We reviewed articles to clarify the current evidence status for 1) types of cancer which related to benzene exposure, and 2) certain benzene exposure level which might cause the hematopoietic cancers. Hematopoietic function of the bone marrow is involved in the production of all blood cells types. The benzene metabolites including benzoquinone and mucoaldehyde affect hematopoietic stem cells as well as differentiation steps of progenitor cells for each blood cell. Hence, we concluded that benzene was associated with all lymphohematic carcinogenesis. First, it is supported by biological plausibility. Second, it is supported by meta-analysis although sing study did not show relationship due to lack of sample size or statistical power. More recent studies show lesser exposed level related to risk of cancer, compare to past studies did. Actually, early studies show the risk of malignancies in workers who exposed more than 200 ppm-years. However, only 0.5 to 1 ppm-year benzene exposed show significant linking to risk of malignancies in recent study. As reviewed research articles, we concluded that the relatively lower exposure level, such as 0.5–1 ppm-year, will be considering at risk of hematopoietic cancer. However, more research needs to be done on dose-response analysis.

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• Review on novel toxicological effects and personalized health hazard in workers exposed to low doses of benzene
  Tongshuai Wang, Yiyi Cao, Zhaolin Xia, David C. Christiani, William W. Au
  Archives of Toxicology.2024; 98(2): 365.     CrossRef
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  Boshen Wang, Fei Li, Juan Hu, Fengmei Sun, Lei Han, Juan Zhang, Baoli Zhu
  Ecotoxicology and Environmental Safety.2024; 283: 116773.     CrossRef
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  Wissawa Malakan, Sarawut Thepanondh, Jutarat Keawboonchu, Vanitchaya Kultan, Akira Kondo, Hikari Shimadera
  Air Quality, Atmosphere & Health.2024;[Epub]     CrossRef
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  Lihua Lu, Luting Luo, Xiang Li, Wanying Liu, Boheng Wu, Qing Cai, Jiazheng Li, Yan Huang, Yanxin Chen, Yongzhi Zheng, Jianda Hu
  Frontiers in Oncology.2024;[Epub]     CrossRef
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  Rayne Holland, M. Anwar H. Khan, James C. Matthews, Sophia Bonifacio, Rhian Walters, Priya Koria, Joanna Clowes, Karla Rodgers, Temi Jones, Leeya Patel, Rhianna Cross, Freya Sandberg, Dudley E. Shallcross
  International Journal of Environmental Research and Public Health.2022; 19(19): 11904.     CrossRef
• Photocatalytic destruction of volatile aromatic compounds by platinized titanium dioxide in relation to the relative effect of the number of methyl groups on the benzene ring
  Jinjian Zhang, Kumar Vikrant, Ki-Hyun Kim, Fan Dong
  Science of The Total Environment.2022; 822: 153605.     CrossRef
• Surface-Modified Wrinkled Mesoporous Nanosilica as an Effective Adsorbent for Benzene, Toluene, Ethylbenzene, and Xylene in Indoor Air
  In-Keun Shim, Jeonghoon Kim, Jin Kyu Lee, Jae-Min Oh, Jin Kuen Park
  ACS Applied Nano Materials.2022; 5(12): 18138.     CrossRef
• LincRNA-p21 promotes p21-mediated cell cycle arrest in benzene-induced hematotoxicity by sponging miRNA-17-5p
  Boshen Wang, Shouxiang Xu, Tong Wang, Kai Xu, Lihong Yin, Xiaoqin Li, Rongli Sun, Yuepu Pu, Juan Zhang
  Environmental Pollution.2022; 296: 118706.     CrossRef
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  John Ibhagbemien Anetor, Temidayo Olamide Adigun, Elizabeth Bosede Bolajoko, Gloria Oiyahumen Anetor, Bose Etaniamhe Orimadegun, Moses Olayemi Akiibinu, Godwin Osaretin Igharo, Ayobola Abolape Iyanda, Oluwakemi O. Ademola-Aremu, Chukwuemelie Zedech Uche
  American Journal of Biopharmacy and Pharmaceutical Sciences.2022; 2: 2.     CrossRef
• Evi1 involved in benzene-induced haematotoxicity via modulation of PI3K/mTOR pathway and negative regulation Serpinb2
  Rongli Sun, Linling Yu, Kai Xu, Yunqiu Pu, Jiawei Huang, Manman Liu, Juan Zhang, Lihong Yin, Yuepu Pu
  Chemico-Biological Interactions.2022; 354: 109836.     CrossRef
• The shape of low-concentration dose–response functions for benzene: implications for human health risk assessment
  Louis A. Cox, Hans B. Ketelslegers, R. Jeffrey Lewis
  Critical Reviews in Toxicology.2021; 51(2): 95.     CrossRef
• Factors Affecting Adverse Health Effects of Gasoline Station Workers
  Umakorn Tongsantia, Sunisa Chaiklieng, Pornnapa Suggaravetsiri, Sari Andajani, Herman Autrup
  International Journal of Environmental Research and Public Health.2021; 18(19): 10014.     CrossRef
• Ayurvedic formulations containing benzoic and ascorbic acids as additives: benzene formation during storage and impact of additives on quality parameters
  Priyanka Sharma, Mukesh Maithani, Vikas Gupta, Parveen Bansal
  Journal of Complementary and Integrative Medicine.2021; 18(1): 59.     CrossRef
• Evidence of inter-species swing adsorption between aromatic hydrocarbons
  Kumar Vikrant, Ki-Hyun Kim, Jan E. Szulejko, Danil Boukhvalov, Jin Shang, Jörg Rinklebe
  Environmental Research.2020; 181: 108814.     CrossRef
• Deciphering the Impact of Early-Life Exposures to Highly Variable Environmental Factors on Foetal and Child Health: Design of SEPAGES Couple-Child Cohort
  Sarah Lyon-Caen, Valérie Siroux, Johanna Lepeule, Philippe Lorimier, Pierre Hainaut, Pascal Mossuz, Joane Quentin, Karine Supernant, David Meary, Laurence Chaperot, Sam Bayat, Flemming Cassee, Sarah Valentino, Anne Couturier-Tarrade, Delphine Rousseau-Ral
  International Journal of Environmental Research and Public Health.2019; 16(20): 3888.     CrossRef
• Cell-specific regulation of Nrf2 during ROS-Dependent cell death caused by 2,3,5-tris(glutathion-S-yl)hydroquinone (TGHQ)
  Fengjiao Zhang, Frances M. Munoz, Lanlan Sun, Shuya Zhang, Serrine S. Lau, Terrence J. Monks
  Chemico-Biological Interactions.2019; 302: 1.     CrossRef