Annals of Occupational and Environmental Medicine

Original Article

Relationship of Biological Indices of Manganese with Pallidal Index on MRI in Liver Cirrhotics: Younghee Choi, Neung Hwa Park, Jung Woo Shin, Hyo Kyung Kim, Sung Ryul Kim, Tae Heum Jeong, Ji Kang Park, Hun Lee, Cheol In Yoo, Choong Ryeol Lee, Ji Ho Lee, Yangho Kim; Korean Journal of Occupational and Environmental Medicine 2004;16(2):129-138. Published online June 30, 2004; DOI: https://doi.org/10.35371/kjoem.2004.16.2.129

Abstract PDF: OBJECTIVES
The objectives of this study were to clarify which biological manganese exposure indices reflect the pallidal signal intensities in magnetic resonance imaging (MRI) in liver cirrhotics.
METHODS
We examined whole blood, plasma, RBC and urinary manganese concentrations, as well as, brain MRI in 22 cirrhotic patients and 10 healthy controls. From MRI scans we calculated the signal intensity of the globus pallidus using the pallidal index (PI), the ratio of the globus pallidus to subcortical frontal white-matter signal intensity in axial T1-weighted MRI planes multiplied by 100. In addition, we studied the relationships between PI and other measurements.
RESULTS
The high signal intensity in the globus pallidus on T1-weighted MRI was observed in 18 (81.8%) patients. There was a significant correlation between whole blood and RBC manganese concentration, and PI on MRI. According to multiple linear regression, whole blood and RBC manganese concentration reflected PI on MRI better the other indices did.
CONCLUSIONS
Whole blood and RBC manganese concentrations could be useful as biological manganese exposure indices that reflect PI on MRI.

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