Annals of Occupational and Environmental Medicine

Original Article

Risk assessment of heavy metals in tuna from Japanese restaurants in the Republic of Korea: Seong-Jin Bae, Kyu-Sik Shin, Chulyong Park, Kiook Baek, So-Young Son, Joon Sakong; Ann Occup Environ Med 2023;35:e3. Published online February 9, 2023; DOI: https://doi.org/10.35371/aoem.2023.35.e3

Abstract Abstract in Korean PDF Supplementary Material PubReader ePub

Background

Studies on the risk of mercury (Hg) in Korean fishery products focus primarily on total Hg levels as opposed to methylmercury (MeHg) levels. None of the few studies on MeHg in tuna investigated tuna from Japanese restaurants. Few have evaluated lead (Pb), cadmium (Cd) and arsenic (As) in tuna. Thus, this study aimed to conduct a risk assessment by evaluating heavy metal concentrations in tuna from Japanese restaurants.

Methods

Thirty-one tuna samples were collected from Japanese restaurants in the Republic of Korea. They were classified according to region and species. The concentration of heavy metals in the samples was analyzed using the Ministry of Food and Drug Safety Food Code method. The rate of exceedance of maximum residue levels (MRLs) and the risk compared to the provisional tolerable weekly intake (PTWI) set by the Joint Food and Agriculture Organization/World Health Organization Expert Committee on Food Additives (%PTWI) were evaluated for risk assessment.

Results

The mean of MeHg, Pb, Cd and As concentrations were 0.56 ± 1.47 mg/kg, 33.95 ± 3.74 μg/kg, 14.25 ± 2.19 μg/kg and 1.46 ± 1.89 mg/kg, respectively. No sample exceeded the MRLs of Pb and Cd, but 9.7% of the samples exceeded the MRL of MeHg. The %PTWIs of MeHg, Pb, Cd and As were 4.2037, 0.0162, 0.0244 and 1.1627, respectively. The %PTWI of MeHg by age group and sex was highest among men aged 19–29 years (10.6494), followed by men aged 30–49 years (7.2458) and women aged 19–29 years (4.8307).

Conclusions

We found that 3 out of 31 samples exceeded the MRL of MeHg. The %PTWI of MeHg showed significant differences based on age and sex, and the value was likely to exceed a safe level depending on individuals’ eating behaviors. Therefore, improved risk management for MeHg is required.

한국의 일식집 유통 참치의 중금속(4종) 위해성평가
목적
국내 수산물의 수은에 관한 위해성 연구는 주로 메틸수은이 아닌 총 수은을 대상으로 이루어졌다. 소수의 참치의 메틸수은에 대한 연구들 중 일식점 유통 참치에 대한 연구는 없었다. 참치의 납, 카드뮴 및 비소에 대한 연구도 거의 이루어지지 않았다. 따라서 본 연구에서는 일식점 유통 참치의 중금속 농도를 평가하여 위해성평가를 실시하고자 하였다.
방법
참치는 한국의 일식집에서 총 31개의 시료가 수집되었다. 지역과 참치의 종에 따라서 분류하였다. 시료의 중금속 농도는 식품의약품안전처의 식품공전에 따라 분석했다. 위해성평가를 위해서 식품의 잔류허용기준을 초과하는 비율과 FAO/WHO합동식품첨가물 전문가위원회가 설정한 잠정주간섭취허용과 비교한 위험도(%PTWI)를 산출하였다.
결과
메틸수은, 납, 카드뮴 및 비소 농도의 기하평균은 각각 0.56 ± 1.47 mg/kg, 33.95 ± 3.74 μg/kg, 14.25 ± 2.19 μg/kg 및 1.46 ± 1.89 mg/kg이었다. 납과 카드뮴의 경우 잔류허용기준을 초과하는 시료가 없었으나 메틸수은의 경우 시료의 9.7%가 초과했다. 메틸수은, 납, 카드뮴 및 비소의 %PTWI는 4.2037, 0.0162, 0.0244 및 1.1627이었다. 메틸수은의 %PTWI는 19-29세의 남성, 30-49세의 남성, 19-29세의 여성 순으로 높았으며, 그 값은 10.6494, 7.2458, 4.8307이었다.
결론
총 31개의 시료 중 3개에서 메틸수은의 잔류허용기준을 초과하는 것으로 나타났다. 메틸수은의 %PTWI는 연령과 성별에 따라 상당한 차이를 보였고, 그리고 그 값은 섭취행태에 따라서 안전 수준을 초과할 가능성을 보였다. 따라서, 메틸수은에 대한 개선된 안전성 관리 방안이 필요할 것으로 보인다.

Citations

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Metal Load of Potentially Toxic Elements in Tuna (Thunnus albacares)—Food Safety Aspects
József Lehel, Zita Papp, András Bartha, Péter Palotás, Rita Szabó, Péter Budai, Miklós Süth
Foods.2023; 12(16): 3038. CrossRef

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Research Articles

The association between mercury concentrations and lipid profiles in the Korean National Environmental Health Survey (KoNEHS) cycle 3: Soo Ho Sohn, Han Cheol Heo, Seongmin Jo, Chulyong Park, Joon Sakong; Ann Occup Environ Med 2020;32:e19. Published online June 22, 2020; DOI: https://doi.org/10.35371/aoem.2020.32.e19

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Background

High concentrations of mercury intake from seafood are known to cause various side effects in humans, including on the nervous system. Various studies have reported the effects of mercury concentrations in humans; however, the association between dyslipidemia, a cardiovascular disease risk factor, and mercury remains controversial. Therefore, this study aimed to investigate the association between mercury accumulation and cholesterol concentrations in a Korean population.

Methods

We analyzed data of a sample of 3,228 respondents obtained from the Korean National Environmental Health Survey cycle 3, surveyed between 2015 and 2017, to determine how lipid profiles changed according to the blood mercury concentrations (BHg) and urine mercury concentrations (UHg). Multiple regression analysis was used to determine the effects of mercury concentrations among various factors affecting blood cholesterol levels.

Results

The arithmetic mean (AM) of BHg was 2.91 (2.81–3.02) μg/L, and the geometric mean (GM) was 2.71 (2.59–2.85) μg/L. The AM of UHg was 0.52 (0.48–0.56) μg/L, and the GM was 0.35 (0.33–0.38) μg/L. Lipid profiles were more related to the BHg than to the UHg. Total cholesterol (total-C), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels increased significantly as BHg increased in males, and total-C, triglyceride, and LDL-C levels increased significantly in females. Multiple regression analysis indicated that BHg were significantly associated with total-C, HDL-C, and LDL-C levels.

Conclusions

We found an association between mercury exposure and the risk of dyslipidemia; however, further studies are required to elucidate a causal association.

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Do blood metals influence lipid profiles? Findings of a cross-sectional population-based survey
Sabit Cakmak, Kimberly Mitchell, Anna Lukina, Robert Dales
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Association of Blood Total Mercury with Dyslipidemia in a sample of U.S. Adolescents: Results from the National Health and Nutrition Examination Survey Database, 2011–2018
Chibuzor Abasilim, Victoria Persky, Mary E. Turyk
Hygiene and Environmental Health Advances.2023; 6: 100047. CrossRef
Association of Blood Mercury Level with Liver Enzymes in Korean Adults: An Analysis of 2015–2017 Korean National Environmental Health Survey
Jin-Wook Chung, Dilaram Acharya, Jitendra Kumar Singh, Joon Sakong
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Heavy metal-induced lipogenic gene aberration, lipid dysregulation and obesogenic effect: a review
Yang Zhou, Frank Peprah Addai, Xinshuang Zhang, Yuelin Liu, Yinfeng Wang, Feng Lin, Alex Tuffour, Jie Gu, Guangxiang Liu, Haifeng Shi
Environmental Chemistry Letters.2022; 20(3): 1611. CrossRef
Mercury may reduce the protective effect of sea fish consumption on serum triglycerides levels in Chinese adults: Evidence from China National Human Biomonitoring
Bing Wu, Yingli Qu, Yifu Lu, Saisai Ji, Liang Ding, Zheng Li, Miao Zhang, Heng Gu, Qi Sun, Bo Ying, Feng Zhao, Xulin Zheng, Yidan Qiu, Zheng Zhang, Ying Zhu, Zhaojin Cao, Yuebin Lv, Xiaoming Shi
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Kaviyarasi Renu, Anirban Goutam Mukherjee, Uddesh Ramesh Wanjari, Sathishkumar Vinayagam, Vishnu Priya Veeraraghavan, Balachandar Vellingiri, Alex George, Ricardo Lagoa, Kamaraj Sattu, Abhijit Dey, Abilash Valsala Gopalakrishnan
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Do-won Kim, Jeongwon Ock, Kyong-Whan Moon, Choong-Hee Park
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Mercury concentration in shark meat from traditional markets of Gyeongsangbuk-do, South Korea: Han Cheol Heo, Yeon Hee Lim, Young Seok Byun, Joon Sakong; Ann Occup Environ Med 2020;32:e3. Published online January 2, 2020; DOI: https://doi.org/10.35371/aoem.2020.32.e3

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Background

Although unusually high levels of blood mercury have been reported in the North Gyeongsang Province (Gyeongsangbuk-do), mercury contents from shark meat distributed in this region have not been assessed yet. Thus, this study aims to identify the hazard by evaluating the mercury contents of the shark meat sold in the traditional market of Gyeongsangbuk-do.

Methods

The shark meat in the form of muscle meat was obtained from 15 traditional markets of Gyeongsangbuk-do in the summer and winter of 2013. Out of 105 samples in total, 49 were collected in the summer and 56 in the winter. The total mercury concentration was measured by the combustion-gold amalgamation method using an automatic mercury analyzer (Milestone DMA-80, Milestone).

Results

The average mercury concentration of shark meat was 2.29 ± 1.77 µg/g, ranging between 0.06–8.93 µg/g with a geometric mean of 1.44 µg/g, which is higher than those reported in many countries. The mercury concentration in 77 of 105 shark meat samples exceeded 1 µg/g. Mercury concentration ranged between 0.09–8.93 µg/g (geometric mean: 1.45) in the summer and 0.06–6.73 µg/g (geometric mean: 1.48) in the winter.

Conclusions

Shark meat sold in the market contained a substantial amount of mercury. This suggests that it is difficult to reduce mercury intake by simply strengthening the standard level of mercury concentration in shark meat. Therefore, it is need to communication and awareness programs with consumers about hazardous effects of mercury inherent in shark meat.

Citations

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Association of Blood Mercury Level with Liver Enzymes in Korean Adults: An Analysis of 2015–2017 Korean National Environmental Health Survey
Jin-Wook Chung, Dilaram Acharya, Jitendra Kumar Singh, Joon Sakong
International Journal of Environmental Research and Public Health.2023; 20(4): 3290. CrossRef
Increase of blood mercury level with shark meat consumption: A repeated-measures study before and after Chuseok, Korean holiday
Kiook Baek, Chulyong Park, Joon Sakong
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William Maher, Frank Krikowa, Michael Ellwood, Detlev Helmig, Ruoyu Sun
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The effects of exposure to lead, cadmium and mercury on follicle-stimulating hormone levels in men and postmenopausal women: data from the Second Korean National Environmental Health Survey (2012–2014): Tae-Woo Lee, Dae Hwan Kim, Ji Young Ryu; Ann Occup Environ Med 2019;31:e21. Published online August 28, 2019; DOI: https://doi.org/10.35371/aoem.2019.31.e21

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Background

Follicle-stimulating hormone (FSH), a gonadotropin secreted by the pituitary gland, is a representative secondary sex hormone and an important indicator of reproductive function. The effects of heavy metals such as lead, cadmium, and mercury on humans have been studied, but reports on their effects on sex hormone levels are lacking. Therefore, we investigated the relationship between heavy metal exposure and FSH levels in Korean men and postmenopausal women.

Methods

A total of 4,689 adults (2,763 men and 1,926 postmenopausal women aged 50 years or over) who participated in the Second Korean National Environmental Health Survey (2012–2014) were included. We compared differences in serum FSH levels by demographic characteristics using the t-test and analysis of variance. Multiple linear regression analysis was used to determine the relationship between the blood levels of lead and mercury and the urine cadmium level, and serum FSH levels.

Results

On multiple linear regression analysis, lead exposure was positively associated with serum FSH concentrations in postmenopausal women (β = 2.929, p = 0.019). However, we found no significant association between serum FSH concentration and blood lead and mercury levels, or urine cadmium level, in men.

Conclusions

This study suggests that lead exposure can affect the FSH level in postmenopausal women. Further studies are needed to evaluate the effects of low-dose long-term exposure to heavy metals on sex hormones.

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Hormonal profile changes under the influence of environmental factors in children residing in the Aral environmental disaster region
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Association of Blood Mercury Level with Liver Enzymes in Korean Adults: An Analysis of 2015–2017 Korean National Environmental Health Survey
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Anna Corry Gerald, Srividya Ganapathy, Jianmin Zhu, Yudan Wei
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A study of relationship between blood mercury concentration and hypertension in residents living in old mine fields and related factors: Jeong Woo Kim, Byoung Gwon Kim, Jeong Woo Park, Jong Woo Yi, Jung Il Kim, Young Seoub Hong; Ann Occup Environ Med 2019;31:e6. Published online May 30, 2019; DOI: https://doi.org/10.35371/aoem.2019.31.e6

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Background

In Korea, around the abandoned metal mines, heavy metals are being accumulating in the cultivated areas. Among exposed heavy metals, mercury is known to harm for cardiovascular system known to affect blood pressure. So, we studied the relationship between blood mercury level and hypertension in residents around abandoned metal mines.

Methods

From 2008 to 2011, we surveyed 7,055 residents in provinces affected by abandoned metal mines and collected data from 6 Hospitals. We conducted a personal questionnaire interview survey with residents on the basis of household questionnaires, sex, age, household income, smoking, and drinking items. Multiple logistic regression analysis was performed to investigate the association between blood mercury level and hypertension.

Results

We compared residents with low and high groups based on blood mercury level 5.8 μg/L, and higher group was significantly higher risk of hypertension than lower group (odds ratio [OR]: 1.277; 95% confidence interval [CI]: 1.135–1.436), also in adjusted model, higher group was significantly higher risk of hypertension than lower group (OR: 1.276; 95% CI: 1.117–1.457).

Conclusions

This study showed a significant correlation between mercury and hypertension in residents around abandoned metal mines. Therefore, we should continuously monitor people who are higher than the standard value and the hypertensive patients.

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The associations between blood mercury levels and shark meat intake among workers in Gyeongsangbuk-do: Gun Il Park, Young Seok Byun, Man Joong Jeon, Joon Sakong; Ann Occup Environ Med 2017;29:29. Published online June 27, 2017; DOI: https://doi.org/10.1186/s40557-017-0185-9

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Background

Shark meat is used as sacrificial food in Gyeongsangbuk-do, and is a major source of dietary mercury. This study aimed to evaluate the effects of shark meat intake or the ritual of Jesa on blood mercury levels within workers living in Gyeongsangbuk-do.

Methods

This study was conducted from September 2016 to October 2016 in two cities of Gyeongsangbuk-do. To compare the differences between urban and rural areas, two workplaces each in Daegu as the urban area and Yeongcheon as the rural area were selected. General characteristics and characteristics related to shark meat consumption of the workers were acquired by personal interviews during their health examination. Blood mercury concentrations were analyzed by the gold amalgamation method using a direct mercury analyzer (DMA-80; Milestone Inc., Shelton, CT, USA).

Results

The shark consumption group had a higher blood mercury concentration than the non-consumption group. The levels of blood mercury increased with the frequency, annual intake, as well as most recent date of shark meat consumption. Moreover, the levels of mercury in blood increased according to the annual frequency of participation in Jesa (times per year) and the annual frequency of shark meat consumption during Jesa (times per year).

Conclusions

Shark meat intake and the ritual of Jesa contributed to an increase in the blood mercury levels of workers in Gyeongsangbuk-do. Therefore, it is necessary to evaluate dietary exposure, occupational as well as other factors that may influence blood mercury concentrations in workers during their health examination, particularly in regions with high mercury exposures.

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Ji-Eun Oh, Tae-Hyeong Kim, Eun-Hee Lee
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Association of Blood Mercury Level with Liver Enzymes in Korean Adults: An Analysis of 2015–2017 Korean National Environmental Health Survey
Jin-Wook Chung, Dilaram Acharya, Jitendra Kumar Singh, Joon Sakong
International Journal of Environmental Research and Public Health.2023; 20(4): 3290. CrossRef
Increase of blood mercury level with shark meat consumption: A repeated-measures study before and after Chuseok, Korean holiday
Kiook Baek, Chulyong Park, Joon Sakong
Chemosphere.2023; 344: 140317. CrossRef
Mercury concentration in shark meat from traditional markets of Gyeongsangbuk-do, South Korea
Han Cheol Heo, Yeon Hee Lim, Young Seok Byun, Joon Sakong
Annals of Occupational and Environmental Medicine.2020;[Epub] CrossRef
Mercury poisoning in a fisherman working on a pelagic fishing vessel due to excessive tuna consumption
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Case Report

Cases of acute mercury poisoning by mercury vapor exposure during the demolition of a fluorescent lamp factory: Sang Yoon Do, Chul Gab Lee, Jae Yoon Kim, Young Hoon Moon, Min Sung Kim, In Ho Bae, Han Soo Song; Ann Occup Environ Med 2017;29:19. Published online June 20, 2017; DOI: https://doi.org/10.1186/s40557-017-0184-x

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Background

In 2015, workers dismantling a fluorescent lamp factory in Korea were affected by mercury poisoning from exposure to mercury vapor.

Case presentation

Eighteen out of the 21 workers who participated in the demolition project presented with symptoms of poisoning and, of these, 10 had persistent symptoms even at 18 months after the initial exposure to mercury vapor. Early symptoms of 18 workers included a general skin rash, pruritus, myalgia, sleep disturbance, and cough and sputum production. Following alleviation of these initial symptoms, late symptoms, such as easy fatigue, insomnia, bad dreams, and anxiety disorder, began to manifest in 10 out of 18 patients. Seven workers underwent psychiatric care owing to sleep disturbance, anxiety disorder, and depression, and three workers underwent dermatologic treatment for hyperpigmentation, erythematous skin eruption, and chloracne-like skin lesions. Furthermore, three workers developed a coarse jerky movement, two had swan neck deformity of the fingers, and two received care at an anesthesiology clinic for paresthesia, such as burning sensation, cold sensation, and pain. Two workers underwent urologic treatment for dysfunction of the urologic system and impotence. However, symptomatic treatment did not result in satisfactory relief of these symptoms.

Conclusion

Awareness of the perils of mercury and prevention of mercury exposure are critical for preventing health hazards caused by mercury vapor. Chelation therapy should be performed promptly following mercury poisoning to minimize damage.

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Research Article

Air pollution and urinary n-acetyl-B-glucosaminidase levels in residents living near a cement plant: Min Soo Jung, Jae Yoon Kim, Hyun Seung Lee, Chul Gab Lee, Han Soo Song; Ann Occup Environ Med 2016;28:52. Published online September 29, 2016; DOI: https://doi.org/10.1186/s40557-016-0138-8

Abstract PDF PubReader ePub

Background

To identify adverse renal effects due to air pollution derived from a cement plant in Korea. Urinary n-acetyl-B-glucosaminidase (U-NAG) levels in residents living near a cement plant were compared to those in a group who lived farther away from the plant.

Methods

From June to August 2013 and from August to November 2014, laboratory tests for U-NAG and heavy metal were conducted on 547 study participants. Based on the level of air pollution exposure, subjects were divided into the “less exposed group,” (LEG) which consisted of 66 persons who lived more than 5 km away from the cement plant, the “more exposed group from the rural area” (MEG-R), which consisted of 272 persons, and the “more exposed group from downtown area” (MEG-D), which consisted of 209 persons who lived within a 1 km radius of the cement plant. U-NAG levels >5.67 U/L were defined as “higher U-NAG” levels. We compared the prevalence of higher U-NAG levels and estimated the adjusted odds ratio (OR) by air pollution exposure using a chi-square test and multiple logistic regression analysis. Further, we estimated the interaction between air pollution exposure and heavy metal exposure in renal toxicity.

Results

The OR of higher U-NAG levels by MEG-D and MEG-R compared to LEG was 2.13 (95 % CI 0.86–4.96) and 4.79 (95 CI 1.65–10.01), respectively. Urinary cadmium (U-Cd), urinary mercury (U-Hg), age, occupation, hypertension, and diabetes had a significant association with higher U-NAG levels. However, blood lead (B-Pb), sex, and smoking were not associated with higher U-NAG. Especially, concurrent exposure to heavy metals (U-Hg or/and U-Cd) and air pollution had an additive adverse effect. In the group with both 4^th quartile heavy metal exposure (U-Cd or/and U-Hg) and air pollution exposure, the OR in MEG-R and MEG-D was 6.49 (95 % 1.42–29.65) and 8.12 (95 % CI 1.74–37.92), respectively, after adjustment for age, occupation, hypertension, diabetes.

Conclusions

U-NAG levels seem to be affected by air pollution exposure as well as age, hypertension, diabetes, and even low levels of cadmium and low levels of mercury. Moreover, concurrent exposure to heavy metals and air pollution can have additive cytotoxic renal effects.

Citations

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Review

Evaluation of mercury exposure level, clinical diagnosis and treatment for mercury intoxication: Byeong-Jin Ye, Byoung-Gwon Kim, Man-Joong Jeon, Se-Yeong Kim, Hawn-Cheol Kim, Tae-Won Jang, Hong-Jae Chae, Won-Jun Choi, Mi-Na Ha, Young-Seoub Hong; Ann Occup Environ Med 2016;28:5. Published online January 22, 2016; DOI: https://doi.org/10.1186/s40557-015-0086-8

Abstract PDF PubReader ePub

Mercury occurs in various chemical forms, and it is different to health effects according to chemical forms. In consideration of the point, the evaluation of the mercury exposure to human distinguished from occupational and environmental exposure.

With strict to manage occupational exposure in factory, it is declined mercury intoxication cases by metallic and inorganic mercury inhalation to occupational exposure. It is increasing to importance in environmental exposure and public health.

The focus on the health impact of exposure to mercury is more on chronic, low or moderate grade exposure—albeit a topic of great controversy—, not high concentration exposure by methylmercury, which caused Minamata disease.

Recently, the issue of mercury toxicity according to the mercury exposure level, health effects as well as the determination of what mercury levels affect health are in the spotlight and under active discussion. Evaluating the health effects and Biomarker of mercury exposure and establishing diagnosis and treatment standards are very difficult.

It can implement that evaluating mercury exposure level for diagnosis by a provocation test uses chelating agent and conducting to appropriate therapy according to the result. but, indications for the therapy of chelating agents with mercury exposure have not yet been fully established.

The therapy to symptomatic patients with mercury poisoning is chelating agents, combination therapy with chelating agents, plasma exchange, hemodialysis, plasmapheresis. But the further evaluations are necessary for the effects and side effects with each therapy.

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Case Report

Four Cases of Abnormal Neuropsychological Findings in Children with High Blood Methylmercury Concentrations: Young-Seoub Hong, Dae-Seon Kim, Seung-Do Yu, Seong-Hwan Kim, Jong-Kuk Kim, Yu-Mi Kim, Jae-Ho Yu, Ji-Hyun Jung, Byoung-Gwon Kim; Ann Occup Environ Med 2013;25:18-18. Published online September 24, 2013; DOI: https://doi.org/10.1186/2052-4374-25-18

Abstract PDF PubReader ePub

Background

Methylmercury (MeHg) easily crosses the blood–brain barrier and accumulates in the brain. Accumulated MeHg will cause neurological symptoms. We report four pediatric cases of neuropsychological findings with high blood MeHg concentrations.

Case presentation

Four children were admitted for follow-up study because their total mercury (THg) concentration in the blood was found to be high during a national survey. Case 1 was a 9-year-old female with a 16.6 μg/ℓ blood THg concentration in the survey. During admission, the blood THg, hair THg, and blood MeHg concentration(mercury indices) were 21.4 μg/ℓ, 7.2 μg/g, and 20.1 μg/ℓ, respectively. In our neuropsychological examination, cognitive impairment and attention deficit were observed. Her diet included fish intake 2–3 times per week, and she had been diagnosed with epilepsy at 3 years of age. Case 2 was a 12-year-old male with blood THg of 15.4 μg/ℓ in the survey and the mercury indices were 12.7 μg/ℓ, 5.7 μg/g, and 11.8 μg/ℓ, respectively, on admission. He was also observed to have attention-deficit/hyperactivity disorder. Case 3 was a 10-year-old male child with blood THg of 17.4 μg/ℓ in the survey, and the mercury indices on admission were 21.6 μg/ℓ, 7.5 μg/g and 21.5 μg/ℓ, respectively. In his case, mild attention deficit was observed. Case 4 was a 9-year-old male with blood THg of 20.6 μg/ℓ in the survey and the mercury indices were 18.9 μg/ℓ, 8.3 μg/g, and 14.4 μg/ℓ, respectively, on admission. Mild attention difficulty was observed.

Conclusion

We suggest that fish consumption may be the main source of MeHg exposure, and that MeHg may have been the cause of the neuropsychological deficits in these cases.

Citations

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Rheumatology International.2020; 40(8): 1333. CrossRef

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Original Articles

The Relationship Between Amalgam Tooth Fillings and Concentration of Blood Mercury in Elementary School Students in Korea: Kyu Hwa Lee, Man Joong Jeon, Yun Chul Hong, Jong Han Leem, Mi Na Ha, Ho Jang Kwon, Joon Sakong; Korean Journal of Occupational and Environmental Medicine 2011;23(4):420-427. Published online December 31, 2011; DOI: https://doi.org/10.35371/kjoem.2011.23.4.420

Abstract PDF: OBJECTIVES
The adverse health effects of mercury in dental amalgam have not yet been clarified. This study was conducted to examine the effects of dental amalgam on the concentration of blood mercury in Korean children.
METHODS
A total of 1,275 students were enrolled in the elementary school in Seoul, Incheon, and Daegu. The number and location of dental amalgam filling of teeth were ascertained by oral examination. Dietary habits-including frequency of seafood intake-and other demographic factors were obtained from the children's parents. The concentration of blood mercury was measured by an atomic absorption spectrophotometer to which a hydride generator was installed.
RESULTS
The geometric mean of blood mercury concentration was 1.91 microg/L. It was found that elementary school students in Seoul and the 4th grade elementary school students have the lowest concentration of blood mercury among the study groups. Both linear and secondary linear increase of the concentration of blood mercury, depending on the number of dental amalgam fillings, were statistically significant (p-trend < 0.01, p-quadratic < 0.01). As a result of multiple regression analysis on the blood mercury concentration of elementary school students, the regression coefficient (beta) of a dental amalgam filling was found to be 0.027 (standard error = 0.014, p = 0.048).
CONCLUSIONS
In children, the dental amalgam fillings were significantly contribute to the concentration of blood mercury. To accurately assess the effect of dental amalgam on the concentration of body mercury, further studies using the concentration of urine mercury are needed.

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Association of Blood Mercury Level and Neurobehavioral Performance in Korean Elementary School Students: Joon Sakong, Man Joong Jeon, Sung Ho Yun, Yun Chul Hong, Chul Gab Lee, Young Ki Kim, Mina Ha, Ho Jang Kwon; Korean Journal of Occupational and Environmental Medicine 2010;22(4):324-330. Published online December 31, 2010; DOI: https://doi.org/10.35371/kjoem.2010.22.4.324

Abstract PDF

OBJECTIVES
This study was conducted to examine the effect of blood mercury on neurobehavioral performance in Korean elementary school students.
METHODS
We measured the blood mercury concentration in 1,077 elementary school students from Seoul, Busan, Daegu and Gwangju, then the students underwent computerized neurobehavioral test.
RESULTS
The mean concentration of blood mercury of study subjects was 2.10 microg/L. An increased blood mercury was associated with an increased reaction time in digit addition and symbol digit.
CONCLUSIONS
The blood mercury concentration of study subjects was very high compared to findings in a foreign country. We found several associations between blood mercury level and neurobehavioral performance.

Citations

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Young Seok Byun, Sung Kyu Park, Joon Sakong, Man Joong Jeon
Annals of Occupational and Environmental Medicine.2018;[Epub] CrossRef
Evaluation of reliability of computerized neurobehavioral tests in Korean children
Kyeong-Soo Lee, Man-Joong Jeon, Tae-Yoon Hwang, Chang-Yoon Kim, Joon Sakong
NeuroToxicology.2012; 33(5): 1362. CrossRef

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The Effects of the Frequency of Fish Consumption on the Blood Mercury Levels in Koreans: Chan Woo Kim, Young Wook Kim, Chang Ho Chae, Jun Seok Son, Seung Hyun Park, Jae Chul Koh, Dae Seon Kim; Korean Journal of Occupational and Environmental Medicine 2010;22(2):114-121. Published online June 30, 2010; DOI: https://doi.org/10.35371/kjoem.2010.22.2.114

Abstract PDF

OBJECTIVE: We studied two districts in Korea in order to investigate if the frequency of fish consumption has an effect on the blood mercury levels.
METHODS
This survey was conducted on 164 fishing district residents in Geoje city and 219 agricultural district residents in Changwon city from July to August in 2008. The data on the demographic characteristics, the living environment, lifestyle habits and the frequency of fish consumption was collected by interviewers. We used ANOVA to estimate the particular relevance between the frequency of fish consumption and the blood mercury concentration, and other various factors.
RESULTS
The mean total blood mercury level was 6.54+/-4.01 microgram/L for the total study population. Our results were even higher than that of the National Health and Nutrition Examination Survey (USA) in, 2001~2002 and the German Environmental Survey in, 1998. In this study, there was a significant difference for the frequency of eating fish between the groups. (p<0.01, The level of the groups that ate fish 3 to 4 times per week was significantly higher as compared with the level of the other groups that ate fish 2 to 3 times per month and 1 to 2 times per week, respectively). As the frequency of fish consumption increased, so did the blood mercury concentration.
CONCLUSIONS
We found that the blood mercury concentration increases along with fish consumption and this was statistically significant and this fact reveals that fish consumption is positively related to the blood levels of mercury. Accordingly, we need systematic and periodic research on the general population to prevent mercury poisoning, which can be caused by low-level mercury exposure from dietary intake such as chronic fish consumption.

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Infantile allergic diseases: a cohort study prenatal fish intake and mercury exposure context
Surabhi Shah, Hae Soon Kim, Yun-Chul Hong, Hyesook Park, Mina Ha, Yangho Kim, Ji Hyen Lee, Eun-Hee Ha
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Association of Blood Mercury Level with the Risk of Depression According to Fish Intake Level in the General Korean Population: Findings from the Korean National Health and Nutrition Examination Survey (KNHANES) 2008–2013
Kyung Won Kim, Sundara Raj Sreeja, Minji Kwon, Ye Lee Yu, Mi Kyung Kim
Nutrients.2020; 12(1): 189. CrossRef
Level of Blood Lead and Urine Cotinine of Residents by Area
Yu-Jin Oh, Hyoung-Wook Kim, Yun-Jae Kim, Yoon-Deok Han, Sung-Hyeon Jung, Jong-Dae Lee, Bong-Ki Jang, Jin-Heon Lee, Bu-Soon Son
Journal of Environmental Science International.2019; 28(3): 329. CrossRef
A Review for the Long-Term Trend and Spatial Distribution of Soil Mercury Concentration in South Korea
Pyung-Rae Kim, Dae-Young Kim, Young-Ji Han
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An analysis of factors affecting the mercury content in the human femoral bone
A. Zioła-Frankowska, M. Dąbrowski, Ł. Kubaszewski, P. Rogala, A. Kowalski, M. Frankowski
Environmental Science and Pollution Research.2017; 24(1): 547. CrossRef
The associations between blood mercury levels and shark meat intake among workers in Gyeongsangbuk-do
Gun Il Park, Young Seok Byun, Man Joong Jeon, Joon Sakong
Annals of Occupational and Environmental Medicine.2017;[Epub] CrossRef
A Study on Mercury Exposure Levels among Schoolchildren and Related Factors in High Mercury Exposure Areas in Korea
Dae Seon Kim, Young Min Kwon, Hee-Ung Chung, Sang Hoon Nam, Seung Do Yu
Korean Journal of Environmental Health Sciences.2015; 41(4): 231. CrossRef
Mercury Exposure Factors among Residents in the Highly Mercury Exposed Area, Seoksan-ri, Korea
Dae Seon KIM, Young Min Kwon, Hee-Ung Chung, Kyunghee CHOI
Korean Journal of Environmental Health Sciences.2015; 41(5): 349. CrossRef
Population correlates of circulating mercury levels in Korean adults: the Korea National Health and Nutrition Examination Survey IV
Seongbeom Cho, David R Jacobs, Kyong Park
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Ji-Young Im, Eun-Kyung Chung, Hee-Jin Park, Seungdo Yu, Bong-Ki Jang, Bu-Soon Son
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Dae-won Kang, Ka-young Lee
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Young A Kim, Young-Nam Kim, Kyung-Dong Cho, Mi Young Kim, Eun Jin Kim, Ok-Hee Baek, Bog-Hieu Lee
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Dae Seon Kim, Geun Bae Kim, Tackshin Kang, Seungchul Ahn
Toxicology and Environmental Health Sciences.2011; 3(4): 254. CrossRef

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The Health Effects of Mercury on the Cardiac Autonomic Activity According to the Heart Rate Variability: Sinye Lim, Min Cheol Choi, Kee Ock Joh, Domyung Paek; Korean Journal of Occupational and Environmental Medicine 2008;20(4):302-313. Published online December 31, 2008; DOI: https://doi.org/10.35371/kjoem.2008.20.4.302

Abstract PDF

OBJECTIVES
The effect of mercury on the cardiovascular system has recently been reported on, but the mechanisms as well as its nature of this effect still need to be confirmed. In this study, the mercury in the hair of a community population was analyzed in relation to the cardiac autonomic activity.
METHODS
A hair sample was obtained from the occiput area and the mercury in the hair was analyzed by using a Direct Mercury Analyzer. We measured the cardiovascular risk factors, including total cholesterol, triglyceride, blood pressure, and the body mass index (BMI). Heart rate variability was assessed for 5 minutes, in the time and frequency domain, by using SA-3000P from the Medi-core(R). company. The association between the mercury in the hair and heart rate variability was assessed after controlling for the other cardiovascular risk factors.
RESULTS
The mean age of the 671 total subjects was 36 years. The geometric mean of the hair mercury was 0.90 ppm. The hair mercury level was elevated in males, adults, smokers and drinkers. Hair mercury and age, the systolic and diastolic blood pressure, total cholesterol, triglyceride, LDL cholesterol and BMI were all positively correlated. However, hair mercury and heart rate, HDL cholesterol, standard deviation of the NN intervals (SDNN), total power (TP), low-frequency (LF), high- frequency (HF) were negatively correlated. In the higher mercury group, heart rate, SDNN, LF and HF indices were significantly lower compared with those of the lower mercury group. Heart rate was decreased 2.6 beats/min, Ln (HF) was decreased 0.131 msec2 and HF norm was decreased 2.550 with a 1 ppm increase of Ln (Hg), according to multiple linear regression analysis after controlling for age, gender and other cardiovascular risk factors.
CONCLUSION
This cross-sectional study showed that mercury may affect the cardiac autonomic activity through parasympathetic dysfunction.

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The association between mercury concentrations and lipid profiles in the Korean National Environmental Health Survey (KoNEHS) cycle 3
Soo Ho Sohn, Han Cheol Heo, Seongmin Jo, Chulyong Park, Joon Sakong
Annals of Occupational and Environmental Medicine.2020;[Epub] CrossRef
Mercury and metabolic syndrome: a review of experimental and clinical observations
Alexey A. Tinkov, Olga P. Ajsuvakova, Margarita G. Skalnaya, Elizaveta V. Popova, Anton I. Sinitskii, Olga N. Nemereshina, Evgenia R. Gatiatulina, Alexandr A. Nikonorov, Anatoly V. Skalny
BioMetals.2015; 28(2): 231. CrossRef

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Mercury Concentrations of Maternal and Umbilical Cord Blood in Korean Pregnant Women: Preliminary Study: Kyung Eun Lee, Young Seoub Hong, Dae Seon Kim, Myoung Seok Han, Byeng Chul Yu, Young Wook Kim, Mee Sook Roh, Hyun Jae Lee, Jae Won Lee, Jong Young Kwak, Joon Youn Kim; Korean Journal of Occupational and Environmental Medicine 2007;19(4):268-275. Published online December 31, 2007; DOI: https://doi.org/10.35371/kjoem.2007.19.4.268

Abstract PDF

OBJECTIVES
To evaluate the level of maternal and prenatal mercury exposure and to analyze the related factors.
METHODS
Fifty-nine pregnant women were recruited into this study after obtaining informed consent. Samples were collected at delivery from normal pregnant women who were living in the city of Busan, Korea. Mercury concentrations in maternal and umbilical cord blood samples were measured using a gold-amalgam collection method. The total and methyl mercury levels of 36 of the 59 pregnant women were analyzed after randomization, and the results were compared.
RESULTS
The mean total mercury concentration was 3.16+/-1.21 ppb and 5.43+/-2.22 ppb in maternal and cord blood, respectively. The average, maternal blood mercury level was lower than the prescribed toxic limit for human (WHO, 5 ppb), whereas the cord blood mercury was higher. The mercury exposure level exceeded the WHO recommendation in 5 (8.47%) cases of maternal blood and 29 of (49.15%) cord blood. There was a significant correlation between maternal and cord blood mercury concentrations. Total mercury and methyl mercury concentrations of the 36 random pregnant women were 3.06+/-1.17 ppb, and 2.60+/-1.11 ppb in maternal blood, and 5.20+/-2.36 ppb, and 4.70+/-1.97 ppb in cord blood, respectively. Methyl mercury accounted for 85.0% of the total mercury in maternal blood and 90.4% in cord blood. There was a significant correlation between total and methyl mercury concentrations.
CONCLUSIONS
The study results suggest that mercury concentrations of cord blood may be regarded as indicative of high prenatal mercury exposure. Therefore, further studies are necessary to explain the cause of high mercury concentrations in cord blood, and to examine its relationship with various health indices.

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Risk assessment of heavy metals in tuna from Japanese restaurants in the Republic of Korea
Seong-Jin Bae, Kyu-Sik Shin, Chulyong Park, Kiook Baek, So-Young Son, Joon Sakong
Annals of Occupational and Environmental Medicine.2023;[Epub] CrossRef
The Relationship between Mercury Exposure Indices and Dietary Intake of Fish and Shellfish in Women of Childbearing Age
Jeong-wook Seo, Byoung-gwon Kim, Young-seoub Hong
International Journal of Environmental Research and Public Health.2020; 17(13): 4907. CrossRef
Biomonitoring of Lead, Cadmium, Total Mercury, and Methylmercury Levels in Maternal Blood and in Umbilical Cord Blood at Birth in South Korea
Yu-Mi Kim, Jin-Young Chung, Hyun An, Sung Park, Byoung-Gwon Kim, Jong Bae, Myoungseok Han, Yeon Cho, Young-Seoub Hong
International Journal of Environmental Research and Public Health.2015; 12(10): 13482. CrossRef
Correlation Between Total Mercury and Methyl Mercury-In Whole Blood of South Korean
Seon A Jung, Dayoung Chung, Jiwon On, Myeong Hee Moon, Jeongae Lee, Heesoo Pyo
Bulletin of the Korean Chemical Society.2013; 34(4): 1101. CrossRef
The Influence of Fish Consumption on Umbilical Cord Blood Mercury Level in Pregnant Women in the City of Tongyeong, Korea
Chul-Won Jang, Sang-Hyun Kim, Jong-Duck Choi
Journal of Food Hygiene and Safety.2012; 27(1): 74. CrossRef

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Case Report

Subcutaneous and Gastrointestinal Exposure to Metallic Mercury: Report of 2 Cases: Sung Kwan Lee, Hyoung Jai Lee, Hong Jae Chae, Jai Dong Moon; Korean Journal of Occupational and Environmental Medicine 2003;15(4):446-451. Published online December 31, 2003; DOI: https://doi.org/10.35371/kjoem.2003.15.4.446

Abstract PDF: BACKGROUND
Mercury poisoning presents a variety of clinical pictures depending on the chemical structure, the route of exposure, the amount absorbed and other individual factors. Therefore, the ingestive and subcutaneous absorption of elemental(metallic) mercury can be considered to be relatively harmless in contrast to the inhalation of mercury vapor.
CASE REPORTS
A 72-year-old man presented to the department of urology due to tenderness, edema and a necrotic abscess of his penis after trauma. The soft tissue abscess required a surgical resection of the penis. For chelation therapy, oral D-penicillamine was administrated. 7 months later, he showed no subjective or objective signs of mercury poisoning. Another 5-yearold girl presented to the emergency department after accidental self-ingestion of elemental mercury. She was followed clinically and did not show any systemic mercury poisoning.
CONCLUSION
The Mercury concentrations in the blood and urine were elevated in the case of subcutaneous exposure, but was unchanged in the case of ingestion. Subcutaneous and gastrointestinal exposure to metallic mercury has a minimal risk for systemic mercury poisoning, which is in contrast to the exposure by inhalation.

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Original Articles

Effect of Glutathione on Apoptosis Induced by Methyl Mercury Chloride: Jung Ho Youm, Dai Ha Koh, Keun Sang Kwon, Me Yae Lee; Korean Journal of Occupational and Environmental Medicine 2002;14(4):377-391. Published online December 31, 2002; DOI: https://doi.org/10.35371/kjoem.2002.14.4.377

Abstract PDF: OBJECTIVES
This study was performed to evaluate the critical role of glutathione(GSH) in methyl mercury chloride(MeHgCl)induced cell apoptosis.
METHODS
The effect of GSH in MeHgCl induced cell apoptosis was observed in mouse macrophage-derived RAW 264.7 cells in vitro. The cells were cultured in Dulbecco's modified Eagle's medium(DMEM).
RESULTS
MeHgCl exerted a dose dependent cytotoxicity,as demonstrated by the MTT assay, which is an assay dependent partially on the mitochondrial function. Moreover, in the presence of NAC, a GSH precursor, the MeHgCl induced cytotoxicity was significantly decreased whereas BSO, a specific GSH synthesis inhibitor,increased the MeHgCl induced cytotoxicity.The MeHgCl induced DNA fragmentation and chromatin condensation was consistent with the morphological alterations. The MeHgCl treated cells exhibited increasing annexin V-FITC binding to the phos-phatidylserine(PS)translocated from the inner to the outer leaflet of the plasma membrane and those cells with NAC pretreatment significantly exhibited decreasing annexin V-FITC binding compared to the cells treated with MeHgCl only. However BSO pretreatment markedly exhibited the increasing annexin V-FITC binding. The MeHgCl treated cells generated ROS, which was evidenced by the oxidation of dihydroethidine and the generation of the fluorescent product, ethidium. In addition, BSO pretreatment further enhanced the extent of ROS generation caused by MeHgCl whereas NAC pretreatment decreased the amount of ROS generation. MeHgCl led to a dose dependent decrease in the GSH content. Although MeHgCl exposure significantly reduced the GSH level, those cells that had a NAC pretreatment contained a higher level of GSH compared to the cells treated with MeHgCl only. In contrast, BSO pretreatment futher enhanced the extent of GSH depletion caused by MeHgCl.
CONCLUSIONS
These results indicate that MeHgCl reduced the GSH content and impaired the defense against oxidative damage caused by ROS formation in RAW 264.7 cells. It is possible that these factors leads to the activation of the apoptosis signaling pathway. Ultimately these results suggest that GSH plays a crucial role in protecting the activity against MeHgCl induced apoptosis.

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Concentration of Lead, Cadmium, and Mercury in Scalp Hair, Cerebellum, Cerebrum, Heart, Kidney, Liver, Lung and Spleen from Autopsy Subjects : Relationship between Scalp Hair and Internal Organs: Jong Hak Chung, Chang Yoon Kim, Joon Sakong, Joong Jung Lee, Man Joong Jeon, Seong Kuk Lee, Jeung Sik Kwak, Sung Hwa Park; Korean Journal of Occupational and Environmental Medicine 1998;10(4):571-586. Published online December 31, 1998; DOI: https://doi.org/10.35371/kjoem.1998.10.4.571

Abstract PDF

This study was conducted to measure the lead, cadmium and mercury levels in the scalp hair, cerebellum, cerebrum, heart, kidney, liver, lung, and spleen of the 60 Korean autopsy subjects and assess the relationship among those samples. The mean lead level in the scalp hair was 12.29+/-12.51 microgram/g and no significant difference was detected in lead concentrations between the two sexes. Among the internal organ tissues the cerebrum contained the highest level of lead. This is followed by the cerebellum, spleen and liver respectively. After which the kidney and lung showed a close similarity at relatively low concentrations and the heart contained the lowest concentration. There was also no significant variation found between sexes in a comparison of lead in the internal organ tissues. The concentrations of cadmium in kidney were 127.33+/-89.36 microgram/g and considerably higher than those in the other internal organs. The liver contained the next highest level of cadmium. In both sexes, the consistent difference was noted in the cadmium concentrations of the kidney, heart and spleen. Yet female cadmium level was higher than the male's. The concentrations of mercury in the kidney and liver were 1.26+/-2.89 microgram/g, 0.59+/-0.54 microgram/g and considerably higher than those in the other internal organs. The mean mercury level in the scalp hair was 1.29+/-0.64 microgram/g and no marked difference was noted in both sexes. The lead concentration in the spleen increased with advancing age, though not statistically significance, and most of the internal organ tissues that were examined showed no evidence of increased lead concentration with age. The kidney, cerebrum, spleen and cerebellum showed increased cadmium concentrations with age. Also as well as the internal organ tissues that were examined showed no evidence of increased mercury concentration with age. The lead concentrations in the liver and lung were higher in the urban area than in the rural area, but the lead concentration in the kidney was higher in the rural area. No difference was noted in tissue cadmium and mercury concentrations as to the area of residence either. The physical workers had greater concentrations of lead in cerebellum than did housewives or the unemployed. Yet no difference was noted in the other tissues between the two groups. In the cerebellum, cerebrum, heart, and spleen, the physical workers had greater concentrations of cadmium than students or mental workers. Also physical workers had greater concentrations of cadmium in lung than housewives or the unemployed. In contrast to lead and cadmium, both the housewives and the unemployed had higher concentrations of mercury in cerebellum and cerebrum than physical workers, but there was no difference was noted in the other tissues between the two groups. In the lead concentration, there was no statistically significant correlation between the scalp hair and examined internal organ tissues. There was a close relationship between lead levels in cerebellum and cerebrum (r=0.465, p<0.01), as well as a relationship between the cerebellum and the kidney(r=0.300, p<0.05). There was no statistically significant correlation between the cadmium levels in the scalp hair and in the examined internal organ tissues. Positive correlations were found between the cadmium concentrations in the cerebellum and the cerebrum(r=0.5543, p<0.01), heart(r=0.480, p<0.01), kidney(r=0.376, p<0.01) and spleen(r=0.408, p<0.01). Also positive correlation was found between in the cerebrum and the heart(r=0.377, p<0.01), kidney(r=0.484, p<0.01), liver(r=0.265, p<0.05), lung(r=0.458, p<0.01) and spleen (r=0.483, p<0.01). There was also no statistically significant correlation between the mercury levels in the scalp hair and in the examined internal organ tissues. Positive correlation was found between the mercury concentrations in the cerebellum and cerebrum(r=0.760, p<0.01), heart(r=0.270, p<0.05), liver(r=0.425, p<0.01), lung (r=0.488, p<0.01) and spleen (r=0.534, p<0.01), and also positive correlation was found between in the cerebrum and heart(r=0.376, p<0.01), liver(r=0.350, p<0.01), lung(r=0.554, p<0.01) and spleen (r=0.489, p<0.01). Various epidemiological studies reported usefulness and reliability of using scalp hair as a monitor of a environmental pollutants. In this study, there was statistically significant correlation of lead, cadmium and mercury levels in most of the tissues that were examined, but there was no statistically significant correlation between the lead, cadmium and mercury levels in the scalp hair and most of examined internal organ tissues. The findings of this study would suggest that it is still uncertain to using scalp hair as a biological monitoring.

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Human Exposure to Metals: Levels in Autopsy Tissues of Individuals Living Near a Hazardous Waste Incinerator
Montse Mari, Martí Nadal, Marta Schuhmacher, Eneko Barbería, Francisco García, José L. Domingo
Biological Trace Element Research.2014; 159(1-3): 15. CrossRef
Effect of metallothionein core promoter region polymorphism on cadmium, zinc and copper levels in autopsy kidney tissues from a Turkish population
Zeliha Kayaaltı, Görkem Mergen, Tülin Söylemezoğlu
Toxicology and Applied Pharmacology.2010; 245(2): 252. CrossRef

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Effects of the Chelating Agent on the Nephrotoxicity and Histopathological Change in Rat after Administration of Inorganic Mercury: Bong Suk Cha, Sang Baek Koh, Soon Won Hong; Korean Journal of Occupational and Environmental Medicine 1997;9(2):292-300. Published online June 30, 1997; DOI: https://doi.org/10.35371/kjoem.1997.9.2.292

Abstract PDF: This study was to determine the effects of Sodium-N-[4-methoxybenzyl]-D-glucamine-N-dithiocarbamate(MeOBGDTC) on the nephrotoxicity of mercury and histopathological change in rats pretreated with mercuric chloride 48h earlier. In a firsts experiment, 3 groups were given a single injection i.p. of 3.5 micromol/kg of HgCl2 mixed with 1microCi of 203Hg2+ in a final volume of 0.5ml of physiologic saline. Subsequently the rats also received the chelator, 1 mmol/kg of MeOBGDTC, at 1h in group 2 (HgCl2-MeOBGDTC 1h) and 12h in group 3 (HgCl2-MeOBGDTC 12h) after injection of mercuric chloride. The results showed that the injection of chelating agent at 1h after mercury injection significantly decreased mercury level in plasma. But not significant in renal cortex. In a second experiment, rats were divided into 4 groups, one group was control group, others were mercury injected group. MeOBGDTC was also administered to mercury-injected rats as described above. The changes in renal function were determined by measurement of proteinuria, plasma creatinine and urinary osmolality. The results showed that the injection of mercuric chloride increased the excretion of urinary protein and plasma creatinine, and decreased the urinary osmolarity. However, the injection of chelating agent at 1h after mercury injection significantly decreases the toxic effects of mercury. Finally, histopathological change at the light microscopic level was comparable effect of chelating agent on nephrotoxicity of mercury. Minimal morphological alterations were seen in kidney of rats of HgCl2-MeOBGDTC 1h. The HgCl2-MeOBGDTC 12h caused necrotic change of the proximal tubule at cortical-medullary junction. These changes were more common and more severe at the HgCl2 alone.

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A Study on Factors Related to NO Synthesis by Mercurial Compounds in the EMT-6 cell: Jung Ho Youm; Korean Journal of Occupational and Environmental Medicine 1997;9(1):122-130. Published online February 28, 1997; DOI: https://doi.org/10.35371/kjoem.1997.9.1.122

Abstract PDF: The effects of several factors on the nitrite synthesis were observed in the culture of EMT-6 cells which are originated from mammary adenocarcinoma of Balb/c mouse. The cells were cultured in Dulbecco's Modified Eagle's Medium containing 10% fetal calf serum. Amounts of nitrite in the culture media after 24 and 36 hours of culture were about 2 fold, and 3-fold of those measured after 12 hours respectively. There were very close associations between the amounts of nitrite measured in the culture media. A significant nitrite synthesis by EMT-6 cells occurred when IL-1 was added to the culture medium with other cytokines as IFN gamma or TNF alpha . One of each cytokines were less effective as an inducer of nitrite than the combinations of cytokines. When mercury chloride or cinnamate was added in the culture medium, the nitrite synthesis was dose-dependently decreased by the concentration of these materials. The viability of EMT-6 cells were kept on 95% or above in 36 hours after beginning of culture without any specific additives except cytokines. While after 48 hours it went down to 85% or less. These viability were decreased by the prolongation of culture time (48 hours or more), the addition of TNF alpha to cytokine mixture, and the higher concentrations of mercury chloride or cinnamate to culture medium. Simultaneous addition of the equimolar dose of selenium completely prevented mercurial compounds-induced inhibitions of nitrite syntheses. But the single addition of selenium neither influenced the viability of cells nor the productions of nitrite. These results suggests that the disorder of cell mediated immunity by mercurial compounds could be related to the inhibition of nitric oxide synthesis and selenium decreased the cytotoxicity of mercurial compounds.

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A Study of Cytotoxical Mechanism of Mercurial Compounds in RAW264.7 Cell Line: Kong Ho Kirn, Byoung Yul Soh, Dai Ha Koh; Korean Journal of Occupational and Environmental Medicine 1996;8(3):560-569. Published online December 31, 1996; DOI: https://doi.org/10.35371/kjoem.1996.8.3.560

Abstract PDF: The effects of glucose on the productions of ATP and nitrite which are inhibited by mercury compounds, were examined in a cell culture system of RAW 264.7 cells. The cells were cultured in Dulbecco's Modified Eagle's medium (DMEM) with cytokines, IL-1 and TNF for 24 hours. The viablility of RAW 264.7 cells at the end of culture was significantly decreased by mercury chloride or methylmercury chloride added into the media in dose-dependent manner, however the viability of RAW 264.7 cells were influenced in the concentrations lese than 0.8micrometer of mercury chloride or 0.4micrometer of methylmercury chloride. The addition of 4.5 g/l glucose to normal DMEM lowered the pH of media to the range of 6.7-6.8 after 48 hours of culture, but not for the cell survivals. This supplement of glucose to the media also prevented the inhibitions of ATP and nitrite syntheses which were caused by mercurial compounds. These results suggest that the disorder of cell mediated immunity by mercurials could be related to the inhibition of nitric oxide synthesis which seams to be caused by the inhibition of ATP synthesis, especially related to the citric acid cycle.

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Effect of Mercury Chloride on Peritoneal Macrophage or EMT-6 cell from Balb/c mice: Dai Ha Koh, Jung Ho Youm, No Suk Ki, Gyung Jae Oh, Kuen Sang Kwon, Sung Yeup Kim, Nam Song Kim; Korean Journal of Occupational and Environmental Medicine 1996;8(2):201-209. Published online September 30, 1996; DOI: https://doi.org/10.35371/kjoem.1996.8.2.201

Abstract PDF: The effect of treatment of mercury chloride on the nitrite and nitrate synthesis was observed in peritoneal macrophages from Balb/c mice and EMT-6 cells in vitro. The cells were cultured in Dulbecco's modified Eagle's medium (DMEM) with cytokines. Amounts of nitrite and nitrate in the culture media after 24 and 36 hours of culture were about 2-fold, and 3-fold of those measured after 12 hours respectively. There were very close associations between the amounts of nitrite and nitrate measured in the culture media, according to culture time. The survival rate of peritoneal macrophages was significantly decreased by mercury chloride added into the media in dose-dependent manner, however the survivals of EMT-6 cells were not influenced by mercury chloride concentration in media. Nitrite and nitrate syntheses were dose-dependently decreased by mercury chloride added in culture media. These results reported here suggest that the disorder of cell mediated immunity by mercurials could be related to the inhibition of nitric oxide synthesis which seems to be caused by the inhibition of metabolism of cells.

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Evaluation of Mercury Concentration in Spot Urine for Biological Monitoring Among Metallic Mercury Exposed Workers: Durumee Hong, Soon Duck Kim, Yong Tae Yum, Jae Wook Choi; Korean Journal of Occupational and Environmental Medicine 1996;8(1):127-136. Published online February 29, 1996; DOI: https://doi.org/10.35371/kjoem.1996.8.1.127

Abstract PDF: Biological monitoring for exposures permits estimation of organ doses or body burdens from exposures through all relevant portals of entry. Biological monitoring data may be used to estimate environmental concentrations when the latter cannot be measured directly. Biological indices are usually surrogates for the concentration of a chemical or its metabolites or its effect at the true receptors. Mercury concentration in urine has-been most-coinmoialy-recommended as a biological exposure index of mercury. For data based on urine analysis, variation in urine volume is the most significant. The urinary concentration related to excretion of the solute provides some correction for fluctuation of urine output. Sampling time must be carefully observed because distribution and elimination of a chemical are kinetic events. This study has evaluated mercury concentration in spot urine compared to the results of 24 hour collected urine by the adjustment methods (specif ic gravity, creatinine) and sampling time. The subjects were 43 workers who had been exposed to the metallic mercury. The results were as follows: 1. The correlation coefficients between mercury concentration in 24 hour urine and that in spot urine were 0.639-0.715 and were not different by adjustment methods. 2. In the high exposure group who were over lOOug/1 of urinary mercury, the correlation coefficients between mercury concentration in 24 hour urine and that in spot urine were 0. 687-0.824 and were not different by adjustment methods. 3. Mercury concentration in spot urine were very variable by sampling time or exposure time. The correlation coefficients between mercury concentration in 24 hour urine and that in spot urine were most highest as 0.85-0.91 at first voiding urine in the morning, and were 0. 77-0.86 at urine collected within four hours before end of shift. In the biological monitoring to exposure of mercury, sampling of spot urine were most proper at first voiding urine in the morning, and then at urine collected within four hours before end of shift. But the adjustment methods of specific gravity and creatinine were no difference of the results.

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Mercury Concentration in air and in Urine of Workers in Fluorescent Lamp Manufacturing Factories in Korea: Kwang Jong Kim, Chul Whan Cha; Korean Journal of Occupational and Environmental Medicine 1990;2(2):179-185. Published online August 31, 1990; DOI: https://doi.org/10.35371/kjoem.1990.2.2.179

Abstract PDF: This research was conducted to investigate the correlations between urinary mercury concentration and each independent variable related with urinary mercury levels. the urinary mercury concentrations of 543 workers exposed to metal mercury vapor in a total of 11 fluorescent lamp manufacturing factories and at the same time mercury concentrations in air were measured from June 1989 to December 1989. And annually mercury consumption per workers, mercury consumption per lamp, numbers of breakage lamps, frequency of mercury infusion, numbers of droppers, and numbers of vacuum exhaustion pumps were also investigated. The results were as follows: 1. The geometric mean of airborne mercury concentration in a total of 11 factories was 47.9 microgram/m3 (5.8~352.2 microgram/m3), six factories(54.5%) of them were exceed the threshold limit value(50.0 microgram/m3). 2. The geometric mean of urinary mercury concentration among 543 workers was 84.3 microgram/l (1.13~533.9 microgram/l), the distribution of workers by urinary mercury concentration showed that 26 workers(4.8%) were above the mercury posioning level(300 microgram/l). 3. The correlation coefficient between urinary mercury concentration and monthly numbers of breakage lamps was the highest(0.74) and next was mercury consumption per lamp (0.67), annually mercury consumption per worker(0.63) in order.

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An Investigation of Mercury Contamination Soures in Fluorescent Lamp Manufacturing Industries in Korea: Chang Joo Lee, Kwang Jong Kim, Chul whan Cha; Korean Journal of Occupational and Environmental Medicine 1990;2(1):58-63. Published online February 28, 1990; DOI: https://doi.org/10.35371/kjoem.1990.2.1.58

Abstract PDF: This research was conducted to study the correlations between the airborne mercury concentration and each independent variable to detect the source of mercury contamination in a total or II fluorescent lamp manufacturing factories- The mercury concentraion in air was measured and informations about production management (operation hour, overtime, vacuum exhaustion system, number of droppers, number of vacuum exhaustion pumps, frequency of mercury infusion, mercury consumption per lamp, number of lamps producted, number of inferior lamps producted, number of breakage lamps, local exhaust ventilation system) were collected from January 1988 to March 1989. The results were as follows: 1. Among the airborne mercury concentrations according to the sampling point the highest mean concentration was 0.162mg/m3(0.016-0.635 mg/m3) at the workplace floor, and 0.074 mg/m3 at the vaccum exhaustion pump site, and 0.06 mg/m3 at the breathing zone in order. 2. The correlation between airborne mercury concentration and each Independent variable was significant in a following order; the number of Inferior lamps productedt(0.485), vacuum exhaustion syatem(-0,405), number of breakage lamps (0.344), operation hourl(0.341), number of vacuum exhaustion pumps(0.337) and local exhaust ventilation systern(0.331). 3. The result of stepwise multiple regression analysis showed that the airborne mercury consumption was affected by number of inferior lamps producted, frequency of mercury infusion, overtime, ventilator, mercury consumption amounts per lamp, local exhaust ventilation system in order. And these six variables explained 36.7% of the variance of airborne mercury concentration.

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Mercury Concentration in Air and in Urine of Workers in A Fluorescent Lamp Manufacturing Factory: Seung Hoi Park, Kwang Jong Kim, Soung Hoon Chang, Chul Whan Cha; Korean Journal of Occupational and Environmental Medicine 1989;1(2):197-205. Published online November 30, 1989; DOI: https://doi.org/10.35371/kjoem.1989.1.2.197

Abstract PDF: In order In interpret the relationship among many variables, urinary mercury and at the same time mercury concentration in air were measured for 254 workers of a fluorescent lamp manufacturing factory. And monthly mercury consumption amounts, numbers of monthly producing fluorescent lamps, numbers of inferior lamps and numbers of breakage lamps, numbers of vacuum exhaustion pumps and frequencies of mercury infusion were also investigated from January 1988 to March in 1989. The results were as follows; 1. On the mercury concentration in air by producing line and by working site, all of them were exceed the threshold limit value (0.05mg/m(2)). 2. The highest mercury concentration in air by sampling point was found at the floor of workplace (0.334mg/m(2)) and next were at vacuum exhaustion pimp (0.183mg/m(2)), and breathing zone of workers (0.103mg/m(2)) in order. 3. The highest mean of the mercury concentration in urine by producing line was the automatic exhausting line (80.8microgram/1) and next were high speed exhausting line (72.4microgram/1), and Manual exhausting line (35.8microgram/1) in order. Distribution of workers of the mercury concentration in urine more than 200microgram/1 by working site was the highest (10%) in the vacuum exhaustion pump part and next were sealing part (6.6%), packing part (4.6%), and stem part (4.1%) in order. 4. The correlation coefficient between mercury concentration in urine and in air was the highest (0.302) and next were numbers of breakage lamps (0.223), frequencies of mercury infusion (0.223), numbers of inferior lamps (0.205) in order.

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