Abstract

Cadmium is a highly toxic element responsible for acute and chronic toxicity in man and induces pathophysiological effects by modulating components of immune system, Cytokines are being increasingly recognized as essential mediators of normal and pathologic immune response. The present study has been investigated the effect of cadmium cyto toxicity for lung fibroblast and expression of cytokine gene in unstimulated and cadmiurn-treated lung fibroblast using reverse transcription-polymerase chain reaction showed that cadmium inhibited the cell proliferation and expression of IL-6, TGF-b-mRNA in both unstimulated and cadmium-treated cell. The expression of IL-6 mRNA increased at 0.8mM and l.OmM cadmium treated for 2 hours and more increased a 0. ImM cadmium treated for 24 hours than for 2 hours. This results suggest that cadmium stimulates expression of D-i-6 mRNA in lung fibroblast.

• Keywords: Cadmium;Lung fibroblast;IL-6