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- Case Report Three Cases of Skin Pigmentation Caused by 2,5-Hexanedione
- Seong Ah Kim, Sang Jae Jung, Chae Yong Lee, Sang Man Lee, Sang Woo Kim
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DOI: https://doi.org/10.35371/kjoem.2002.14.2.199
Published online: June 30, 2002
1Department of Occupational and Environmental Medicine, Kumi CHA Hospital, and Pochun CHA University, Korea. drsakim@hanmail.net 
2Health Management Center, Kumi CHA Hospital, Pochun CHA University, Korea.
2Health Management Center, Kumi CHA Hospital, Pochun CHA University, Korea.
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Abstract
OBJECTIVES
To report on the skin discoloration experienced by three workers handling 2 , 5 -hexanedione METHODS: Three workers, who showed orange-brown discoloration of the palms during observation under the Kumi occupational disease surveillance system, had their history evaluated and underwent physical examination. A workplace survey was performed by an occupational physician and an industrial hygienist.
RESULTS
The three workers were determined to have been experiencing skin discoloration since the introduction of a new cleaning solvent. The new solvent contained 2,5-hexanedione, which is reported in the literature to be possibly capable of causing orangebrown discoloration of the skin. After discontinuation of solvent use, the workers recovered within a week.
CONCLUSIONS
These cases demonstrate that 2,5-hexanedione can produce skin pigmentation.
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