Annals of Occupational and Environmental Medicine

Research Article

Association of arsenobetaine with beta-cell function assessed by homeostasis model assessment (HOMA) in nondiabetic Koreans: data from the fourth Korea National Health and Nutrition Examination Survey (KNHANES) 2008-2009: Kiook Baek, Namhoon Lee, Insung Chung; Ann Occup Environ Med 2017;29:31. Published online July 10, 2017; DOI: https://doi.org/10.1186/s40557-017-0181-0

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Background

Arsenic is known as an endocrine disruptor that people are exposed to through various sources such as drinking water and indigestion of marine products. Although some epidemiological and animal studies have reported a correlation between arsenic exposure and diabetes development, there are limited studies regarding the toxic effects of organic arsenic including arsenobetaine on the human body. Here, we analyzed the association between urine arsenobetaine and the homeostasis model assessment of β-cell function (HOMA-β), which is an index for predicting diabetes development and reflecting the function of pancreatic β-cells.

Methods

In the fourth Korea National Health and Nutrition Examination Survey (KNHANES), health and nutrition surveys and screening tests were performed. Of the total survey population, people with confirmed values for urine total arsenic and arsenobetaine were included, and known diabetic patients were excluded. A total 369 participants were finally included in the study. We collected surveys on health, height, body weight, body mass index, blood mercury level, fasting glucose level, and serum insulin level and calculated HOMA index. Owing to sexual discrepancy, we performed sexually stratified analysis.

Results

Urine total arsenic and total arsenic minus arsenobetaine was not associated with HOMA-IR and HOMA-β in univariate analysis or in sexually stratified analysis. However, urine arsenobetaine showed a statistically significant relationship with HOMA-β in univariate analysis, and only male participants showed a significant correlation in sexually stratified analysis. In the analysis adjusted for age, BMI, smoking, alcohol drinking, physical activity and blood mercury, the HOMA-β value in the group below the 25th percentile of arsenobetaine was significantly higher than the group between 50 and 75th percentile, while no difference was shown for HOMA-IR. In sexually stratified analysis, The value of HOMA-β was significantly higher in male participants with below the 25th percentile urine arsenobetaine than the group between 25 and 50th and between 50 and 75th, while no difference was shown for HOMA-IR. However, female participants did not demonstrate a relationship between HOMA–IR, HOMA-β and urine arsenobetaine.

Conclusion

This study revealed the association between urine arsenobetaine and pancreatic β-cell function assessed by HOMA-β in the normal population (without diabetes), especially in males, despite adjusting for factors affecting pancreatic β-cell function and diabetes.

Electronic supplementary material

The online version of this article (doi:10.1186/s40557-017-0181-0) contains supplementary material, which is available to authorized users.

Citations

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Research for type 2 diabetes mellitus in endemic arsenism areas in central China: role of low level of arsenic exposure and KEAP1 rs11545829 polymorphism
Chenlu Fan, Zaihong Zhan, Xin Zhang, Qun Lou, Ning Guo, Mengyao Su, Yue Gao, Ming Qin, Liaowei Wu, Wei Huang, Meichen Zhang, Fanshuo Yin, Yanhui Wu, Jingbo Pi, Yuanyuan Xu, Yanmei Yang, Yanhui Gao
Archives of Toxicology.2022; 96(6): 1673. CrossRef
Arsenic exposure during pregnancy and postpartum maternal glucose tolerance: evidence from Bangladesh
Abby F. Fleisch, Sudipta Kumer Mukherjee, Subrata K. Biswas, John F. Obrycki, Sheikh Muhammad Ekramullah, D. M. Arman, Joynul Islam, David C. Christiani, Maitreyi Mazumdar
Environmental Health.2022;[Epub] CrossRef
Maternal and childhood exposure to inorganic arsenic and airway allergy – A 15-Year birth cohort follow-up study
Tsung-Lin Tsai, Wei-Te Lei, Chin-Chi Kuo, Hai-Lun Sun, Pen-Hua Su, Shu-Li Wang
Environment International.2021; 146: 106243. CrossRef
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Environment International.2021; 156: 106741. CrossRef
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Evin Kocatürk, Ezgi Kar, Zeynep Küskü Kiraz, Özkan Alataş
Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2020; 14(6): 2147. CrossRef
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Current Research in Green and Sustainable Chemistry.2020; 3: 100009. CrossRef
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Tania Ruíz-Vera, Ángeles C. Ochoa-Martínez, Sergio Zarazúa, Leticia Carrizales-Yáñez, Iván N. Pérez-Maldonado
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Tahereh Farkhondeh, Saeed Samarghandian, Mohsen Azimi‐Nezhad
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Shadassa Ourshalimian, Abu Mohd Naser, Mahbubur Rahman, Solaiman Doza, Jennifer Stowell, K.M. Venkat Narayan, Mohammad Shamsudduha, Matthew O. Gribble
Environmental Research.2019; 172: 249. CrossRef

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Research Article

Assessment of Arsenic Exposure by Measurement of Urinary Speciated Inorganic Arsenic Metabolites in Workers in a Semiconductor Manufacturing Plant: Kiwhan Byun, Yong Lim Won, Yang In Hwang, Dong-Hee Koh, Hosub Im, Eun-A Kim; Ann Occup Environ Med 2013;25:21-21. Published online October 11, 2013; DOI: https://doi.org/10.1186/2052-4374-25-21

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Objectives

The purpose of this study was to evaluate the exposure to arsenic in preventive maintenance (PM) engineers in a semiconductor industry by detecting speciated inorganic arsenic metabolites in the urine.

Methods

The exposed group included 8 PM engineers from the clean process area and 13 PM engineers from the ion implantation process area; the non-exposed group consisted of 14 office workers from another company who were not occupationally exposed to arsenic. A spot urine specimen was collected from each participant for the detection and measurement of speciated inorganic arsenic metabolites. Metabolites were separated by high performance liquid chromatography-inductively coupled plasma spectrometry-mass spectrometry.

Results

Urinary arsenic metabolite concentrations were 1.73 g/L, 0.76 g/L, 3.45 g/L, 43.65 g/L, and 51.32 g/L for trivalent arsenic (As³⁺), pentavalent arsenic (As⁵⁺), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), and total inorganic arsenic metabolites (As³⁺ + As⁵⁺ + MMA + DMA), respectively, in clean process PM engineers. In ion implantation process PM engineers, the concentrations were 1.74 g/L, 0.39 g/L, 3.08 g/L, 23.17 g/L, 28.92 g/L for As³⁺, As⁵⁺, MMA, DMA, and total inorganic arsenic metabolites, respectively. Levels of urinary As³⁺, As⁵⁺, MMA, and total inorganic arsenic metabolites in clean process PM engineers were significantly higher than that in the non-exposed group. Urinary As³⁺ and As⁵⁺ levels in ion implantation process PM engineers were significantly higher than that in non-exposed group.

Conclusion

Levels of urinary arsenic metabolites in PM engineers from the clean process and ion implantation process areas were higher than that in office workers. For a complete assessment of arsenic exposure in the semiconductor industry, further studies are needed.

Citations

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Julie M. Croff, Ryan Bogdan, Sara B. Johnson, Ludmila N. Bakhireva
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Dong-Uk Park, Sangjun Choi, Seunghee Lee, Dong-Hee Koh, Hyoung-Ryoul Kim, Kyong-Hui Lee, Jihoon Park
Safety and Health at Work.2019; 10(3): 347. CrossRef
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Bo-Xi Liao, Neng-Chun Tseng, Ziyi Li, Yingshu Liu, Jen-Kun Chen, Chuen-Jinn Tsai
Journal of Nanoparticle Research.2018;[Epub] CrossRef
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The Annals of Occupational Hygiene.2015;[Epub] CrossRef
Considerations in deriving quantitative cancer criteria for inorganic arsenic exposure via inhalation
Ari S. Lewis, Leslie A. Beyer, Ke Zu
Environment International.2015; 74: 258. CrossRef
Reproductive Hazards Still Persist in the Microelectronics Industry: Increased Risk of Spontaneous Abortion and Menstrual Aberration among Female Workers in the Microelectronics Industry in South Korea
Inah Kim, Myoung-Hee Kim, Sinye Lim, Roger C. Young
PLOS ONE.2015; 10(5): e0123679. CrossRef
The separation of arsenic metabolites in urine by high performance liquid chromatographyinductively coupled plasma-mass spectrometry
Jin-Yong Chung, Hyoun-Ju Lim, Young-Jin Kim, Ki-Hoon Song, Byoung-Gwon Kim, Young-Seoub Hong
Environmental Health and Toxicology.2014; 29: e2014018. CrossRef

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