Abstract

The authors have experinced 8 cases of chronic carbon disulfide poisoning in workers engaged in the viacase rayon industry during the period between March 1987 and September 1988. Cases of carbon disulfide poisoning has not been reported in Korea till then. Carbon disulfide is primarily a neurotoxic poison, therefore those symptoms indicating central and peripheral nervous damage are very important. And it has toxic effects on the various organs such as skin, eye, ear, and respiratory, cardiovascular, gastrointestinal, hepatic, genitourinary, hematological, and endocrine system. Occupational histories were obtained, and clinical findings and laboratory findings were analysed on all cases. 1. Seven (7) cases had been exposed to carbon disulfide for more than 10 years, and 1 case has been exposed for 6 years. 2. Most common symptoms were neurological symptoms such as gait disturbance, extremity weakness, paresthesia, and speech disturbance. 3. Involvement of central nervous system was noted in 7 cases through abnormal findings of electroencephalography, brain computerized tomography, neurological signs, and psychological test. Needle electromyography and nerve conduction study showed polyneuropathy in all cases. Ophthalmological abnormalities were found in 7 cases, mainly retinal microaneurysms and peripheral constriction of the visual field. Renal damage appeared in 4 cases, increase of serum cholesterol and/or triglyceride level appeared in 3 cases, and dercrease of erythrocyte and hemoglobin appeared in 2 cases. And hypertenison appeared in 2 cases, and diabetes appeared in 1 case. One(1) case who has been exposed tn carbon disulfide for 6 years showed polyneuropathy and peripheral constriction of the visual field.

• Keywords: Carbon disulfide poisoning;Chronic CS2 poisoning