Sister-Chromatid Exchanges in Lymphocytes of Medical Students Exposed to Formaldehyde

Soo Jin Lee; Jeong Il Son; Sang Hyo Sim; Kee Young Kim; Jaecheol Song; Suo Ja Chu; Sung Han Shim; Youl Hee Cho; Doo Jin Park

doi:10.35371/kjoem.1998.10.2.282

Original Article Sister-Chromatid Exchanges in Lymphocytes of Medical Students Exposed to Formaldehyde: Soo Jin Lee, Jeong Il Son, Sang Hyo Sim, Kee Young Kim, Jaecheol Song, Suo Ja Chu, Sung Han Shim, Youl Hee Cho, Doo Jin Park; DOI: https://doi.org/10.35371/kjoem.1998.10.2.282
Published online: May 31, 1998

¹Department of Occupational medicine, Hanyang University Hospital, Korea.

²Department of Medical Genetics, College of Medicine, Hanyang University, Korea.

³Department of Anatomy, College of medicine, Hanyang University, Korea.

⁴Koryo Industrial Medical Center, Young Nam Medical Foundation, Korea.

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Abstract

Sister-chromatic exchanges measured in the peripheral lymphocytes of 15 non-smoking medical students after exposure to formaldehyde during a 24-week anatomy class showed a small but significant (p=0.0468) increase when compared with samples obtained from the same individuals immediately before exposure. Mean frequencies of sister-chromatic exchange of cultured peripheral lymphocytes were 5.40+/-0.24 from the samples before exposure and 5.87+/-0.22 from the same samples after exposure. Breathing-zone air samples collected by formaldehyde monitoring kit with digital colorimeter (SKC) showed a mean concentration of 0.72+/-0.02 ppm formaldehyde.

Keywords: Sister-chromatid exchange (SCE);Formaldehyde;Mutagenicity

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