Annals of Occupational and Environmental Medicine

Research Article

Urinary arsenic species concentration in residents living near abandoned metal mines in South Korea: Jin-Yong Chung, Byoung-Gwon Kim, Byung-Kook Lee, Jai-Dong Moon, Joon Sakong, Man Joong Jeon, Jung-Duck Park, Byung-Sun Choi, Nam-Soo Kim, Seung-Do Yu, Jung-Wook Seo, Byeong-Jin Ye, Hyoun-Ju Lim, Young-Seoub Hong; Ann Occup Environ Med 2016;28:67. Published online November 22, 2016; DOI: https://doi.org/10.1186/s40557-016-0150-z

Background

Arsenic is a carcinogenic heavy metal that has a species-dependent health effects and abandoned metal mines are a source of significant arsenic exposure. Therefore, the aims of this study were to analyze urinary arsenic species and their concentration in residents living near abandoned metal mines and to monitor the environmental health effects of abandoned metal mines in Korea.

Methods

This study was performed in 2014 to assess urinary arsenic excretion patterns of residents living near abandoned metal mines in South Korea. Demographic data such as gender, age, mine working history, period of residency, dietary patterns, smoking and alcohol use, and type of potable water consumed were obtaining using a questionnaire. Informed consent was also obtained from all study subjects (n = 119). Urinary arsenic species were quantified using high performance liquid chromatography (HPLC) and inductively coupled plasma mass spectrometry (ICP/MS).

Results

The geometric mean of urinary arsenic (sum of dimethylarsinic acid, monomethylarsonic acid, As³⁺, and As⁵⁺) concentration was determined to be 131.98 μg/L (geometric mean; 95% CI, 116.72–149.23) while urinary inorganic arsenic (As³⁺ and As⁵⁺) concentration was 0.81 μg/L (95% CI, 0.53–1.23). 66.3% (n = 79) and 21.8% (n = 26) of these samples exceeded ATSDR reference values for urinary arsenic (>100 μg/L) and inorganic arsenic (>10 μg/L), respectively. Mean urinary arsenic concentrations (geometric mean, GM) were higher in women then in men, and increased with age. Of the five regions evaluated, while four regions had inorganic arsenic concentrations less than 0.40 μg/L, one region showed a significantly higher concentration (GM 15.48 μg/L; 95% CI, 7.51–31.91) which investigates further studies to identify etiological factors.

Conclusion

We propose that the observed elevation in urinary arsenic concentration in residents living near abandoned metal mines may be due to environmental contamination from the abandoned metal mine.

Trial registration

Not Applicable (We do not have health care intervention on human participants).

Citations

Citations to this article as recorded by

Assessing Acute and Chronic Risks of Human Exposure to Arsenic: A Cross-Sectional Study in Ethiopia Employing Body Biomarkers
Solomon Demissie, Seblework Mekonen, Tadesse Awoke, Bezatu Mengistie
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Chen Zhao, Meng Du, Jun Yang, Guanghui Guo, Lingqing Wang, Yunxian Yan, Xuewen Li, Mei Lei, Tongbin Chen
Science of The Total Environment.2023; 855: 158652. CrossRef
Concentrations of blood and urinary arsenic species and their characteristics in general Korean population
Jeong Weon Choi, Yoon Chae Song, Nam-Yong Cheong, Kiyoung Lee, Sunmi Kim, Kyoung-Mu Lee, Kyunghee Ji, Mi-Yeon Shin, Sungkyoon Kim
Environmental Research.2022; 214: 113846. CrossRef
MTHFR, As3MT and GSTO1 Polymorphisms Influencing Arsenic Metabolism in Residents Near Abandoned Metal Mines in South Korea
Ulziikhishig Surenbaatar, Byoung-Gwon Kim, Hyun-Jin Son, Seong-Sik Cho, Gwon-Min Kim, Hyoun-Ju Lim, Jung-Yeon Kwon, Ki-Hwan Kim, Young-Seoub Hong
Journal of Environmental Health Sciences.2021; 47(6): 530. CrossRef

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Research Article

Association of cadmium with diabetes in middle-aged residents of abandoned metal mines: the first health effect surveillance for residents in abandoned metal mines: Hee-seung Son, Soo-geun Kim, Byung-seong Suh, Dong-uk Park, Dae-seon Kim, Seung-do Yu, Yeong-seoub Hong, Jung-duck Park, Byung-kook Lee, Jai-dong Moon, Joon Sakong; Ann Occup Environ Med 2015;27:20. Published online August 24, 2015; DOI: https://doi.org/10.1186/s40557-015-0071-2

Abstract PDF PubReader ePub

Objective

The aim of this study was to determine the association between urinary cadmium (U-cd) concentration and diabetes in middle-aged Korean residents of abandoned mines using the first Health Effect Surveillance for Residents in Abandoned Metal mines (HESRAM).

Methods

This study was cross-sectional study conducted on 719 residents between 40–70 years in 38 abandoned metal mines in Korea. Data was collected by HESRAM from 2008 to 2011. The correlation coefficient of U-cd and fasting blood glucose, odds ratio in urinary cadmium tertiles and diabetes prevalence was analyzed according to the sex category.

Results

The correlation coefficient U-cd concentration and fasting blood glucose was 0.182 in male. Logistic regression analysis in male revealed a third tertile odds ratio of U-cd (2 μg/g creatinine < U-cd) while diabetes prevalence was 1.81 (95 % CI 1.05-3.12) with adjusted age, BMI, smoking and alcohol consumption, region, family income. On the other hand, the odds ratio for third tertile of U-cd (3 μg/g creatinine < U-cd) between diabetes prevalence in female was 1.39 (95 % CI 0.52-3.72) in addition to adjusted menopausal status.

Conclusions

Environmental exposure to cadmium in abandoned mine residents was associated with diabetes in male. Closed monitoring and periodic evaluation of the health effects of chronic environmental exposure on abandoned mines residents will be needed.

Citations

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Soisungwan Satarug
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Research Article

Association of Diabetes Mellitus with a Combination of Vitamin D Deficiency and Arsenic Exposure in the Korean General Population: Analysis of 2008–2009 Korean National Health and Nutrition Examination Survey Data: Byung-Kook Lee, Yangho Kim; Ann Occup Environ Med 2013;25:7-7. Published online May 21, 2013; DOI: https://doi.org/10.1186/2052-4374-25-7

Abstract PDF PubReader ePub

Objectives

We present data from the Korean National Health and Nutritional Examination Survey (KNHANES) 2008–2009 on the combination of vitamin D deficiency and arsenic exposure on diabetes mellitus (DM) in a representative sample of the adult Korean population.

Methods

This study was based on data obtained from the KNHANES 2008–2009, which was conducted for 3 years (2007–2009) using a rolling sampling design that involved a complex, stratified, multistage, probability-cluster survey of a representative sample of the non-institutionalized civilian population in South Korea.

Results

Data analysis revealed that subjects who showed both vitamin D levels in the 1^st quartile (Q) and urinary arsenic levels in the 4^th Q, had a 302% increased risk of having DM, as compared with those whose vitamin D and urinary arsenic levels were in the 4^th Q and 1^st Q, respectively.

Conclusion

The present study reconfirmed an association of DM with low vitamin D levels and arsenic exposure, and further showed a combination of vitamin D deficiency and arsenic exposure on DM in the general Korean population. To the best of our knowledge, this is the first report describing a combination of vitamin D deficiency and arsenic exposure on DM. The present findings have important public health implications.

Citations

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Association between urinary arsenic species and vitamin D deficiency: a cross-sectional study in Chinese pregnant women
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BioMed Research International.2015; 2015: 1. CrossRef

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