Alshammari, Rasha Mohammed M Alanazi, Nirah Mohammed M Alanazi
Cureus.2024;[Epub] CrossRef - Unveiling the lead exposure attributed burden in Iran from 1990 to 2019 through the lens of the Global Burden of Disease study 2019
Hanie Karimi, Sara Mahdavi, Sahar Saeedi Moghaddam, Mohsen Abbasi-Kangevari, Zahra Soleimani, Zahra Esfahani, Masoud Masinaei, Sahar Mohammadi Fateh, Ali Golestani, Arezou Dilmaghani-Marand, Farzad Kompani, Negar Rezaei, Erfan Ghasemi, Bagher Larijani, Fa
Scientific Reports.2024;[Epub] CrossRef - Evaluation of the X-ray Shielding Ability of Lead Free Board Shielding in the CT Room
Sung-Joon Kim, Tae-Ho Han, Hyo-Won Lee, Yu-Whan Oh, Seung-Chul Kim, Jung-Min Kim
Journal of Radiological Science and Technology.2024; 47(4): 249. CrossRef -
Nostoc commune Vauch. polysaccharide alleviates Pb-induced hepatorenal toxicity by changing gut bacteriome, mycobiome, and metabolome
Yue Liu, Ping Ren, Hailong Li, Yingying Liu, Yiting Yang, Wanting Wang, Jiaming Zhou, Ling Su, Lili Guan, Hongxia Ma
Food Science and Human Wellness.2024; 13(6): 3482. CrossRef - Association between Polymorphisms of Hemochromatosis (HFE), Blood Lead (Pb) Levels, and DNA Oxidative Damage in Battery Workers
Willian Gomes, Paula Devóz, Bruno Rocha, Denise Grotto, Juliana Serpeloni, Bruno Batista, Alexandros Asimakopoulos, Kurunthachalam Kannan, Fernando Barbosa Jr., Gustavo Barcelos
International Journal of Environmental Research and Public Health.2023; 20(4): 3513. CrossRef - Contamination and health risks of trace metals in water and sediments of May Sieley stream, Ethiopia
Elias Habineza, Rodgers Makwinja, Yoshihiko Inagaki
Physics and Chemistry of the Earth, Parts A/B/C.2023; 129: 103315. CrossRef - Lead induces mouse skin fibroblast apoptosis by disrupting intracellular homeostasis
Hui Wang, Huinuan Wang, Jiawen Guan, Weijun Guan, Zheng Liu
Scientific Reports.2023;[Epub] CrossRef - Assessment of heavy metal contamination in street dust: concentrations, bioaccessibility, and human health risks in coal mine and thermal power plant complex
Mala Kumari, Abhishek Kumar, Tanushree Bhattacharya
Environmental Geochemistry and Health.2023; 45(10): 7339. CrossRef - Severe Abdominal Pain as a Presentation of Lead Poisoning: A Case Presentation
Wei Ge, Li-Hua Shao, Hai-Yan Gong, Gang Chen
International Medical Case Reports Journal.2023; Volume 16: 245. CrossRef - The toxic effect of lead on human health
Gopal Chandra Mandal, Arpita Mandal, Arya Chakraborty
Human Biology and Public Health.2023;[Epub] CrossRef - Health Risks from Intake and Contact with Toxic Metal-Contaminated Water from Pager River, Uganda
Patrick Onen, Robin Akemkwene, Caroline K. Nakiguli, Daniel Nimusiima, Daniel Hendry Ruma, Alice V. Khanakwa, Christopher Angiro, Gadson Bamanya, Boniface Opio, Allan Gonzaga, Timothy Omara
Journal of Xenobiotics.2023; 13(4): 544. CrossRef - A state-of-the-science review and guide for measuring environmental exposure biomarkers in dried blood spots
Tyler A. Jacobson, Jasdeep S. Kler, Yeunook Bae, Jiexi Chen, Daniel T. Ladror, Ramsunder Iyer, Denise A. Nunes, Nathan D. Montgomery, Joachim D. Pleil, William E. Funk
Journal of Exposure Science & Environmental Epidemiology.2023; 33(4): 505. CrossRef - Synergistic action of indole-3-carbinol with membrane-active agents against multidrug-resistant Gram-negative bacteria
Tso-Ping Wang, Tzu-Hui Yeh, Chung-Cheng Lo, Kuan-Hua Lin, Mei-Han Huang, Horng-Ren Lo
Letters in Applied Microbiology.2023;[Epub] CrossRef - Evaluation the Effect of Serum Lead Levels on Thyroid Function in Battery Industry Workers
Farzaneh Rahimpour, Orang Abdollahi, Ehsan Rafeemanesh, Shabnam Niroumand
Indian Journal of Occupational and Environmental Medicine.2023; 27(2): 120. CrossRef - Enriched stable 204Pb as tracer at ultra-low levels in clinical investigations
Johanna Irrgeher, Thomas Berger, Anastassiya Tchaikovsky, Cornelius Tschegg, Ghazaleh Gouya, Peter Lechner, Anika Retzmann, Christine Opper, Christa Firbas, Michael Freissmuth, Kerstin Peschel-Credner, Karolina Anderle, Claudia Meisslitzer, Michael Wolzt,
Analytical and Bioanalytical Chemistry.2023; 415(2): 255. CrossRef - Analysis of blood lead level and its clinical significance among occupational exposed painters in chennai based population: A cross sectional study
Ragunanthanan S, Govardhini Vaiyakkani, Senthil kumar S, Arunkumar Ramachandran, Karthick Rajendran, Narayanasamy Krishnasamy, Priyadarshini Panneerselvam, Jayakrishna Pamarthi, Muthukumaran Rajaram
Journal of Trace Elements in Medicine and Biology.2023; 79: 127257. CrossRef - Combating lead and cadmium exposure with an orally administered chitosan-based chelating polymer
Jordyn Ann Howard, Halyna Kuznietsova, Natalia Dziubenko, Axel Aigle, Marco Natuzzi, Eloise Thomas, Vladimir Lysenko, Laurent David, Thomas Brichart, François Lux, Olivier Tillement
Scientific Reports.2023;[Epub] CrossRef - Lead Leakage of Pb-Based Perovskite Solar Cells
Kai Ma, Xiaofang Li, Feng Yang, Hairui Liu
Coatings.2023; 13(6): 1009. CrossRef - Succimer chelation does not produce lasting reductions of blood lead levels in a rodent model of retained lead fragments
Shannon M. Twardy, Sarah M. Hanson, Thomas Jursa, Joanna M. Gaitens, John M. Kalinich, Melissa A. McDiarmid, Don R. Smith
Environmental Toxicology and Pharmacology.2023; 104: 104283. CrossRef - Sustainable Pb Management in Perovskite Solar Cells toward Eco‐Friendly Development
Huaiqing Luo, Pengwei Li, Junjie Ma, Liyuan Han, Yiqiang Zhang, Yanlin Song
Advanced Energy Materials.2022;[Epub] CrossRef - Heavy Metal Contamination of Sediments from an Exoreic African Great Lakes’ Shores (Port Bell, Lake Victoria), Uganda
Gabson Baguma, Andrew Musasizi, Hannington Twinomuhwezi, Allan Gonzaga, Caroline K. Nakiguli, Patrick Onen, Christopher Angiro, Augastine Okwir, Boniface Opio, Thomas Otema, Daniel Ocira, Ivan Byaruhanga, Eric Nirigiyimana, Timothy Omara
Pollutants.2022; 2(4): 407. CrossRef - Mask Protection Against Lead Exposure and Its Correlation with Erythropoiesis in Automotive Body Painters at Ligu District, Semarang, Indonesia
Budi Santosa, Ali Rosidi, Herlisa Anggraini, Zahra Maharani Latrobdiba, Fitriani Nur Damayanti, Heru Santoso Wahito Nugroho
Journal of Blood Medicine.2022; Volume 13: 113. CrossRef - Lactobacillus plantarum WSJ-06 alleviates neurobehavioral injury induced by lead in mice through the gut microbiota
Yunting Li, Anfei Liu, Lixuan Chen, Yang Xiang, Dingbang Huang, Wanwen Huang, Zhenhui Chen, Hongying Fan, Xiaojing Meng
Food and Chemical Toxicology.2022; 167: 113308. CrossRef - Association of blood lead level with vitamin D binding protein, total and free 25-hydroxyvitamin D levels in middle-school children
Abdur Rahman, Reem Al-Sabah, Reem Jallad, Muddanna S. Rao
British Journal of Nutrition.2022; 127(7): 982. CrossRef - In Situ Measurements of Domestic Water Quality and Health Risks by Elevated Concentration of Heavy Metals and Metalloids Using Monte Carlo and MLGI Methods
Delia B. Senoro, Kevin Lawrence M. de Jesus, Ronnel C. Nolos, Ma. Rowela L. Lamac, Khainah M. Deseo, Carlito B. Tabelin
Toxics.2022; 10(7): 342. CrossRef - A Physiological behavior and tolerance of Lactuca sativa to lead nitrate and silver nitrate heavy metals
J. D. O. Santos, E.S. Silva, P. Silva, M. A. C. Silva, L. A. Santos, A. F. Santos, T. J. Matos-Rocha, J. M. S. J. Pavão
Brazilian Journal of Biology.2022;[Epub] CrossRef - Post-mortem blood lead analysis; a comparison between LeadCare II and graphite furnace atomic absorption spectrometry analysis results
Nasibeh Hassanpour, Nasim Zamani, Maryam Akhgari, Amir Salimi, Hedieh Ahangar, Scott Phillips, Mohammadjavad Hedayatshodeh, Hossein Hassanian-Moghaddam
Journal of Forensic and Legal Medicine.2022; 86: 102317. CrossRef - Trends in global burden of diseases attributable to lead exposure in 204 countries and territories from 1990 to 2019
Nan Zhou, Yue Huang, Mingma Li, Lu Zhou, Hui Jin
Frontiers in Public Health.2022;[Epub] CrossRef - Hesperidin and hesperetin against heavy metal toxicity: Insight on the molecular mechanism of mitigation
Ademola C. Famurewa, Kaviyarasi Renu, Mohamed Ahmed Eladl, Rituraj Chakraborty, Haritha Myakala, Mohamed El-Sherbiny, Dalia Mahmoud Abdelmonem Elsherbini, Balachandar Vellingiri, Harishkumar Madhyastha, Uddesh Ramesh Wanjari, Anirban Goutam Mukherjee, Abi
Biomedicine & Pharmacotherapy.2022; 149: 112914. CrossRef - Children's exposure to environmental lead: A review of potential sources, blood levels, and methods used to reduce exposure
Benjamin F. Swaringen, Emory Gawlik, George D. Kamenov, Nancy E. McTigue, David A. Cornwell, Jean-Claude J. Bonzongo
Environmental Research.2022; 204: 112025. CrossRef - Protective Effect of Chlorogenic Acid and Its Analogues on Lead-Induced Developmental Neurotoxicity Through Modulating Oxidative Stress and Autophagy
Xiuna Ji, Baokun Wang, Yam Nath Paudel, Zhihui Li, Shanshan Zhang, Lei Mou, Kechun Liu, Meng Jin
Frontiers in Molecular Biosciences.2021;[Epub] CrossRef - Heavy Metals in Indian Traditional Systems of Medicine: A Systematic Scoping Review and Recommendations for Integrative Medicine Practice
Sanchari Mukhopadhyay, Shalu Elizabeth Abraham, Bharath Holla, Kishore Kr Ramakrishna, Kamala Lakshmi Gopalakrishna, Akhila Soman, Umesh C. Chikkanna, Muchukunte Mukunda Srinivas Bharath, Hemant Bhargav, Shivarama Varambally, Bangalore Nanjundaiah Gangadh
The Journal of Alternative and Complementary Medicine.2021; 27(11): 915. CrossRef - Lead Exposure Influences Serum Biomarkers, Hepatocyte Survival, Bone Marrow Hematopoiesis, and the Reproductive Cycle in Japanese Quails
Damir Suljević, Nejira Handžić, Muhamed Fočak, Ivan Lasić, Faris Sipović, Jasmina Sulejmanović, Sabina Begić, Andi Alijagic
Biological Trace Element Research.2021; 199(4): 1574. CrossRef - Induction of cellular senescence as a late effect and BDNF-TrkB signaling-mediated ameliorating effect on disruption of hippocampal neurogenesis after developmental exposure to lead acetate in rats
Risako Yamashita, Yasunori Takahashi, Kazumi Takashima, Hiromu Okano, Ryota Ojiro, Qian Tang, Satomi Kikuchi, Mio Kobayashi, Bunichiro Ogawa, Meilan Jin, Reiji Kubota, Yoshiaki Ikarashi, Toshinori Yoshida, Makoto Shibutani
Toxicology.2021; 456: 152782. CrossRef - The impact of elevated blood lead levels in children on maternal health-related quality of life
Hokuto Nakata, Harukazu Tohyama, Wakako Fujita, Shouta M.M. Nakayama, Mayumi Ishizuka, John Yabe, Nosiku S. Munyinda, Doreen Sakala, Kennedy Choongo, Shojiro Yamasaki, Natsumi Nagai, Takahiko Yoshida, Takeshi Saito
Chemosphere.2021; 279: 130490. CrossRef - Reproductive and embryological toxicity of lead acetate in male mice and their offspring and mitigation effects of quercetin
Parisa Dolati, Mohammad Javad Zamiri, Amir Akhlaghi, Zahra Khodabandeh, Davood Mehrabani, Hadi Atashi, Iman Jamhiri
Journal of Trace Elements in Medicine and Biology.2021; 67: 126793. CrossRef - Adult Lead Poisoning Caused by Contaminated Opium: A Two-Year Longitudinal Follow-Up Study
Malihe-Sadat Hosseini, Amir Salimi, Scott Phillips, Nasim Zamani, Hossein Hassanian-Moghaddam
Annals of Global Health.2021;[Epub] CrossRef - Geospatial Distributions of Lead Levels Found in Human Hair and Preterm Birth in San Francisco Neighborhoods
Chinomnso N. Okorie, Marilyn D. Thomas, Rebecca M. Méndez, Erendira C. Di Giuseppe, Nina S. Roberts, Leticia Márquez-Magaña
International Journal of Environmental Research and Public Health.2021; 19(1): 86. CrossRef - Is release of rehabilitated wildlife with embedded lead ammunition advisable? Plumbism in a Jaguar Panthera Onca (Mammalia: Carnivora: Felidae), survivor of gunshot wounds
Eduardo A. Díaz, Carolina Sáenz, E. Santiago Jiménez, David A. Egas, Kelly Swing
Journal of Threatened Taxa.2021; 13(12): 19808. CrossRef - Lead Encephalopathy with Distinctive Brain Magnetic Resonance Imaging Findings
Ameya Patwardhan, Nalini Atchayaram, Jitender Saini, Manu S Girija, Jagadish Annapureddy, Mishab Alumkadavath, Tanushree Chawla, Leena Shingavi, Seena Vengalil
Neurology India.2021; 69(5): 1421. CrossRef - Sub-chronic treatment with high doses of ascorbic acid reduces lead levels in hen eggs intentionally exposed to a concentrated source of lead: a pilot study
Ramzi Shawahna, Ahed Zyoud, Elaf Haj Yahia, Rahma Sulieman, Abeer Haddad, Mohammad Makhlof, Bilal Abu-Hilal, Ghulam Murtaza, Hikmat Hilal
BMC Pharmacology and Toxicology.2020;[Epub] CrossRef - Therapeutic role of garlic and vitamins C and E against toxicity induced by lead on various organs
Shumaila Mumtaz, Shaukat Ali, Rida Khan, Hafiz Abdullah Shakir, Hafiz Muhammad Tahir, Samiara Mumtaz, Saiqa Andleeb
Environmental Science and Pollution Research.2020; 27(9): 8953. CrossRef - Role of silica mid-layer in thermal and chemical stability of hierarchical Fe3O4-SiO2-TiO2 nanoparticles for improvement of lead adsorption: Kinetics, thermodynamic and deep XPS investigation
Naeemeh Esfandiari, Mehrdad Kashefi, Mostafa Mirjalili, Sima Afsharnezhad
Materials Science and Engineering: B.2020; 262: 114690. CrossRef - Opium-Related Lead Toxicity: An Integrative Review and Case Series
Ali Tafazoli Moghadam, Maryam Bahreini, Babak Choobi Anzali
The Journal of Emergency Medicine.2020; 59(1): 33. CrossRef - Blood lead level and Helicobacter pylori infection in a healthy population: A cross-sectional study
Won-Ju Park, Soo-Hyeon Kim, WonYang Kang, Ji-Sung Ahn, Seunghyeon Cho, Dae-Young Lim, Suwhan Kim, Jai-Dong Moon
Archives of Environmental & Occupational Health.2020; 75(6): 333. CrossRef - (Ascorb)ing Pb Neurotoxicity in the Developing Brain
Faraz Ahmad, Ping Liu
Antioxidants.2020; 9(12): 1311. CrossRef - RyRs mediate lead-induced neurodegenerative disorders through calcium signaling pathways
Fankun Zhou, Guihua Du, Jie Xie, Junwang Gu, Qiyue Jia, Ying Fan, Han Yu, Zhipeng Zha, Kai Wang, Lu Ouyang, Lijian Shao, Chang Feng, Guangqin Fan
Science of The Total Environment.2020; 701: 134901. CrossRef - Evaluating the role of vitexin on hematologic and oxidative stress markers in lead-induced toxicity in mice
Nathaniel Ohiemi Amedu, Gabriel Olaiya Omotoso
Toxicology and Environmental Health Sciences.2020; 12(3): 257. CrossRef - Protection through participation: Crowdsourced tap water quality monitoring for enhanced public health
Sarah Jakositz, Lana Pillsbury, Scott Greenwood, Maria Fahnestock, Bridie McGreavy, Julie Bryce, Weiwei Mo
Water Research.2020; 169: 115209. CrossRef - Educational interventions for preventing lead poisoning in workers
Sara Allaouat, Viraj K Reddy, Kimmo Räsänen, Sohaib Khan, Mieke EGL Lumens
Cochrane Database of Systematic Reviews.2020;[Epub] CrossRef - Changes in inflammatory cytokines, antioxidants and liver stiffness after chelation therapy in individuals with chronic lead poisoning
Tongluk Teerasarntipan, Roongruedee Chaiteerakij, Piyapan Prueksapanich, Duangporn Werawatganon
BMC Gastroenterology.2020;[Epub] CrossRef - Dealing with Lead in Hybrid Perovskite: A Challenge to Tackle for a Bright Future of This Technology?
Kevin Dedecker, Giulia Grancini
Advanced Energy Materials.2020;[Epub] CrossRef - Environmental toxins and Alzheimer's disease progression
Maryam Vasefi, Ehsan Ghaboolian-Zare, Hamzah Abedelwahab, Anthony Osu
Neurochemistry International.2020; 141: 104852. CrossRef - Determinants of Erythrocyte Lead Levels in 454 Adults in Florence, Italy
Saverio Caini, Benedetta Bendinelli, Giovanna Masala, Calogero Saieva, Melania Assedi, Andrea Querci, Thomas Lundh, Soterios A. Kyrtopoulos, Domenico Palli
International Journal of Environmental Research and Public Health.2019; 16(3): 425. CrossRef - Ascorbic Acid Supplementation Prevents the Detrimental Effects of Prenatal and Postnatal Lead Exposure on the Purkinje Cell and Related Proteins in the Cerebellum of Developing Rats
Sung Min Nam, Jin Seok Seo, Tae-Hun Go, Sang-Soep Nahm, Byung-Joon Chang
Biological Trace Element Research.2019; 190(2): 446. CrossRef - Probiotics against alleviation of lead toxicity: recent advances
Sanjib Bhattacharya
Interdisciplinary Toxicology.2019; 12(2): 89. CrossRef - A Case of Severe Lead Poisoning with Basophilic Stippling Teardrop Cell
Wonyang Kang, Seunghyeon Cho, Dae-Young Lim, Suwhan Kim, Won-Ju Park
Journal of Korean Medical Science.2019;[Epub] CrossRef - Evaluation of Nanoparticles Emission in Simulation of Experimental Model of Technological Process of Pig Lead Smelting
O V Demetska, A O Lukianenko, I M Andrusishina, V O Movchan, O G Beliuha
IOP Conference Series: Earth and Environmental Science.2019; 224: 012012. CrossRef - Expression of metallothionein encoding gene bmtA in biofilm-forming marine bacterium Pseudomonas aeruginosa N6P6 and understanding its involvement in Pb(II) resistance and bioremediation
Supriya Kumari, Surajit Das
Environmental Science and Pollution Research.2019; 26(28): 28763. CrossRef - ECG conduction disturbances and ryanodine receptor expression levels in occupational lead exposure workers
Jie Xie, Guihua Du, Yuanyuan Zhang, Fankun Zhou, Junfang Wu, Huan Jiao, Yanshu Li, Ying Chen, Lu Ouyang, Dandan Bo, Chang Feng, Wei Yang, Guangqin Fan
Occupational and Environmental Medicine.2019; 76(3): 151. CrossRef - Effects of ascorbic acid treatment on developmental alterations in calcium-binding proteins and gamma-aminobutyric acid transporter 1 in the cerebellum of lead-exposed rats during pregnancy and lactation
Sung Min Nam, Jin Seok Seo, Sang-Soep Nahm, Byung-Joon Chang
The Journal of Toxicological Sciences.2019; 44(11): 799. CrossRef - Oxidative stress in the neurodegenerative brain following lifetime exposure to lead in rats: Changes in lifespan profiles
Chang Feng, Sisi Liu, Fankun Zhou, Yanyan Gao, Yanshu Li, Guihua Du, Ying Chen, Huan Jiao, Jiangao Feng, Yuanyuan Zhang, Dandan Bo, Zongguang Li, Guangqin Fan
Toxicology.2019; 411: 101. CrossRef - Lead Poisoning in Opium-Addicted Subjects, Its Correlation with Pyrimidine 5′-Nucleotidase Activity and Liver Function Tests
Mandana Fakoor, Maryam Akhgari, Hamed Shafaroodi
International Journal of Preventive Medicine.2019;[Epub] CrossRef - Collective exposure to lead from an approved natural product-derived drug in Korea
Dae-Young Lim, Won-Yang Kang, Ji-Sung Ahn, Seunghyeon Cho, Suwhan Kim, Jai-Dong Moon, Byung-Chan Lee, Won-Ju Park
Annals of Occupational and Environmental Medicine.2019;[Epub] CrossRef - Childhood lead poisoning in Gaza Strip, the Palestinian Authority
Jamal M. Safi, Maged M. Yassin, Yasser Z. El-Nahhal, Yehia A. Abed, Mohamed J. Safi, Hassan D. Suleiman
Journal of Trace Elements in Medicine and Biology.2019; 54: 118. CrossRef - Particulate matter in the cultivation area may contaminate leafy vegetables with heavy metals above safe levels in Korea
Kyungdeok Noh, Luc The Thi, Byoung Ryong Jeong
Environmental Science and Pollution Research.2019; 26(25): 25762. CrossRef - Gamma ray attenuation of hafnium dioxide- and tungsten trioxide-epoxy resin composites
Maria C. Molina Higgins, Nicholus A. Radcliffe, Miguel Toro-González, Jessika V. Rojas
Journal of Radioanalytical and Nuclear Chemistry.2019; 322(2): 707. CrossRef - Changes in blood pressure associated with lead, manganese, and selenium in a Bangladeshi cohort
Catherine M. Bulka, Molly Scannell Bryan, Victoria W. Persky, Martha L. Daviglus, Ramon A. Durazo-Arvizu, Faruque Parvez, Vesna Slavkovich, Joseph H. Graziano, Tariqul Islam, John A. Baron, Habibul Ahsan, Maria Argos
Environmental Pollution.2019; 248: 28. CrossRef - Lead‐induced DNA damage and cell apoptosis in human renal proximal tubular epithelial cell: Attenuation via N‐acetyl cysteine and tannic acid
Manushi Siddarth, Diwesh Chawla, Alpana Raizada, Neelam Wadhwa, Basu D Banerjee, Meera Sikka
Journal of Biochemical and Molecular Toxicology.2018;[Epub] CrossRef - Beneficial effects of naringenin in liver diseases: Molecular mechanisms
Erika Hernández-Aquino, Pablo Muriel
World Journal of Gastroenterology.2018; 24(16): 1679. CrossRef - The Effects of Lead Contamination in Public Health Case: Pesarean Village, Tegal District, Indonesia
Indah Lestari, Tri Edhi Budhi Soesilo, Haruki Agustina, M. Amin
E3S Web of Conferences.2018; 68: 03012. CrossRef - LncRNA Uc.173 is a key molecule for the regulation of lead-induced renal tubular epithelial cell apoptosis
Jiabi Qin, Huacheng Ning, Yao Zhou, Yue Hu, Bo Huang, Yue Wu, Ruixue Huang
Biomedicine & Pharmacotherapy.2018; 100: 101. CrossRef - Vestibular dysfunction in the adult CBA/CaJ mouse after lead and cadmium treatment
Katarina E. M. Klimpel, Min Young Lee, W. Michael King, Yehoash Raphael, Jochen Schacht, Richard L. Neitzel
Environmental Toxicology.2017; 32(3): 869. CrossRef - Green remediation. Tool for safe and sustainable environment: a review
Mamta Singh, Gaurav Pant, Kaizar Hossain, A. K. Bhatia
Applied Water Science.2017; 7(6): 2629. CrossRef - Lead Poisoning at an Indoor Firing Range
Kyung Wook Kang, Won-Ju Park
Journal of Korean Medical Science.2017; 32(10): 1713. CrossRef - Heavy metals (lead, cadmium, methylmercury, arsenic) in commonly imported rice grains ( Oryza sativa ) sold in Saudi Arabia and their potential health risk
Iman Al-Saleh, Mai Abduljabbar
International Journal of Hygiene and Environmental Health.2017; 220(7): 1168. CrossRef - Clinical and molecular aspects of lead toxicity: An update
Prasenjit Mitra, Shailja Sharma, Purvi Purohit, Praveen Sharma
Critical Reviews in Clinical Laboratory Sciences.2017; 54(7-8): 506. CrossRef - Lead Poisoning: Awareness in Medical and Non-Medical Population of Karachi
Sana Ahmed Sarfaraz, Aqsa Naz, Amber Shahid, Maryam Qayyum, Islam Uddin
Advanced Journal of Graduate Research.2016; 1(1): 3. CrossRef - LEAD EXPOSURE AND ENVIRONMENTAL HEALTH
Jiří Patočka, Kamil Kuča
Military Medical Science Letters.2016; 85(4): 147. CrossRef - Urinary KIM-1: a novel biomarker for evaluation of occupational exposure to lead
Rong Zhou, Yahong Xu, Jie Shen, Lin Han, Xi Chen, Xuefang Feng, Xingya Kuang
Scientific Reports.2016;[Epub] CrossRef
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Case Report
- High lead exposure in two leaded bronze ingot foundry workers
- Yoojun Song, Chunhui Suh, Shin-Ae Kim, Nami Kim, Sung-Min Kim, Seong-Wook Jeong, Se-Yeong Kim, Kun-Hyung Kim, Jeong-Ho Kim, Byung-Chul Son, Chae-Kwan Lee, Jong-Tae Lee
- Ann Occup Environ Med 2014;26:38. Published online December 1, 2014
- DOI: https://doi.org/10.1186/s40557-014-0038-8
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Abstract
PDF
Background Awareness about lead poisoning in South Korea has increased; however, occupational exposures occurring in small-scale businesses have not been thoroughly investigated. We report two cases of high lead exposure in a leaded bronze ingot foundry.
Case presentation Two employees, a 54-year-old primary operator and a 46-year-old assistant, at a small-scale metalworking company who had been employed for 18 years and 1 month, respectively, showed elevated blood lead levels (61.1 μg/dL and 51.7 μg/dL, respectively) at an occupational health checkup. Neither worker complained of abnormal symptoms nor signs related to lead poisoning. Health assessment follow-ups were conducted and biological exposure indices of lead were calculated every four weeks. After the initial follow-up assessment, both workers were relocated from the foundry process to the metalworking process. In addition, a localized exhaust system was installed after the second follow-up.
Conclusions Foundry workers in a small-scale businesses might be at high risk of lead exposure because these businesses might be vulnerable to poor industrial hygiene. Therefore, regular occupational health checkups are required.
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Citations
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Sungjin Park, Jaeyoung Park, Bumjoon Lee, Yi-Ryoung Lee, Jiho Kim, Younmo Cho, Hyeongyeong Choi, Kyeongyeon Kim
Journal of Korean Medical Science.2025;[Epub] CrossRef - Comparison of Blood Lead Levels in Children and Adolescents with and Without Functional Abdominal Pain
Fatemeh Famouri, Maryam Yazdi, Awat Feizii, Hossein Saneian, Peiman Nasri, Roya Kelishadi
Advanced Biomedical Research.2023;[Epub] CrossRef - Association Between Blood Lead Level With High Blood Pressure in US (NHANES 1999–2018)
Ziyao Huang
Frontiers in Public Health.2022;[Epub] CrossRef - A systematic review of clinical and laboratory findings of lead poisoning: lessons from case reports
Saeed Samarghandian, Farshad M. Shirazi, Farhad Saeedi, Babak Roshanravan, Ali Mohammad Pourbagher-Shahri, Emad Yeganeh Khorasani, Tahereh Farkhondeh, Jan Olav Aaseth, Mohammad Abdollahi, Omid Mehrpour
Toxicology and Applied Pharmacology.2021; 429: 115681. CrossRef - Exposure to lead and other toxic metals from informal foundries producing cookware from scrap metal
Renee Anne Street, Walter Goessler, Saloshni Naidoo, Busisiwe Shezi, Nokulunga Cele, Jaqueline Rieger, Karl Ettinger, Tarylee Reddy, Angela Mathee
Environmental Research.2020; 191: 109860. CrossRef - Bayesian network model to diagnose WMSDs with working characteristics
Gilseung Ahn, Sun Hur, Myung-Chul Jung
International Journal of Occupational Safety and Ergonomics.2020; 26(2): 336. CrossRef - Challenges in diagnosing lead poisoning: A review of occupationally and nonoccupationally exposed cases reported in India
Monica Shirley Mani, Divyani Gurudas Nayak, Herman Sunil Dsouza
Toxicology and Industrial Health.2020; 36(5): 346. CrossRef - Lead Poisoning at an Indoor Firing Range
Kyung Wook Kang, Won-Ju Park
Journal of Korean Medical Science.2017; 32(10): 1713. CrossRef - Occupational Lead Exposure from Indoor Firing Ranges in Korea
Won-Ju Park, Suk-Ho Lee, Se-Ho Lee, Hye-Sik Yoon, Jai-Dong Moon
Journal of Korean Medical Science.2016; 31(4): 497. CrossRef
- Occupational Lead Exposure Among Civilian Indoor Shooting Range Workers in Korea: A Report of Blood Lead Levels and Airborne Lead
- 1,333 View
- 2 Download
- 9 Web of Science
- 9 Crossref
Research Article
- Blood lead levels of Korean lead workers in 2003–2011
- Ji-Hye Kim, Eun-A Kim, Dong-Hee Koh, Kiwhan Byun, Hyang-Woo Ryu, Sang-Gil Lee
- Ann Occup Environ Med 2014;26:30. Published online October 1, 2014
- DOI: https://doi.org/10.1186/s40557-014-0030-3
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Abstract
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Objectives This study aimed to document the trend in blood lead levels in Korean lead workers from 2003 until 2011 and blood lead levels within each of the main industries.
Methods Nine years (2003–2011) of blood lead level data measured during a special health examination of Korean lead workers and collected by the Korea Occupational Safety and Health Agency were analyzed. Blood lead levels were determined by year, and a geometric mean (GM) was calculated for each industry division.
Results The overall GM blood lead level for all years combined (n = 365,331) was 4.35 μg/dL. The GM blood lead level decreased from 5.89 μg/dL in 2003 to 3.53 μg/dL in 2011. The proportion of the results ≥30 μg/dL decreased from 4.3% in 2003 to 0.8% in 2011. In the “Manufacture of Electrical Equipment” division, the GM blood lead level was 7.80 μg/dL, which was the highest among the industry divisions. The GM blood lead levels were 7.35 μg/dL and 6.77 μg/dL in the “Manufacturers of Rubber and Plastic Products” and the “Manufacture of Basic Metal Products” division, respectively.
Conclusions The blood lead levels in Korean lead workers decreased from 2003 to 2011 and were similar to those in the US and UK. Moreover, workers in industries conventionally considered to have a high risk of lead exposure also tended to have relatively high blood lead levels compared to those in other industries.
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Citations
Citations to this article as recorded by- Occupational Lead Exposure Among Civilian Indoor Shooting Range Workers in Korea: A Report of Blood Lead Levels and Airborne Lead
Sungjin Park, Jaeyoung Park, Bumjoon Lee, Yi-Ryoung Lee, Jiho Kim, Younmo Cho, Hyeongyeong Choi, Kyeongyeon Kim
Journal of Korean Medical Science.2025;[Epub] CrossRef - Evaluation Polluted by Some Heavy Elements in Blood Serum Patients Admitted to Al-Rifai General Hospital in Al-Rifai City Located South of the Al-Garraf Oil Field
Ali Sabeeh Ali
European Journal of Theoretical and Applied Sciences.2024; 2(6): 305. CrossRef - Evaluation of Temporal Trends of Lead Exposure in Korean Workers Using Workplace Monitoring Data
Dong-Hee Koh, Sangjun Choi, Ju-Hyun Park, Sang-Gil Lee, Hwan-Cheol Kim, Inah Kim, Jong-Uk Won, Dae Sung Lim, Hoekyeong Seo, Dong-Uk Park
Journal of Korean Medical Science.2023;[Epub] CrossRef - The lead burden of occupational lead-exposed workers in Guangzhou, China: 2006–2019
Jiabin Liang, Jieyan Cai, Jiaming Guo, Jianping Mai, Liping Zhou, Jinwei Zhang, Yimin Liu, Zhi Wang
Archives of Environmental & Occupational Health.2022; 77(5): 403. CrossRef - Does Exposure of Lead and Cadmium Affect the Endometriosis?
Min-Gi Kim, Young-Sun Min, Yeon-Soon Ahn
International Journal of Environmental Research and Public Health.2021; 18(17): 9077. CrossRef - Chronic Stress and Cardiovascular Disease among Individuals Exposed to Lead: A Pilot Study
Emmanuel Obeng-Gyasi, Barnabas Obeng-Gyasi
Diseases.2020; 8(1): 7. CrossRef - Joint Toxicity of a Multi-Heavy Metal Mixture and Chemoprevention in Sprague Dawley Rats
Yafei Wang, Yuqing Tang, Zhou Li, Qihang Hua, Li Wang, Xin Song, Baobo Zou, Min Ding, Jinshun Zhao, Chunlan Tang
International Journal of Environmental Research and Public Health.2020; 17(4): 1451. CrossRef - Collective exposure to lead from an approved natural product-derived drug in Korea
Dae-Young Lim, Won-Yang Kang, Ji-Sung Ahn, Seunghyeon Cho, Suwhan Kim, Jai-Dong Moon, Byung-Chan Lee, Won-Ju Park
Annals of Occupational and Environmental Medicine.2019;[Epub] CrossRef - Estimation of Lead Exposure Prevalence in Korean Population through Combining Multiple Experts’ Judgment based on Objective Data Sources
Dong-Hee Koh, Ju-Hyun Park, Sang-Gil Lee, Hwan-Cheol Kim, Sangjun Choi, Hyejung Jung, Jae-Oh Park, Dong-Uk Park
Annals of Work Exposures and Health.2018; 62(2): 210. CrossRef - Mean Blood Lead Level in Iranian Workers: A Systematic and Meta-Analysis
Milad Azami, Zainab Tardeh, Akram Mansouri, Ali Soleymani, Kourosh Sayehmiri
Iranian Red Crescent Medical Journal.2018;[Epub] CrossRef - Lead Poisoning at an Indoor Firing Range
Kyung Wook Kang, Won-Ju Park
Journal of Korean Medical Science.2017; 32(10): 1713. CrossRef - Occupational Lead Exposure from Indoor Firing Ranges in Korea
Won-Ju Park, Suk-Ho Lee, Se-Ho Lee, Hye-Sik Yoon, Jai-Dong Moon
Journal of Korean Medical Science.2016; 31(4): 497. CrossRef - Blood Lead Levels and Cause-Specific Mortality of Inorganic Lead-Exposed Workers in South Korea
Min-Gi Kim, Jae-Hong Ryoo, Se-Jin Chang, Chun-Bae Kim, Jong-Ku Park, Sang-Baek Koh, Yeon-Soon Ahn, Max Costa
PLOS ONE.2015; 10(10): e0140360. CrossRef
- Occupational Lead Exposure Among Civilian Indoor Shooting Range Workers in Korea: A Report of Blood Lead Levels and Airborne Lead
- 1,467 View
- 3 Download
- 13 Web of Science
- 13 Crossref
Case Report
- A Case of Lead Poisoning due to a Mixture of Talisman Ash
- Han Hui Ye, Jae Uk Jeong, Nak Joon Baek, Chang Yul Choi, Man Joong Jeon, Joon Sakong
- Ann Occup Environ Med 2013;25:37. Published online November 28, 2013
- DOI: https://doi.org/10.1186/2052-4374-25-37
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Abstract
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Background Lead is a metal that has no biological function useful for the human body. In Korea, non-occupational exposure to lead has mostly occurred through taking oriental medicine. However, in this paper we report a case of lead poisoning caused by ingesting talisman material.
Case presentation A 16-year-old male patient complained of severe abdominal pain after taking cinnabar, a talisman material. He was diagnosed with lead poisoning accompanied by acute hepatitis. We confirmed that the cinnabar the patient took contained about 10% elemental lead. After symptom management, the patients’ symptoms, liver function test results, and blood lead concentration level improved.
Conclusion Lead poisoning can be accompanied by hepatitis, although rarely. As we have confirmed that cinnabar as a talisman material is harmful to the human body, measures to prevent its misuse are needed.
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Citations
Citations to this article as recorded by- A systematic review of clinical and laboratory findings of lead poisoning: lessons from case reports
Saeed Samarghandian, Farshad M. Shirazi, Farhad Saeedi, Babak Roshanravan, Ali Mohammad Pourbagher-Shahri, Emad Yeganeh Khorasani, Tahereh Farkhondeh, Jan Olav Aaseth, Mohammad Abdollahi, Omid Mehrpour
Toxicology and Applied Pharmacology.2021; 429: 115681. CrossRef - Collective exposure to lead from an approved natural product-derived drug in Korea
Dae-Young Lim, Won-Yang Kang, Ji-Sung Ahn, Seunghyeon Cho, Suwhan Kim, Jai-Dong Moon, Byung-Chan Lee, Won-Ju Park
Annals of Occupational and Environmental Medicine.2019;[Epub] CrossRef - Lead Poisoning at an Indoor Firing Range
Kyung Wook Kang, Won-Ju Park
Journal of Korean Medical Science.2017; 32(10): 1713. CrossRef - Effect of Lead Exposure on the Status of Reticulocyte Count Indices among Workers from Lead Battery Manufacturing Plant
Ravibabu Kalahasthi, Tapu Barman
Toxicological Research.2016; 32(4): 281. CrossRef
- A systematic review of clinical and laboratory findings of lead poisoning: lessons from case reports
- 1,400 View
- 0 Download
- 3 Web of Science
- 4 Crossref
Research Article
- The Relevance of Hyperuricemia and Metabolic Syndrome and the Effect of Blood Lead Level on Uric Acid Concentration in Steelmaking Workers
- Deul Lee, Won-Jun Choi, Jae-Seok Oh, Min-Kee Yi, Sung-Woo Han, Jong-Wan Yun, Sang-Hwan Han
- Ann Occup Environ Med 2013;25:27. Published online October 25, 2013
- DOI: https://doi.org/10.1186/2052-4374-25-27
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Abstract
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Objectives Uric acid concentration is known to increase the prevalence of metabolic syndrome by affecting its components, resulting in increased risk of cerebrovascular and cardiovascular diseases, and long-term lead exposure is known to affect this serum uric acid level. In this study, we aimed to examine the association between the causes of hyperuricemia and metabolic syndrome, and to determine whether an increased blood lead level affects hyperuricemia.
Method Anthropometric measurements, surveys, and blood tests were conducted between May and June 2012 in 759 men working in the steelmaking process at a domestic steel company. Workers were divided into 2 groups according to the presence or absence of hyperuricemia, and an analysis was performed to examine its association with metabolic syndrome. In addition, the workers were divided into 3 groups according to the blood lead level to analyze the association between blood lead and hyperuricemia.
Results The geometric mean (standard deviation) of the blood lead levels in the hyperuricemia group was significantly higher than that of the healthy group (3.8 [1.8] vs. 3.3 [1.8] μg/dL). The adjusted odds ratio for metabolic syndrome of the hyperuricemia group increased significantly to 1.787 (1.125–2.839) compared with the healthy group. In addition, the adjusted odds ratios for the occurrence of hyperuricemia in the tertile 2 (2.61–4.50 μg/dL) and tertile 3 groups (>4.50 μg/dL) according to blood lead level significantly increased to 1.763 (1.116–2.784) and 1.982 (1.254–3.132), respectively, compared with the tertile 1 group (< 2.61 μg/dL).
Conclusion Hyperuricemia is believed to function as an independent risk factor for metabolic syndrome, while lead seems to increase the serum uric acid level even at a considerably low blood level. Therefore, attention should be given to patients with hyperuricemia and metabolic syndrome who are prone to lead exposure, and a prospective study should be conducted to identify their causal relationship.
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Tingting Gu, Guorong Cao, Miao Luo, Nannan Zhang, Ting Xue, Rongchun Hou, Min Leng
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Environmental Research.2022; 212: 113377. CrossRef - Association of hyperuricemia and metabolic syndrome in type 2 diabetes mellitus patients in Dakar
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African Journal of Biochemistry Research.2021; 15(3): 43. CrossRef - Frequency of daily tooth brushing and subsequent cardiovascular events
Daiki Kobayashi, Atsushi Mizuno, Rie Mitsui, Takuro Shimbo
Coronary Artery Disease.2020; 31(6): 545. CrossRef - Occupational exposure to inorganic dust and risk of gout: a population-based study
Valgerdur Sigurdardottir, Lennart Jacobsson, Linus Schiöler, Anna Svärd, Mats Dehlin, Kjell Toren
RMD Open.2020; 6(2): e001178. CrossRef - Associations between blood lead, cadmium, and mercury levels with hyperuricemia in the Korean general population: A retrospective analysis of population‐based nationally representative data
Wonkil Jung, Yunkyung Kim, Hoseob Lihm, Jihun Kang
International Journal of Rheumatic Diseases.2019; 22(8): 1435. CrossRef - The role of cadmium in obesity and diabetes
Alexey A. Tinkov, Tommaso Filippini, Olga P. Ajsuvakova, Jan Aaseth, Yordanka G. Gluhcheva, Juliana M. Ivanova, Geir Bjørklund, Margarita G. Skalnaya, Eugenia R. Gatiatulina, Elizaveta V. Popova, Olga N. Nemereshina, Marco Vinceti, Anatoly V. Skalny
Science of The Total Environment.2017; 601-602: 741. CrossRef
- A systematic review and meta-analysis of the hyperuricemia risk from certain metals
- 1,222 View
- 1 Download
- 7 Web of Science
- 7 Crossref
Research Article
- The Relationship of Liver Function Tests to Mixed Exposure to Lead and Organic Solvents
- Won-Joon Chang, Kyu-Tak Joe, Hye-Young Park, Jong-Do Jeong, Duk-Hee Lee
- Ann Occup Environ Med 2013;25:5. Published online May 21, 2013
- DOI: https://doi.org/10.1186/2052-4374-25-5
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Abstract
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Objective This study aims to compare liver function indices (aspartate aminotransferase [AST], alanine aminotransferase [ALT], and gamma glutamyl transferase [GGT]) among males who work with lead, organic solvents, or both lead and organic solvents, under the permissible exposure limit (PEL).
Methods A total of 593 (out of 2,218) male workers who agreed to share their personal health information for medical research were selected for this study. Those excluded were hepatitis B carriers, individuals exposed to occupational risk factors other than lead and organic solvents, and individuals without liver function results. The 593 were divided into five groups: a lead-exposed group, an organic solvent-exposed group exposed to trichloroethylene (TCE co-exposed solvent group), an organic solvent-exposed group not exposed to trichloroethylene (TCE non-exposed solvent group), a lead and organic solvent-exposed group (mixed exposure group), and a non-exposed group (control group).
We performed a one way-analysis of variance (one way-ANOVA) test to compare the geometric means of liver function indices among the groups, using a general linear model (GLM) to adjust for age, work duration, body mass index (BMI), smoking, and alcohol intake. In addition, we performed a binary logistic regression analysis to compare the odds ratios among groups with an abnormal liver function index, according to a cut-off value.
Results The ALT and AST of the mixed exposure group were higher than those of the other groups. The GGT of the mixed exposure group was higher than the TCE co-exposed solvent group, but there was no difference among the control group, TCE non-exposed solvent group, lead-exposed group, and mixed exposure group. The same result was evident after adjusting by GLM for age, work duration, BMI, smoking, and alcohol intake, except that ALT from the mixed exposure group showed no difference from the TCE co-exposed solvent group.
When the cut-off values of the AST, ALT, and GGT were 40 IU/L, 42 IU/L, and 63 IU/L, respectively, a logistic regression analysis showed no differences in the odds ratios of those who had an abnormal liver function index among the groups. However, if the cut-off values of the AST, ALT, and GGT were 30 IU/L, 30 IU/L, and 40 IU/L, respectively, the odds ratio of the AST in the mixed exposure group was 4.39 (95% CI 1.86-10.40) times higher than the control.
Conclusion This study indicates that a mixed exposure to lead and organic solvents is dangerous, even if each single exposure is safe under the permissible exposure limit. Therefore, to ensure occupational health and safety in industry, a continuous efforts to study the effects from exposure to mixed chemicals is needed.
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Immacolata Maietta, Clara Otero‐Martínez, Sabela Fernández, Laura Sánchez, África González‐Fernández, Lakshminarayana Polavarapu, Rosana Simón‐Vázquez
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Jyotshna Saikia, Th. Gomti Devi, T. Karlo
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G. Gnanamani Simiyon, T. Mary Vergheese, B. Nivetha
Resonance.2023; 28(5): 817. CrossRef - Potential diagnostic biomarkers for lead-induced hepatotoxicity and the role of synthetic chelators and bioactive compounds
Netranandini Lakka, Bhagyashree Pai, Monica Shirley Mani, Herman Sunil Dsouza
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Chemosphere.2022; 287: 132250. CrossRef - Association between cumulative childhood blood lead exposure and hepatic steatosis in young Mexican adults
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Environmental Research.2021; 196: 110980. CrossRef - Preventive potency of sumbawa forest honey on rats exposed by lead acetate based on liver histopathology and AST-ALT level
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Environmental Science and Pollution Research.2017; 24(26): 20859. CrossRef - A Retrospective Mid- and Long-term Follow-up Study on the Changes in Hematologic Parameters in the Highly Exposed Residents of the Hebei Spirit Oil Spill in Taean, South Korea
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Osong Public Health and Research Perspectives.2017; 8(5): 358. CrossRef - Differential diagnosis between occupational chronic intoxication with organic solvents and ethanol abuse by biological markers. Case report and literature review
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Mark A D’Andrea, G Kesava Reddy
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- The Toxicity of Lead and Lead‐Free Perovskite Precursors and Nanocrystals to Human Cells and Aquatic Organisms
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- 10 Download
- 30 Web of Science
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Case Report
- Detection of Cases and a Cause of Lead Exposure in Korean Steel Company
- Bon Hak Koo, Young Ki Kim, Sang Gil Lee, Dong Mug Kang, Jong Eun Kim
- Korean Journal of Occupational and Environmental Medicine 2012;24(4):441-448. Published online December 31, 2012
- DOI: https://doi.org/10.35371/kjoem.2012.24.4.441
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Abstract
PDF
- BACKGROUND
We report cases of high lead exposure in a Korean steel manufacturing company and a likely cause for these cases.
CASE
REPORT: Neurological examinations, neurobehavioral tests, blood tests, and urine tests were performed to detect an association between high lead exposure and physical symptoms for workers in a steel manufacturing company. In order to determine the cause of high lead exposure, the work process and environment was assessed. The highest lead exposure was during the work process. We found that the interior of an oil storage tank was coated with lead-containing paint, leading to severe exposure during the cutting process. In two observations, 4 of 12 workers diagnosed with occupational disease were found to have high exposure to lead from the storage tank and three had increased beta-2 microglobulin levels in the blood (indicative of urinary tract damage).
CONCLUSIONS
Lead management, including routine measurements of the working environment and examinations of lead concentrations in workers, are needed in the korean scrap metal industry. In addition, rules requiring workers to wear personal protective equipment and receive education about lead exposure should be strictly enforced. -
Citations
Citations to this article as recorded by- Evaluation of Temporal Trends of Lead Exposure in Korean Workers Using Workplace Monitoring Data
Dong-Hee Koh, Sangjun Choi, Ju-Hyun Park, Sang-Gil Lee, Hwan-Cheol Kim, Inah Kim, Jong-Uk Won, Dae Sung Lim, Hoekyeong Seo, Dong-Uk Park
Journal of Korean Medical Science.2023;[Epub] CrossRef - Occupational Lead Exposure from Indoor Firing Ranges in Korea
Won-Ju Park, Suk-Ho Lee, Se-Ho Lee, Hye-Sik Yoon, Jai-Dong Moon
Journal of Korean Medical Science.2016; 31(4): 497. CrossRef
- Evaluation of Temporal Trends of Lead Exposure in Korean Workers Using Workplace Monitoring Data
- 615 View
- 1 Download
- 2 Crossref
Case Report
- A Case of Amyotrophic Lateral Sclerosis in an Equipment Maintenance Worker Exposed to Lead
- In Ki Yoon, Hyoung Jun Lim, Young Su Ju, Se Jin An, Young Jun Kwon
- Korean Journal of Occupational and Environmental Medicine 2012;24(2):195-205. Published online June 30, 2012
- DOI: https://doi.org/10.35371/kjoem.2012.24.2.195
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Abstract
PDF
- OBJECTIVES
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease involving the upper and lower motor neuron of the brain and spinal cord, leading ultimately to death due to respiratory failure in most cases. The etiology of ALS is currently unknown, but several studies show that lead exposure might be one of the potential environmental causes of ALS. In this perspective, we introduce a case involving an ALS patient exposed to lead while maintaining mechanical equipment in a waste treatment plant.
METHODS
The patient was interviewed and his medical records were investigated to confirm the final diagnosis of ALS. The results of his health examination and working environment measurement were reviewed in order to evaluate the relation of his work with ALS. We also performed an analysis of lead concentration from samples taken from his workplace when we visited the plant to survey the work environment.
RESULTS
Based on the patient's clinical information, work environment, relatively high level of blood lead concentration, and several studies proposing the occupational relationship between lead and ALS, his ALS may possibly have been caused by lead exposure at his workplace.
CONCLUSIONS
Given the recent situation where the causal association between lead exposure and ALS is still unclear, this case report could be used as a basis to support the relevance of lead exposure with ALS, and to help improve the health and work environment of other workers who are likely to be exposed to lead.
- 408 View
- 1 Download
Original Article
- Association Between Blood Lead Concentration and Computerized Neurobehavioral Performance in Korean Elementary School Students
- Yeon Cheol Kim, Man Joong Jeon, Yun Chul Hong, Chul Gab Lee, Mi Na Ha, Ho Jang Kwon, Joon Sakong
- Korean Journal of Occupational and Environmental Medicine 2011;23(2):183-191. Published online June 30, 2011
- DOI: https://doi.org/10.35371/kjoem.2011.23.2.183
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Abstract
PDF
- OBJECTIVES
This study was conducted to evaluate association between computerized neurobehavioral performance and blood lead concentration in Korean elementary school students.
METHODS
The subjects were 1,077 elementary school students of Seoul, Busan, Daegu and Gwangju. Blood lead concentration was measured and computerized neurobehavioral performance tests were performed.
RESULTS
Blood lead concentration of the subjects was in the range of 0.20 and 7.39 microg/dl. The geometric mean of the subjects' blood lead concentration was 1.41 microg/dl. As blood lead concentration increased, reaction time to the symbol digit tended to increase significantly and linearly. As a result of LOWESS(locally weighted scatterplot smoothing), increasing reaction time to the symbol digit was observed.
CONCLUSIONS
As blood lead concentration under the CDC (center for disease control and prevention) reference value increased, reaction time to the symbol digit tended to increase. But, as the number of subjects over 3 microg/dl is small, it is difficult to make a definite conclusion. If confounding variables are controlled properly in a follow-up study, we can obtain a more definite conclusion. -
Citations
Citations to this article as recorded by- Association of heavy metal complex exposure and neurobehavioral function of children
Minkeun Kim, Chulyong Park, Joon Sakong, Shinhee Ye, So young Son, Kiook Baek
Annals of Occupational and Environmental Medicine.2023;[Epub] CrossRef - Performance assessment on the Korean Computerized Neurobehavioral Test using a mobile device and a conventional computer: an experimental study
Young Seok Byun, Sung Kyu Park, Joon Sakong, Man Joong Jeon
Annals of Occupational and Environmental Medicine.2018;[Epub] CrossRef - The association between lead concentration in the blood and neurobehavioral performance of children
Dae-Seon Kim, Seungchul Ahn, Seungdo Yu, Eun-Hee Lee
Toxicology and Environmental Health Sciences.2012; 4(2): 87. CrossRef - Evaluation of reliability of computerized neurobehavioral tests in Korean children
Kyeong-Soo Lee, Man-Joong Jeon, Tae-Yoon Hwang, Chang-Yoon Kim, Joon Sakong
NeuroToxicology.2012; 33(5): 1362. CrossRef
- Association of heavy metal complex exposure and neurobehavioral function of children
- 557 View
- 0 Download
- 4 Crossref
Original Article
- The Effects of Smoking and Drinking on Blood Lead and Cadmium Levels: Data from the Fourth Korea National Health and Nutrition Examination Survey
- Boram Lee, Jaehyeok Ha
- Korean Journal of Occupational and Environmental Medicine 2011;23(1):31-41. Published online March 31, 2011
- DOI: https://doi.org/10.35371/kjoem.2011.23.1.31
-
Abstract
PDF
- OBJECTIVES
The purpose of this study is to assess the effects of smoking and drinking on blood lead and cadmium levels based on a dose-response relationship in the general Korean adult population.
METHODS
The study population consisted of 1,901 Koreans, who took part in the 2008 Korean National Health and Nutrition Examination Survey, in which blood lead and cadmium levels were measured. Geometric mean concentrations and their 95% confidence intervals of metals in blood were estimated by analysis of covariance (ANCOVA) adjusting for demographic and lifestyle factors.
RESULTS
We observed a statistically significant dose-response relationship with daily smoking amount/alcohol intake and blood lead/cadmium levels. While daily smoking amount was more consistent with blood cadmium level (0.1-0.2 microg/L per 5 cigarettes), blood lead concentrations were higher as daily alcohol intake increased (0.1-0.2 microg/dL per 10 gram of alcohol).
CONCLUSIONS
Our findings clearly support a relationship between daily smoking amount/alcohol intake and blood lead/cadmium levels, suggesting an additional reason towards efforts to reduce smoking and drinking habits. -
Citations
Citations to this article as recorded by- Association between Suicidal Ideation and Blood Cadmium Levels Based on the 3rd to 7th Korea National Health and Nutrition Examination Surveys
Sunmi Kim
STRESS.2024; 32(1): 46. CrossRef - Association between Atopic Dermatitis and Hyperuricemia in the Adult Korean Population based on the 7th and 8th Korea National Health and Nutrition Examination Survey
Sunmi Kim
Korean Journal of Health Promotion.2023; 23(4): 198. CrossRef - Relationship between Age-Related Macular Degeneration and Hyperuricemia Based on the 7th and 8th Korea National Health and Nutrition Examination Survey
Sunmi Kim
Korean Journal of Clinical Geriatrics.2023; 24(3): 104. CrossRef - Exposure Assessment of Heavy Metals using Exposure Biomarkers among Residents Living Near a Chungcheongnam-do Province Industrial Complex Area
Yosub Joo, Sangchul Roh
Korean Journal of Environmental Health Sciences.2016; 42(3): 213. CrossRef - Health Effect and Blood Lead Concentration among Residents in Gwangyang and Yeosu
Heejin Park, Myung-Kyu Park, Tack-Shin Kang, Geun-Bae Kim, Jong-Wha Lee, Bong-Ki Jang, Bu-Soon Son
Korean Journal of Environmental Health Sciences.2016; 42(3): 205. CrossRef - Association of among alcohol consumption and blood vitamin D and lead concentrations: Based on 2010-2012 Korea national health and nutrition examination survey
Ho-Ki An, Jae-Yong Park, Hee-Jung Yoon
Journal of the Korea Academia-Industrial cooperation Society.2015; 16(1): 498. CrossRef - Association between secondhand smoke exposure and blood lead and cadmium concentration in community dwelling women: the fifth Korea National Health and Nutrition Examination Survey (2010–2012)
Se Young Jung, Suyeon Kim, Kiheon Lee, Ju Young Kim, Woo Kyung Bae, Keehyuck Lee, Jong-Soo Han, Sarah Kim
BMJ Open.2015; 5(7): e008218. CrossRef - Simultaneous Exposure to Heavy Metals among Residents in the Industrial Complex: Korean National Cohort Study
Heejin Park, Kyoungho Lee, Chan-Seok Moon, Kyungsook Woo, Tack-Shin Kang, Eun-Kyung Chung, Bu-Soon Son
International Journal of Environmental Research and Public Health.2015; 12(6): 5905. CrossRef - A Study on Concentrations of Heavy Metal in Blood and Urine of Local Area in Korea
Ji-Young Im, Eun-Kyung Chung, Hee-Jin Park, Seungdo Yu, Bong-Ki Jang, Bu-Soon Son
Journal of Environmental Science International.2013; 22(1): 59. CrossRef - Smoking Prevalence and the Association between Smoking and Sociodemographic Factors Using the Korea National Health and Nutrition Examination Survey Data, 2008 to 2010
Sungroul Kim
Tobacco Use Insights.2012;[Epub] CrossRef - The association of heavy metals in blood, fish consumption frequency, and risk of cardiovascular diseases among Korean adults: The Korean National Health and Nutrition Examination Survey (2008-2010)
Ji-Ye Shin, Ji-Myung Kim, Yuri Kim
Korean Journal of Nutrition.2012; 45(4): 347. CrossRef
- Association between Suicidal Ideation and Blood Cadmium Levels Based on the 3rd to 7th Korea National Health and Nutrition Examination Surveys
- 597 View
- 2 Download
- 11 Crossref
Case Report
- A Case of Lead Poisoning by Ingesting Herbal Pills Tainted by Lead during the Manufacturing Process
- Young Hoo Shin, Jun Seok Son, Young Wook Kim, Chang Ho Chae, Ja Hyeon Kim, Chan Woo Kim, Jun Ho Lee
- Korean Journal of Occupational and Environmental Medicine 2010;22(3):271-277. Published online September 30, 2010
- DOI: https://doi.org/10.35371/kjoem.2010.22.3.271
-
Abstract
PDF
- BACKGROUND
This is a case report of lead poisoning after herbal pill ingestion. We report this case here as a reminder that contamination during the manufacturing process is an important issue regarding herbal pills. Case Report: A 37-year-old male was admitted to the hospital with abdominal pain caused by cholecystitis. He was transferred to the Department of Occupational and Environmental Medicine on 26 December 2008, because of anemia. On follow-up examination post cholecystectomy, the patient had increasing blood lead levels. There was no specific finding in his medical history, but he had been taking herbal pills for 3 months to treat dyspepsia. We performed an analysis on the herbal pills, and determined a lead concentration of 1485 mg/kg. When he was admitted to the hospital, the patient had a blood lead level of 84.13 microgram/dL and a zinc protoporphyrin level was 230 microgram/dL. The patient was treated with 250 mg of Penicillamine, 4 times per day. During follow-up 3 weeks later, the patient's blood lead level had been reduced to 36.52 microgram/dL which allowed us to take him off of Penicillamine. By 7 months follow-up, the patient's blood lead concentration had fallen from 36.52 microgram/dL to 20.93 microgram/dL.
CONCLUSION
Lead poisoning was confirmed by analyzing blood lead levels and the cause was herbal pills. Upon analysis of the herbal pills, we have discovered that the herbal pills contained an amount of lead acquired during the manufacturing process, based on the high levels of this heavy metal in comparison to other metals. Private herbal pill manufacturing plants need systematic management and oversight. -
Citations
Citations to this article as recorded by- Collective exposure to lead from an approved natural product-derived drug in Korea
Dae-Young Lim, Won-Yang Kang, Ji-Sung Ahn, Seunghyeon Cho, Suwhan Kim, Jai-Dong Moon, Byung-Chan Lee, Won-Ju Park
Annals of Occupational and Environmental Medicine.2019;[Epub] CrossRef - Monitoring of Heavy Metal Contents in Commercial Herbal Medicines in Korea: Cultivated Herbal Medicines in the Seoul and Daegu Areas
Seol Jang, Ah-Reum Lee, A-Eong Lee, Go-Ya Choi, Ho-Kyoung Kim
Korean Journal of Environmental Health Sciences.2015; 41(1): 30. CrossRef
- Collective exposure to lead from an approved natural product-derived drug in Korea
- 639 View
- 2 Download
- 2 Crossref
Case Report
- A Case Study on the Effect of Chelation Therapy with Dimercaptosuccinic Acid (DMSA) for Lead Poisoning in an Adult
- Yong Jin Lee
- Korean Journal of Occupational and Environmental Medicine 2010;22(1):69-76. Published online March 31, 2010
- DOI: https://doi.org/10.35371/kjoem.2010.22.1.69
-
Abstract
PDF
- OBJECTIVES
We wanted to investigate the efficacy of dimercaptosuccinic acid (DMSA) for the treatment of lead poisoning in an adult.
METHODS
The chelation therapy was applied using oral DMSA after measuring the blood lead and performing, renal function tests, liver tests and a physical examination. This therapy with oral DMSA 30 mg/kg/day was administered three times a day for 5 days to an adult patient with a pre-chelation blood lead concentration of 75 microgram/dL. Testing was performed by assessing the daily blood lead level, the blood ZPP, the urine ALA, the symptoms and side effects were assessed by conducting a physical examination.
RESULTS
DMSA therapy given for the duration of 5 days reduced the blood lead concentration from 75 microgram/dL to 21.8 microgram/dL. The blood ZPP concentration fell from 366 microgram/dL to 300 microgram/dL. The urine ALA concentration fell from 9.71 mg/L to 0.38 mg/L. In addition, the symptoms of headache, dizziness and abdominal pain that were induced by lead were improved after 2 days of chelation therapy. The vomiting did not improve after 5 days of chelation therapy, but this resolved 14 days following cessation of therapy. No adverse effects of DMSA therapy were seen.
CONCLUSIONS
Oral chelation therapy with DMSA 30 mg/kg/day is possible without being admitted to a hospital and it is generally effective, safe, and relatively inexpensive. DMSA provides a positive effect on adult patients who have lead poisoning. -
Citations
Citations to this article as recorded by- Probit analysis of comparative assays on toxicities of lead chloride and lead acetate to in vitro cultured human umbilical cord blood lymphocytes
Rajashree Patnaik, Rabindra N. Padhy
Interdisciplinary Toxicology.2015; 8(1): 35. CrossRef - A Case of Lead Poisoning with Drug-induced Liver Injury after Ingestion of Herbal Medicine
Gi Jung Jeon, Jongha Park, Min Sung Kim, Jong Won Yu, Jae Hyun Park, Min Sik Kim
The Korean Journal of Gastroenterology.2015; 65(6): 375. CrossRef
- Probit analysis of comparative assays on toxicities of lead chloride and lead acetate to in vitro cultured human umbilical cord blood lymphocytes
- 1,120 View
- 1 Download
- 2 Crossref
Original Article
- Relationship between Blood Lead Concentration and Neurobehavioral Function of Children
- Kwang Seub Park, Jae Yong Park, Joon Sakong
- Korean Journal of Occupational and Environmental Medicine 2009;21(2):131-142. Published online June 30, 2009
- DOI: https://doi.org/10.35371/kjoem.2009.21.2.131
-
Abstract
PDF
- OBJECTIVES
To evaluate effects of lead on the central nervous system of children by measuring blood lead concentration, computerized neurobehavioral function and intelligence of elementary school students.
METHODS
The study was conducted with 208 elementary school students living in the vicinity of Pohang Industrial Complex in October and November, 2005. Data on demographic characteristics, living environments and lifestyle habits were collected from subjects.
RESULTS
Blood lead levels of elementary school students ranged from 0.76-4.97 microg/dl, which is below the 10 microg/dl recommended level of CDC. The blood lead levels were similar with those reported in other domestic and international studies. Neurobehavioral tests revealed that most third grade students reacted slowly and their speed declined in simple reaction time (p<0.05), choice reaction time (p<0.05), symbol digit substitution (p<0.01), finger tapping speed nondominant hand (p<0.05) as blood lead levels increased. Sixth grade students demonstrated significance in test performance, and displayed blood lead levels of 2.00-4.00 microg/dl. Results of intelligence testing showed significantly low performance in IQ (p<0.05), vocabulary ability (p<0.05), reasoning ability (p<0.05), mathematical ability (p<0.05) and perception ability (p<0.05) among third grade students who displayed high levels of blood lead concentration. Sixth grade students showed significantly low performance in vocabulary ability (p<0.05) at high level of blood lead concentration. The difference in mean IQ scores between the group with blood lead level of < or =2.00 microg/dl and the group with blood lead level > or =3.00 microg/ dl was 3.21 in third grade students and 4.28 in sixth grade students. Low academic achievement was observed among third grade students (p<0.05) and six grade students (p<0.05) as the average blood lead level increased. Correlation analysis on the association of blood lead concentration with neurobehavioral tests revealed a positive correlation between blood lead levels and reaction time of choice reaction time and symbol digit substitution in third grade students. A positive correlation was observed between blood lead levels and reaction time of symbol digit substitution and finger tapping speed in sixth grade students. There was a negative correlation between blood lead levels and reasoning ability of third grade students (r=-0.247) and vocabulary ability of six grade students (r=-0.255).
CONCLUSION
There have been few studies on the effects of blood lead on the central nervous systems of children in Korea. The study supports the findings of earlier studies that blood lead has an impact on children. However, the study did not confirm significant association of blood lead concentration with each neurological and motor test conducted for this study due to a small sample size and relatively low blood lead levels of elementary school students. Further studies using a similar assessment methods would be helpful to evaluate the effects of low blood lead levels on the central nervous systems of children. -
Citations
Citations to this article as recorded by- Association of heavy metal complex exposure and neurobehavioral function of children
Minkeun Kim, Chulyong Park, Joon Sakong, Shinhee Ye, So young Son, Kiook Baek
Annals of Occupational and Environmental Medicine.2023;[Epub] CrossRef - The Impact of Aircraft Noise on the Cognitive Function of Elementary School Students in Korea
Kiook Baek, Chulyong Park, Joon Sakong
Noise and Health.2023; 25(117): 83. CrossRef - The association between lead concentration in the blood and neurobehavioral performance of children
Dae-Seon Kim, Seungchul Ahn, Seungdo Yu, Eun-Hee Lee
Toxicology and Environmental Health Sciences.2012; 4(2): 87. CrossRef - Evaluation of reliability of computerized neurobehavioral tests in Korean children
Kyeong-Soo Lee, Man-Joong Jeon, Tae-Yoon Hwang, Chang-Yoon Kim, Joon Sakong
NeuroToxicology.2012; 33(5): 1362. CrossRef
- Association of heavy metal complex exposure and neurobehavioral function of children
- 642 View
- 0 Download
- 4 Crossref
Original Article
- Blood Lead Level as a Predictor of Coronary Artery Disease
- Ryoung Jin Park, Seung Hyun Kim, Ji Ung Park, Yang Hyun Kim, Myoung Bo Kim, Won Ju Park, Jai Dong Moon
- Korean Journal of Occupational and Environmental Medicine 2009;21(1):38-45. Published online March 31, 2009
- DOI: https://doi.org/10.35371/kjoem.2009.21.1.38
-
Abstract
PDF
- OBJECTIVES
Lead exposure is known to be associated with high blood pressure, hypertension, coronary artery disease, peripheral arterial disease, left ventricular hypertropy, and electrocardiographic abnormalities. We investigated the association between blood lead and coronary artery calcification and stenosis.
METHODS
Between April 2006 and July 2007, 502 adults (345 males and 157 females), who had no history of cardiovascular disease or occupational exposure to lead, were recruited as study subjects. All subjects underwent coronary CT angiography and blood lead measurement.
RESULTS
Blood lead levels were distributed from 0.43 to 11.30 (microgram/dL with a geometric mean blood lead level of 2.98+/-1.5 (microgram/dL. The geometric mean blood lead levels were higher in men than women (3.31+/-1.5 (microgram/dL vs. 2.36+/-1.5 (microgram/dL, P < 0.01). Based on a multivariate analysis, a 1 unit ((microgram/dL) increase in blood lead level was associated with a 1.09 (95% confidence interval, 0.92~1.29) and a 1.01 fold (95% confidence interval, 0.63~1.63) greater risk for coronary artery calcification in men and women, respectively. Similarly, a 1 unit (microgram/dL) increase in blood lead level was associated with a 1.25 (95% confidence interval, 1.03~1.51) and a 1.42 fold (95% confidence interval, 0.73~2.75) greater risk for coronary artery stenosis in men and women, respectively.
CONCLUSIONS
The results suggest that increased blood lead levels are associated with an increased risk of coronary artery stenosis. -
Citations
Citations to this article as recorded by- Lead-induced actin polymerization aggravates neutrophil extracellular trap formation and contributes to vascular inflammation
Qiying Nong, Yanjun Wu, Suhui Liu, Yinyin Tang, Jiayun Wu, Hongmei Huang, Jiaying Hong, Yiru Qin, Ruimei Xu, Wenxia Zhao, Baowei Chen, Zhenlie Huang, Ligang Hu, Na Zhao, Yongshun Huang
Ecotoxicology and Environmental Safety.2025; 290: 117598. CrossRef - Blood Lead Levels and Cardiovascular Disease Risk: Results from the Korean National Health and Nutrition Examination Survey
Yoonjin Park, Jungjin Han
International Journal of Environmental Research and Public Health.2021; 18(19): 10315. CrossRef - Blood lead concentration and related factors in Korea from the 2008 National Survey for Environmental Pollutants in the Human Body
Seong Wook Jeong, Chae Kwan Lee, Chun Hui Suh, Kun Hyung Kim, Byung Chul Son, Jeong Ho Kim, Jong Tae Lee, Soo Woong Lee, Yeong Beom Park, Jong Wha Lee, Seung-Do Yu, Chan Seok Moon, Dae Hwan Kim, Sang Yoon Lee
International Journal of Hygiene and Environmental Health.2014; 217(8): 871. CrossRef - The Effects of Blood Lead on Blood Pressure Among Non-smokers
Yun-Suk Pak, Sang-Sin Park, Tae-Hun Kim, Sang-Yoon Lee, Young-Lim Kho, Eun-Hee Lee
Korean Journal of Environmental Health Sciences.2012; 38(4): 311. CrossRef - National estimates of blood lead, cadmium, and mercury levels in the Korean general adult population
Nam-Soo Kim, Byung-Kook Lee
International Archives of Occupational and Environmental Health.2011; 84(1): 53. CrossRef
- Lead-induced actin polymerization aggravates neutrophil extracellular trap formation and contributes to vascular inflammation
- 547 View
- 1 Download
- 5 Crossref
Case Report
- A Case of Chronic Renal Failure and Renal Cancer in a Worker Exposed to Lead
- Somin Park, Jongeun Kim, Jungwon Kim, Daegyun Hong, Sangbum Ye, Dongmug Kang, Euna Kim
- Korean Journal of Occupational and Environmental Medicine 2008;20(3):272-281. Published online September 30, 2008
- DOI: https://doi.org/10.35371/kjoem.2008.20.3.272
-
Abstract
PDF
- INTRODUCTION: Studies evaluating rats and mice have provided convincing evidence that renal adenoma and carcinoma are induced by oral doses of lead acetate and lead subacetate, as well as by parenteral doses of lead phosphate. In addition, at least 2 cases of kidney cancer associated with heavy exposure to lead have been reported. However, there is still not enough information to confirm or rule out an association between kidney cancer and exposure to lead.
CASE
REPORT: In this study, we describe a case of kidney cancer in 54-year-old male worker that was exposed to lead-stearate while employed in the polyvinyl chloride processing industry for 17 years. The patient presented with gout and hypertension. Further examination revealed proteinuria, glucose in the urine and elevated blood urea nitrogen/creatinine levels. Renal ultrasonography, renal computed tomography and renal biopsy revealed chronic renal failure and renal cell cancer.
CONCLUSION
We concluded that the gout and chronic renal failure in this case was caused by chronic lead exposure. However, further study is required to determine if the renal cancer was induced by lead exposure. -
Citations
Citations to this article as recorded by- Combined Toxicity Assessment of Deoxynivalenol and Pb2+ on HK-2 Cells Involved in Excessive ROS-Induced Ferroptosis
Zuoyin Zhu, Jie Wang, Haisheng Cheng, Hanke Zhao, Chengbin Liu, Xinli Zhou, Junhua Yang
Journal of Agricultural and Food Chemistry.2025; 73(4): 2573. CrossRef
- Combined Toxicity Assessment of Deoxynivalenol and Pb2+ on HK-2 Cells Involved in Excessive ROS-Induced Ferroptosis
- 520 View
- 1 Download
- 1 Crossref
Original Article
- A Study on the Association between Blood Lead Levels and Habitual Tobacco and Alcohol Use in Koreans with No Occupational Lead Exposure
- Ji Ung Park, Se Won Oh, Seung Hyun Kim, Yang Hyun Kim, Ryoung Jin Park, Jai Dong Moon
- Korean Journal of Occupational and Environmental Medicine 2008;20(3):165-173. Published online September 30, 2008
- DOI: https://doi.org/10.35371/kjoem.2008.20.3.165
-
Abstract
PDF
- OBJECTIVES
The purpose of this study was to estimate the normal blood lead (PbB) levels in a group of Korean subjects and to evaluate the association between PbB levels and habitual tobacco and alcohol use.
METHODS
We recruited 532 adults (320 males and 212 females) with no history of occupational exposure to lead, as study subjects.
RESULTS
PbB levels ranged between 0.43 microgram/dl and 9.45 microgram/dl. The adjusted geometric mean PbB in men was 3.19 microgram/dl, which was significantly higher than that seen in women: 2.66 microgram/dl (P=0.017). Geometric mean PbBs were not significantly different between urban and rural patients. The adjusted geometric mean PbB in smokers was 3.31 microgram/dl, which was significantly higher than that seen in nonsmokers: 2.64 microgram/dl (P=0.035). The adjusted geometric mean PbB in drinkers was 3.10 microgram/dl, which was significantly higher than that seen in non-drinkers: 2.75 microgram/dl (P=0.049).
CONCLUSIONS
The PbB levels of some Korean adults seem to be comparable to those seen in foreign countries. Our results suggest that tobacco and alcohol cessation will be helpful in decreasing the harmful effect of lead. -
Citations
Citations to this article as recorded by- Prenatal Exposure to Lead and Chromium is Associated with IL-13 Levels in Umbilical Cord Blood and Severity of Atopic Dermatitis: COCOA Study
Jihyun Kim, Seonwoo Kim, Sook-young Woo, Jin-Yong Chung, Young-Seoub Hong, Se-Young Oh, Suk-Joo Choi, Soo-Young Oh, Kyung Won Kim, Youn Ho Shin, Hye-Sung Won, Kyung-Ju Lee, Soo Hyun Kim, Ja Young Kwon, Si Hyeon Lee, Soo-Jong Hong, Kangmo Ahn
Immune Network.2019;[Epub] CrossRef - Level of Blood Lead and Urine Cotinine of Residents by Area
Yu-Jin Oh, Hyoung-Wook Kim, Yun-Jae Kim, Yoon-Deok Han, Sung-Hyeon Jung, Jong-Dae Lee, Bong-Ki Jang, Jin-Heon Lee, Bu-Soon Son
Journal of Environmental Science International.2019; 28(3): 329. CrossRef - Association of Blood Pressure with Blood Lead and Cadmium Levels in Korean Adolescents: Analysis of Data from the 2010–2016 Korean National Health and Nutrition Examination Survey
Jaeouk Ahn, Nam-Soo Kim, Byung-Kook Lee, Jungsun Park, Yangho Kim
Journal of Korean Medical Science.2018;[Epub] CrossRef - The association between cadmium and lead exposure and blood pressure among workers of a smelting industry: a cross-sectional study
Hyun Chan An, Joo Hyun Sung, Jiho Lee, Chang Sun Sim, Sang Hoon Kim, Yangho Kim
Annals of Occupational and Environmental Medicine.2017;[Epub] CrossRef - Health Effect and Blood Lead Concentration among Residents in Gwangyang and Yeosu
Heejin Park, Myung-Kyu Park, Tack-Shin Kang, Geun-Bae Kim, Jong-Wha Lee, Bong-Ki Jang, Bu-Soon Son
Korean Journal of Environmental Health Sciences.2016; 42(3): 205. CrossRef - Association of Blood Pressure with Exposure to Lead and Cadmium: Analysis of Data from the 2008–2013 Korean National Health and Nutrition Examination Survey
Byung-Kook Lee, Jaeouk Ahn, Nam-Soo Kim, Chan Boo Lee, Jungsun Park, Yangho Kim
Biological Trace Element Research.2016; 174(1): 40. CrossRef - A Case of Lead Poisoning with Drug-induced Liver Injury after Ingestion of Herbal Medicine
Gi Jung Jeon, Jongha Park, Min Sung Kim, Jong Won Yu, Jae Hyun Park, Min Sik Kim
The Korean Journal of Gastroenterology.2015; 65(6): 375. CrossRef - Probit analysis of comparative assays on toxicities of lead chloride and lead acetate to in vitro cultured human umbilical cord blood lymphocytes
Rajashree Patnaik, Rabindra N. Padhy
Interdisciplinary Toxicology.2015; 8(1): 35. CrossRef - Association of among alcohol consumption and blood vitamin D and lead concentrations: Based on 2010-2012 Korea national health and nutrition examination survey
Ho-Ki An, Jae-Yong Park, Hee-Jung Yoon
Journal of the Korea Academia-Industrial cooperation Society.2015; 16(1): 498. CrossRef - Blood lead concentration and related factors in Korea from the 2008 National Survey for Environmental Pollutants in the Human Body
Seong Wook Jeong, Chae Kwan Lee, Chun Hui Suh, Kun Hyung Kim, Byung Chul Son, Jeong Ho Kim, Jong Tae Lee, Soo Woong Lee, Yeong Beom Park, Jong Wha Lee, Seung-Do Yu, Chan Seok Moon, Dae Hwan Kim, Sang Yoon Lee
International Journal of Hygiene and Environmental Health.2014; 217(8): 871. CrossRef - Environmental Exposure to Lead (Pb) and Variations in Its Susceptibility
Jina Kim, Youngeun Lee, Mihi Yang
Journal of Environmental Science and Health, Part C.2014; 32(2): 159. CrossRef - Blood cadmium, mercury, and lead and metabolic syndrome in South Korea: 2005–2010 Korean National Health and Nutrition Examination Survey
Byung‐Kook Lee, Yangho Kim
American Journal of Industrial Medicine.2013; 56(6): 682. CrossRef - Monitoring Study on Exposure Levels of Environmental Pollutants in Residents of a Non-Industrial Area, Korea
Dae-Seon Kim, Seung Chul Ahn, Jung Min Ryu, Seung Do Yu
Korean Journal of Environmental Health Sciences.2012; 38(6): 482. CrossRef - Associations of blood lead, cadmium, and mercury with estimated glomerular filtration rate in the Korean general population: Analysis of 2008–2010 Korean National Health and Nutrition Examination Survey data
Yangho Kim, Byung-Kook Lee
Environmental Research.2012; 118: 124. CrossRef - National estimates of blood lead, cadmium, and mercury levels in the Korean general adult population
Nam-Soo Kim, Byung-Kook Lee
International Archives of Occupational and Environmental Health.2011; 84(1): 53. CrossRef - Blood Lead Concentration and Hypertension in Korean Adults Aged 40 and Over According to KNHANES IV (2008)
Sun-Young Kim, Duk-Hee Lee
Korean Journal of Environmental Health Sciences.2011; 37(6): 418. CrossRef - A Study of Working Environment for Automotive Painting in Auto Repair Shops and Workers' Exposure to Hazardous Chemicals
Sang-Hyo Sim, Chun-Hwa Jeoung, Jin-Suk Lim, Hyung-Gu Lee, Yoon-Shin Kim
Korean Journal of Environmental Health Sciences.2009; 35(3): 153. CrossRef
- Prenatal Exposure to Lead and Chromium is Associated with IL-13 Levels in Umbilical Cord Blood and Severity of Atopic Dermatitis: COCOA Study
- 685 View
- 2 Download
- 17 Crossref
Original Article
- Bone and Blood Lead Levels of Middle Aged Koreans not Occupationally Exposed to Lead
- Nam Soo Kim, Sung Woo Choi, Jin Ho Kim, Jung O Ham, Hae Yoon Park, Kyu Dong Ahn, Byung Kook Lee
- Korean Journal of Occupational and Environmental Medicine 2007;19(4):285-292. Published online December 31, 2007
- DOI: https://doi.org/10.35371/kjoem.2007.19.4.285
-
Abstract
PDF
- OBJECTIVES
In order to investigate the level and the association between bone lead and blood lead levels of non-occupationally, lead-exposed Koreans, the authors studied the lead biomarkers of 137 middle aged Koreans (86 males and 51 females) older than whose age were above 40 years.
METHODS
The tibia lead level was selected as the bone lead indicator of cortical bone, and the blood lead level was also measured. The tibia lead level was measured by K-shell XRF with 30-minute measurement of each subjects. The blood lead level was analyzed by AAS method.
RESULTS
The mean (SD) of the tibia lead level of the 137 study subjects was 3.49 (4.99) microgram/g, and tended to be higher. The mean (SD) of tibia lead level in male subjects (was 3.90 (4.88) microgram/g) and larger than in that of female subjects (2.80 (5.14) microgram/g), but without no statistical significance was observed. The mean (SD) of blood lead level of all total subjects was 3.70 (1.35)microgram/dl, and tended to be higher. The mean (SD) of blood lead level in male subjects (was 3.93 (1.25) microgram/dl) and larger than in that of female subjects (3.30 (1.42) microgram/dl), but without no statistical significance was observed. In multiple regression analysis of blood lead levels after adjusting for covariates, age was a significant independent variable. A weak association of age with tibia lead in female subjects was also observed in multiple regression analysis.
CONCLUSION
The mean (SD) of tibia and blood lead levels of middle aged Koreans whose ages were over 40 years old were 3.49 (4.99) microgram/g and 3.70 (1.35) microgram/dl, respectively. Age and sex were positive predictors of blood lead level in multiple regression analysis after controlling for the covariates. However, in multiple regression analysis whereas age was weakly association with tibia lead level only in female subjects in multiple regression analysis. -
Citations
Citations to this article as recorded by- Blood lead concentration and related factors in Korea from the 2008 National Survey for Environmental Pollutants in the Human Body
Seong Wook Jeong, Chae Kwan Lee, Chun Hui Suh, Kun Hyung Kim, Byung Chul Son, Jeong Ho Kim, Jong Tae Lee, Soo Woong Lee, Yeong Beom Park, Jong Wha Lee, Seung-Do Yu, Chan Seok Moon, Dae Hwan Kim, Sang Yoon Lee
International Journal of Hygiene and Environmental Health.2014; 217(8): 871. CrossRef - National estimates of blood lead, cadmium, and mercury levels in the Korean general adult population
Nam-Soo Kim, Byung-Kook Lee
International Archives of Occupational and Environmental Health.2011; 84(1): 53. CrossRef
- Blood lead concentration and related factors in Korea from the 2008 National Survey for Environmental Pollutants in the Human Body
- 658 View
- 0 Download
- 2 Crossref
Case Report
- A Case of Lead Poisoning After Ingestion of Herb Pills
- Se Won Oh, Hyung Jai Lee, Hong Jae Chae, Sung Kwan Lee, Jai Dong Moon, Deok Cho
- Korean Journal of Occupational and Environmental Medicine 2007;19(3):231-237. Published online September 30, 2007
- DOI: https://doi.org/10.35371/kjoem.2007.19.3.231
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Abstract
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- BACKGROUND
Lead is a common environmental metal and has been used for various purposes for a long time, leading to frequent reports of lead poisoning. The concern about lead poisoning starts has been mostly focused on occupational exposure and is linked to the prevention and management of lead exposure in refining and manufacturing processes. Nowadays, however, there is growing concern about nonoccupational lead exposure by many pollutants. Especially, lead poisoning by herb medicine has commonly been observed in clinics in Southeast Asia and South Korea. This case report contains diagnosis of inpatients who suffered from lead poisoning from a herb medicine, arthritis remedy and who complained of abdominal symptoms and dizziness. The study purpose was to awaken our healthful interest in lead poisoning.
CASE
REPORT: A 53-year-old female patient complaining of abdominal pain, dizziness, and numbness of hand and foot came to our hospital due to the continuation of her anemic finding symptoms while undergoing treatment at a secondary hospital. Her past medical history was unremarkable except she had taken herb pills for about a year which were administered by herb medicine to treat arthritis. Physical examination was unremarkable except for oral ulcer finding. Hemoglobin was 8.5 g/dl, reticulocyte count was 4.10%, bilirubin was 1.3 mg/dl (direct 0.3 mg/dl), and Zinc protoporphyrin 169.12 ug/dl. In urinalysis results, WBC increased to 30~39 /HPF, While AST/ALT, BUN/Cr, PT/aPTT, and nerve conduction velocity were normal. Basophilic stippling was observed through peripheral blood smear. The blood lead level was 80.4 microgram/dl and the urine lead level continued to increase to 541 microgram/l. Analysis of the pills that the patient had been taking showed that they contained 30 mg/g lead. By oral chelation therapy with D-penicillamine four times per day for five days, the patient's hemoglobin increased to 11.8 g/dl, while blood lead level decreased to 39.2 microgram/dl, and urine level to 196 microgram/l. Although the soles of her feet remained cold, but other symptoms and anemia finding were improved considerably. However, after discontinuing D-penicillamine medication, the blood lead level increased to 41.4 microgram/dl again. The further administration of D-penicillamine for five days reduced the blood lead level to 31.5 microgram/dl. At two years after the discontinuance of D-penicillamine, the followup findings were normal; hemoglobin was 13.1 g/dl, hematocrit 39.6%, reticulocyte count 1.22%, blood lead level 13.3 microgram/dl, and urine lead level 9.17 microgram/l.
CONCLUSION
After taking herb medicine pills for one year, the patient was admitted to hospital chiefly complaining of abdominal pain, dizziness, and numbness of the hand and foot. The high blood and urine and lead levels and lead chemical analysis of the herb pills confirmed lead poisoning which was treated with D-penicillamine for five days. The follow-up result after two years indicated normal blood and urine lead levels. -
Citations
Citations to this article as recorded by- Sources, distribution, bioavailability, toxicity, and risk assessment of heavy metal(loid)s in complementary medicines
Shiv Bolan, Anitha Kunhikrishnan, Balaji Seshadri, Girish Choppala, Ravi Naidu, Nanthi S. Bolan, Yong Sik Ok, Ming Zhang, Chun-Guang Li, Feng Li, Barry Noller, Mary Beth Kirkham
Environment International.2017; 108: 103. CrossRef - A Case of Lead Poisoning with Drug-induced Liver Injury after Ingestion of Herbal Medicine
Gi Jung Jeon, Jongha Park, Min Sung Kim, Jong Won Yu, Jae Hyun Park, Min Sik Kim
The Korean Journal of Gastroenterology.2015; 65(6): 375. CrossRef - Adverse Events Associated with Metal Contamination of Traditional Chinese Medicines in Korea: A Clinical Review
Hyunah Kim, Peter J. Hughes, Emily M. Hawes
Yonsei Medical Journal.2014; 55(5): 1177. CrossRef
- Sources, distribution, bioavailability, toxicity, and risk assessment of heavy metal(loid)s in complementary medicines
- 618 View
- 1 Download
- 3 Crossref
Original Article
- The Change of Non-smoking Knowledge and Attitude of Intensive Course of Anti-smoking Leadership Training
- Seon Young Lee, Kang Sook Lee, Hyun Woo Yim, Jeong Ho Chae, Dae Jin Kim, Jong Hoo Lee, Jae Hee Yu, Sook Kyoung Choi
- Korean Journal of Occupational and Environmental Medicine 2007;19(3):171-178. Published online September 30, 2007
- DOI: https://doi.org/10.35371/kjoem.2007.19.3.171
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Abstract
PDF
- OBJECTIVES
To evaluate the effectiveness of an anti-smoking readership training program on the knowledge, attitude and practice in health managers and supervisors in the workplace.
METHODS
We surveyed 482 health managers and supervisors in the workplace from April 2005 to September 2005. The questionnaire included whether or not a smoking cessation program was conducted in their workplace. We assessed before and after educations program about knowledge, attitude and practice for smoking cessation. The 10-hour education program included the benefit of quit smoking, the law for smoking restriction, cognitive therapy, stress management, nicotine addiction, replacement therapy, case study about workplace for anti-smoking policy and program.
RESULTS
For the change in the mean scores of all items in knowledge, attitude and practice were significantly increased after the intervention.
CONCLUSION
Even a short, 10-hour intervention course of anti-smoking leadership training program was effective for improving the knowledge, attitude, practice to quit smoking activity in workplace. Nevertheless, the program effectiveness would be increased by including a re-training course and website support. -
Citations
Citations to this article as recorded by- Research Trend Analysis of Dental Scaling Using Topic Modeling
Kyung Hui Moon
International Journal of Clinical Preventive Dentistry.2022; 18(1): 8. CrossRef - Effect of Standardized Smoking Cessation Training Program for Healthcare Professionals on Their Knowledge
Cheol-Min Lee, Jong-Hyuck Park, Young-Ju Kim
Journal of the Korean Society for Research on Nicotine and Tobacco.2016; 7(1): 1. CrossRef - Risk factors of musculoskeletal symptoms in university hospital nurses
Eunkwang Ryu, Byeongjin Ye, Youngil Yi, Jungwon Kim
Annals of Occupational and Environmental Medicine.2014;[Epub] CrossRef - Work-related Musculoskeletal Diseases and Occupational Injuries in Health Care Workers
Jung-Yeon Hong, Jung-Wan Koo
Journal of the Korean Medical Association.2010; 53(6): 446. CrossRef
- Research Trend Analysis of Dental Scaling Using Topic Modeling
- 548 View
- 2 Download
- 4 Crossref
Original Article
- Effect of Cumulative Blood Lead and Cumulative Blood ZPP as Lead Body Burden on Renal Lead Biomarkers
- Gang Ho Yoon, Nam Soo Kim, Jin Ho Kim, Hwa Sung Kim, Byung Kook Lee
- Korean Journal of Occupational and Environmental Medicine 2006;18(4):298-306. Published online December 31, 2006
- DOI: https://doi.org/10.35371/kjoem.2006.18.4.298
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Abstract
PDF
- OBJECTIVE: To evaluate the possibility of cumulative blood lead and blood ZPP as surrogates of lead body burden and to investigate their association with renal function as an index of lead body burden.
METHODS
The study subjects comprised 678 lead workers with past blood lead and blood ZPP data from their employment. Cumulative blood and ZPP were calculated by accumulating the every year mean value of both indices from the new employment since 1983. To assess the cumulative data of lead workers who started their lead work before 1983, the years before 1983 were simulated with the first available data from 1983. Study variables for lead body burden were tibia bone lead and DMSA chelatable lead, whereas those for current lead biomarkers were blood lead and blood ZPP. BUN and serum creatinine were selected as clinical renal biomarkers, while NAG (N-acetyl-D-glucosamine) and RBP (Retinol binding protein) were selected as early renal biomarkers.
RESULTS
The association between cumulative blood lead and blood ZPP with tibia bone lead was statistically significant with determinant coefficients (r(2)) of 0.72 and 0.567, respectively, and their relationships were better explained by the curvilinear regression model. In multiple regression analysis of current lead biomarkers on the renal biomarkers after controlling for possible confounders (age, sex, job duration, smoking and drinking status), blood lead was associated only with log-transformed NAG, whereas blood ZPP was associated with 3 other renal biomarkers. On the other hand, in multiple regression analysis of biomarkers of lead body burden on renal biomarkers after controlling for possible confounders (age, sex, job duration, smoking and drinking status), cumulative blood ZPP and tibia bone lead were associated with all 4 renal function biomarkers, whereas cumulative blood lead and DMSA chelatable lead were associated with 3 renal biomarkers except BUN.
CONCLUSION
Cumulative blood and ZPP were demonstrated to be good surrogates of lead burden. Furthermore, the cumulative blood ZPP was confirmed to have a better association than the cumulative blood lead.
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Original Article
- The Effect of ALAD and VDR Polymorphism on the Hematopoietic Biomarkers in Lead Exposed Workers
- Sung Soo Lee, Nam Soo Kim, Jin Ho Kim, Yong Bae Kim, Young Hwangbo, Hwa Sung Kim, Kyu Dong Ahn, Byung Kook Lee
- Korean Journal of Occupational and Environmental Medicine 2005;17(4):343-351. Published online December 31, 2005
- DOI: https://doi.org/10.35371/kjoem.2005.17.4.343
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Abstract
PDF
- OBJECTIVES
This study was conducted with new workers who entered lead industries from 1992 to 2001 to evaluate the genetic susceptibility of ALAD (delta-aminolevulinic acid dehydratase) and VDR (vitamin D receptor) gene on health effect of lead exposure.
METHODS
Among the subjects of the database of lead industries at the Soonchunhyang University Institute of Industrial Medicine, only new workers were selected for this study. The total of eligible workers for this category was 3,540 workers, including non lead exposed workers of same lead industries. From stored blood in specimen bank of Soonchunhyang University, genotype of ALAD and VDR were measured using PCR method. Variables for this study were blood lead as an index of lead exposure, ZPP (zinc protoporphyrin in blood), urine ALA (delta-aminolevulinic acid), and hemoglobin as an index of hematopoietic effect of lead. Information on sex, job duration, and weight were collected for personal information. The data were analyzed using SAS (version 8.2) with descriptive analysis of t-test and multiple regression analysis.
RESULTS
Among 3,540 new employed study subjects during period of 1992-2001, 3,204 workers (90.5%) had ALAD genotype 1-1, while 336 workers (9.5%) had variant type of ALAD (1-2 or 2-2). For VDR genotype, 2,903 workers (89.7%) out of total tested 3,238 workers were belonged to type bb and 335 workers (10.5%) were type bB or BB. The distribution of genotype of ALAD and VDR were not different according to the job duration in male workers, but were different in female workers. The effect of ALAD and VDR genotype on blood lead were positively significant in the analysis of all cumulative data of new employed workers for 10 years. The effect of VDR genotype on blood lead were stronger than that of ALAD. While the variant ALAD gene made decrease of mean ZPP and ALA in urine after controlling for blood lead and other covariate, the variant VDR gene made increased the mean ZPP and ALA in urine in all cumulative data analysis and cross sectional analysis by job duration. For hemoglobin, ALAD and VDR genotype did not affect the mean value.
CONCLUSIONS
From the above our results, we found that ALAD and VDR genotype exerted significant effect in various way. We confirmed that the finding of a cross sectional study of protective effect of variant ALAD on the effect of blood lead on blood ZPP in our retrospective study design. It was found that VDR did not exert protective effect for lead exposure as the variant ALAD did.
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- 1 Download
Original Article
- Effect of Developmental Lead Exposure on the Expression of Hippocampal NMDA Receptor Subunit mRNA
- Tae Wan Kim, In Sung Chung, Jae Hoon Bae, Dong Hoon Shin, Mi Young Lee, Joon Sik Kim
- Korean Journal of Occupational and Environmental Medicine 2005;17(4):278-287. Published online December 31, 2005
- DOI: https://doi.org/10.35371/kjoem.2005.17.4.278
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Abstract
PDF
- OBJECTIVES
The purpose of the present study was to examine the differential effects of lead (Pb) exposure on the expression of specific NMDA receptor subunit mRNAs on the hippocampal cells depending on the neuronal developmental stage.
METHODS
Expression of the NR2A and NR2B subunits of the NMDA receptors mRNA on the hippocampal neurons was measured by in situ hybridization in the control and Pb treated groups. Pb-treated and NMDA cytotoxicity was assessed by morphological examination and LDH measurements.
RESULTS
Hippocampal NR2A subunit mRNA expression was gradually increased with increasing age, and was significantly decreased after Pb exposure. The expression of NR2B subunit mRNA was not changed during development in the rat hippocampus and the developmental effect of Pb exposure on NR2B expression was minimal. These results indicate that chronic Pb exposure may decrease the levels of NR2A-containing NMDA receptors and may thereby alter normal synaptic signal transmission. Pb or NMDA-induced cytotoxicity in vitro differed significantly between the immature and the mature hippocampal cells.
CONCLUSIONS
This study demonstrates that chronic Pb exposure during brain development alters the levels of specific NMDA receptor subunit mRNA in the rat hippocampus. These results suggest that chronic Pb exposure may attenuate the precise neuronal synaptic transmission through the differential alteration of the composition of the NMDA receptor subunit on the hippocampus depending on neuronal developmental stage.
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- 2 Download
Original Article
- Blood Pb, Urine Cd and Health Assessment of Residents in the Vicinity of Abandoned Mines in Gyeongsangbuk-do
- Jong Hak Chung, Pock Soo Kang, Chang Yoon Kim, Kyung Soo Lee, Tae Yoon Hwang, Gyu Tae Kim, Jong Seo Park, Si Young Park, Dae Seop Kim, Ou Taek Lim, Joon Sakong
- Korean Journal of Occupational and Environmental Medicine 2005;17(3):225-237. Published online September 30, 2005
- DOI: https://doi.org/10.35371/kjoem.2005.17.3.225
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Abstract
PDF
- OBJECTIVES
The objective of this health assessment is to evaluate the health risks that may result from exposure to abandoned mine tailings in Gyeongsangbuk-do. The tailings are remnants from an earlier flotation mill and mining operation that was in business from the early 1930's until 1970.
METHODS
The soil, stream water, and drinking water in and around three abandoned mine areas, Soochul, Gumjang, Darock, and three control areas located in Gyeongsangbuk-do were analyzed for level of Cd, Pb, Cu, As, and Hg. Potential chronic health effects were evaluated by interview and medical examination.
RESULTS
Some soil and stream samples exceeded the Korean standard for soil contamination in farmland and the Korean standard of water contamination in streams respectively. Blood lead (5.37 microgram/dl) and urine cadmium (2.79 microgram/g Cr) levels of the residents in the vicinity of the abandoned mine sites were significantly higher than of the residents in the control areas (blood lead, 4.34 microgram/dl; urine cadmium, 1.62 microgram/g Cr). There were no significant differences between the mining and control areas in terms of blood pressure, Hb, BUN, creatinine, SGOT, SGPT, fasting blood sugar, and the prevalence of potential chronic diseases.
CONCLUSIONS
The results of the assessment suggested that the three abandoned mine sites do not pose an apparent health risk to nearby residents. Nevertheless, the elevated blood lead and urine cadmium levels in the residents of the abandoned mine site suggested that it might be an important source of heavy metals contamination. Therefore, a nationwide evaluation program is needed to assess the potential health risks of residents living in the vicinity of abandoned mine sites. -
Citations
Citations to this article as recorded by- A review on heavy metal and metalloid contamination of vegetables: addressing the global safe food security concern
Sweta, Bhaskar Singh
International Journal of Environmental Analytical Chemistry.2024; 104(16): 4762. CrossRef - Bioaccumulation of Lead, Cadmium, and Arsenic in a Mining Area and Its Associated Health Effects
Ulziikhishig Surenbaatar, Seungho Lee, Jung-Yeon Kwon, Hyunju Lim, Jeong-Jin Kim, Young-Hun Kim, Young-Seoub Hong
Toxics.2023; 11(6): 519. CrossRef - Association between levels of exposure to heavy metals and renal function indicators of residents in environmentally vulnerable areas
Jung-Yeon Kwon, Seungho Lee, Ulziikhishig Surenbaatar, Hyoun-Ju Lim, Byoung-Gwon Kim, Sang-Yong Eom, Yong Min Cho, Woo Jin Kim, Byeng-Chul Yu, Kwan Lee, Young-Seoub Hong
Scientific Reports.2023;[Epub] CrossRef - Association of Blood Heavy Metal Levels and Renal Function in Korean Adults
Yoonjin Park, Su-Jung Lee
International Journal of Environmental Research and Public Health.2022; 19(11): 6646. CrossRef - Potential of biochar for clean-up of heavy metal contaminated soil and water
Adaobi Onmonya Yvonne, Galadima Adamu Sadiq, Sadiq Maryam
African Journal of Environmental Science and Technology.2022; 16(4): 146. CrossRef - Exposure factors of cadmium for residents in an abandoned metal mine area in Korea
Seung Chul Ahn, Jun Young Chang, Jung Sub Lee, Hwa Yon Yu, A-Ra Jung, Jee-Young Kim, Jong-Woo Choi, Young-Seoub Hong, Seung Do Yu, Kyounghee Choi
Environmental Geochemistry and Health.2017; 39(5): 1059. CrossRef - Time trend of cadmium intake in Korea
Chan-Seok Moon, Hye-Ran Yang, Haruo Nakatsuka, Masayuki Ikeda
Environmental Health and Preventive Medicine.2016; 21(3): 118. CrossRef - Measuring the Environmental Burden of Disease in South Korea: A Population-Based Study
Seok-Jun Yoon, Hyeong-Su Kim, Jongsik Ha, Eun-Jung Kim
International Journal of Environmental Research and Public Health.2015; 12(7): 7938. CrossRef - Blood Cadmium Concentration of Residents Living near Abandoned Metal Mines in Korea
Young-Seoub Hong, Byung-Kook Lee, Jung-Duck Park, Joon Sakong, Jae-Wook Choi, Jai-Dong Moon, Dae-Seon Kim, Byoung-Gwon Kim
Journal of Korean Medical Science.2014; 29(5): 633. CrossRef - Association of arsenic levels in soil and water with urinary arsenic concentration of residents in the vicinity of closed metal mines
YongMin Cho, SungChul Seo, Seung-Hyun Choi, SeungKil Lee, KyungHee Kim, Hae-Joon Kim, Jae-Wook Choi
International Journal of Hygiene and Environmental Health.2013; 216(3): 255. CrossRef - Relationship between Urine Cadmium and Bone Mineral Density of Residents Around Abandoned Metal Mines
Kyung-Sick Jung, Nam-Soo Kim, Seung-Chul Ahn, Byung-Kook Lee
Korean Journal of Environmental Health Sciences.2012; 38(4): 323. CrossRef - The association of heavy metals in blood, fish consumption frequency, and risk of cardiovascular diseases among Korean adults: The Korean National Health and Nutrition Examination Survey (2008-2010)
Ji-Ye Shin, Ji-Myung Kim, Yuri Kim
Korean Journal of Nutrition.2012; 45(4): 347. CrossRef - Blood lead levels of residents living around 350 abandoned metal mines in Korea
Nam-Soo Kim, Joon Sakong, Jae-Wook Choi, Young-Seoub Hong, Jai-Dong Moon, Byung-Kook Lee
Environmental Monitoring and Assessment.2012; 184(7): 4139. CrossRef - The Effect of Exposure Factors on the Concentration of Heavy Metals in Residents Near Abandoned Metal Mines
Sanghoo Kim, Yong-Min Cho, Seung-Hyun Choi, Hae-Joon Kim, Jaewook Choi
Journal of Preventive Medicine and Public Health.2011; 44(1): 41. CrossRef - Lessons of Goseong Abandoned Metal Mine Accident
Ho-Jang Kwon
Korean Journal of Environmental Health Sciences.2011; 37(5): 335. CrossRef - Relationship between Heavy Metal Concentrations in the Soil with the Blood and Urine of Residents around Abandoned Metal Mines
Bong-Ki Jang, Sang-Il Park, Nam-Soo Kim, Kyung-Sick Jung, Byung-Kook Lee, Jong-Wha Lee
Korean Journal of Environmental Health Sciences.2011; 37(5): 348. CrossRef - Blood Lead Level in Populations Resident in Some Abandoned Mine Area
Sun-Ho Song, Sang-Yong Eom, Yong-Dae Kim, Heon Kim, Jang-Soo Hong
Journal of Environmental Science International.2010; 19(4): 527. CrossRef - Investigation on Health Effects of an Abandoned Metal Mine
Soyeon Kim, Ho-Jang Kwon, Hae-Kwan Cheong, Kyungho Choi, Jae-Yeon Jang, Woo-Chul Jeong, Dae-Seon Kim, Seungdo Yu, Young-Wook Kim, Kwang-Young Lee, Seoung-Oh Yang, Ik Jae Jhung, Won-Ho Yang, Yun-Chul Hong
Journal of Korean Medical Science.2008; 23(3): 452. CrossRef
- A review on heavy metal and metalloid contamination of vegetables: addressing the global safe food security concern
- 745 View
- 3 Download
- 18 Crossref
Original Article
- Blood Lead Levels in Umbilical Cord and Neonatal Neurobehavioral Status
- Jung Are Kim, Seong Ah Kim, Chae Yong Lee, Sang Jae Jung, Byung Yeol Chun
- Korean Journal of Occupational and Environmental Medicine 2005;17(1):58-69. Published online March 31, 2005
- DOI: https://doi.org/10.35371/kjoem.2005.17.1.58
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Abstract
PDF
- OBJECTIVES
To investigate the relation between umbilical cord blood lead level lower than 10 microgram/dl and neonatal neurobehavioral performance.
METHODS
Umbilical cord blood lead level, as an indicator for prenatal exposure to lead, and Brazelton neonatal behavioral assessment scale (NBAS), as an indicator for effect, were determined in 86 neonates in Gumi, Kyungpook, Korea. The blood levels were measured by graphite furnace atomic absorption spectrophotometer. Development was assessed by NBAS at birth in 86 neonates and at 1 month in 55 neonates.
RESULTS
The mean cord blood lead levels of the 86 and 55 neonates were 3.90 +/- 0.71 microgram/dl (range 2.24 - 5.39 microgram/dl) and 3.88 +/- 0.70 microgram/dl (range 2.24~5.03 microgram/dl), respectively. We used the median value of 4 microgram/dl to divide into low- and high- lead level groups. There was a significant difference in the peak of excitement at birth, and in the animate visual, inanimate visual, inanimate auditory, activity level, peak of excitement, and liability of states at one month, between the two groups. For cluster scores, motor system and state organization scores showed significant differences between the two groups. For adjusting the potential confounding effect of intial difference, differences of the scores between the two groups at one month were analysed with ANCOVA. The results of ANCOVA showed the significant difference between the two groups.
CONCLUSIONS
The findings suggest that prenatal low-level lead exposure, even lower than 10 microgram/dl, might affect the neonatal neurobehavioral development.
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Original Article
- Associations of ALAD Genotype with Renal Function Indices in Lead Workers
- Sung Soo Lee, Jin Ho Kim, Nam Soo Kim, Hwa Sung Kim, Kyu Dong Ahn, Byung Kook Lee
- Korean Journal of Occupational and Environmental Medicine 2004;16(2):200-209. Published online June 30, 2004
- DOI: https://doi.org/10.35371/kjoem.2004.16.2.200
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Abstract
PDF
- OBJECTIVES
delta-Aminolevulinic acid dehydratase (ALAD) is a polymorphic enzyme that has two alleles, ALAD1 (ALAD1-1 as genotype) and ALAD2 (ALAD1-2 or ALAD2-2 as genotype). ALAD genotype has been reported to modify the pharmacokinetics and toxicity of lead. The authors investigated the influence of ALAD genotype polymorphism on renal function in lead workers METHODS: We studied 935 male lead workers and 87 male non-lead workers in the same industries. For cross-sectional renal indices, blood urea nitrogen (BUN), serum creatinine, serum uric acid and urine total protein were selected. Blood lead level was also measured an index of lead exposure. Information on weight, age, job duration, and smoking and drinking habits was collected.
RESULTS
Whereas the mean blood lead level of lead workers was 25.4+/-10.9 microgram/dL, that of non-lead workers in the same premise was 10.1+/-2.8 microgram/dL, and the difference between the two groups was statistically significant. Whereas the prevalence of the variant allele, ALAD2 in 935 lead workers was 10.6%, that in 87 non-lead workers was 4.6%. However there was no difference of prevalence between the two groups. The mean blood lead level of subjects with ALAD1 was 23.9+/-11.4 microgram/dL, which was slightly lower than that of subjects with ALAD2 (25.8+/-10.7 microgram/dL). However, this difference was not statistically significant. After adjustment for the covariates, the subjects with ALAD2 allele were 12.8% less likely to have a median value or more of BUN than subject with ALAD1. The adjusted odds ratio was 0.59 (95% confidence interval; 0.38-0.91). After adjustment for the covariates, the subjects with ALAD2 allele were 9.3% less likely to have a median value or more of serum creatinine than subject with ALAD1. The adjusted odds ratio was 0.64 (95% confidence interval; 0.41-0.98).
CONCLUSIONS
From the above results, it was found that the variant allele, ALAD2 appeared to modify the association of lead and renal function, and that ALAD2 genotype may be supportive for the protective effect of lead. -
Citations
Citations to this article as recorded by- Effects of Factors Associated with Urine Hippuric Acid Correction Values in Urinary Creatinine by HPLC and Jaffe Method and Specific Gravity HPLC Jaffe Method
Key-Young Kim, Jong-Gyu Kim, Ki-Nam Yoon, Wha-Me Park, Hun-Hee Park
Journal of Korean Society of Occupational and Environmental Hygiene.2015; 25(4): 493. CrossRef - Environmental Exposure to Lead (Pb) and Variations in Its Susceptibility
Jina Kim, Youngeun Lee, Mihi Yang
Journal of Environmental Science and Health, Part C.2014; 32(2): 159. CrossRef
- Effects of Factors Associated with Urine Hippuric Acid Correction Values in Urinary Creatinine by HPLC and Jaffe Method and Specific Gravity HPLC Jaffe Method
- 634 View
- 2 Download
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Original Article
- Musculoskeletal Symptoms and Related Factors for Nurses and Radiological Technologists Wearing a Lead Apron for Radiation Protection
- Jung Im Yoo, Jung Wan Koo
- Korean Journal of Occupational and Environmental Medicine 2004;16(2):166-177. Published online June 30, 2004
- DOI: https://doi.org/10.35371/kjoem.2004.16.2.166
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Abstract
PDF
- OBJECTIVES
To determine the complaint rates of musculoskeletal symptoms and understand the related factors of musculoskeletal symptoms in nurses and radiological technologists wearing a lead apron for radiation protection.
METHOD
The study subjects were 192 nurses and radiological technologists who work at the cardiac catheterization room or angioroom in the department of radiology. A self-recording questionnaire was used to investigate the general characteristics, occupational characteristics, characteristics related to wearing a lead apron, and subjective musculoskeletal symptoms designed by the National Institute for Occupational Safety and Health (NIOSH).
RESULTS
Complaint rates of musculoskeletal symptoms by NOISH were 51.0% in the upper /lower back, 49.0% in the shoulder, and 47.9% in the leg/knee/ankle. From multiple logistic regression analysis, musculoskeletal symptoms of the shoulder were influenced by two-piece type apron and long time wearing an apron, symptoms of upper/lower back by long time wearing an apron, sex, higher average working hours per a day and short resting time, symptoms of leg/knee/ankle by long time wearing an apron, working career at the present department (cardiac catheterization room or angioroom) and short resting time.
CONCLUSION
The complaint rates of the musculoskeletal symptoms were affected by the characteristics of wearing a lead apron for radiation protection such as wearing time and apron type. Therefore, it is suggested that the workers who are wearing an apron need the proper wearingtime and resting time, and suitable apron type and size for the body. -
Citations
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Jason D. Hout, JuHyeong Ryu
Safety Science.2025; 181: 106669. CrossRef - Convergence Performance Evaluation of Radiation Protection for Apron using the PSNR
Dae-Ho Kim, Sang-Hyun Kim
Journal of Digital Convergence.2015; 13(10): 377. CrossRef - Risk Factors for Musculoskeletal Symptoms Among Korean Radiation Workers
Jae-Hwan Cho, Moo-Seong Cho, Jae-Ouk Ahn
Archives of Environmental & Occupational Health.2015; 70(3): 160. CrossRef - A study on the relationship between stress and fatigue and the musculoskeletal symptoms experienced by Korean radiation workers
Jin Lee, Hae-Kag Lee, Jae-Hwan Cho
Journal of Physical Therapy Science.2015; 27(2): 427. CrossRef - Analysis of Risk Factors for Work-related Musculoskeletal Disorders in Radiological Technologists
Taehyung Kim, Hyolyun Roh
Journal of Physical Therapy Science.2014; 26(9): 1423. CrossRef - Survey of the musculoskeletal disorders of radiological technologists
Jin Lee, Jae-Hwan Cho
Journal of the Korean Society of Radiology.2012; 6(1): 53. CrossRef
- The association between musculoskeletal disorders and lead apron use in healthcare workers: A systematic review and meta-analysis
- 1,022 View
- 24 Download
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Original Article
- A Study on Liver Function Indices in Male Lead Workers
- Young Hwangbo, Yong Bae Kim, Gap Soo Lee, Sung Soo Lee, Kyu Dong Ahn, Byung Kook Lee
- Korean Journal of Occupational and Environmental Medicine 2002;14(3):270-279. Published online September 30, 2002
- DOI: https://doi.org/10.35371/kjoem.2002.14.3.270
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Abstract
PDF
- OBJECTIVES
To evaluate the effects of lead on the liver function indices in male lead workers.
METHODS
The study comprised of 274 lead workers and 113 non-lead workers who were confirmed not to have HBsAg (Hepatitis B surface Antigen). Blood lead (PbB), blood zinc protoporphyrin (ZPP) and urinary delta-aminolevulinic acid (ALAU) were selected as parameters for monitoring exposure to lead while aspartate aminotransferase (SGOT), alanine aminotransferase (SGPT) and gamma-glutamyltransferase (gamma-GTP) were chosen as parameters for monitoring liver function. Demographic information, such as age, smoking and drinking histories were collected. The duration of work for the lead workers, and their BMI(body mass index), were also obtained.
RESULTS
After adjusting for possible confounders {age, BMI, work duration, smoking (pack-year) and drinking (bottles of Soju consumed per week)}, blood lead was observed to be a significant variable from the logistic regression analysis of the abnormalities of SGOT( >35 IU/L), with an odds ratio of 1.04 (95 % CI, 1.008-1.066). The amount of alcohol drunk (odds ratio 1.28: 95 % CI, 1.054-1.549) and BMI (odds ratio 1.24: 95 % CI, 1.075-1.421) were also significant variables. From the multiple linear regression analyses, blood lead was significantly, and positively, associated with SGOT (p<0.05).
CONCLUSIONS
These findings suggest that exposure to lead may have an effect on SGOT in male lead workers. -
Citations
Citations to this article as recorded by- Effect of Pork Consumption on Renal and Hematochemical Indices in Workers Occupationally Exposed to Unclean Environments
Chan-Kyu Han, Jeong-Hae Rho, Bog-Hieu Lee
Korean Journal for Food Science of Animal Resources.2008; 28(1): 91. CrossRef
- Effect of Pork Consumption on Renal and Hematochemical Indices in Workers Occupationally Exposed to Unclean Environments
- 508 View
- 0 Download
- 1 Crossref
Original Article
- Associations between Lead Exposure and Dose and Protein Kinase C Activation in Erythrocytes Among Lead Workers
- Kyu Yoon Hwang, Young Hwangbo, Hyun Cheol Ahn, Yong Bae Kim, Gap Soo Lee, Sung Soo Lee, Kyu Dong Ahn, Byung Kook Lee
- Korean Journal of Occupational and Environmental Medicine 2001;13(4):369-375. Published online December 31, 2001
- DOI: https://doi.org/10.35371/kjoem.2001.13.4.369
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Abstract
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- OBJECTIVES
Protein kinase C(PKC), a calcium and phospholipid dependent enzyme, is activated by lead in vitro at picomolar concentrations. However, the effect of lead on PKC has never been studied in a human population. The purpose of the study was to evaluate whether lead exposure was associated with PKC mediated-phosphorylation in erythrocytes among lead workers.
METHODS
Two hundred and twelve lead workers were studied. To determine the levels of phosphorylation in vivo, an in vitro back phosphorylation technique was used by adding PKC and gamma-32P to preparations of erythrocyte membranes. We measured back phosphorylations of erythrocyte membrane proteins, spectrin, and 52 kDa and 48 kDa, as an indirect measure of PKC activation in vivo.
RESULTS
The mean(SD) age and exposure duration was 39.1(10.0) years and 8.1(6.5) years, respectively. Tibial lead ranged from 0.8 to 290.8 microgram Pb/g bone mineral with a mean(SD) of 34.4(35.2) microgram Pb/g bone mineral. The means(SD) of back phosphorylation levels of the three proteins were 540.7(304.1), 198.6(78.2), and 247.7(83.3) photostimulated luminescence units(PSL), respectively, by phosphoimager. After adjustment for potential confounding factors, tibial lead and exposure duration were significantly and inversely associated with back phosphorylation levels. One unit of increase in tibial lead(1 microgram Pb/g bone mineral) is associated with a decline in spectrin, band 4.9 52 kDa, and band 4.9 48 kDa back phosphorylation levels by 1.4(P<0.05), 0.34(P<0.05), and 0.47(P<0.01), respectively. However, there were no associations between the back phosphorylation levels and either blood lead or ZPP levels.
CONCLUSIONS
These findings suggest that the PKC activity in erythrocytes is increased by chronic lead exposure and that erythrocyte membrane protein phosphorylation may be a biomarker of lead exposure.
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Original Article
- The Effect of ALAD Polymorphism on the Relationship of Blood and Bone Lead with Hematologic Biomarkers in Lead Exposed Workers
- Hwa Sung Kim, Sung Soo Lee, Yong Bae Kim, Young Hwangbo, Gap Soo Lee, Kyu Dong Ahn, Bong Ki Jang, Byung Kook Lee
- Korean Journal of Occupational and Environmental Medicine 2001;13(1):75-86. Published online March 31, 2001
- DOI: https://doi.org/10.35371/kjoem.2001.13.1.75
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Abstract
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- OBJECTIVES
To evaluate the effect of ALAD polymorphism on the relationship of blood and bone lead with hematologic biomarkers in lead exposed workers, 450 lead exposed workers and 85 non-lead exposed workers were selected.
METHODS
Blood lead and tibia bone lead were selected as parameters of lead exposure and blood ZPP, urinary ALA (ALAU), hemoglobin (Hb) and hematocrit (Hct) were chosen as parameters of hematologic effect of lead exposure. Genotype of each subject was assayed and expressed as ALAD1 and ALAD2. Demographic information such as sex, age and personal habit of smoking and drinking were collected. Job duration of lead exposed workers was also obtained.
RESULTS
The overall prevalence of the variant allele, ALAD2 in lead exposed workers was 9.6 %(43 out of 450 lead workers) which was not differed from control workers (9.4 % : 8 out of 85). The means of tibial lead and blood ZPP in lead workers with ALAD2 were lower than those of lead workers with ALAD1, but the differences were not statistically significant. After adjusting for possible confounders (sex, job duration, BMI, drinking and smoking status) only blood lead and bone lead contributed negatively to the level of hemoglobin with statistical significance without any contribution of ALAD genotype. On the other hand, no significant effect of blood lead, bone lead and ALAD genotype were observed on the level of hematocrit after controlling possible confounder. ALAD genotype in the multiple regression analysis of blood lead and bone lead with log transformed urinary ALA (LogALAU) after adjusting for possible confounders showed significant main and interaction effect on LogALAU simultaneously, which resulted lower LogALAU in lead exposed workers of ALAD2 than ALAD1. It was also observed only main effect of ALAD gene type on blood ZPP after adjusting possible confounder resulting lower ZPP in lead workers of ALAD2 than ALAD1.
CONCLUSIONS
With above results, it was found that ALAD polymorphism did not affect on the level of hemoglobin and hematocrit, but ALAD polymorphism made significant effect on the association of blood and bone lead with urinary ALA and blood ZPP. The lower urinary ALA and blood ZPP in ALAD2 lead workers suggested that ALAD2 genotype may be supportive for the protective effect of lead.
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Original Article
- Effect of Occupational Lead on Male Sex Hormones
- Hyeong Su Kim, Soung Hoon Chang, Won Jin Lee, Jae Wook Choi, Jong Tae Park, Nam Won Paik, Rok Ho Kim
- Korean Journal of Occupational and Environmental Medicine 2001;13(1):44-54. Published online March 31, 2001
- DOI: https://doi.org/10.35371/kjoem.2001.13.1.44
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Abstract
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- OBJECTIVES
This study was performed to evaluate the relationship between biological markers of lead exposure and level of sex hormones in men occupationally exposed to lead.
METHODS
In this study, 33 male workers who employed at smelting and battery factories were compared with 33 male workers who were not exposed to lead. As biological markers of lead exposure, hemoglobin, ZPP, blood lead and urine lead were measured. As sex hormones, FSH, LH, testosterone, SHBG and FTI were determined.
RESULTS
Hemoglobin level was significantly lower in exposed than in nonexposed group. Level of ZPP, blood lead, and urine lead were significantly higher in exposed than in nonexposed group. There was a trend that level of FSH, testosterone, SHBG, and FTI was lower in exposed than in nonexposed group respectively, but there were no statistical significance. In exposed group, FSH level was correlated with age, ZPP, and blood lead; testosterone level was correlated with hemoglobin, blood lead, urine lead, and SHBG; and FTI level was correlated with age.
CONCLUSIONS
Level of some sex hormones were lower in exposed than in nonexposed group but there were no statistical significance between the exposed and the nonexposed group. But level of sex hormones were correlated with several biological markers of lead in exposed group. It suggests that occupational lead exposure might affect sex hormones.
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Original Article
- The Relationship between Psychosocial Distress and Lead Exposure Indices in Lead Workers
- Yong Bae Kim, Hyun Cheol Ahn, Young Hwangbo, Gap Soo Lee, Kyu Yoon Hwang, Sung Soo Lee, Kyu Dong Ahn, Byung Kook Lee
- Korean Journal of Occupational and Environmental Medicine 2000;12(1):128-138. Published online March 31, 2000
- DOI: https://doi.org/10.35371/kjoem.2000.12.1.128
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Abstract
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- OBJECTIVES
This study was carried out to assess psychosocial distress of lead workers and to examine the relationship between lead exposure indices and psychosocial distress.
METHODS
The study design was cross-sectional and research subjects were 234 lead workers in primary smelting industry. General characteristics, job characteristics and social support were obtained by self-administered questionnaire and history taking. Psychosocial distress was measured using PWI(Psychosocial Well-being Index), a 45-item self-administered instrument. Blood lead(PbB), zinc protoporphyrin(ZPP), -aminolevulinic acid in urine(ALAU) were selected as indicators of lead exposure.
RESULTS
There was significant difference in PWI according to lead exposure level and job characteristics. The results of correlation analysis showed that PWI was significantly correlated with PbB(r=0.203, P=0.002).
CONCLUSIONS
Our results supported the association between lead exposure and psychosocial distress. The inclusion of psychosocial distress measurement as a special health examination for lead workers was highly recommended for the effective health management.
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Original Article
- Apoptosis of Neuronal Cells Induced by Lead
- Seon Hee Yang, Dong Hoon Shin, Won Ki Baek
- Korean Journal of Occupational and Environmental Medicine 1999;11(2):254-263. Published online June 30, 1999
- DOI: https://doi.org/10.35371/kjoem.1999.11.2.254
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Abstract
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- Lead is a major environmental and occupational neurotoxicant. It has been shown that long-term exposure to a low level of lead impairs the development of brain. For example, it was reported that lead exposure during the childhood causes a learning difficulty and a memory deficit of children. Neurotoxic agents including the lead are believed to cause neuronal death in developing brain by two mechanisms: apoptosis and necrosis. However, the exact mechanism of neuronal death caused by lead exposure is still not known explicitly. In this study, we conducted a study to clarify a mechanism of hippocampal neuronal cell death caused by lead acetate. Hippocampal neurons were cultured for 14-16 days and treated with lead acetate of 1. 10, 100 1 microM concentrations for 12 hours. With the MTT(methyl tetrazolium test) kit, the viability of neuronal cells was measured. Next, in order to examine apoptosis caused by lead acetate, TUNEL (TdT-mediated d-UTP Nick End Labelling) assay was performed. It has been shown that lead acetate reduced the viability of neuronal cells in a dose dependent manner, especially at the concentration of 100 ~M lead acetate. TUNEL immunostain showed brownish signals in the nucleus of apoptotic cells. The proportions of apoptotic cells in the lead?acetate treated group were more higher than those in the controls and increased as lead acetate concentration increased. From above results, it may be concluded that lead in the hippocampal neuronal cells reduced cell viability and one of mechanisms in neuronal cell death by lead appears to be apoptosis.
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Citations
Citations to this article as recorded by- Teratogenic Effects of Lead in the Developing Chick Embryos
Aqsa Shafiq, . Mahnoor, Mirza Fahad Baig, Yashal Fatima, Arooj Haer, Shakila Parveen, Muhammad Akram Tariq, Muhammad Khalil Ahmad Khan
MARKHOR (The Journal of Zoology).2023; : 16. CrossRef
- Teratogenic Effects of Lead in the Developing Chick Embryos
- 565 View
- 4 Download
- 1 Crossref
Original Article
- A Study on Thyroid Function among Male Workers Occupationally Exposed to Inorganic Lead
- Hyeong Su Kim, Yun Cheol Park, Jae Wook Choi, Woo Whan Rho, Dae Seong Kim, Jong Tae Park
- Korean Journal of Occupational and Environmental Medicine 1999;11(2):153-160. Published online June 30, 1999
- DOI: https://doi.org/10.35371/kjoem.1999.11.2.153
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Abstract
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- This study was performed to evaluate the relationship between biological markers of lead exposure and thyroid functions among male workers occupationally exposed to inorganic lead. 30 male workers exposed to inorganic lead at smelting and battery factories were investigated, and 30 male control workers who were not exposed to inorganic lead occupationally were chosen for this study. The data were obtained using direct interview and assessment of biological markers of lead exposure and thyroid indices. As biological markers for lead exposure, blood ZPP. blood lead, urine lead and hemoglobin were measured. As thyroid indices. TSH and FT4were determined. The results of the study were summarized as follows 1. Levels of ZPP, blood lead, and urine lead were significantly higher in lead-exposed group than in nonexposed control group(p<0.01 all). Hemoglobin level was significantly lower in lead-exposed group than in nonexposed group(p<0.01). 2. Study subjects had normal values of TSH and FT4 But TSH level was insignificantly lower in lead-exposed group than in nonexposed control group(p=0.11) and FT4 level was significantly lower in lead-exposed group than in nonexposed group(p<0.01). 3. As the result of simple regression analysis in lead-exposed group. FT4 level was negatively correlated with the amount of smoke, blood ZPP, and blood lead(p < 0.05 all). 4. In lead-exposed group, FT4 was used as a independent variable and age, the amount of smoke, blood ZPP, and blood lead were entered as a dependent variables in the model. As the result of multiple regression analysis with stepwise selection method, the amount of smoke and blood ZPP were negative predictors of FT4(p=0. 04, p=0.09, respectively). In conclusion, levels of TSH and FT4were lower in lead-exposed group than in nonexposed control group. In lead-exposed group, FT4 level was negatively correlated with amount of smoke, blood ZPP, and blood lead in simple regression analysis. To clarify this relation, further research between lead exposure and thyroid function may be required for worker with long-term lead exposure or high lead exposure.
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Citations
Citations to this article as recorded by- Occupational Hearing Loss in Korea
Kyoo Sang Kim
Journal of Korean Medical Science.2010; 25(Suppl): S62. CrossRef
- Occupational Hearing Loss in Korea
- 578 View
- 0 Download
- 1 Crossref
Original Article
- Concentration of Lead, Cadmium, and Mercury in Scalp Hair, Cerebellum, Cerebrum, Heart, Kidney, Liver, Lung and Spleen from Autopsy Subjects : Relationship between Scalp Hair and Internal Organs
- Jong Hak Chung, Chang Yoon Kim, Joon Sakong, Joong Jung Lee, Man Joong Jeon, Seong Kuk Lee, Jeung Sik Kwak, Sung Hwa Park
- Korean Journal of Occupational and Environmental Medicine 1998;10(4):571-586. Published online December 31, 1998
- DOI: https://doi.org/10.35371/kjoem.1998.10.4.571
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Abstract
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- This study was conducted to measure the lead, cadmium and mercury levels in the scalp hair, cerebellum, cerebrum, heart, kidney, liver, lung, and spleen of the 60 Korean autopsy subjects and assess the relationship among those samples. The mean lead level in the scalp hair was 12.29+/-12.51 microgram/g and no significant difference was detected in lead concentrations between the two sexes. Among the internal organ tissues the cerebrum contained the highest level of lead. This is followed by the cerebellum, spleen and liver respectively. After which the kidney and lung showed a close similarity at relatively low concentrations and the heart contained the lowest concentration. There was also no significant variation found between sexes in a comparison of lead in the internal organ tissues. The concentrations of cadmium in kidney were 127.33+/-89.36 microgram/g and considerably higher than those in the other internal organs. The liver contained the next highest level of cadmium. In both sexes, the consistent difference was noted in the cadmium concentrations of the kidney, heart and spleen. Yet female cadmium level was higher than the male's. The concentrations of mercury in the kidney and liver were 1.26+/-2.89 microgram/g, 0.59+/-0.54 microgram/g and considerably higher than those in the other internal organs. The mean mercury level in the scalp hair was 1.29+/-0.64 microgram/g and no marked difference was noted in both sexes. The lead concentration in the spleen increased with advancing age, though not statistically significance, and most of the internal organ tissues that were examined showed no evidence of increased lead concentration with age. The kidney, cerebrum, spleen and cerebellum showed increased cadmium concentrations with age. Also as well as the internal organ tissues that were examined showed no evidence of increased mercury concentration with age. The lead concentrations in the liver and lung were higher in the urban area than in the rural area, but the lead concentration in the kidney was higher in the rural area. No difference was noted in tissue cadmium and mercury concentrations as to the area of residence either. The physical workers had greater concentrations of lead in cerebellum than did housewives or the unemployed. Yet no difference was noted in the other tissues between the two groups. In the cerebellum, cerebrum, heart, and spleen, the physical workers had greater concentrations of cadmium than students or mental workers. Also physical workers had greater concentrations of cadmium in lung than housewives or the unemployed. In contrast to lead and cadmium, both the housewives and the unemployed had higher concentrations of mercury in cerebellum and cerebrum than physical workers, but there was no difference was noted in the other tissues between the two groups. In the lead concentration, there was no statistically significant correlation between the scalp hair and examined internal organ tissues. There was a close relationship between lead levels in cerebellum and cerebrum (r=0.465, p<0.01), as well as a relationship between the cerebellum and the kidney(r=0.300, p<0.05). There was no statistically significant correlation between the cadmium levels in the scalp hair and in the examined internal organ tissues. Positive correlations were found between the cadmium concentrations in the cerebellum and the cerebrum(r=0.5543, p<0.01), heart(r=0.480, p<0.01), kidney(r=0.376, p<0.01) and spleen(r=0.408, p<0.01). Also positive correlation was found between in the cerebrum and the heart(r=0.377, p<0.01), kidney(r=0.484, p<0.01), liver(r=0.265, p<0.05), lung(r=0.458, p<0.01) and spleen (r=0.483, p<0.01). There was also no statistically significant correlation between the mercury levels in the scalp hair and in the examined internal organ tissues. Positive correlation was found between the mercury concentrations in the cerebellum and cerebrum(r=0.760, p<0.01), heart(r=0.270, p<0.05), liver(r=0.425, p<0.01), lung (r=0.488, p<0.01) and spleen (r=0.534, p<0.01), and also positive correlation was found between in the cerebrum and heart(r=0.376, p<0.01), liver(r=0.350, p<0.01), lung(r=0.554, p<0.01) and spleen (r=0.489, p<0.01). Various epidemiological studies reported usefulness and reliability of using scalp hair as a monitor of a environmental pollutants. In this study, there was statistically significant correlation of lead, cadmium and mercury levels in most of the tissues that were examined, but there was no statistically significant correlation between the lead, cadmium and mercury levels in the scalp hair and most of examined internal organ tissues. The findings of this study would suggest that it is still uncertain to using scalp hair as a biological monitoring.
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Citations
Citations to this article as recorded by- Human Exposure to Metals: Levels in Autopsy Tissues of Individuals Living Near a Hazardous Waste Incinerator
Montse Mari, Martí Nadal, Marta Schuhmacher, Eneko Barbería, Francisco García, José L. Domingo
Biological Trace Element Research.2014; 159(1-3): 15. CrossRef - Effect of metallothionein core promoter region polymorphism on cadmium, zinc and copper levels in autopsy kidney tissues from a Turkish population
Zeliha Kayaaltı, Görkem Mergen, Tülin Söylemezoğlu
Toxicology and Applied Pharmacology.2010; 245(2): 252. CrossRef
- Human Exposure to Metals: Levels in Autopsy Tissues of Individuals Living Near a Hazardous Waste Incinerator
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- 2 Crossref
Original Article
- Occupational Lead Exposure of Storage Battery Industry Workers in Korea
- Pil Kyu Kang, Yong Bae Kim, Ik Soo Ahn, Jong Kyu Lee, Ku Seok Han, Hwa Sung Kim, Kyu Yoon Hwang, Gap Soo Lee, Kyu Dong Ahn, Byung Kook Lee
- Korean Journal of Occupational and Environmental Medicine 1998;10(4):438-449. Published online December 31, 1998
- DOI: https://doi.org/10.35371/kjoem.1998.10.4.438
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Abstract
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- In order to investigate the level of lead absorption of lead workers and to evaluate the effect of blood lead on blood zinc protoporphyrin (ZPP) and prevalence of lead related symptoms, 1,782 lead workers(male: 1,506, female: 276) from 8 storage battery industries were studied. Selected variables as indices of lead exposure were blood lead, blood ZPP, and hemoglobin (HB). Fifteen questionnaires of lead related symptoms were provided to all lead workers and filled up by themselves and confirmed by medical doctors. Personal variables such as age, work duration, smoking and drinking habits were also collected. The results were follows : 1. While the mean blood lead of lead workers of all lead companies was 31.0+/-3.0 ug/100ml (male: 31.5+/-2.9 ug/100ml, female: 27.9+/-3.3 ug/100m1), the mean blood ZPP of all lead workers was 66.7+/-4.1 ug/100ml (male: 59.6+/-3.3, female: 105.3+/-3.0 ug/100ml). The mean hemoglobin of male lead workers was 15.7+/-.3 gm/100ml and that of female lead workers was 13.0+/-.3 gm/100ml. 2. The percentage of lead workers whose blood lead was over 60.0 ug/100m1 and 40.0-59.9 ug/100ml was 2.81 % and 19.08 %, respectively. On the other hand, the percentage of lead workers whose blood ZPP was over 150 ug/100ml and 100-149 ug/100ml was 5.89 % and 8.31 %, respectively. 3. The slopes of simple linear regression of blood lead (independent variable) and blood ZPP in female lead workers was significantly steeper than that of male lead workers. The slope of storage battery industries with better working condition in terms of low air concentration of lead were less steeper than those with poor working condition with high mean air concentration of lead. 4. Stepwise multiple regression analysis, using overall symptom prevalence as a dependent variables, blood lead, blood ZPP, hemoglobin, age, work duration, drinking and smoking habits as independent variables, indicated that only drinking habit and age were significantly contributed to the dependent variable.
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Citations
Citations to this article as recorded by- Occupational Lead Exposure from Indoor Firing Ranges in Korea
Won-Ju Park, Suk-Ho Lee, Se-Ho Lee, Hye-Sik Yoon, Jai-Dong Moon
Journal of Korean Medical Science.2016; 31(4): 497. CrossRef - Blood lead levels of Korean lead workers in 2003–2011
Ji-Hye Kim, Eun-A Kim, Dong-Hee Koh, Kiwhan Byun, Hyang-Woo Ryu, Sang-Gil Lee
Annals of Occupational and Environmental Medicine.2014;[Epub] CrossRef
- Occupational Lead Exposure from Indoor Firing Ranges in Korea
- 657 View
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- 2 Crossref
Original Article
- Some Renal Function Indices in Workers Occupationally Exposed to Lead
- Je Sung Nam, Yong Bae Kim, Hyun Cheol Ahn, Hwa Sung Kim, Gap Soo Lee, Kyu Yoon Hwang, Sung Soo Lee, Kyu Dong Ahn, Byung Kook Lee
- Korean Journal of Occupational and Environmental Medicine 1998;10(2):139-148. Published online May 31, 1998
- DOI: https://doi.org/10.35371/kjoem.1998.10.2.139
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Abstract
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- The influence of lead exposure on renal function was studied. Three hundred forty two male lead exposed workers who worked in 3 storage battery factories, 5 secondary smelting factories and 3 litharge making factories, and 60 male control workers who were not exposed to lead occupationally were chosen for this study. Blood lead (PbB), zinc protoporphyrin in whole blood (ZPP) and delta-aminolevulinic acid in urine (DALA) were selected as indicators of lead exposure. As indicators of renal function blood urea nitrogen(BUN) , serum creatinine(S-Cr), serum uric acid (S-UA), N-acetyl-beta-D-glucosaminidase in urine (NAG) and urine protein (U-TP) were selected. While the mean values of lead exposure indicators of lead workers were significantly different from non-exposed ones, the mean values of renal function indicators of exposed except S-UA were significantly different from non-exposed. The frequency of workers whose value of renal function indicators were over the nor mal criteria (BUN>20 mg/dl ; S-Cr>1.2 mg/dl ; S-UA>7.0 mg/dl ; NAG>8.0 U/liter; U-TP>8.0 mg/dl) by the level of lead absorption in terms of PbB, ZPP and DALA were calculated. Age adjusted odds ratio of over the normal value of BUN and NAG were statistically significant by the level of ZPP and that of BUN only showed the dose-dependant relationship. But the frequency of over the normal criteria of renal function indicators were not increased by the level of PbB and DALA. On stepwise multiple regression using renal function indicators as a dependent variable and each lead exposure indicator and age as independent variables, only BUN, NAG and U-TP were contributed by the lead exposure indicators. It was found that only NAG of renal function indices was most reliable indicator who showed dose-response relationship with lead exposure and the measurement of NAG for lead workers whose relatively high exposure is highly recommended.
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Citations
Citations to this article as recorded by- Effect of Pork Consumption on Renal and Hematochemical Indices in Workers Occupationally Exposed to Unclean Environments
Chan-Kyu Han, Jeong-Hae Rho, Bog-Hieu Lee
Korean Journal for Food Science of Animal Resources.2008; 28(1): 91. CrossRef
- Effect of Pork Consumption on Renal and Hematochemical Indices in Workers Occupationally Exposed to Unclean Environments
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- 1 Crossref
Original Article
- A Study of the Correlation Between the Activity of Erythrocyte Pyrimidine 5'-Nucleotidase and Urinary N-Acetyl-beta-D-Glucosaminidase in Lead Exposed Workers
- Soung Hoon Chang, Cheon Hyun Hwang, Won Jin Lee, Soung Soo Lee, Byung Kook Lee, Hong Kyu Suh, Jae Wook Choi
- Korean Journal of Occupational and Environmental Medicine 1997;9(2):258-266. Published online June 30, 1997
- DOI: https://doi.org/10.35371/kjoem.1997.9.2.258
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Abstract
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- In this study, we measured the activity of the erythrocyte pyrimidine 5'-nucleotidase (P5N) and urinary N-acetyl-beta-D-glucosaminidase (NAG) from 154 workers exposed to lead and 43 workers not exposed. We analyzed the correlation of the P5N activity and NAG activity with other biological exposure indices of lead such as blood lead (PbB) and zinc protoporphyrin (ZPP). The measurement was performed by using high performance liquid chromatography (HPLC), spectrophotometer and atomic absorption spectrophotometer. The results are as follows: 1. The mean value of P5N activity for workers exposed to lead was 9.50+/-.13 micromol uridine/hr/g Hb and 11.60+/-.2 micromol uridine/hr/g Hb for workers not exported. The P5N activity showed a normal distribution, but the other indices of lead showed logarithmic normal distributions. 2. The P5N activity and ZPP were decreased as PbB wag increased. But the NAG activity had no correlation with changes of PbB. 3. The correlation coefficients of the P5N activity with other biological exposure indices of lead such as PbB, ZPP, NAG activity were -0.72, -0.55, and 0.05, respectively. We speculated that the P5N activity can be used as a reliable biological exposure index of lead but NAG activity can be used as a biological management index of lead.
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Original Article
- A Study on the Lead Exposure of Workers in Secondary Smelting and Litharge Making Industries
- Je Myung Chae, Gap Soo Lee, Sung Soo Lee, Kyu Dong Ahn, Byung Kook Lee
- Korean Journal of Occupational and Environmental Medicine 1997;9(1):131-139. Published online February 28, 1997
- DOI: https://doi.org/10.35371/kjoem.1997.9.1.131
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Abstract
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- Two hundred and six male lead workers (86 lead workers from secondary smelting industries and 120 lead workers from litharge making industries) and 212 office workers who were not exposed to lead occupationally were studied to investigate the effect of lead on the health of lead workers in high risk operation to lead. Blood lead (PbB), zinc protoporphyrin in whole blood (ZPP), delta-aminolevulinic acid in urine (ALAU), Hematocrit (Hct) and hemoglobin (Hb) were selected as an index of lead exposure. Questionnaires of 15 lead related symptoms were provided to all study subject and filled up by themselves and reconfirmed the symptom answers by interviewing medical doctor. While the mean value of PbB, ZPP and ALAU of lead workers in secondary smelting industries were 62.7+/-14.6 microgram/dl, 103.1+/-60.5 microgram/dl and 7.4+/-10.3 mg/liter, those of lead workers in litharge making industries were 58.8+/-14.1 microgram/dl, 74.2+/-45.2 microgram/dl and 5.3+/- 7.9 mg/liter respectively, and there were statistically significant difference of mean values between two groups. Simple linear regression analysis of PBB on ZPP and ALAU shoved the steeper slope in secondary smelting industries than litharge making industries. Higher symptom prevalence rates of lead exposed group were observed in lead colic related symptom (S4) and neuromuscular symptoms compared with non-exposed workers. The prevalence of neuromuscular symptoms only showed dose-response relationship by the increase of PBB and ZPP. But more statistical significances were observed in neuromuscular symptoms by the increase of PBB than ZPP. On stepwise multiple regression using total symptom score as a dependent variable and PBB, ZPP, ALAU, Hct, Hb, age and work duration as a independent variables only ZPP and age contributed to the lead related symptoms.
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Citations
Citations to this article as recorded by- The association between cadmium and lead exposure and blood pressure among workers of a smelting industry: a cross-sectional study
Hyun Chan An, Joo Hyun Sung, Jiho Lee, Chang Sun Sim, Sang Hoon Kim, Yangho Kim
Annals of Occupational and Environmental Medicine.2017;[Epub] CrossRef - Blood lead levels of Korean lead workers in 2003–2011
Ji-Hye Kim, Eun-A Kim, Dong-Hee Koh, Kiwhan Byun, Hyang-Woo Ryu, Sang-Gil Lee
Annals of Occupational and Environmental Medicine.2014;[Epub] CrossRef
- The association between cadmium and lead exposure and blood pressure among workers of a smelting industry: a cross-sectional study
- 618 View
- 0 Download
- 2 Crossref
Original Article
- Lead Levels in Maternal and Umbilical Cord Blood
- Jin Ha Kim, Jong Kook Moon, Gang Won Park, Kang Woo Bae, Duk Hee Lee, Yong Hwan Lee
- Korean Journal of Occupational and Environmental Medicine 1996;8(3):414-422. Published online December 31, 1996
- DOI: https://doi.org/10.35371/kjoem.1996.8.3.414
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Abstract
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- This study was conducted to evaluate the blood lead levels in 141 pregnant women who were not occupationally exposed to lead and their umbilical cord, arid to identify some differences in blood lead levels by living area. ; The subjects-were all delivered at St. Benedict Hospital in Pusan and the blood lead levels were measured by graphite furance atomic absorption spectrophotometer. The summarized results were as follows. 1. The geometric mean lead levels in maternal and cord blood were 8.0+/-1.8microgram/dl, 5.0+/-0.6lmicrogram/dl respectively. 2. Lead levels in maternal (8.7+/-1.7microgram/dl) and cord blood(5.4+/-0.7microgram/dl) of industrial area(n=24) were higher than residential area(n= 124) which were 7.9+/-1.7microgram/dl and 5.0+/-0.6microgram/dl respectively (p<0.05). 3. Maternal blood lead concentration was significantly correlated to cord blood lead concentration (r=0.6090, p<0.001), but other variables (maternal age, paternal smoking, birth weight, etc) were not correlated.
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- 2 Download
Original Article
- Renal Dysfunction Indicators in Lead Exposed Workers
- Sang Ju Lee, Young Seoub Hong, Sung Ryul Kim, Dong Il Kim, Joon Youn Kim, Kap Yeol Jung
- Korean Journal of Occupational and Environmental Medicine 1996;8(2):340-349. Published online September 30, 1996
- DOI: https://doi.org/10.35371/kjoem.1996.8.2.340
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Abstract
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- A range of indicators is available to assess renal dysfunction in lead exposure. This study was undertaken to find out which indicators were most valuable as markers of renal dysfunction. We selected 75 male workers from the secondary lead smelter, plastic stabilizer and radiator manufacturing industries (the "exposed" group) and 64 male office workers (the "control" group). Blood lead; blood zinc protoporphyrin; urine lead; urine coproporphyrin; delta-aminolevulinic acid dehydratase activity; and urine delta-aminolevulinic acid were chosen as indicators of lead exposure. Blood urea nitrogen; serum creatinine; serum uric acid; urine N-acetyl-beta-D-glucosaminidase; urine albumin; urine alpha1-microglobu-lin; and urine beta2-microglobulin were used as indicators of renal dysfunction. Urine alpha1-microglobulin level was significantly associated with, the lead exposure level. Blood urea nitrogen, urine N-acetyl-beta-D-glucosaminidase and urine alpha1-microglobulin levels were highly correlated with indicators of lead exposure. Urine alpha1-microglobulin had the highest correlation with other indicators of renal function. In addition, the proportion of subjects with high urine alpha1-microglobulin levels showed a gradient with lead exposure. Conclusively, Blood urea nitrogen, urine N-acetyl-beta-D-glucosaminidase and urine alpha1-microglobulin are useful indicators, but urine alpha1-microglobulin is ; the early 'and the most valuable indicator of renal dysfunction related to lead exposure.
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Original Article
- Blood Lead Levels in Children
- Yong Hwan Lee, Duk Hee Lee, Jin Ha Kim, In Geun Park, Tae Young Han, She Han Jang
- Korean Journal of Occupational and Environmental Medicine 1995;7(1):82-87. Published online February 28, 1995
- DOI: https://doi.org/10.35371/kjoem.1995.7.1.82
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Abstract
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- The authors conducted this study to evaluate some differences in blood lead levels between inner-city and suburban children and obtain the basic data of the reference value of the blood lead concentrations in children. The subjects were composed of 102 children residing in inner-city and 86 children in suburban. Their age range were 6 to 8 years old and the obtained results were as follow; 1. The arithmetic means of the blood lead level in male and fenlale, male, and female children were 7.24, 7,40, 7.08 microgram/100ml, and geometric means were 6.92, 7.08, 6.76 microgram/100ml, respectively. 2. The children residing in inner-city had the higher blood lead levels both male and female than suburban children with statistical signficance (p < 0.05) 3. Seventeen percent of the total subjects had lead cencentrations ( 5 microgram/100ml, and 5.88% of inner-city children and 30.23 % of suburban children had this lead values. But in > or = 10 microgram/100ml group, the inner-city children (20.39 %) were more distributed than suburban chilren(2.33 %) , and 12.33 % of total subjects had this lead values.
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Citations
Citations to this article as recorded by- Effects of CO/CO2/NO on elemental lead adsorption on carbonaceous surfaces
Zhengyang Gao, Weijie Yang
Journal of Molecular Modeling.2016;[Epub] CrossRef
- Effects of CO/CO2/NO on elemental lead adsorption on carbonaceous surfaces
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- 1 Crossref
Original Article
- A Study on the Reference Value of Erythrocyte Pyrimidine 5'-Nueleotidase Activity
- Jong Yeon Kim, Hae Joon Kim, Soung Hoon Chang, Kwang Jong Kim
- Korean Journal of Occupational and Environmental Medicine 1995;7(1):63-81. Published online February 28, 1995
- DOI: https://doi.org/10.35371/kjoem.1995.7.1.63
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Abstract
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- For the purpose of determining the reference value of erythrocyte pyrimidine 5'-nucleotidase (P5N) activity as a biological indicator to lead exposure, this study was conducted on the total of 225 healthy men who had not been exposed to lead occupationally, in July, 1994. The parameters selected in this study were age, hemoglobin, hematocrit, number of red blood cell, mean corpuscular hemoglobin (MCH), mean corpuscular herloglobin concentration (MCHC), blood lead, and erythrocyte P5N activity. The blood lead concentrations were measured using a flameless atomic absorption spectrophotometer, and erythrocyte P5N activities by Sakai's simple method using a HPLC(1986). The results were obtaina as follows; 1. The distribution of blood lead concentrations revealed log-normal distribution, and geometric mean and standard deviation of blood lead were 4.09 microgram/dl and 1.55 microgram/dl, respectively. 2. The erythrocyte P5N activity showed normal distribution, and the mean and standard deviation of the erythroeyte P5N activity were 12.34 umole uridine/h/g Hb and 2.21 umole uridine/h/g Hb, respectively. 3. All of the selected variables including blood lead concentration did not affect the erythrocyte P5N activity. Although the erythrocyte P5N activities were negatively associated with blood lead level, the correlation coefficient was not statistically significant. 4. From the result of this study, 8.7 micromole uridine/h/g Hb was obtained as a reference value of erythrocyte pyrimidine 5'-nucleotidase activity for the healthy adult male who had not been exposed to lead occupationally.
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