Annals of Occupational and Environmental Medicine

Research Article

Association between shift work and hyperhomocysteinemia in male workers: Dukyun Kang, Seong-Kyu Kang, Won-Jun Choi, Sang Ha Lee, Jun-Hyung Lee, Kyeongmin Kwak; Ann Occup Environ Med 2019;31:e1. Published online May 1, 2019; DOI: https://doi.org/10.35371/aoem.2019.31.e1

Background

Shift work is associated with a higher risk of cardiovascular diseases. Here, we sought to assess the relationship between shift work and plasma homocysteine levels. Determining the correlations between shift work and homocysteine levels may provide a better understanding of the mechanisms underlying cardiovascular diseases.

Methods

This study was performed using data from routine health examinations of steel workers in 2017. In total, 431 male workers (70 daytime workers and 361 shift workers) employed on a rolling departure schedule were recruited. Plasma homocysteine levels > 15 μmol/L were considered elevated. The χ², analysis of variance, and multiple logistic regression analyses were used to examine the association between shift work and plasma homocysteine levels.

Results

In comparison to daytime workers, the odds ratio (OR) of hyperhomocysteinemia in individuals with < 10 years of shift work was 1.14 (95% confidence interval [CI]: 0.64–2.03), compared to 2.01 (95% CI: 1.14–3.54) for workers with ≥ 10 years of experience. After adjusting for confounding variables, the adjusted OR for shift workers with < 10 years of experience was 0.95 (95% CI: 0.50–1.80), compared to 2.00 (95% CI: 1.07–3.74) for workers with ≥ 10 years of experience.

Conclusions

The risk of hyperhomocysteinemia was significantly higher in shift workers compared to those working normal daytime hours, particularly among long-term shift workers.

Citations

Citations to this article as recorded by

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Kuo-Wei Lee, Chen-Cheng Yang, Chun-Hung Chen, Chih-Hsing Hung, Hung-Yi Chuang
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Jae Won Lim, Chan Woo Kim, Hyoung Ouk Park, Eui Yup Chung, Changho Chae, JunSeok Son, Young Hoo Shin, Seung Hyun Park, Sang Moon Choi
Annals of Occupational and Environmental Medicine.2023;[Epub] CrossRef
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BMJ Open.2020; 10(12): e041576. CrossRef

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Research Article

Association between serum ferritin and hypertension according to the working type in Korean men: the fifth Korean National Health and nutrition examination survey 2010–2012: Dong-Hoon Lee, Seong-Kyu Kang, Won-Jun Choi, Kyeong Min Kwak, Dukyun Kang, Sang Ha Lee, Jun-Hyung Lee; Ann Occup Environ Med 2018;30:40. Published online June 11, 2018; DOI: https://doi.org/10.1186/s40557-018-0251-y

Abstract PDF PubReader ePub

Background

Several studies suggest that serum ferritin concentrations reflect systemic inflammation, and high ferritin levels can increase the risk of hypertension in adult men. Shift work is also known to increase the risk of hypertension; however, there has been no study about the relationship between serum ferritin levels and the prevalence of hypertension according to the working type.

Methods

This cross-sectional study included 4,442 male participants (3,651 daytime workers and 791 shift workers) who participated in the fifth Korean National Health and Nutrition Examination Survey. Hypertension was defined as a systolic blood pressure greater than or equal to 140 mmHg, a diastolic blood pressure greater than or equal to 90 mmHg or the current use of antihypertensive medications regardless of blood pressure values. For the statistical analyses, serum ferritin levels were reclassified into quartiles, and complex sample analyses were used to evaluate the relationship between serum ferritin levels and the prevalence of hypertension according to the working type in this study.

Results

Serum ferritin and shift work were positively associated with the prevalence of hypertension. The effect of interaction was above multiplicative. When compared to participants in the lowest serum ferritin quartile, the odds ratio for hypertension for participants in the highest serum ferritin quartile was 1.372 (1.027–1.833) in daytime workers and 2.009 (1.042–3.873) in shift workers after adjustment.

Conclusions

The prevalence of hypertension increased as ferritin levels increased in individuals, especially in shift workers.

Citations

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