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Case Report
- Two Cases of Methemoglobinemia Induced by the Exposure to Nitrobenzene and Aniline
- Chang Hwan Lee, Soo Hyeon Kim, Do Hyung Kwon, Keun Ho Jang, Yong Hoon Chung, Jai Dong Moon
- Ann Occup Environ Med 2013;25:31-31. Published online November 1, 2013
- DOI: https://doi.org/10.1186/2052-4374-25-31
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Abstract
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ePub Objective To report two cases of methemoglobinemia induced by inhaled nitrobenzene and dermally absorbed aniline.
Methods We have evaluated a 37-year-old male worker exposed to nitrobenzene by inhalation while conducting maintenance job of mononitrobenzene pump and a 25-year-old male worker exposed dermally to aniline while unloading.
Results The first case is a 37-year-old male exposed to nitrobenzene. His blood methemoglobin concentration level was initially 19.8%, and chest X-ray was normal. After oxygen therapy, the blood methemoglobin concentration level decreased to 2.1%, and the symptoms were alleviated. The second case is a 25-year-old male exposed dermally to aniline. His chest X-ray was normal, but blood methemoglobin concentration level reached maximally 46.8%. He was treated with methylene blue due to relatively high blood methemoglobin level. Gradually after the treatment, his methemoglobin concentration level was normalized to 0.8% and simultaneously symptoms were resolved.
Conclusions After the thorough exposure investigations and medical evaluations, we have concluded that these cases were methemoglobinemia induced by occupational exposure to nitrobenzene and aniline. We suggest that businesses which handle methemoglobinemia-causing substances control the engineering process strictly, implement periodic screening, and establish emergency patient management system.
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Citations
Citations to this article as recorded by
- Investigating structural dynamics and sensing capabilities: Spectroscopic and DFT analysis of novel AIEE active deferasirox based organic sensor
Sania, Mohammed A. Assiri, Sanwa Rafique, Hasher Irshad, Zulfiqar Ali Khan, Farhan A. Khan, Sohail Anjum Shahzad
Journal of Molecular Structure.2024; 1307: 137963. CrossRef - Methaemoglobinaemia: a potential confounder in COVID-19 respiratory failure
Yang Lin Ting, Jonathan Zhao Min Lim, Pei Ming Yeo, Wen Yuan Sim
Singapore Medical Journal.2024; 65(Suppl 1): S24. CrossRef - Methaemoglobinaemia due to nitrobenzene poisoning
K. Chandrasekhar, P. Chandana Sree, Bhattaram Siddhartha Kumar, Mounika Nemilete
Journal of Clinical and Scientific Research.2023; 12(Suppl 2): S123. CrossRef - A Case of Methemoglobinemia Caused by Toluidine Revelation with Dyspnea and Cyanosis
Ayaka SANADA, Shun-ichi NIHEI, Shigeto ISHIKAWA, Misako YAMASHITA, Chikako MONOE, Hiroki OOTSUBO, Masayuki KAMOCHI, Toshihiko MAYUMI
Journal of UOEH.2022; 44(2): 185. CrossRef - Herbicide poisoning assocaited methhemoglobinemia as a cause of hypoxia — approach & emergency management — A case report
Sudhir Deshpande, Sagar Gupta, Yashawini Tupkary, Shivprasad Sankpal
Indian Journal of Forensic and Community Medicine.2022; 9(1): 36. CrossRef - Physiology-based toxicokinetic modelling in the frame of the European Human Biomonitoring Initiative
Dimosthenis A. Sarigiannis, Spyros Karakitsios, Elena Dominguez-Romero, Krystalia Papadaki, Celine Brochot, Vikas Kumar, Marta Schuhmacher, Moustapha Sy, Hans Mielke, Mathias Greiner, Marcel Mengelers, Martin Scheringer
Environmental Research.2019; 172: 216. CrossRef - Methemoglobinemia Following Monolinuron Ingestion
Guillaume Mortamet, Mehdi Oualha, Sylvain Renolleau, Christian Moesch, Jean-Marc Treluyer
Pediatric Emergency Care.2018; 34(3): e55. CrossRef - Methemoglobinemia resulting from exposure in a confined space: Exothermic self-polymerization of 4,4′-methylene diphenyl diisocyanate (MDI) material
Philip A. Smith, Jeffrey Lodwick, Joe Dartt, Jenny R. Amani, Kathleen M. Fagan
Journal of Occupational and Environmental Hygiene.2017; 14(1): D13. CrossRef - Unintentional mass sodium nitrite poisoning with a fatality
Changhwan Lee, Eun Jung Jang, Hyesun Yum, Young Shik Choi, Jeongik Hong
Clinical Toxicology.2017; 55(7): 678. CrossRef - Crystal structure of bis(prop-2-yn-1-yl) 5-nitroisophthalate
K. S. Ezhilarasi, Sivasamy Selvarani, Perumal Rajakumar, B. K. Revathi, G. Usha
Acta Crystallographica Section E Crystallographic Communications.2015; 71(6): o435. CrossRef - The painted shoes
Natália Noronha, André Rosa Alexandre, Joana Cavaca Santos, Fernanda Rodrigues
BMJ Case Reports.2015; : bcr2015210619. CrossRef
- Investigating structural dynamics and sensing capabilities: Spectroscopic and DFT analysis of novel AIEE active deferasirox based organic sensor
- 191 View
- 1 Download
- 11 Web of Science
- 11 Crossref
Case Report
- A Suspicious Case of Chloroform Induced Acute Toxic Hepatitis in Laboratory Worker
- Dae Gwang Lee, Chang Hwan Lee, Keun Ho Jang, Hong Jae Chae, Jai Dong Moon
- Korean Journal of Occupational and Environmental Medicine 2012;24(3):304-310. Published online September 30, 2012
- DOI: https://doi.org/10.35371/kjoem.2012.24.3.304
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Abstract
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- OBJECTIVES
To report upon a case of toxic hepatitis in a worker exposed to chloroform.
METHODS
A 28-year-old female who had worked as chemical analysis engineer in a laboratory using chloroform was hospitalized due to nausea, vomiting and generalized weakness. The authors evaluated her using blood tests, abdominal CT scan and her occupational history.
RESULTS
The blood tests revealed acute toxic hepatitis. Other causes of hepatitis such as viral, drug induced or alcoholic hepatitis could be excluded. But autoimmune hepatitis couldn't be totally ruled out(ANA (++), IgG(serum) 1780 mg/dL). After admission, her symptoms improved and her liver enzyme levels(AST and ALT) were markedly reduced. She returned to her workplace after discharge. Afterwards, however, her liver enzyme levels increased again one week after returning to her workplace. Subsequent to a job change, her liver enzyme levels reduced and normalized after eight weeks. The airbone laboratory chloroform ranged from 3.155 to 9.037 ppm.
CONCLUSIONS
The authors presume that this patient's liver injury was related to an interaction of chloroform toxicity and a predisposition to autoimmune hepatitis. The rapid improvement of the clinical symptoms and the progressive normalization of the liver function tests once the chloroform exposure eliminated supports the diagnosis. -
Citations
Citations to this article as recorded by- Recent advances in non-fullerene organic photovoltaics enabled by green solvent processing
Shilin Li, Hong Zhang, Shengli Yue, Xi Yu, Huiqiong Zhou
Nanotechnology.2022; 33(7): 072002. CrossRef - A case report of toxic hepatitis caused by chloroform in automotive parts manufacturer coating process
Jong Hyun Hwang, Jung Il Kim
Annals of Occupational and Environmental Medicine.2022;[Epub] CrossRef - Aliphatic Halogenated Hydrocarbons: Report and Analysis of Liver Injury in 60 Patients
Rolf Teschke
Journal of Clinical and Translational Hepatology.2018;[Epub] CrossRef - A Study on Fabrication of 3D Dual Pore Scaffold by Fused Deposition Modeling and Salt-Leaching Method
Hae-Ri Shim, Jong Young Kim
Transactions of the Korean Society of Mechanical Engineers A.2015; 39(12): 1229. CrossRef - Acute liver injury in two workers exposed to chloroform in cleanrooms: a case report
Young Joong Kang, Jungho Ahn, Yang-In Hwang
Annals of Occupational and Environmental Medicine.2014;[Epub] CrossRef
- Recent advances in non-fullerene organic photovoltaics enabled by green solvent processing
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- 5 Crossref
Original Article
- Comparison of Cardiovascular Disease Status Between Large Scale Industry Office and Self Employed Male Workers
- Keun Ho Jang, Won Ju Park, Myeong Bo Kim, Dae Kwang Lee, Hong Jae Chae, Jai Dong Moon
- Korean Journal of Occupational and Environmental Medicine 2011;23(2):130-138. Published online June 30, 2011
- DOI: https://doi.org/10.35371/kjoem.2011.23.2.130
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Abstract
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- OBJECTIVES
The aim of this study is to compare the cardiovascular disease status between large scale industry office and self employed male workers who have gaps in their intensive health management.
METHODS
The cross sectional study was carried out with subjects composed of 244 shipyard office male workers and 381 self employed male workers, aged 30 to 55 years. They were given a health exam in a general hospital from January 2007 to June 2009. Information was based on data from self-administered questionnaires, physical examination and laboratory results on blood samples. The degree of coronary artery calcification and stenosis was evaluated by a 64 channel multi-detector computed tomography angiography.
RESULTS
The prevalence of hypertension(p<0.01) and diabetes mellitus(p=0.02) and waist circumference(p<0.01) was significantly lower in the shipyard office workers than in self employed workers. Proper drinking(p<0.01) was more commmon in shipyard office workers. The rates of coronary artery calcification and stenosis were estimated to be 18.4% and 11.5% respectively for shipyard office workers and were significantly lower than the 26.5% and 21.5% for self employed workers. After adjustment for age, the probability of coronary artery stenosis in shipyard office workers was lower than in self employed workers (OR=0.56, 95% CI=0.35~0.90).
CONCLUSIONS
The study results verified the benefits of a health promotion and intervention program and the healthy worker effect for cardiovascular diseases. More specifically, it verified the benefits regarding coronary artery stenosis in large scale industry office workers. This result should encourage the establishment of health promotion programs and the study of occupational epidemiology. -
Citations
Citations to this article as recorded by- The effect of employment transitions on physical health among the elderly in South Korea: A longitudinal analysis of the Korean Retirement and Income Study
Juyeon Lee, Myoung-Hee Kim
Social Science & Medicine.2017; 181: 122. CrossRef - Association of Work-related Characteristics and Hypertension among White Collar Workers
Chae-Bong Kim, KyooSang Kim
Journal of Korean Society of Occupational and Environmental Hygiene.2015; 25(3): 418. CrossRef - Comparison of oral health status by metabolic syndrome risk factors in workers
In-Young Ku, Seon-Jeong Moon, Myeong-Seon Lee, Kyung-Hwan Ka
Journal of Korean society of Dental Hygiene.2013; 13(4): 581. CrossRef
- The effect of employment transitions on physical health among the elderly in South Korea: A longitudinal analysis of the Korean Retirement and Income Study
- 71 View
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- 3 Crossref
Original Article
- Comparison of Cardiovascular Disease Risk Assessment Tools by Using Coronary CT Angiography
- Myeong Bo Kim, Won Ju Park, Keun Ho Jang, Dae Kwang Lee, Hong Jae Chae, Jai Dong Moon
- Korean Journal of Occupational and Environmental Medicine 2010;22(2):102-113. Published online June 30, 2010
- DOI: https://doi.org/10.35371/kjoem.2010.22.2.102
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Abstract
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- OBJECTIVE: The prevalence and mortality rate of cardiovascular disease (CVD) have increased among Koreans over the past 20 years. To manage and control this disease, various CVD risk assessment tools such as KOSHA (Korean Occupational Safety and Health Agent) CVD risk assessment, the presence of metabolic syndrome and the Framingham risk score (FRS) have been developed and applied to employees at the workplace. This study was designed to compare the validity of the CVD risk assessment tools mentioned above with the findings of coronary CT angiography (CCTA).
METHODS
The subjects of this study who were 490 male-workers aged between 31 and 70, and these subjects were selected among those who had visited a University Hospital for a general health examination and who underwent CCTA from January 2007 to June 2009. Chi-square tests and logistic regression analysis were used to compare and analyze the associations between the CVD risk assessment tools and the coronary artery changes such as calcification and stenosis.
RESULTS
Metabolic syndrome (OR=1.90, 95% CI 1.23-2.95) and the Framingham risk score (OR=2.71, 95% CI 1.83-4.01) were the significant and meaningful predictors of coronary artery calcification. On the analysis of the association with coronary artery stenosis, only the Framingham risk score (OR=2.21, 95% CI 1.46-3.36) turned out to be a significant and meaningful predictor.
CONCLUSION
The results suggest that the Framingham risk score is a relatively valid CVD risk assessment tool. Henceforth, to effectively manage cardiovascular diseases in the workplace, advanced tools and indicators for management should be considered and provided based on meaningful study results. -
Citations
Citations to this article as recorded by- Sex differences in the relationship between depression and cardiovascular disease risk: a nationwide study in Korea
Seol-bin Kim, Ihn Sook Jeong
Osong Public Health and Research Perspectives.2021; 12(2): 105. CrossRef - Factors related to Coronary Artery Disease in Korean Adults: Based on the Korean National Health and Nutrition Examination Survey 2013~2015
Sook Young Kim
The Korean Journal of Rehabilitation Nursing.2018; 21(1): 33. CrossRef - The Assessment of Framingham Risk Score and 10 Year CHD Risk according to Application of LDL Cholesterol or Total Cholesterol
Se Young Kwon, Young Ak Na
Korean Journal of Clinical Laboratory Science.2016; 48(2): 54. CrossRef - The Relationship between Coronary Risk Factors and Coronary Calcium Score Detected by Computed Tomography Coronary Angiography in Korean Middle Aged Men
Seung-Hyun Park, Young-Wook Kim, Chang-Ho Chae, Ja-Hyun Kim, Yune-Sik Kang, Yong Whi Park, Baek Geun Jeong
Journal of agricultural medicine and community health.2014; 39(1): 25. CrossRef - Relationship between Conventional Cardiovascular Disease Risk Assessment and Coronary Artery Calcification in Group Exposed to Inorganic Dusts
Won-Jeong Lee, So Young Park
Journal of the Korean Society of Radiology.2013; 68(5): 397. CrossRef - Relation of Pulmonary Function Impairment and Coronary Artery Calcification by Multi-detector Computed Tomography in Group Exposed to Inorganic Dusts
Won-Jeong Lee, Jae Hoon Shin, So Young Park
Tuberculosis and Respiratory Diseases.2013; 74(2): 56. CrossRef - Evaluate the diagnostic accuracy in the assessment of coronary artery stenoses using MDCT
Won-Seok Yang, Sung-Gyu Sin, Jae-Hong Park
Journal of the Korean Society of Radiology.2012; 6(4): 275. CrossRef
- Sex differences in the relationship between depression and cardiovascular disease risk: a nationwide study in Korea
- 65 View
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- 7 Crossref
Original Article
- The Relationship of Serum CEA Levels and Type of Work in Shipyard Workers
- Won Ju Park, Myoung Bo Kim, Yang Hyun Kim, Ryoung Jin Park, Keun Ho Jang, Hong Jae Chae, Jai Dong Moon
- Korean Journal of Occupational and Environmental Medicine 2009;21(4):293-300. Published online December 31, 2009
- DOI: https://doi.org/10.35371/kjoem.2009.21.4.293
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Abstract
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- OBJECTIVES
Benign conditions have been known to cause an increase in the levels of serum carcinoembryonic antigen, a level change that is often associated with an increase in the occurrence of malignancy. The purpose of this study was to elucidate the relationship between serum CEA levels and type of work in shipyard workers.
METHODS
From July-August 2007, 637 study subjects were enrolled into the study with the following characteristics: age 37~58 years, healthy shipyard workers, and who undergone an examination in a general hospital. Data on general characteristics was gathered from self-administered questionnaires. Information on job factors was collected from company personnel data. Serum CEA levels were measured after 10 hours'fasting.
RESULTS
The level of mean serum CEA was 1.83+/-1.20 ng/mL. On univariate analysis, the mean CEA level was significantly higher in older age groups (P<0.05), current smokers, lower education, and in production workers (P<0.01). After adjusting for age, BMI, cigarette smoking, job pattern, and educational level, the serum CEA level was higher in production workers than in office workers(P<0.01). This is particularly true in the shipyard painters, who had the highest level of CEA across job groups.
CONCLUSIONS
The goal of this was to determine if there were differences in serum CEA levels according to occupational role in shipyard workers. Production shipyard workers had relatively higher level of serum CEA than office workers, most likely due to occupational exposure. This serum CEA level is influenced by occupation role. Serum CEA level could be a parameter for evaluating pollutant effects. -
Citations
Citations to this article as recorded by- The association between cadmium and lead exposure and blood pressure among workers of a smelting industry: a cross-sectional study
Hyun Chan An, Joo Hyun Sung, Jiho Lee, Chang Sun Sim, Sang Hoon Kim, Yangho Kim
Annals of Occupational and Environmental Medicine.2017;[Epub] CrossRef
- The association between cadmium and lead exposure and blood pressure among workers of a smelting industry: a cross-sectional study
- 62 View
- 0 Download
- 1 Crossref
Original Article
- Predictors of Metabolic Syndrome Among Shipyard Workers and its Prevalence
- Yang Hyun Kim, Ryoung Jin Park, Won Ju Park, Myoung Bo Kim, Jai Dong Moon
- Korean Journal of Occupational and Environmental Medicine 2009;21(3):209-217. Published online September 30, 2009
- DOI: https://doi.org/10.35371/kjoem.2009.21.3.209
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Abstract
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- OBJECTIVES
The purpose of this study was to evaluate the predictors of metabolic syndrome in shipyard workers in the Southwestern part of South Korea and determine its prevalence.
METHODS
The study subjects were composed of 1,198 medical check-up examinees, age 37 to 58 years who were examined in a general hospital from July, 2007 to August, 2008. Information about age, smoking, drinking and exercise was based on data from self-administered questionnaires. We collected job factors, education level and marital status from company personnel data and the indices of metabolic syndrome from the medical check-up.
RESULTS
The prevalence of metabolic syndrome among the 1,198 shipyard workers was 15.0%. The prevalence of the components of metabolic syndrome was as follows: 26.9% for central obesity, 31.7% for hypertension, 32.2% for hypertriglyceridemia, 19.2% for low HDL-cholesterolemia and 5.2% for hyperglycemia. Adjusted odds ratio for metabolic syndrome was significantly decreased in productive workers (OR: 0.500, 95% CI: 0.327-0.764). Furthermore, factors such as age, smoking, drinking, exercise, work duration and job type were significantly associated with metabolic syndrome.
CONCLUSIONS
Our findings suggest that even though shipyard workers work for the same employer, the prevalence of metabolic syndrome varies to job type, shift work and work duration. Therefore, general metabolic syndrome management programs for shipyard workers should be designed and tailor-made for specified job characteristics to prevent cardiovascular disease more effectively. Also, thorough control and management of the tailor made metabolic syndrome management programs is needed in the early stages of metabolic syndrome for good health outcomes. -
Citations
Citations to this article as recorded by- Study on nutrition, dietary and health status of middle-aged Korean men according to sedentary hours: based on the 2019 Korea National Health and Nutrition Examination Survey
Dajeong Jeong, Jeehyun Lee, Eunju Yoon
Journal of Nutrition and Health.2022; 55(3): 359. CrossRef - Association between metabolic syndrome and shift work in chemical plant workers
Seong-Ryol Chai, Soon-Chan Kwon, Yong-Jin Lee, Eun-Chul Jang, Young-Sun Min, Su-yeon Lee
Annals of Occupational and Environmental Medicine.2021;[Epub] CrossRef - Effectiveness of workers’ general health examination in Korea by health examination period and compliance: retrospective cohort study using nationwide data
Huisu Eom, Jun-Pyo Myong, Eun-A Kim, Bohwa Choi, Soon Woo Park, Young Joong Kang
Annals of Occupational and Environmental Medicine.2017;[Epub] CrossRef - Metabolic Syndromes Improvement and Its Related Factors among Health Checkup Examinees in a University Hospital
Mal-Suk Jo, Soon-Rim Suh, Keon-Yeop Kim
Journal of the Korea Academia-Industrial cooperation Society.2016; 17(6): 147. CrossRef - The Effects of Shift Work and Hours of Sleep on Metabolic Syndrome in Korean Workers
Hyunju Park
Korean Journal of Occupational Health Nursing.2016; 25(2): 96. CrossRef - Influence of Occupational Type and Lifestyle Risk Factors on Prevalence of Metabolic Syndrome among Male Workers: A Retrospective Cohort Study
So Hui Kang, Seon Young Hwang
Korean Journal of Adult Nursing.2016; 28(2): 180. CrossRef - Effect of working patterns on eating habits in manufacturing workers of Gwangju area
Ji-Suk Yim, Young-Ran Heo, Eun Jeong, Jae-Joon Lee
Journal of Nutrition and Health.2016; 49(6): 495. CrossRef - Cardiovascular Disease According to Job Type and Life Style
Wan-Young Yoon
Journal of Digital Convergence.2016; 14(2): 501. CrossRef - Association between Metabolic Syndrome and Participation in Clean-up Work at the Hebei Spirit Oil Spill
Ik-Jin Lee, Bong-Ki Jang, Jong-Wha Lee, Bu-Soon Son, Hae-Kwan Cheong, Mina Ha, Young-Hyun Choi, Myungsook Park
Korean Journal of Environmental Health Sciences.2015; 41(5): 335. CrossRef - Factors Affecting Health Promotion Behavior among Workers with High Risk of Metabolic Syndrome: Based on Theory of Planned Behavior
Sungwon Park, Sook Ja Yang
Journal of Korean Academy of Community Health Nursing.2015; 26(2): 128. CrossRef - Prevalence of Metabolic Syndrome and Its Predicting Factors among Small-sized Company Workers
Soo Kyoung Choi, Jeong A Jo, Seon Young Hwang
Korean Journal of Adult Nursing.2014; 26(2): 244. CrossRef - A Study on the Prevalence and Influencing Factors of Metabolic Syndrome among Police Officers
Ju Hee Hong, Sa-Woo Lee
Journal of Korean Society of Occupational and Environmental Hygiene.2014; 24(4): 566. CrossRef - Comparison of oral health status by metabolic syndrome risk factors in workers
In-Young Ku, Seon-Jeong Moon, Myeong-Seon Lee, Kyung-Hwan Ka
Journal of Korean society of Dental Hygiene.2013; 13(4): 581. CrossRef - An Investigation on the Metabolic Syndromes and Health-Related Risk Factors among Male Workers
Sun-Young Choi, Na-Eun Kang, Sung-Hee Kim
The Korean Journal of Food And Nutrition.2013; 26(4): 975. CrossRef - Prevalence and Associated Risk Factors of the Metabolic Syndrome in the Korean Workforce
Dae Ryong KANG, Yeongmi HA, Won Ju HWANG
Industrial Health.2013; 51(3): 256. CrossRef - Relation of Health Promotion Behaviors and Metabolic Syndrome in Daytime Workers
Dae-Sik Ko, Bu-Yeon Park, Gyeong-Hyu Seok
The Journal of the Korea institute of electronic communication sciences.2013; 8(12): 1941. CrossRef - The Factors related to Dyslipidemia and Hypertension among Male Office Workers
Eun Kyung Lee, Ok Soo Kim
Korean Journal of Adult Nursing.2013; 25(4): 432. CrossRef
- Study on nutrition, dietary and health status of middle-aged Korean men according to sedentary hours: based on the 2019 Korea National Health and Nutrition Examination Survey
- 79 View
- 3 Download
- 17 Crossref
Original Article
- Blood Lead Level as a Predictor of Coronary Artery Disease
- Ryoung Jin Park, Seung Hyun Kim, Ji Ung Park, Yang Hyun Kim, Myoung Bo Kim, Won Ju Park, Jai Dong Moon
- Korean Journal of Occupational and Environmental Medicine 2009;21(1):38-45. Published online March 31, 2009
- DOI: https://doi.org/10.35371/kjoem.2009.21.1.38
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Abstract
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- OBJECTIVES
Lead exposure is known to be associated with high blood pressure, hypertension, coronary artery disease, peripheral arterial disease, left ventricular hypertropy, and electrocardiographic abnormalities. We investigated the association between blood lead and coronary artery calcification and stenosis.
METHODS
Between April 2006 and July 2007, 502 adults (345 males and 157 females), who had no history of cardiovascular disease or occupational exposure to lead, were recruited as study subjects. All subjects underwent coronary CT angiography and blood lead measurement.
RESULTS
Blood lead levels were distributed from 0.43 to 11.30 (microgram/dL with a geometric mean blood lead level of 2.98+/-1.5 (microgram/dL. The geometric mean blood lead levels were higher in men than women (3.31+/-1.5 (microgram/dL vs. 2.36+/-1.5 (microgram/dL, P < 0.01). Based on a multivariate analysis, a 1 unit ((microgram/dL) increase in blood lead level was associated with a 1.09 (95% confidence interval, 0.92~1.29) and a 1.01 fold (95% confidence interval, 0.63~1.63) greater risk for coronary artery calcification in men and women, respectively. Similarly, a 1 unit (microgram/dL) increase in blood lead level was associated with a 1.25 (95% confidence interval, 1.03~1.51) and a 1.42 fold (95% confidence interval, 0.73~2.75) greater risk for coronary artery stenosis in men and women, respectively.
CONCLUSIONS
The results suggest that increased blood lead levels are associated with an increased risk of coronary artery stenosis. -
Citations
Citations to this article as recorded by- Blood Lead Levels and Cardiovascular Disease Risk: Results from the Korean National Health and Nutrition Examination Survey
Yoonjin Park, Jungjin Han
International Journal of Environmental Research and Public Health.2021; 18(19): 10315. CrossRef - Blood lead concentration and related factors in Korea from the 2008 National Survey for Environmental Pollutants in the Human Body
Seong Wook Jeong, Chae Kwan Lee, Chun Hui Suh, Kun Hyung Kim, Byung Chul Son, Jeong Ho Kim, Jong Tae Lee, Soo Woong Lee, Yeong Beom Park, Jong Wha Lee, Seung-Do Yu, Chan Seok Moon, Dae Hwan Kim, Sang Yoon Lee
International Journal of Hygiene and Environmental Health.2014; 217(8): 871. CrossRef - The Effects of Blood Lead on Blood Pressure Among Non-smokers
Yun-Suk Pak, Sang-Sin Park, Tae-Hun Kim, Sang-Yoon Lee, Young-Lim Kho, Eun-Hee Lee
Korean Journal of Environmental Health Sciences.2012; 38(4): 311. CrossRef - National estimates of blood lead, cadmium, and mercury levels in the Korean general adult population
Nam-Soo Kim, Byung-Kook Lee
International Archives of Occupational and Environmental Health.2011; 84(1): 53. CrossRef
- Blood Lead Levels and Cardiovascular Disease Risk: Results from the Korean National Health and Nutrition Examination Survey
- 55 View
- 1 Download
- 4 Crossref
Original Article
- Change of Urinary Trans, Trans-Muconic Acid before and after Turnaround Process in a Petrochemical Plant
- Seung Hyun Kim, Ji Ung Park, Jai Dong Moon
- Korean Journal of Occupational and Environmental Medicine 2008;20(4):335-342. Published online December 31, 2008
- DOI: https://doi.org/10.35371/kjoem.2008.20.4.335
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Abstract
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- OBJECTIVES
This study was performed to estimate the exposure to benzene, one of the most serious health hazards, in four phases of a turnaround in a petrochemical company, and to evaluate the suitability of trans,trans-muconic acid (tt-MA) to act as a biomarker of exposure to low benzene levels.
METHODS
tt-MA was determined in 152 urine samples collected in 4 phases ('before daily work', 'after daily work', 'purge', and 'inspection' of turnaround work) from 19 exposed workers involved in turnaround work and 19 clerical workers. The ambient benzene levels were monitored simultaneously during the 'purge' process of turnaround work in the exposed group.
RESULTS
The median urinary tt-MA for the 4 phases was 0.046 mg/L, 0.082 mg/L, 0.507 mg/L, and 0.468 mg/L in the exposed group and 0.050 mg/L, 0.065 mg/L, 0.269 mg/L, and 0.331 mg/L in the clerical workers, respectively. The median urinary tt-MA for the exposed group was significantly higher than that of the clerical workers during the purge process (P<0.05). In the exposed group, median urinary tt-MA for the 'before daily work' phase was significantly lower than that of the other three phases (P<0.05). Even in the clerical workers, the urinary tt-MA level for the 'before daily work' phase was significantly lower than that of the turnaround (P<0.05). There was a very significant correlation between urinary tt-MA levels and ambient benzene levels (r(s) = 0.795, P<0.01).
CONCLUSION
The turnaround process increased the benzene exposure for all workers, even the clerical workers, in a petrochemical company handling benzene. Urinary tt-MA was found to be suitable as a biomarker for the exposure to low-level benzene. -
Citations
Citations to this article as recorded by- Estimating Benzene Exposure Level over Time and by Industry Type through a Review of Literature on Korea
Donguk Park, Sangjun Choi, Kwonchul Ha, Hyejung Jung, Chungsik Yoon, Dong-Hee Koh, Seunghun Ryu, Soogeun Kim, Dongmug Kang, Kyemook Yoo
Safety and Health at Work.2015; 6(3): 174. CrossRef - The Relationship between Exposure to Benzene and the Excretion of Urinary Trans, Trans-muconic Acid in Petrochemical Factory Turnaround Process Workers
Seung Min Lee, Jong Uk Won, Chi Nyon Kim, Jaehoon Roh
Journal of Korean Society of Occupational and Environmental Hygiene.2014; 24(1): 52. CrossRef
- Estimating Benzene Exposure Level over Time and by Industry Type through a Review of Literature on Korea
- 85 View
- 0 Download
- 2 Crossref
Original Article
- A Study on the Association between Blood Lead Levels and Habitual Tobacco and Alcohol Use in Koreans with No Occupational Lead Exposure
- Ji Ung Park, Se Won Oh, Seung Hyun Kim, Yang Hyun Kim, Ryoung Jin Park, Jai Dong Moon
- Korean Journal of Occupational and Environmental Medicine 2008;20(3):165-173. Published online September 30, 2008
- DOI: https://doi.org/10.35371/kjoem.2008.20.3.165
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Abstract
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- OBJECTIVES
The purpose of this study was to estimate the normal blood lead (PbB) levels in a group of Korean subjects and to evaluate the association between PbB levels and habitual tobacco and alcohol use.
METHODS
We recruited 532 adults (320 males and 212 females) with no history of occupational exposure to lead, as study subjects.
RESULTS
PbB levels ranged between 0.43 microgram/dl and 9.45 microgram/dl. The adjusted geometric mean PbB in men was 3.19 microgram/dl, which was significantly higher than that seen in women: 2.66 microgram/dl (P=0.017). Geometric mean PbBs were not significantly different between urban and rural patients. The adjusted geometric mean PbB in smokers was 3.31 microgram/dl, which was significantly higher than that seen in nonsmokers: 2.64 microgram/dl (P=0.035). The adjusted geometric mean PbB in drinkers was 3.10 microgram/dl, which was significantly higher than that seen in non-drinkers: 2.75 microgram/dl (P=0.049).
CONCLUSIONS
The PbB levels of some Korean adults seem to be comparable to those seen in foreign countries. Our results suggest that tobacco and alcohol cessation will be helpful in decreasing the harmful effect of lead. -
Citations
Citations to this article as recorded by- Prenatal Exposure to Lead and Chromium is Associated with IL-13 Levels in Umbilical Cord Blood and Severity of Atopic Dermatitis: COCOA Study
Jihyun Kim, Seonwoo Kim, Sook-young Woo, Jin-Yong Chung, Young-Seoub Hong, Se-Young Oh, Suk-Joo Choi, Soo-Young Oh, Kyung Won Kim, Youn Ho Shin, Hye-Sung Won, Kyung-Ju Lee, Soo Hyun Kim, Ja Young Kwon, Si Hyeon Lee, Soo-Jong Hong, Kangmo Ahn
Immune Network.2019;[Epub] CrossRef - Level of Blood Lead and Urine Cotinine of Residents by Area
Yu-Jin Oh, Hyoung-Wook Kim, Yun-Jae Kim, Yoon-Deok Han, Sung-Hyeon Jung, Jong-Dae Lee, Bong-Ki Jang, Jin-Heon Lee, Bu-Soon Son
Journal of Environmental Science International.2019; 28(3): 329. CrossRef - Association of Blood Pressure with Blood Lead and Cadmium Levels in Korean Adolescents: Analysis of Data from the 2010–2016 Korean National Health and Nutrition Examination Survey
Jaeouk Ahn, Nam-Soo Kim, Byung-Kook Lee, Jungsun Park, Yangho Kim
Journal of Korean Medical Science.2018;[Epub] CrossRef - The association between cadmium and lead exposure and blood pressure among workers of a smelting industry: a cross-sectional study
Hyun Chan An, Joo Hyun Sung, Jiho Lee, Chang Sun Sim, Sang Hoon Kim, Yangho Kim
Annals of Occupational and Environmental Medicine.2017;[Epub] CrossRef - Health Effect and Blood Lead Concentration among Residents in Gwangyang and Yeosu
Heejin Park, Myung-Kyu Park, Tack-Shin Kang, Geun-Bae Kim, Jong-Wha Lee, Bong-Ki Jang, Bu-Soon Son
Korean Journal of Environmental Health Sciences.2016; 42(3): 205. CrossRef - Association of Blood Pressure with Exposure to Lead and Cadmium: Analysis of Data from the 2008–2013 Korean National Health and Nutrition Examination Survey
Byung-Kook Lee, Jaeouk Ahn, Nam-Soo Kim, Chan Boo Lee, Jungsun Park, Yangho Kim
Biological Trace Element Research.2016; 174(1): 40. CrossRef - A Case of Lead Poisoning with Drug-induced Liver Injury after Ingestion of Herbal Medicine
Gi Jung Jeon, Jongha Park, Min Sung Kim, Jong Won Yu, Jae Hyun Park, Min Sik Kim
The Korean Journal of Gastroenterology.2015; 65(6): 375. CrossRef - Probit analysis of comparative assays on toxicities of lead chloride and lead acetate to in vitro cultured human umbilical cord blood lymphocytes
Rajashree Patnaik, Rabindra N. Padhy
Interdisciplinary Toxicology.2015; 8(1): 35. CrossRef - Association of among alcohol consumption and blood vitamin D and lead concentrations: Based on 2010-2012 Korea national health and nutrition examination survey
Ho-Ki An, Jae-Yong Park, Hee-Jung Yoon
Journal of the Korea Academia-Industrial cooperation Society.2015; 16(1): 498. CrossRef - Blood lead concentration and related factors in Korea from the 2008 National Survey for Environmental Pollutants in the Human Body
Seong Wook Jeong, Chae Kwan Lee, Chun Hui Suh, Kun Hyung Kim, Byung Chul Son, Jeong Ho Kim, Jong Tae Lee, Soo Woong Lee, Yeong Beom Park, Jong Wha Lee, Seung-Do Yu, Chan Seok Moon, Dae Hwan Kim, Sang Yoon Lee
International Journal of Hygiene and Environmental Health.2014; 217(8): 871. CrossRef - Environmental Exposure to Lead (Pb) and Variations in Its Susceptibility
Jina Kim, Youngeun Lee, Mihi Yang
Journal of Environmental Science and Health, Part C.2014; 32(2): 159. CrossRef - Blood cadmium, mercury, and lead and metabolic syndrome in South Korea: 2005–2010 Korean National Health and Nutrition Examination Survey
Byung‐Kook Lee, Yangho Kim
American Journal of Industrial Medicine.2013; 56(6): 682. CrossRef - Monitoring Study on Exposure Levels of Environmental Pollutants in Residents of a Non-Industrial Area, Korea
Dae-Seon Kim, Seung Chul Ahn, Jung Min Ryu, Seung Do Yu
Korean Journal of Environmental Health Sciences.2012; 38(6): 482. CrossRef - Associations of blood lead, cadmium, and mercury with estimated glomerular filtration rate in the Korean general population: Analysis of 2008–2010 Korean National Health and Nutrition Examination Survey data
Yangho Kim, Byung-Kook Lee
Environmental Research.2012; 118: 124. CrossRef - National estimates of blood lead, cadmium, and mercury levels in the Korean general adult population
Nam-Soo Kim, Byung-Kook Lee
International Archives of Occupational and Environmental Health.2011; 84(1): 53. CrossRef - Blood Lead Concentration and Hypertension in Korean Adults Aged 40 and Over According to KNHANES IV (2008)
Sun-Young Kim, Duk-Hee Lee
Korean Journal of Environmental Health Sciences.2011; 37(6): 418. CrossRef - A Study of Working Environment for Automotive Painting in Auto Repair Shops and Workers' Exposure to Hazardous Chemicals
Sang-Hyo Sim, Chun-Hwa Jeoung, Jin-Suk Lim, Hyung-Gu Lee, Yoon-Shin Kim
Korean Journal of Environmental Health Sciences.2009; 35(3): 153. CrossRef
- Prenatal Exposure to Lead and Chromium is Associated with IL-13 Levels in Umbilical Cord Blood and Severity of Atopic Dermatitis: COCOA Study
- 112 View
- 1 Download
- 17 Crossref
Case Report
- A Case of Polyneuropathy Associated with Methyl Bromide Intoxication
- Hyung Jae Lee, Se Won Oh, Jong Seong Lee, Hong Jae Chae, Jai Dong Moon
- Korean Journal of Occupational and Environmental Medicine 2007;19(3):238-243. Published online September 30, 2007
- DOI: https://doi.org/10.35371/kjoem.2007.19.3.238
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Abstract
PDF
- BACKGROUND
The diagnosis and treatment of intoxication induced by methyl bromide depends on the patient's exposure history. In the present case, the patient showed various neurologic symptoms which were helpful to confirm the diagnosis and to determine the concentration of bromide ion in his body. The reduction rate of bromide ion concentration was another important clue to estimate the patient's health state in treatment.
CASE
REPORT: Some neurologic disorders were manifested in a 35-year-old man who had been engaged in a fumigation company for 12 years. Although he had been complaining of abnormal symptoms for 10 days, he had left his work only 3 days before being admitted to our hospital in serious state via the emergency department. Comprehensive clinical evaluations confirmed he was suffering from polyneuropathy, optic neuropathy and cerebellar signs. We diagnosed his condition as methyl bromide intoxication, and ruled out other possible diseases, after taking his occupational history and evaluating the elevation of bromide ion concentration in the sampled blood, urine and cerebrospinal fluid. With decreasing bromide ion concentration, his abnormal symptoms improved and he was discharged 22 days after admission without any neurologic sequela.
CONCLUSION
This case report confirmed the usefulness of measuring the concentrations of bromide ion in the diagnosis of methyl bromide intoxication. We therefore suggest that the regular measuring of bromide ion concentration be included in the occupation specified health examination. -
Citations
Citations to this article as recorded by- Acute Occupational Poisoning in Korea
Hyunjoo Kim, Jia Ryu
The Ewha Medical Journal.2016; 39(4): 99. CrossRef - Compensation for Occupational Neurological and Mental Disorders
Dong-Mug Kang, Inah Kim
Journal of Korean Medical Science.2014; 29(Suppl): S59. CrossRef - Occupational Neurologic Disorders in Korea
Yangho Kim, Kyoung Sook Jeong, Yong-Hun Yun, Myoung-Soon Oh
Journal of Clinical Neurology.2010; 6(2): 64. CrossRef - Occupational Neurological Disorders in Korea
Eun-A Kim, Seong-Kyu Kang
Journal of Korean Medical Science.2010; 25(Suppl): S26. CrossRef
- Acute Occupational Poisoning in Korea
- 59 View
- 0 Download
- 4 Crossref
Case Report
- A Case of Lead Poisoning After Ingestion of Herb Pills
- Se Won Oh, Hyung Jai Lee, Hong Jae Chae, Sung Kwan Lee, Jai Dong Moon, Deok Cho
- Korean Journal of Occupational and Environmental Medicine 2007;19(3):231-237. Published online September 30, 2007
- DOI: https://doi.org/10.35371/kjoem.2007.19.3.231
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Abstract
PDF
- BACKGROUND
Lead is a common environmental metal and has been used for various purposes for a long time, leading to frequent reports of lead poisoning. The concern about lead poisoning starts has been mostly focused on occupational exposure and is linked to the prevention and management of lead exposure in refining and manufacturing processes. Nowadays, however, there is growing concern about nonoccupational lead exposure by many pollutants. Especially, lead poisoning by herb medicine has commonly been observed in clinics in Southeast Asia and South Korea. This case report contains diagnosis of inpatients who suffered from lead poisoning from a herb medicine, arthritis remedy and who complained of abdominal symptoms and dizziness. The study purpose was to awaken our healthful interest in lead poisoning.
CASE
REPORT: A 53-year-old female patient complaining of abdominal pain, dizziness, and numbness of hand and foot came to our hospital due to the continuation of her anemic finding symptoms while undergoing treatment at a secondary hospital. Her past medical history was unremarkable except she had taken herb pills for about a year which were administered by herb medicine to treat arthritis. Physical examination was unremarkable except for oral ulcer finding. Hemoglobin was 8.5 g/dl, reticulocyte count was 4.10%, bilirubin was 1.3 mg/dl (direct 0.3 mg/dl), and Zinc protoporphyrin 169.12 ug/dl. In urinalysis results, WBC increased to 30~39 /HPF, While AST/ALT, BUN/Cr, PT/aPTT, and nerve conduction velocity were normal. Basophilic stippling was observed through peripheral blood smear. The blood lead level was 80.4 microgram/dl and the urine lead level continued to increase to 541 microgram/l. Analysis of the pills that the patient had been taking showed that they contained 30 mg/g lead. By oral chelation therapy with D-penicillamine four times per day for five days, the patient's hemoglobin increased to 11.8 g/dl, while blood lead level decreased to 39.2 microgram/dl, and urine level to 196 microgram/l. Although the soles of her feet remained cold, but other symptoms and anemia finding were improved considerably. However, after discontinuing D-penicillamine medication, the blood lead level increased to 41.4 microgram/dl again. The further administration of D-penicillamine for five days reduced the blood lead level to 31.5 microgram/dl. At two years after the discontinuance of D-penicillamine, the followup findings were normal; hemoglobin was 13.1 g/dl, hematocrit 39.6%, reticulocyte count 1.22%, blood lead level 13.3 microgram/dl, and urine lead level 9.17 microgram/l.
CONCLUSION
After taking herb medicine pills for one year, the patient was admitted to hospital chiefly complaining of abdominal pain, dizziness, and numbness of the hand and foot. The high blood and urine and lead levels and lead chemical analysis of the herb pills confirmed lead poisoning which was treated with D-penicillamine for five days. The follow-up result after two years indicated normal blood and urine lead levels. -
Citations
Citations to this article as recorded by- Sources, distribution, bioavailability, toxicity, and risk assessment of heavy metal(loid)s in complementary medicines
Shiv Bolan, Anitha Kunhikrishnan, Balaji Seshadri, Girish Choppala, Ravi Naidu, Nanthi S. Bolan, Yong Sik Ok, Ming Zhang, Chun-Guang Li, Feng Li, Barry Noller, Mary Beth Kirkham
Environment International.2017; 108: 103. CrossRef - A Case of Lead Poisoning with Drug-induced Liver Injury after Ingestion of Herbal Medicine
Gi Jung Jeon, Jongha Park, Min Sung Kim, Jong Won Yu, Jae Hyun Park, Min Sik Kim
The Korean Journal of Gastroenterology.2015; 65(6): 375. CrossRef - Adverse Events Associated with Metal Contamination of Traditional Chinese Medicines in Korea: A Clinical Review
Hyunah Kim, Peter J. Hughes, Emily M. Hawes
Yonsei Medical Journal.2014; 55(5): 1177. CrossRef
- Sources, distribution, bioavailability, toxicity, and risk assessment of heavy metal(loid)s in complementary medicines
- 62 View
- 0 Download
- 3 Crossref
Original Article
- Effect of Genetic Polymorphisms of CYP2E1 and ALDH2 on the Relationship between the Levels of Urinary 8-Hydroxydeoxyguanosine and t,t-Muconic Acid
- Yong Dae Kim, Jong Won Kang, Sang Yong Eom, Yan Wei Zhang, Sung Hoon Kim, Eun Young Kim, Chul Ho Lee, Jai Dong Moon, Heon Kim
- Korean Journal of Occupational and Environmental Medicine 2007;19(2):164-170. Published online June 30, 2007
- DOI: https://doi.org/10.35371/kjoem.2007.19.2.164
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Abstract
PDF
- OBJECTIVES
This study was performed to investigate the effect of genetic polymorphisms on the oxidative genetic damage caused by benzene exposure in workers.
METHODS
We measured urinary t,t-muconic acid levels as a biomarker for benzene exposure and measured the level of urinary 8-OHdG to assess oxidative DNA damage in benzene-exposed healthy male workers. Genetic polymorphisms of ALDH2 and CYP2E1 were determined by TaqMan assay. We estimated Pearson correlation coefficients between urinary t,t-muconic acid and 8-OHdG according to the genetic polymorphisms of CYP2E1 and ALDH2.
RESULTS
There was a significant relationship between urinary t,t-muconic acid and 8-OHdG concentrations in overall subjects (R=0.532, p<0.001). Smokers showed a higher correlation coefficient between the markers than nonsmokers did (R=0.520 vs. 0.010). Individuals with CYP2E1 c1/c1 genotype also showed a higher correlation coefficient between them than those with CYP2E1 c1/c2 or c2/c2 genotypes (R=0.670 vs. -0.145). In multiple linear regression analysis including smoking status, sorbic acid intake, age and genetic polymorphisms of CYP2E1 and ALDH2 as the independent variables, urinary t,t-muconic acid showed a significant association with urinary 8-OHdG.
CONCLUSIONS
There was a significant correlation between urinary 8-OHdG and urinary t,t-muconic acid in benzene-exposed workers. This relationship was affected by genetic polymorphisms of CYP2E1and ALDH2.
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Case Report
- Subcutaneous and Gastrointestinal Exposure to Metallic Mercury: Report of 2 Cases
- Sung Kwan Lee, Hyoung Jai Lee, Hong Jae Chae, Jai Dong Moon
- Korean Journal of Occupational and Environmental Medicine 2003;15(4):446-451. Published online December 31, 2003
- DOI: https://doi.org/10.35371/kjoem.2003.15.4.446
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Abstract
PDF
- BACKGROUND
Mercury poisoning presents a variety of clinical pictures depending on the chemical structure, the route of exposure, the amount absorbed and other individual factors. Therefore, the ingestive and subcutaneous absorption of elemental(metallic) mercury can be considered to be relatively harmless in contrast to the inhalation of mercury vapor.
CASE REPORTS
A 72-year-old man presented to the department of urology due to tenderness, edema and a necrotic abscess of his penis after trauma. The soft tissue abscess required a surgical resection of the penis. For chelation therapy, oral D-penicillamine was administrated. 7 months later, he showed no subjective or objective signs of mercury poisoning. Another 5-yearold girl presented to the emergency department after accidental self-ingestion of elemental mercury. She was followed clinically and did not show any systemic mercury poisoning.
CONCLUSION
The Mercury concentrations in the blood and urine were elevated in the case of subcutaneous exposure, but was unchanged in the case of ingestion. Subcutaneous and gastrointestinal exposure to metallic mercury has a minimal risk for systemic mercury poisoning, which is in contrast to the exposure by inhalation.
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Case Report
- Exfoliative Dermatitis and Toxic Hepatitis Associated with Occupational Exposure to Trichloroethylene
- Hong Jae Chae, Seong Kwan Lee, Kang Jin Lee, Jong Youl Kim, Seung Chul Lee, Dong Hyeon Shin, Jai Dong Moon
- Korean Journal of Occupational and Environmental Medicine 2003;15(1):111-117. Published online March 31, 2003
- DOI: https://doi.org/10.35371/kjoem.2003.15.1.111
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Abstract
PDF
- A 28-year-old male began working as a degreaser. The solvent used in the degreasing operation was trichloroethylene. Over the next month the man experienced fever, chills, and an erythematous skin rash and itching. At that time he had a marked elevation in his liver enzyme, with cholestasis. Over the next few days the rash persisted then peeled. There was an elevation of Ig E, and a positive patch test reaction to trichloroethylene. His dermatitis and hepatitis were considered to be mediated by a hypersensitivity mechanism.
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Citations
Citations to this article as recorded by- A case report of toxic hepatitis caused by chloroform in automotive parts manufacturer coating process
Jong Hyun Hwang, Jung Il Kim
Annals of Occupational and Environmental Medicine.2022;[Epub] CrossRef - Trichloroethylene Hypersensitivity Syndrome: Should Be Considered When Diagnosing DRESS Syndrome
Young Joong Kang, Jihye Lee, Jungho Ahn, Soonwoo Park, Mu Young Shin, Hye Won Lee
Journal of Korean Medical Science.2018;[Epub] CrossRef - Late-onset trichloroethylene-induced hypersensitivity syndrome after intermittent exposure to low-dose trichloroethylene
Seung Yun Lee, Se Hwan Oh, Hyuck Jae Choi, Woo Young Choi, Jee Young Han, Hong-Lyeol Lee, Cheol-Woo Kim
Allergy, Asthma & Respiratory Disease.2016; 4(2): 145. CrossRef - Follow-up assessment of two cases of trichloroethylene hypersensitivity syndrome: A case report
Yong-Shun Huang, Han-Lin Huang, Qi-Feng Wu, Li-Hua Xia, Ming Huang, Xin-Xiang Qiu, Shan-Yu Zhou
Experimental and Therapeutic Medicine.2016; 12(2): 895. CrossRef - Trichloroethylene Hypersensitivity Syndrome Is Potentially Mediated through Its Metabolite Chloral Hydrate
Yongshun Huang, Lihua Xia, Qifeng Wu, Zifang Zeng, Zhenlie Huang, Shanyu Zhou, Jiachun Jin, Hanlin Huang, Edda Fiebiger
PLOS ONE.2015; 10(5): e0127101. CrossRef - Severe acute hepatitis in a printing company worker: A case study
Shoji Kubo, Koichi Matsuzaki, Toshihito Seki, Masahiko Ohsawa, Shinji Kumagai, Ginji Endo
Journal of Occupational Health.2015; 57(1): 87. CrossRef - Trichloroethylene Hypersensitivity Syndrome: A Disease of Fatal Outcome
Hyun Gul Jung, Hyung Hun Kim, Bong Gun Song, Eun Jin Kim
Yonsei Medical Journal.2012; 53(1): 231. CrossRef - Hypersensitivity syndrome due to trichloroethylene exposure: A severe generalized skin reaction resembling drug‐induced hypersensitivity syndrome
Hideaki WATANABE
The Journal of Dermatology.2011; 38(3): 229. CrossRef - Occupational Skin Diseases in Korea
Yeon-Soon Ahn, Min-Gi Kim
Journal of Korean Medical Science.2010; 25(Suppl): S46. CrossRef - Occupational Hepatic Disorders in Korea
Hyoung Ryoul Kim, Tae Woo Kim
Journal of Korean Medical Science.2010; 25(Suppl): S36. CrossRef - Occupational trichloroethylene exposure as a cause of idiosyncratic generalized skin disorders and accompanying hepatitis similar to drug hypersensitivities
Michihiro Kamijima, Naomi Hisanaga, Hailan Wang, Tamie Nakajima
International Archives of Occupational and Environmental Health.2007; 80(5): 357. CrossRef
- A case report of toxic hepatitis caused by chloroform in automotive parts manufacturer coating process
- 85 View
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- 11 Crossref
Original Article
- Characteristics of Work-Related Musculoskeletal Disorders and Effect of Intervention Program in Shipyard Workers
- Hong Jae Chae, Seong Kwan Lee, Kang Jin Lee, Jai Dong Moon
- Korean Journal of Occupational and Environmental Medicine 2002;14(4):468-477. Published online December 31, 2002
- DOI: https://doi.org/10.35371/kjoem.2002.14.4.468
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Abstract
PDF
- OBJECTIVES
This study was conducted to estimate the characteristics of work-related musculoskeletal disorders and the effect of intervention program in shipyard workers.
METHODS
Information on work related absences,due to musculoskeletal disorders, were collected between January, 1 2000 and August, 31 2002. Age, duration of work, job type, anatomical site of disease, cause and duration of absence due to sickness were investigated.
RESULTS
From a total of 158 cases there were 108(68.4%)and 50(31.6%)cases of back, and other musculoskeletal complaints,respectively. 55(34.8%)of the cases were caused by repetitive trauma and 103(65.2%)were due to non-repetitive causes. 90(83.3%)of the back complaint cases were due to non-repetitive causes, but there was a repetitive cause of other musculoskeletal complaints in 37(74.0%)cases. Back complaints were higher in workers carrying heavy materials, but other musculoskeletal complaints were higher in painting workers.Half of workers after an absence due to sickness had returned to work within 32.0 weeks and 25.4 weeks,in the cases of back and other musculoskeletal complaints, respectively. After the application of an intervention program for musculoskeletal disease, the incidence rate of absence due to work-related musculoskeletal disorders was reduced significantly.
CONCLUSION
The introduction of a musculoskeletal intervention program reduced absences due to work-related musculoskeletal disorders. -
Citations
Citations to this article as recorded by- A study on Related Factor and Knowledge of Back Pain in Workers Employed at Cement factory
Gi-Yeol Kim, Jung-Lim Oh, Kyoung-Ok Hwang
Journal of the Korea Academia-Industrial cooperation Society.2015; 16(1): 536. CrossRef - Ergonomic Research Trends in the Shipbuilding Industry: Present and the Future
Yu-Chang Kim
Journal of the Ergonomics Society of Korea.2012; 31(1): 131. CrossRef - Medical Managements of Musculoskeletal Diseases in Shipbuilding Industry
Jong-Eun Kim, Young-Ki Kim, Dong-Mug Kang
Journal of the Ergonomics Society of Korea.2012; 31(1): 157. CrossRef - Related Factors to Musculoskeletal Discomfort Symptoms on Some Middle·High school Teachers
Jae-Yoon Lee, Byeong-Yeon Moon, Youn-Hong Jeong, Hyun-Kyung Woo
Journal of the Korea Academia-Industrial cooperation Society.2012; 13(1): 264. CrossRef
- A study on Related Factor and Knowledge of Back Pain in Workers Employed at Cement factory
- 74 View
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- 4 Crossref
Original Article
- Low Back Pain Assessment Using Surface Electromyography and Digital Infrared Thermographic Imaging
- Kang Jin Lee, In Sung Choi, So Young Lee, Jae Young Han, Sam Gyu Lee, Hong Jae Chai, Seong Kwan Lee, Jai Dong Moon
- Korean Journal of Occupational and Environmental Medicine 2001;13(3):306-314. Published online September 30, 2001
- DOI: https://doi.org/10.35371/kjoem.2001.13.3.306
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Abstract
PDF
- OBJECTIVES
We studied the efficacy of surface electromyography(SEMG) and digital infrared thermographic imaging(DITI) in the assessment of low back pain both(LBP) quantitatively and qualitatively.
METHODS
We compared electromygraphic signals from electrodes placed in the lumbar area and the digital thermographic images in 16 LBP patients and 16 control subjects. The LBP patients and the control subjects were matched for age, gender, and body mass index(BMI) to adjust for any confounding effects RESULTS: In the static analyses of SEMG, median value was 198.1 microV for the LBP patients and 161.3 microV for the controls on the right side, and they were 194.2 microV and 180.5 microV on left side respectively. There was a statistically significant difference between the two groups on the right side(p<0.01), but not on the left side. In the dynamic analyses of the SEMG, the median values of the extension per flexion ratio of right side were 1.12 for LBP patients and 1.39 for controls. and those on the left side were 1.08 and 1.21 respectively. There were statistically significant differences in both sides(p<0.05). The sensitivity and specificity were 100% and 81.3% in DITI, 78.6% and 72.2% in SEMG .
CONCLUSIONS
These results indicate that SEMG and DITI are useful methods for indirect assessments of LBP, and that DITI is more sensitive and specific than SEMG. -
Citations
Citations to this article as recorded by- The effect of middle and lower trapezius strength exercises and levator scapulae and upper trapezius stretching exercises in upper crossed syndrome
Won-Sik Bae, Hyun-Ok Lee, Jae-Wook Shin, Keon-Cheol Lee
Journal of Physical Therapy Science.2016; 28(5): 1636. CrossRef
- The effect of middle and lower trapezius strength exercises and levator scapulae and upper trapezius stretching exercises in upper crossed syndrome
- 62 View
- 0 Download
- 1 Crossref
Review
- Local occupational disease surveillance system in Korea: Current status and issues
- Jong Han Leem, Seong Sil Chang, Seong Ah Kim, Jai Dong Moon, Chang Ho Chae, Yun Chul Hong, Soo Young Kim, Jin Seok Kim, Young Wook Kim, Sang Hwan Han, Hae Sook Lee, Jong Uk Won, Dong Bin Song, Eun Hee Ha, Seong Kyu Kang
- Korean Journal of Occupational and Environmental Medicine 2001;13(2):101-115. Published online June 30, 2001
- DOI: https://doi.org/10.35371/kjoem.2001.13.2.101
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Abstract
PDF
- No abstract available.
-
Citations
Citations to this article as recorded by- Management System of Occupational Diseases in Korea: Statistics, Report and Monitoring System
Kyung Yong Rhee, Seong Weon Choe
Journal of Korean Medical Science.2010; 25(Suppl): S119. CrossRef
- Management System of Occupational Diseases in Korea: Statistics, Report and Monitoring System
- 51 View
- 0 Download
- 1 Crossref
Original Article
- Assessment of Genotoxic Hazard in Petrochemical Workers
- Jai Dong Moon, Soon Phal Suh, Jung Sun Park, Jin Hyung Cho, Ki Won Ahn
- Korean Journal of Occupational and Environmental Medicine 1998;10(1):53-60. Published online February 28, 1998
- DOI: https://doi.org/10.35371/kjoem.1998.10.1.53
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Abstract
PDF
- In order to evaluate the genotoxic hazard among workers potentially exposed to low level petrochemical substances, the analyses of micronuclei (MN) and sister chromatid exchanges (SCEs) in lymphocytes were performed in 46 male workers (as exposed group) and 46 nonexposed subjects (as control group). Mean frequencies of MN and SCEs (respectively, 12.9/1000 cells and 6.5/cell) in exposed group were very significantly higher than those (10.2/1000 cells and 5.4/cell) in control group. And there were also significant differences in mean frequencies of MN and SCEs adjusted for age, employment duration, smoking, and drinking between two groups. Median frequencies of MN and SCEs in exposed group were very significantly higher than those in control group. Frequencies of SCEs were higher in smokers than in non-smoker. Frequencies of MN in smokers, however, were similiar to those of non-smoker. Interaction between exposure and smoking on MN and SCEs induction was not observed. The results suggest that there is genotoxic hazard in high risk group like workers handling carcinogens in petrochemical plants and the analyses of MN and SCEs are useful biomarkers for the exposure to hazard substances even at the level below the exposure limit.
-
Citations
Citations to this article as recorded by- Micronuclei assay: A potential biomonitoring protocol in occupational exposure studies
L. Palanikumar, N. Panneerselvam
Russian Journal of Genetics.2011; 47(9): 1033. CrossRef
- Micronuclei assay: A potential biomonitoring protocol in occupational exposure studies
- 54 View
- 0 Download
- 1 Crossref
Original Article
- Significance of Time-dependent Exposure Variable in Occupational Disease Study
- Jai Dong Moon
- Korean Journal of Occupational and Environmental Medicine 1997;9(2):201-207. Published online June 30, 1997
- DOI: https://doi.org/10.35371/kjoem.1997.9.2.201
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Abstract
PDF
- Although the final cumulative exposure has been used as a exposure variable on the cohort study for the relation between exposure and disease, the bias from the use of fixed exposure can be developed because the exposure amount changes across the time. We developed the program to handle the Cox model with irregularly changing time-dependent exposure variable and covariates, and the validity about the application of time-dependent exposure variable and lagged interval was practically evaluated by analyzing the data collected for typical retrospective cohort study with that program. The results were as follows : The exposure-response relations between the deaths from lung cancer and exposures (fixed or time-dependent) were not clear when 0 year lagged interval was applied. When 15 years lagged interval was applied, the exposure-response relations between the deaths from lung cancer and the time-dependent exposures to crystalline silica were observed and relative risky increased like 1.00, 1.17, 1.30 and 2.45 across the exposure levels. The relative risk estimates for lung cancer with time-dependent exposure variable were higher than those with fixed exposure variable without regard to the application of lagged interval. The exposure-response relations between the deaths from non-malignant respiratory disease (NMRD) and exposures (fixed or time-dependent) were observed across exposure levels when 0 year lagged interval was applied. When 15 years lagged interval wag applied, the exposure-response relations between the deaths from NMRD and the time-dependent exposures to crystalline silica were observed, but were not with fixed exposure variable. The relative risk estimates for NMRD mortality with time-dependent exposure variable were higher than those with fixed exposure variable, and the application of lagged interval on the evaluation of NMRD mortality was meaningless. The results suggests that the application of time-dependent exposure variable on the study of exposure-effect relation should be considered and the application of lagged interval should be decided according to the time needed from disease detection to death.
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