Annals of Occupational and Environmental Medicine

Review

A brief review of relationship between occupational benzene exposure and hematopoietic cancer: Jin-Ha Yoon, Woo Seok Kwak, Yeon-Soon Ahn; Ann Occup Environ Med 2018;30:33. Published online May 10, 2018; DOI: https://doi.org/10.1186/s40557-018-0245-9

We reviewed articles to clarify the current evidence status for 1) types of cancer which related to benzene exposure, and 2) certain benzene exposure level which might cause the hematopoietic cancers. Hematopoietic function of the bone marrow is involved in the production of all blood cells types. The benzene metabolites including benzoquinone and mucoaldehyde affect hematopoietic stem cells as well as differentiation steps of progenitor cells for each blood cell. Hence, we concluded that benzene was associated with all lymphohematic carcinogenesis. First, it is supported by biological plausibility. Second, it is supported by meta-analysis although sing study did not show relationship due to lack of sample size or statistical power. More recent studies show lesser exposed level related to risk of cancer, compare to past studies did. Actually, early studies show the risk of malignancies in workers who exposed more than 200 ppm-years. However, only 0.5 to 1 ppm-year benzene exposed show significant linking to risk of malignancies in recent study. As reviewed research articles, we concluded that the relatively lower exposure level, such as 0.5–1 ppm-year, will be considering at risk of hematopoietic cancer. However, more research needs to be done on dose-response analysis.

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Original Article

Area-Based Occupational Disease Surveillance in Incheon, Korea: Results of an 11-year Data Survey: Jeong Hoon Kim, Shin Goo Park, Jong Han Leem, Jong Uk Won, Sang Hwan Han, Soo Young Chung, Sang Hoon Kim, Hwan Cheol Kim, Yun Chul Hong, Cheol Woo Kim, Chang Hwan Kim, Dong Hyun Kim, Dong Hoon Lee, Seung Jun Lee, Young Joong Kang, Woo Seok Kwak, Jeongbae Rhie; Korean Journal of Occupational and Environmental Medicine 2010;22(3):183-199. Published online September 30, 2010; DOI: https://doi.org/10.35371/kjoem.2010.22.3.183

Abstract PDF

OBJECTIVES
Between Jan 1998 and Dec 2008, area-based occupational disease surveillance in Incheon was used to collect data on occupational diseases. The long-term data was used to estimate the scale of disease, to analyze disease characteristics, and to achieve surveillance in order to determine development tasks.
METHODS
For a period of 11 years, occupation-related disease surveillance was performed on an annual basis for employees of Incheon industries. All cases of occupational disease were reported by means of the Incheon Occupational Disease Information Network (IODIN) web site, downloaded, and analyzed, subsequently.
RESULTS
Between Jan 1998 and Dec 2008, 1577 cases of occupational disease were reported. Of these, there were 1043(66.1%) cases of occupational musculoskeletal disorders, 172(10.9%) cases of occupational asthma, 162(10.3%) cases of occupational dermatoses, 135(8.6%) cases of occupationally-related cancers, 30(1.9%) cases of pneumoconiosis, 27(1.7%) cases of toxic hepatitis, and 8(0.5%) cases of occupational neuronal disease.
CONCLUSION
In the Incheon area, small and medium industries comprise 99% of business. The composition of the industry by category, in Incheon, is similar to the country on the whole. In actually, the data on occupational diseases in Korea are almost workers' compensation data. Thus, the survey of occupational disease based in Incheon, Korea, can serve as an estimate of the trends and size of the occupational disease throughout the entire country.

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Soon-Chan Kwon, Jaechul Song, Yong-kyu Kim, Geoffrey M. Calvert
Allergy, Asthma & Immunology Research.2015; 7(1): 51. CrossRef

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