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HOME > Ann Occup Environ Med > Volume 29; 2017 > Article
Research Article Exposure to occupational hazards for pregnancy and sick leave in pregnant workers: a cross-sectional study
Jean-Bernard Henrotin1, Monique Vaissière2, Maryline Etaix3, Mathieu Dziurla1, Stéphane Malard4, Dominique Lafon5
Annals of Occupational and Environmental Medicine 2017;29:12.
DOI: https://doi.org/10.1186/s40557-017-0170-3
Published online: May 15, 2017

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• Received: January 6, 2017   • Accepted: May 10, 2017

© The Author(s). 2017

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  • Background
    This study aimed to investigate the association between exposure to occupational hazards for pregnancy and sick leave (SL) in pregnant workers.
  • Methods
    A cross-sectional study was performed in French occupational health services in 2014. Occupational hazards for pregnancy were assessed by occupational health physicians (OHPs). After delivery and at the time of returning to work, 1,495 eligible workers were interviewed by OHPs. Information on SL was self-reported. Risk ratios (RRs) were calculated from multivariable analyses based on a generalized linear model with a Bernoulli distribution and a log link adjusted for selected confounders for binary outcomes or zero-inflated negative binomial regression for count outcomes.
  • Results
    Among recruited workers, 74.9% presented “at least one SL” during pregnancy. After adjustment, the cumulative index of occupational hazards (0, 1–2, 3–4, ≥ 5 risks) for pregnancy was significantly associated with “at least one SL” during pregnancy in a dose–response relationship. This gradient was also observed with “early SL” (<15 week gestation): from 1 to 2 risks, RR = 1.48 (95% confidence intervals (CIs): 0.92-2.38); from 3 to 4 risks, RR = 2.03 (95% CI: 1.25-3.30); equal to or higher than five risks, RR = 2.90 (95% CI: 1.89-4.44); with “duration of absence” (adjusted mean): from 1 to 2 risks, m = 38.6 days; from 3 to 4 risks, m = 46.8 days; equal to or higher than five risks, m = 53.8 days. We also found that deprivation, pregnancy at risk, assisted reproductive therapy, work-family conflicts, home-work commuting felt as difficult and young age are associated with a higher risk of SL.
  • Conclusions
    Our results support the assertion that pregnant workers exposed to occupational hazards for pregnancy without medical complications are also at risk of taking SL during pregnancy. More prevention in the workplace for pregnant workers exposed to occupational hazards could reduce SL.
In several European countries concerning pregnant workers, it exists in the workplace protective legislation where employers should adjust work conditions according to the needs of pregnancy [1–3]. Despite this, sick leave (SL) levels among pregnant workers have increased over the last few decades and remain extremely high today without clear explanations [4–12]. In France, pregnant workers may take legal prenatal leaves (from 6 to 8 weeks) before the date of delivery or “pathological leave” (2 weeks) in case of medical complications during pregnancy. Outside of these periods, a pregnant worker may take ordinary SL but will receive 50% of her salary. Several factors have been reported in the literature to be associated with SL during pregnancy: occupational groups [4, 8, 9, 12–14], assisted reproductive therapy (ART) [15], body mass index [14, 15], social benefits [16, 17], attitudes regarding SL in the workplace [6, 10, 16], and young women [8]. Also, some occupational exposures have also been associated with SL during pregnancy [4, 7, 13, 15, 16, 18, 19].
However, particularly in pregnant workers, studies remain scarce and occupational explanations of the high rate of SL need to be confirmed. The studies are rather small in size [7, 13], limited to certain occupations [7], without accurate exposure measurements [4, 7] and often limited or no adjustment for potential confounders [4, 7, 13]. Almost studies from the available literature have been carried out in north European countries [4, 7, 15, 17, 20–22] and to our knowledge, none in France. It is important to note that several studies report that job adjustment is associated with reduced SL during pregnancy [23, 24]. Therefore, in order to propose preventive measures in the workplace and reduce the risk of SL, it is necessary to deepen relationship between occupational exposures and SL during pregnancy.
We hypothesized that pregnant workers without medical complications during pregnancy exposed to occupational hazards for pregnancy are at risk of taking SL during pregnancy. The aim of this study was to investigate the association between exposure to occupational hazards for pregnancy and SL in pregnant workers.
Design and study population
A cross-sectional study was performed from January 1, 2014 to December 31, 2014 in the occupational health services of the Languedoc-Roussillon region and in the town of Roanne in France. Eighty-three occupational health physicians (OHP) participated in the recruitment of workers.
According to French labor law, each woman having worked during pregnancy must benefit from a medical visit with an OHP after delivery and at the time of returning to work. This is a compulsory visit for employers and employees. Also, at the first postnatal visit, all women (no selection method) were invited to participate in the study by the OHP. The inclusion criteria were that they: (i) must have worked for an employer during their last pregnancy (our study did not include workers without employment contract (such as self-employed, craftsman, farmer, company head…) because these workers were not followed by French occupational health services); (ii) to be older than 18 years of age (legal majority in France) (iii) must have had a postnatal visit with an OHP in the year after delivery; or (iv) within three years after delivery if they had full-time parental leave; and (v) be sufficiently fluent in French to participate in the interview. Before the medical visit, the OHPs asked eligible workers to fill-in a self-administered questionnaire to obtain sociodemographic information; during the visit, a second occupational questionnaire was administered face-to-face by the OHP. The computerized medical record system in each occupational health service was declared to the French National Commission for Data Protection. All the volunteer participants gave their informed consent to be enrolled and data were collected anonymously. Because we used anonymised data from routine medical visits, in 2013 according to French law, ethics approval was not required.
Outcomes of interest
Information on SL during pregnancy was obtained from workers with the following questions by taking account of leaves for legal reasons and sickness: (i) for the first and second trimester of the pregnancy (“did you have one SL before a pathological or legal leave (regardless of the cause and duration)?, yes/no); (ii) on the duration (“what was the total duration of your SL, before a pathological or legal leave?, in days during pregnancy); (iii) “did you take a SL without returning to work before a pathological or legal leave ?, yes/no ? If yes, at what time of your pregnancy did you stop working completely? in which week of gestation (WG)”. In this study, we defined each trimester in the following way: first trimester when < 15 WG; second trimester from 15 WG to 28 WG. Early SL was defined as leaving job before 15 WG.
Exposure of interest
The exposure assessment of potential hazards for pregnancy was conducted by OHPs based on knowledge of workstations in early pregnancy. Seventeen potential hazards were selected [3]: biological hazards (working with very young children, sick persons, animals); chemical hazards; night work (between 9:00.p.m and 5:00 a.m.); physical hazards (standing > 1 h a day, stair climbing (several times a day), forward bending ≥ 1 h a day, difficult postures (upper and/or lower limbs), heavy lifting > 5 kg, repetitive tasks, vibration (driving), temperature (>30 °C, <10 °C), noise >80 dB, work on industrial machines); ionizing radiation and electromagnetic fields. The responses were based on a 4-point Likert scale ranging from 1: no; 2: very rarely (a few per month); 3: sometimes (a few times a week); 4: frequently (a few times a day or more). Then, all these variables were transformed into binary variables and were coded as either 0 (to indicate the reference category) or 1 (to indicate the category at risk). For all the variables, the category at risk was the “frequently” category (level 4) except for three variables: ionizing radiation (level from 2 to 4); night work (at least one night); Electromagnetic fields (level from 3 to 4). A cumulative index of occupational hazards for pregnancy in four classes (0, 1–2, 2–4, ≥ 5 risks) was built using these seventeen occupational variables.
Potential confounders
The choice of potential confounders was based on the literature data (age, deprivation, occupational data, number of children, assisted reproductive therapy (ART), and pregnancy at risk) except for smoking, alcohol consumption, and body mass index. We have considered that socioeconomic deprivation was a proxy measure for these last three variables because very positively correlated to them [25]. Socioeconomic deprivation was assessed using the Evaluation of Deprivation and Inequalities in Health Examination (EPICES) individual scale [25]. This is a reliable proxy in workplace settings for population-based measures of deprivation which is strongly correlated with the Townsend and Carstairs indices [25]. Workers with an EPICES score equal to or higher than 30 were classified as being deprived. Occupational skill level was classified according to the French standard classification of occupations (version 2003) from the French National Institute of Statistics [26]. The occupations were classified into four skill levels: managers/supervisors, intermediate occupations, employees, and manual workers. Women were asked if they had been followed-up for “pregnancy at risk of medical complications” (yes/no) and whether they had had assisted reproductive therapy (yes/no). Other explored factors were maternal age at delivery, company size at four levels (<10, 10–49, 50–199, ≥ 200 workers), type of contract (non-fixed term, fixed term), home-work commuting (duration, mode), working time (full-time, part-time), and job duration (<2, ≥ 2 years).
Several factors, no used in literature like confounders until now, related to concept “work-family conflict” were also used [27, 28]. This concept focuses on the difficulties that employees have in balancing their work and family responsibilities which could increase fatigue during pregnancy and the occurrence of SL [27, 28]. In our study, several predictors of work-family conflict were used as follows. An index of cumulated work-family conflict risks in four classes (0, 1, 2, ≥ 3 risks) was built using five dichotomous variables: preschool-age children at home (yes/no), home-work commuting > 50 min/d (yes/no), duration of working hours > 8 h/d (yes/no), irregular working hours (yes/no), and absence of two consecutive rest days in a week (yes/no).
Statistical analyses
In bivariate analyses, chi-square tests were used to compare binary variables. Also for continuous variables, the Kolmogorov-Smirnov test was used to evaluate the normal distribution. A Student’s t-test was used to analyze the normally distributed quantitative values, and the Mann–Whitney U test or the Kruskal-Wallis test was used to analyze the non-normally distributed ones. In multivariate analyses for binary outcomes, adjusted relative risks (RRa) with 95% confidence intervals (CIs) were calculated based on a generalized linear model with a Bernoulli distribution and a log link adjusted for selected confounders [29]. A stepwise forward procedure was conducted to identify the variables having a significant association with the outcome. For “at least one sick leave” variable, we have conducted analyses separately for each trimester of pregnancy because the impact of the factor may be different according to the pregnancy period. To compare the results between trimesters, we have presented the significant variables from final models of the stepwise forward procedure but also the non-significant variables adjusted for these significant variables. Also, we tested interaction terms between several variables. Notably, to answer our hypothesis, analyses between “number of occupational risks for pregnancy” and “pregnancy at risk” were carried out separately when a positive interaction was identified between these two variables. For count outcome, zero-inflated negative binomial regression (ZINB) was carried out to take into account over-dispersion and/or excess of the zero value in data [30]. For this outcome the purpose of the analysis was exploratory, we have presented the results without a selection procedure of the variables. A two-sided p-value of less than 0.05 was considered statistically significant in our study. Statistical power was estimated on the basis of a binomial test with unequal group sizes (ratio 1/4). In this case to detect an effect size of RR = 2 with 80% power at a significance level of 0.05 and a control-group proportion at 5%, 1,245 pregnant workers were required. As the responses were relatively complete, analyses excluded missing data. All the statistical analyses were performed using STATA statistical software, version 14.0 (Stata Corp, College Station, Texas, USA).
During the study time period, the number of workers recruited was 1,581 (Fig. 1). The number of cases excluded was 64 workers (non-valid files). Very few women refused to participate, with only 22 cases not included in the study. Thus, our final sample was composed of 1,495 workers. The mean of the proportion of missing data was 1.8% per variable with two variables above 5%: deprivation (6.2%) and job duration (6.5%).
Fig. 1
Flow chart of the study population
40557_2017_170_Fig1_HTML.jpg
Table 1 presents a description of the pregnant workers according to the occurrence of “at least one SL” before a pathological or legal prenatal leaves (Table 1). The proportion of “at least one SL” was 74.9%. SLs were less frequent in the managers/supervisors group and in small companies (<50 workers). Workers with “non-fixed contracts”, “pregnancy at risk” or ART had an increased proportion of SL. Note that the age mean was not different between the two groups.
Table 1
Characteristics of the pregnant workers according to the variable “at least one sick leave” (SL) during pregnancy
SL no SL p-value
(N = 1113) (N = 373)
N % Mean sd N % Mean sd
Age (y) 30.6 4.5 31.1 4.4 0.08
Age group
  < 25 y 108 9.8 27 7.4 0.18
 25- < 30 y 408 37.1 122 33.3
 30- < 35 y 405 36.9 151 41.3
  ≥ 35 y 178 16.2 66 18.0
Family structure
 Living with a partner (yes) 1063 96.5 352 95.4 0.31
 Children at home
  0 child 577 52.1 196 52.8 0.91
  1 child 449 40.5 146 39.4
   ≥ 2 children 82 7.4 29 7.8
Home-work commuting
  > 50 min/d (yes) 248 23.2 77 21.3 0.45
 In car (yes) 1022 92.7 348 94.0 0.38
Home-work commuting felt as difficult
 Yes 245 22.3 48 13.0 <0.001
Deprivation
 EPICES score ≥ 30 (yes) 231 22.0 61 17.7 0.08
Occupational groups
 Managers/supervisors 93 8.4 51 13.7 0.001
 Intermediate occupations 374 33.6 91 24.4
 Employees 591 53.1 216 57.9
 Manual workers 55 4.9 15 4.0
Type of contract
 Non-fixed term (yes) 1508 96.1 342 92.9 0.01
Working time
 Full-time (yes) 868 78.8 300 81.3 0.31
Job duration
  < 2 years (yes) 239 21.6 90 24.4 0.27
Company size
  < 10 workers 253 23.0 114 31.2 <0.001
 10 - 49 workers 332 30.2 137 37.4
  ≥ 50 -199 workers 295 26.8 83 22.7
  ≥ 200 workers 219 19.9 32 8.7
Pregnancy at risk
 Yes 334 30.3 34 9.2 <0.001
Assisted reproductive therapy
 Yes 84 7.6 13 3.5 0.006
N number, y years, min minutes, d day, sd standard deviation
Figure 2 displays the frequencies of the potential occupational hazards for pregnancy in worker groups with and without SL (Fig. 2). We observed that exposures to physical hazards (standing > 1 h, heavy lifting, forward bending, stair climbing, and difficult postures) and, although less frequent, biological hazards, exposure to chemical products and night work were significantly associated with SL.
Fig. 2
Comparison of the frequencies of occupational hazards for pregnancy according to the occurrence of “at least one sick leave” (*p < 0.05, **p < 0.01, ***p < 0.001)
40557_2017_170_Fig2_HTML.jpg
Table 2 shows adjusted relative risks (RRa) with 95% confidence intervals for “at least one SL” from 1st trimester to 3rd trimester of gestation (Table 2). In the first trimester, the “number of occupational hazards”, deprivation, “pregnancy at risk” and ART were associated with higher RRa of SL compared to the reference group. Note that the RRa of the “number of occupational hazards” increased in a dose-dependent way. In the two other trimesters the results were presented separately for pregnant workers without and with “pregnancy at risk” because of statistical interaction between “pregnancy at risk” and the “number of occupational hazards”. Like ART variable was very correlated to “pregnancy at risk“(data not shown), this variable was not presented to second and third trimester. The gradient with “number of occupational hazards” was also observed for all the strates except for 3rd trimester in the strate with “pregnancy at risk” and the strength of effect was strongest to 2nd trimester. There were positive associations with “number of work-family conflicts” for 2nd trimester but not for 3rd trimester. The others variables (occupational group, type of contract (fixed-term), company size, home-work commuting and, age) were positively associated with outcomes but only in the strate without PR.
Table 2
Bernoulli generalized linear model with « at least one sick leave» (SL) as dependent variable according to 1st and 2nd trimester
1st trimester 2nd trimester 3rd trimester
with & without PR (N = 1257) strate without PR (N = 939)a strate with PR (N = 306)a strate without PR (N = 939)a strate with PR (N = 306)a
RRab 95% CI p RRac 95% CI p RRad 95% CI p RRah 95% CI p RRai 95% CI p
Number of occupational riskse
 No risk Ref <0.001 Ref <0.001 Ref <0.001 Ref <0.001 Ref 0.25
 1 or 2 risks 1.10 0.78 - 1.54 1.96 1.44 - 2.66 1.16 0.89 - 1.52 1.32 1.12 - 1.54 1.12 0.95 - 1.32
 3 or 4 risks 1.50 1.06 - 2.12 2.05 1.48 - 2.86 1.41 1.09 - 1.82 1.55 1.32 - 1.82 1.15 0.98 - 1.35
  ≥ 5 risks 1.84 1.40 - 2.50 2.46 1.81 - 3.34 1.67 1.34 - 2.08 1.57 1.35 - 1.83 1.16 1.00 - 1.34
Work-family conflictf
 No risk Ref 0.57 Ref <0.001 Ref 0.07 Ref 0.36 Ref 0.50
 1 risks 0.93 0.68 - 1.27 1.27 0.98 - 1.61 1.13 0.89 - 1.44 1.11 0.97 - 1.26 1.07 0.92 - 1.24
 2 risks 1.00 0.73 - 1.38 1.40 1.07 - 1.81 1.29 1.02 - 1.64 1.09 0.95 - 1.25 1.09 0.94 - 1.27
  ≥ 3 risks 1.17 0.81 - 1.67 1.69 1.29 - 2.22 1.14 0.87 - 1.50 1.03 0.87 - 1.22 1.12 0.96 - 1.31
Deprivation (EPICES score ≥ 30)
 No Ref 0.02 Ref 0.98 Ref 0.17 Ref 0.56 Ref 0.64
 Yes 1.28 1.04 - 1.60 1.00 0.82 - 1.22 1.09 0.96 - 1.23 0.97 0.87 - 1.08 1.02 0.93 - 1.13
Home-work commuting felt as difficult
 No Ref 0.27 Ref 0.16 Ref 0.78 Ref <0.001 Ref 0.63
 Yes 1.13 0.99 - 1.60 1.13 0.94 - 1.35 1.01 0.89 - 1.17 1.25 1.14 - 1.37 0.97 0.87 - 1.08
Age group (years)
  < 25 1.01 0.71 - 1.43 0.65 1.52 1.24 - 1.85 <0.001 1.00 0.81 - 1.25 0.55 1.34 1.17 - 1.54 <0.001 0.89 0.70 - 1.13 0.30
 25- < 30 0.94 0.74 - 1.20 1.04 0.87 - 1.24 1.01 0.87 - 1.18 1.14 1.04 - 1.26 1.04 0.93 - 1.16
 30- < 35 Ref Ref Ref Ref Ref
  ≥ 35 0.83 0.61 - 1.23 0.97 0.73 - 1.28 0.87 0.71 - 1.07 1.02 0.88 - 1.17 0.94 0.82 - 1.08
Occupational group
 Managers/supervisors Ref 0.34 Ref 0.001 Ref 0.33 Ref 0.006 Ref 0.97
 Intermediate occupations 1.11 0.70 - 1.74 1.80 1.19 - 2.70 1.36 0.90 - 1.96 1.30 1.04 - 1.60 1.00 0.81 - 1.25
 Employees 1.16 0.75 - 1.79 1.43 0.96 - 2.16g 1.31 0.87 - 1.96g 1.16 0.93 - 1.44g 1.02 0.85 - 1.22g
 Manual workers 1.54 0.89 - 2.65 - -
Company size (workers)
  < 10 0.76 0.52 - 1.13 0.55 0.85 0.69 - 1.06 0.38 0.88 0.72 - 1.08 0.55 0.79 0.69 - 0.90 <0.001 0.89 0.78 - 1.02 0.40
 10 - 49 0.82 0.58 - 1.15 0.84 0.67 - 1.04 0.95 0.82 - 1.11 0.82 0.74 - 0.91 0.95 0.84 - 1.07
 50 - 199 0.82 0.58 - 1.17 0.86 0.68 - 1.09 0.91 0.77 - 1.08 0.87 0.80 - 0.96 0.94 0.82 - 1.07
  ≥ 200 Ref Ref Ref Ref Ref
Type of contract
 Non-fixed term Ref 0.20 Ref 0.008 Ref 0.56 Ref 0.007 Ref 0.57
 Fixed-term 1.51 0.80 - 2.85 2.06 1.21 - 3.51 1.10 0.80 - 1.50 1.47 1.11 - 1.94 1.10 0.79 - 1.51
Pregnancy at risk
 No Ref - <0.001
 Yes 2.12 1.72 - 2.63
Assisted reproductive therapy
 No Ref - 0.001
 Yes 1.54 1.19 - 2.00
RRa ajusted relative risk, 95% CI 95% confidence intervals, p p-value, PR pregnancy at risk, Ref reference
aPositive interaction between variable pregnancy at risk and variable number of occupational risks at 2nd trimester and at 3rd trimester: presentation according to strate with pregnancy at risk and without pregnancy at risk
bAjusted for: number of occupational risks (0, 1 or 2, 3 or 4, ≥5 risks), deprivation EPICES score ≥ 30 (yes/no), pregnancy at risk (yes/no), assisted reproductive therapy (yes/no)
cAjusted for: number of occupational risks (0, 1 or 2, 3 or 4, ≥5 risks), number of home-work conflicts (0, 1, 2, >2 risks), age group (<25, 25- <30, 30- < 35, ≥ 35 years), occupational group (managers/supervisors, intermediate occupations, employees + manual workers), type of contract (non-fixed term, fixed-term)
dAjusted for: number of occupational risks (0, 1 or 2, 3 or 4, ≥5 risks)
eAmong 17 selected occupational risks in this study
fAmong preschool-age children at home (yes/no), home-work commuting > 50 min/d (yes/no), duration of working hours >8 h/d (yes/no), irregular working hours (yes/no), and absent of two consecutive rest days in a week (yes/no)
gGrouping manual workers and employees because of small number of manual workers
hAjusted for: number of occupational risks (0, 1 or 2, 3 or 4, ≥5 risks), home-work commuting felt as difficult (yes/no), age group (<25, 25- <30, 30- < 35, ≥ 35 years), occupational group (managers/supervisors, intermediate occupations, employees + manual workers), company size (<10, 10–49, 50–199, ≥ 200 workers), type of contract (non-fixed term, fixed-term)
iAjusted for: number of occupational risks (0, 1 or 2, 3 or 4, ≥5 risks), number of home-work conflicts (0, 1, 2, >2 risks)
Table 3 shows the RRa for “early SL” (<15 WG) without returning to work until delivery (Table 2). The variables “number of occupational hazards”, deprivation and “pregnancy at risk” were found to be associated with increased RRa of SL compared with the reference group. We always observed a gradient with “number of occupational hazards”. Overall, 14.4% of pregnant workers left their job before 15 WG.
Table 3
Bernoulli generalized linear model with “early sick leave” (SL) without returning to work until delivery (<15 WG) as dependent variable
Early sick leave (N = 1257)
RRa a 95% CI p
Number of occupational risksb
 No risk Ref - <0.001
 1 or 2 risks 1.48 0.92 - 2.38
 3 or 4 risks 2.03 1.25 - 3.30
  ≥ 5 risks 2.90 1.89 - 4.44
Deprivation (EPICES score ≥ 30)
 No Ref - 0.005
 Yes 1.45 1.12 - 1.88
Pregnancy at risk
 No Ref <0.001
 Yes 2.42 1.87 - 3.12
RRa risk, 95% CI 95% confidence intervals, p p-value, WG week gestation
aAjusted for: number of occupational risks (0, 1 or 2, 3 or 4, ≥ 5 risks), deprivation, EPICES score ≥ 30” (yes/no), pregnancy at risk (yes/no)
bAmong 17 selected occupational risks in this study
Table 4 displays the results for the ZINB model (Table 4). The logistic portion is based on the probability of zero days of SL. This probability decreased with the number of “occupational hazards for pregnancy”, “work-home conflicts” or for “pregnancy at risk”. Working in a small company or having a non-fixed term contract was also associated with no SL. For the negative binomial portion, the duration of SL was found to be clearly associated with “number of occupational hazards”, “work-family conflicts”, deprivation and “pregnancy at risk”. Here also the gradient with “number of occupational hazards” was reported.
Table 4
Zero-inflated negative binomial model for number days of sick leave before pathological and legal maternity leaves
Logistic portiona Negative binomial portion
βb 95% CI p Probability of being an extra zero βb 95% CI p Adjusted mean NOLDc Difference (factor-intercept)c
Intercept 0.92 −0.08 – 1.91 0.07 0.71 3.46 3.06 – 3.87 <0.001 31.9 0
Number of occupational risks
 1 or 2 risks vs 0 risk −0.44 −0.83 – -0.06 <0.001 0.62 0.19 0.03 – 0.35 <0.001 38.6 +06.7
 3 or 4 risks vs 0 risk −0.74 −1.23 – -0.24 0.54 0.38 0.19 – 0.57 46.8 +14.9
  ≥ 5 risks vs 0 risk −1.05 −1.54 – -0.57 0.46 0.52 0.35 – 0.70 53.8 +21.9
Work-family conflict
 1 risks vs 0 risk 0.14 −0.23 – 0.52 0.35 0.74 0.20 0.04 – 0.35 0.03 38.8 +6.9
 2 risks vs 0 risk −0.14 −0.60 – 0.32 0.68 0.23 0.06 – 0.39 40.0 +8.1
  ≥ 3 risks vs 0 risk −0.33 −0.99 – 0.34 0.64 0.21 0.01 – 0.41 39.4 +7.6
Deprivation (EPICES score ≥ 30)
 Yes vs no −0.17 −0.59 – 0.25 0.42 0.68 0.17 0.04 – 0.31 0.01 37.9 +6.0
Working time
 Full-time vs part-time 0.15 −0.24 – 0.53 0.46 0.74 −0.15 −0.29 – -0.01 0.03 27.4 −4.5
Home-work commuting felt as difficult
 Yes vs no <0.001 0.53 0.09 −0.04 – -0.22 0.17 35.0 +3.1
Pregnancy at risk
 Yes vs no −1.26 −1.72 – -0.80 <0.001 0.41 0.42 0.29 – 0.54 <0.001 48.3 +16.5
 Company size (workers)
  ≥ 50 -199 vs ≥ 200 0.64 0.09 – 1.18 0.02 0.68 0.07 −0.12 – 0.25 0.34 34.0 +2.1
 10 – 49 vs ≥ 200 0.69 0.17 – 1.20 0.83 0.02 −0.14 – 0.19 32.7 +0.8
  < 10 vs ≥ 200 0.29 −0.25 – 0.82 0.77 −0.08 −0.24 – 0.09 29.4 −2.4
Type of contract
 Fixed-term vs non-fixed term −1.03 −1,71 – -0.35 0.003 0.47 0.26 −0.06 – 0.58 0.11 41.2 +9.4
RRa ajusted relative risk, 95% CI 95% confidence intervals, p p-value, NOLD number of sick leave days vs: versus
aModeling the probability of being an extra zero
bAjusted for: number of occupational risks (0, 1 or 2, 3 or 4, ≥5 risks), number of home-work conflicts (0, 1, 2, ≥3 risks), deprivation EPICES score ≥ 30 (yes/no), pregnancy at risk (yes/no), working time (full-time, part-time), company size (<10, 10–49, ≥ 50 – 199,≥ 200 workers), type of contract (non-fixed term, fixed term), home-work commuting felt as difficult (yes/no)
cin days
In our study, the rate of SL in pregnant workers was very high. After adjustment, the cumulative index of occupational hazards for pregnancy was clearly associated with SL (for “at least one leave”, according to duration and for “early leave”) in a dose–response relationship. We also found deprivation, pregnancy at risk, ART, work-family conflicts, home-work commuting felt as difficult, and young age to be associated with a higher risk of SL. For some factors, the results varied according to the trimesters of pregnancy. Moreover, we observed that there were less SL in small companies or for non-fixed term contract to 2nd or 3rd trimester.
The study has a number of strengths and limitations. Among its strengths, it is noteworthy that exposure data and outcomes were collected independently of each other. The assessment of occupational exposures was carried out by OHPs with good knowledge of the workstations and the workers answered the questionnaire before visiting the OHPs. Also our results were improved by adjustment for socioeconomic deprivation based on the EPICES scale [12, 31]. The other advantages of our study were its large size and the wide range of possible confounders collected, for which we adjusted our data. The large participation of OHPs in two French regions throughout the duration of the study and the high participation rate also improved the generalisability of our work. However, several potential limitations exist. High absence rates among pregnant workers may be caused by other characteristics not captured by the variables chosen in our study (e.g. job strain, other psychosocial factors) [19]. Information on outcomes was based on retrospectively collected self-reported information which may lead to errors with respect to both time of occurrence and duration. However, according to some studies, the duration from self-reported data tend to be shorter than those based on recorded data and agreement between self-reported and recorded days of absence decreased as the total number of days increased [32, 33]. Consequently, our results tend to rather underestimate reality. Also we did not have access to medical records relating to maternity and information on “pregnancy at risk” was based on self-reporting by workers. There was no consensual definition and literature data on this variable are scarce [34, 35]. In a report from the French National Authority for Health, the rate of “pregnancy at risk” was 20% versus 24.8% for our study [34]. Our rate was probably overestimated since there was no medical control of the declarations from the workers.
The high rate of “at least one SL” (74.9%) in our study is similar to that of a Norwegian study (75.3%, similar definition) [20] but higher than other studies from Norway (51%) [24] and from Denmark (31%) [7]. Our rate of “early leave” (14.4% before 15 WG) was consistent with the results from other studies: 27.5% before 24 WG [15]; 43% before 28 WG [36]. With respect to the average number of days’ absence without inclusion of the 15 days accepted for pathological leave, one study in French hospitals from 2005 to 2008 using data obtained from employers’ records reported 33.6 days on average versus 31.9 to 53.8 days for our study (see Table 3) [9]. But it is difficult to compare the different studies globally because the populations studied and the definitions chosen are not similar [4, 19].
SL is expected when a pregnant woman is sick or medically at risk as this was confirmed by our results with the variables “pregnancy at risk” and ART, and reported by other studies [12, 15, 20]. However, our results adjusted for “pregnancy at risk” and ART argue strongly for the independent implication of occupational factors in the decision to take SL. Several studies have also reported that some working conditions were statistically related to SL: heavy lifting [7, 19, 37]; work with a lot of walking or standing [7]; uncomfortable working positions [7, 19]; night or shift work [7, 19, 24]; long working days [7]. Several studies have reported an association between the combination of occupational hazards and SL [9, 18, 37]. A French study in 1985 on hospital workers reported a longer duration of SL (including the supplementary week for pathological leave) was associated with the accumulation of occupational factors: 37 days on average for 0 to 1 risk; 50 days on average for 2 or 3 risks [18]. In another French study on hospital workers in 2008, the average number of days’ absence after exclusion of women having had a pregnancy-related illness, increased with the physical load of the workstations [9].
Like other authors, we reported an association between early SL and socioeconomic deprivation in pregnant workers [12, 20]. From literature data, early SL was more frequent among pregnant workers with unstable jobs and with less-qualified occupational categories [12]. Deprived pregnant workers were exposed to more occupational hazards for pregnancy and higher risk of pregnancy-related illnesses [12, 31]. In France, pregnant workers can adapt their jobs using occupational health services, but not all women seem to benefit from those adjustments. Consequently, some deprived pregnant workers could leave early the workplace for those different reasons. In France in 2014 before legal or pathological leaves, except for some great companies, ordinary sick leaves were paid to 50% of the salary. From our study, pregnant workers with social vulnerabilities may decide to leave their job earlier than they legally can, even if they lose part of their income [12]. But this could have financial and social important consequences (isolation, less medical care). It is important to note that, in contrast with our result about early SL, sick leaves paid to 50% of the salary could also affect the use of sick leave among the poorest workers frequently exposed to occupational hazards during pregnancy (particularly of a physical nature) and could have some consequences on adverse perinatal outcomes [31]. One French study has reported that deprived pregnant workers exposed to three or more occupational hazards were significantly associated with pre-term birth [31].
We observed an association between “at least one SL” and “number of home-work conflicts” or “home-work commuting felt as difficult”. Fatigue, pain or discomfort during pregnancy are expected to be more frequent in the last trimesters than in the 1st trimester and could explain these specific associations. However, some women also still have the double burden of combining their household and child-rearing responsibilities with their jobs [11]. Pregnant workers may need to leave their job when this double burden can no longer be ensured [11]. Furthermore, we found an association between “at least one SL” and younger women (<25 years), as in certain other studies [8, 11, 16], but not others with different cut-offs [7, 19]. First pregnancy and inexperience related to age or specific representation such as “absence from work is considered beneficial for the child” may explain this result [11]. In our study, the relationship between occupational classes and SL after adjustment is not clear. This may be explained by a lower SL rate in the reference group rather than higher rates in other groups; underreporting of SL cannot be ruled out, because in general managers/supervisors are averse to declaring SL. In contrast, the observations of less SL in small companies or for non-fixed term contract are expected results because the risk losing his job (during or after pregnancy) is more important in these situations.
Our study has some practical perspectives. French labor law provides for a visit with an OHP after delivery but not before [3]. Consequently, few pregnant workers see an OHP during pregnancy. However, the situation for an OHP who receives pregnant workers may be difficult if they cannot propose job adjustments or other preventive measures in the workplace. Indeed, sometimes job adjustment is not possible because some employers may prefer pregnant workers to take sick leave so they can employ a healthy person to replace them during their absence [37]. Moreover, social conditions and, specific attitudes (for example, related to health beliefs) among pregnant workers may explain some SLs [16]. Also, some prenatal caregivers who care for pregnant workers without real knowledge of the workstation and without contact with OHPs may opt to prescribe SL to prevent disorders associated with pregnancy [21, 22]. At present, the management of employment during pregnancy results from complex interplay between the worker, employer, prenatal caregiver and, other influences [21, 22]. In addition, some pregnant workers are likely excluded from work without having had an assessment of possible preventive measures in the workplace [2, 31]. When occupational hazards for pregnancy exist, our results argue for a risk assessment in the workplace during early pregnancy, preferably with an OHP [3]. The aim would be to avoid reproductive risks by removing hazards or adjusting work [2, 3, 23].
Our results argue for the implication of exposure of the occupational hazards for pregnancy as an explanation for the occurrence of SL. More prevention in the workplace for pregnant workers exposed to occupational hazards could reduce SL. Further studies are needed to demonstrate that reducing SL might not be associated with a higher number of pregnancy-related illnesses and convince all the stakeholders (workers, employers, caregivers) to go in this direction. Our results also suggest that the duration and occurrence of early SL are significant in deprived pregnant workers. In addition, future studies should also take into account this vulnerable population in their analyses.
The authors would like to acknowledge the effort of the occupational health physicians who collected the data through the medical visits.
Funding
Not applicable.
Availability of data and materials
Please contact author for data request.
Author’s contribution
JBH, MV, ME and DL edited the protocol. JBH, MV, ME, DL and MD built the questionnaire. MV and ME coordinated the collection of data. MD managed global data. JBH and MD analysed data. JBH, MV, ME, SM and DL drafted the manuscript. All authors read and approved the final manuscript.
Competing interests
The authors declare that they have no competing interests.
Consent for publication
Not applicable.
Ethics approval and consent to participate
All the volunteer participants gave their informed consent to be enrolled and data were collected anonymously. Ethics approval, not applicable.
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

ART

Assisted reproductive therapy

OHPs

Occupational health physicians

RRa

Adjusted relative risks

SL

Sick leave

WG

Week of gestation

ZINB

Zero-inflated negative binomial
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      Exposure to occupational hazards for pregnancy and sick leave in pregnant workers: a cross-sectional study
      Ann Occup Environ Med. 2017;29:12  Published online May 15, 2017
      DOI: https://doi.org/10.1186/s40557-017-0170-3
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    Exposure to occupational hazards for pregnancy and sick leave in pregnant workers: a cross-sectional study
    Image Image
    Fig. 1 Flow chart of the study population
    Fig. 2 Comparison of the frequencies of occupational hazards for pregnancy according to the occurrence of “at least one sick leave” (*p < 0.05, **p < 0.01, ***p < 0.001)

    Fig. 1

    Fig. 2

    Exposure to occupational hazards for pregnancy and sick leave in pregnant workers: a cross-sectional study
    SLno SL p-value
    (N = 1113)(N = 373)
    N%MeansdN%Meansd
    Age (y)30.64.531.14.40.08
    Age group
      < 25 y1089.8277.40.18
     25- < 30 y40837.112233.3
     30- < 35 y40536.915141.3
      ≥ 35 y17816.26618.0
    Family structure
     Living with a partner (yes)106396.535295.40.31
     Children at home
      0 child57752.119652.80.91
      1 child44940.514639.4
       ≥ 2 children827.4297.8
    Home-work commuting
      > 50 min/d (yes)24823.27721.30.45
     In car (yes)102292.734894.00.38
    Home-work commuting felt as difficult
     Yes24522.34813.0<0.001
    Deprivation
     EPICES score ≥ 30 (yes)23122.06117.70.08
    Occupational groups
     Managers/supervisors938.45113.70.001
     Intermediate occupations37433.69124.4
     Employees59153.121657.9
     Manual workers554.9154.0
    Type of contract
     Non-fixed term (yes)150896.134292.90.01
    Working time
     Full-time (yes)86878.830081.30.31
    Job duration
      < 2 years (yes)23921.69024.40.27
    Company size
      < 10 workers25323.011431.2<0.001
     10 - 49 workers33230.213737.4
      ≥ 50 -199 workers29526.88322.7
      ≥ 200 workers21919.9328.7
    Pregnancy at risk
     Yes33430.3349.2<0.001
    Assisted reproductive therapy
     Yes847.6133.50.006
    1st trimester2nd trimester3rd trimester
    with & without PR (N = 1257)strate without PR (N = 939)a strate with PR (N = 306)a strate without PR (N = 939)a strate with PR (N = 306)a
    RRab 95% CI p RRac 95% CI p RRad 95% CI p RRah 95% CI p RRai 95% CI p
    Number of occupational riskse
     No riskRef <0.001 Ref <0.001 Ref <0.001 Ref <0.001 Ref 0.25
     1 or 2 risks1.100.78 - 1.541.961.44 - 2.661.160.89 - 1.521.321.12 - 1.541.120.95 - 1.32
     3 or 4 risks1.501.06 - 2.122.051.48 - 2.861.411.09 - 1.821.551.32 - 1.821.150.98 - 1.35
      ≥ 5 risks1.841.40 - 2.502.461.81 - 3.341.671.34 - 2.081.571.35 - 1.831.161.00 - 1.34
    Work-family conflictf
     No riskRef 0.57 Ref <0.001 Ref 0.07 Ref 0.36 Ref 0.50
     1 risks0.930.68 - 1.271.270.98 - 1.611.130.89 - 1.441.110.97 - 1.261.070.92 - 1.24
     2 risks1.000.73 - 1.381.401.07 - 1.811.291.02 - 1.641.090.95 - 1.251.090.94 - 1.27
      ≥ 3 risks1.170.81 - 1.671.691.29 - 2.221.140.87 - 1.501.030.87 - 1.221.120.96 - 1.31
    Deprivation (EPICES score ≥ 30)
     NoRef 0.02 Ref 0.98 Ref 0.17 Ref 0.56 Ref 0.64
     Yes1.281.04 - 1.601.000.82 - 1.221.090.96 - 1.230.970.87 - 1.081.020.93 - 1.13
    Home-work commuting felt as difficult
     NoRef 0.27 Ref 0.16 Ref 0.78 Ref <0.001 Ref 0.63
     Yes1.130.99 - 1.601.130.94 - 1.351.010.89 - 1.171.251.14 - 1.370.970.87 - 1.08
    Age group (years)
      < 251.010.71 - 1.43 0.65 1.521.24 - 1.85 <0.001 1.000.81 - 1.25 0.55 1.341.17 - 1.54 <0.001 0.890.70 - 1.13 0.30
     25- < 300.940.74 - 1.201.040.87 - 1.241.010.87 - 1.181.141.04 - 1.261.040.93 - 1.16
     30- < 35RefRefRefRefRef
      ≥ 350.830.61 - 1.230.970.73 - 1.280.870.71 - 1.071.020.88 - 1.170.940.82 - 1.08
    Occupational group
     Managers/supervisorsRef 0.34 Ref 0.001 Ref 0.33 Ref 0.006 Ref 0.97
     Intermediate occupations1.110.70 - 1.741.801.19 - 2.701.360.90 - 1.961.301.04 - 1.601.000.81 - 1.25
     Employees1.160.75 - 1.791.430.96 - 2.16g 1.310.87 - 1.96g 1.160.93 - 1.44g 1.020.85 - 1.22g
     Manual workers1.540.89 - 2.65--
    Company size (workers)
      < 100.760.52 - 1.13 0.55 0.850.69 - 1.06 0.38 0.880.72 - 1.08 0.55 0.790.69 - 0.90 <0.001 0.890.78 - 1.02 0.40
     10 - 490.820.58 - 1.150.840.67 - 1.040.950.82 - 1.110.820.74 - 0.910.950.84 - 1.07
     50 - 1990.820.58 - 1.170.860.68 - 1.090.910.77 - 1.080.870.80 - 0.960.940.82 - 1.07
      ≥ 200RefRefRefRefRef
    Type of contract
     Non-fixed termRef 0.20 Ref 0.008 Ref 0.56 Ref 0.007 Ref 0.57
     Fixed-term1.510.80 - 2.852.061.21 - 3.511.100.80 - 1.501.471.11 - 1.941.100.79 - 1.51
    Pregnancy at risk
     NoRef- <0.001
     Yes2.121.72 - 2.63
    Assisted reproductive therapy
     NoRef- 0.001
     Yes1.541.19 - 2.00
    Early sick leave (N = 1257)
    RRa a 95% CI p
    Number of occupational risksb
     No riskRef- <0.001
     1 or 2 risks1.480.92 - 2.38
     3 or 4 risks2.031.25 - 3.30
      ≥ 5 risks2.901.89 - 4.44
    Deprivation (EPICES score ≥ 30)
     NoRef- 0.005
     Yes1.451.12 - 1.88
    Pregnancy at risk
     NoRef <0.001
     Yes2.421.87 - 3.12
    Logistic portiona Negative binomial portion
    βb 95% CI p Probability of being an extra zeroβb 95% CI p Adjusted mean NOLDc Difference (factor-intercept)c
    Intercept0.92−0.08 – 1.91 0.07 0.713.463.06 – 3.87 <0.001 31.90
    Number of occupational risks
     1 or 2 risks vs 0 risk−0.44−0.83 – -0.06 <0.001 0.620.190.03 – 0.35 <0.001 38.6+06.7
     3 or 4 risks vs 0 risk−0.74−1.23 – -0.240.540.380.19 – 0.5746.8+14.9
      ≥ 5 risks vs 0 risk−1.05−1.54 – -0.570.460.520.35 – 0.7053.8+21.9
    Work-family conflict
     1 risks vs 0 risk0.14−0.23 – 0.52 0.35 0.740.200.04 – 0.35 0.03 38.8+6.9
     2 risks vs 0 risk−0.14−0.60 – 0.320.680.230.06 – 0.3940.0+8.1
      ≥ 3 risks vs 0 risk−0.33−0.99 – 0.340.640.210.01 – 0.4139.4+7.6
    Deprivation (EPICES score ≥ 30)
     Yes vs no−0.17−0.59 – 0.25 0.42 0.680.170.04 – 0.31 0.01 37.9+6.0
    Working time
     Full-time vs part-time0.15−0.24 – 0.53 0.46 0.74−0.15−0.29 – -0.01 0.03 27.4−4.5
    Home-work commuting felt as difficult
     Yes vs no <0.001 0.530.09−0.04 – -0.22 0.17 35.0+3.1
    Pregnancy at risk
     Yes vs no−1.26−1.72 – -0.80 <0.001 0.410.420.29 – 0.54 <0.001 48.3+16.5
     Company size (workers)
      ≥ 50 -199 vs ≥ 2000.640.09 – 1.18 0.02 0.680.07−0.12 – 0.25 0.34 34.0+2.1
     10 – 49 vs ≥ 2000.690.17 – 1.200.830.02−0.14 – 0.1932.7+0.8
      < 10 vs ≥ 2000.29−0.25 – 0.820.77−0.08−0.24 – 0.0929.4−2.4
    Type of contract
     Fixed-term vs non-fixed term−1.03−1,71 – -0.35 0.003 0.470.26−0.06 – 0.58 0.11 41.2+9.4
    Table 1 Characteristics of the pregnant workers according to the variable “at least one sick leave” (SL) during pregnancy

    N number, y years, min minutes, d day, sd standard deviation

    Table 2 Bernoulli generalized linear model with « at least one sick leave» (SL) as dependent variable according to 1st and 2nd trimester

    RRa ajusted relative risk, 95% CI 95% confidence intervals, p p-value, PR pregnancy at risk, Ref reference

    aPositive interaction between variable pregnancy at risk and variable number of occupational risks at 2nd trimester and at 3rd trimester: presentation according to strate with pregnancy at risk and without pregnancy at risk

    bAjusted for: number of occupational risks (0, 1 or 2, 3 or 4, ≥5 risks), deprivation EPICES score ≥ 30 (yes/no), pregnancy at risk (yes/no), assisted reproductive therapy (yes/no)

    cAjusted for: number of occupational risks (0, 1 or 2, 3 or 4, ≥5 risks), number of home-work conflicts (0, 1, 2, >2 risks), age group (<25, 25- <30, 30- < 35, ≥ 35 years), occupational group (managers/supervisors, intermediate occupations, employees + manual workers), type of contract (non-fixed term, fixed-term)

    dAjusted for: number of occupational risks (0, 1 or 2, 3 or 4, ≥5 risks)

    eAmong 17 selected occupational risks in this study

    fAmong preschool-age children at home (yes/no), home-work commuting > 50 min/d (yes/no), duration of working hours >8 h/d (yes/no), irregular working hours (yes/no), and absent of two consecutive rest days in a week (yes/no)

    gGrouping manual workers and employees because of small number of manual workers

    hAjusted for: number of occupational risks (0, 1 or 2, 3 or 4, ≥5 risks), home-work commuting felt as difficult (yes/no), age group (<25, 25- <30, 30- < 35, ≥ 35 years), occupational group (managers/supervisors, intermediate occupations, employees + manual workers), company size (<10, 10–49, 50–199, ≥ 200 workers), type of contract (non-fixed term, fixed-term)

    iAjusted for: number of occupational risks (0, 1 or 2, 3 or 4, ≥5 risks), number of home-work conflicts (0, 1, 2, >2 risks)

    Table 3 Bernoulli generalized linear model with “early sick leave” (SL) without returning to work until delivery (<15 WG) as dependent variable

    RRa risk, 95% CI 95% confidence intervals, p p-value, WG week gestation

    aAjusted for: number of occupational risks (0, 1 or 2, 3 or 4, ≥ 5 risks), deprivation, EPICES score ≥ 30” (yes/no), pregnancy at risk (yes/no)

    bAmong 17 selected occupational risks in this study

    Table 4 Zero-inflated negative binomial model for number days of sick leave before pathological and legal maternity leaves

    RRa ajusted relative risk, 95% CI 95% confidence intervals, p p-value, NOLD number of sick leave days vs: versus

    aModeling the probability of being an extra zero

    bAjusted for: number of occupational risks (0, 1 or 2, 3 or 4, ≥5 risks), number of home-work conflicts (0, 1, 2, ≥3 risks), deprivation EPICES score ≥ 30 (yes/no), pregnancy at risk (yes/no), working time (full-time, part-time), company size (<10, 10–49, ≥ 50 – 199,≥ 200 workers), type of contract (non-fixed term, fixed term), home-work commuting felt as difficult (yes/no)

    cin days

    Table 1

    Table 2

    Table 3

    Table 4

    Ann Occup Environ Med : Annals of Occupational and Environmental Medicine
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