Annals of Occupational and Environmental Medicine

Original Article

Association between sitting-time at work and incidence of erosive esophagitis diagnosed by esophagogastroduodenoscopy: a Korean cohort study: Daehoon Kim, Yesung Lee, Eunchan Mun, Eunhye Seo, Jaehong Lee, Youshik Jeong, Jinsook Jeong, Woncheol Lee; Ann Occup Environ Med 2022;34:e15. Published online July 21, 2022; DOI: https://doi.org/10.35371/aoem.2022.34.e15

Abstract Abstract in Korean PDF PubReader ePub

Background

Most previous longitudinal studies on lifestyle and gastroesophageal reflux disease (GERD) have focused on physical activity rather than sitting time. The main purpose of this study was to investigate the relationship between prolonged sitting time and the development of erosive esophagitis (EE).

Methods

A self-report questionnaire was used for measuring sitting time in the Kangbuk Samsung Health Study. Sitting time was categorized into four groups: ≤ 6, 7–8, 9–10, and ≥ 11 hours/day. Esophagogastroduodenoscopy (EGD) was performed by experienced endoscopists who were unawared of the aims of this study. Hazard ratios (HRs) and 95% confidence intervals (CIs) for the development of EE were estimated using Cox proportional hazards analyses with ≤ 6 hours/day sitting time as the reference.

Results

There were 6,524 participants included in the study. During a mean follow-up of 3.14 years, 2,048 incident cases developed EE. In age- and sex-adjusted models, the HR in the group sitting ≥ 11 hours per day compared ≤ 6 hours per day was 0.88 (95% CI: 0.76–0.99). After further adjusting for alcohol intake, smoking status, educational level, history of diabetes, and history of dyslipidemia, sitting time was still significantly related to the risk of EE (HR, 0.87; 95% CI: 0.76–0.98). After further adjustment for exercise frequency, this association persisted (HR, 0.86; 95% CI: 0.76–0.98). In subgroup analysis by obesity, the relationship between sitting time and EE was only significant among participants with body mass index < 25 kg/m² (HR, 0.82; 95% CI: 0.71–0.95).

Conclusions

Generally, prolonged sitting time is harmful to health, but with regard to EE, it is difficult to conclude that this is the case.

업무상 앉아 있는 시간과 식도위 십이지장 내시경으로 진단된 미란성 식도염 발병률의 연관성: 일개 한국인 코호트 연구
목적
생활습관이 역류성 식도염에 어떤 영향을 미치는지에 대한 종단 연구는 대부분 신체활동에 대한 내용이다. 따라서 이번 연구에서는 하루 중 앉아 있는 시간이 Erosive esophagitis 발병에 어떤 영향을 미치는지에 대해 알아보고자 한다.
방법
본원 건강검진센터를 방문한 수검자의 데이터를 이용하였다. Sitting time 의 측정은 설문지를 사용하였으며, 다음과 같이 총 4그룹으로 범주화하였다: ≤6, 7–8, 9–10, and ≥11 hours/day. 내시경 전문가에 의해 시행된 위내시경 소견 자료를 이용하였으며, Sitting time 이 Erosive esophagitis 발병에 어떤 영향을 미치는지 알아보고자 하루 평균 6시간 이하 앉아 있는 그룹을 기준으로 Cox proportional hazard model 을 이용해 생존분석을 시행했다.
결과
총 6,524 명의 대상자를 평균 3.14년 추적관찰하였고, 그 결과 2,048 명의 incident cases 를 발견하였다. 연령과 성별을 보정한 모델 1에서 기준 그룹보다 하루 평균 11시간 이상 앉아 있는 그룹에서 Hazard ratio(HR) 가 0.88 (95% CI 0.76-0.99) 로 발병위험도가 낮은 것으로 나타났다. 음주, 흡연, 교육 수준, 당뇨병 및 고지혈증 과거력을 보정한 모델 2에서도 HR 가 0.87(95% CI 0.76-0.98) 로 발병위험도가 여전히 낮았으며, 운동 빈도를 추가로 보정한 모델 3에서도 HR 가 0.86(0.76-0.98) 으로 발병위험도가 낮은 것으로 나타났다. 비만 유무에 따라 층화분석을 시행하였을 때, BMI < 25 kg/m2 인 비비만 그룹에서만 통계적으로 유의미한 결과를 보였다. (HR = 0.82, 95% CI : 0.71–0.95).
결론
일반적으로, prolonged sitting time 은 건강에 해롭지만, 역류성 식도염에 대해서는 그렇게 결론 내리기 어렵다.

Citations

Citations to this article as recorded by

Causal links between socioeconomic status, leisure sedentary behaviours and gastro-oesophageal reflux disease: a multivariable two-sample Mendelian randomisation study
Xingji Lian, Yifen Lin, Xiaohui Peng, Yanhui Wang, Ting He, Ziyong He, Wenlong Gu, Hongwu Wang, Feng He, Yuyu Huang
Journal of Epidemiology and Community Health.2023; 77(7): 460. CrossRef

71 View
0 Download
1 Web of Science
1 Crossref

Case Report

Work-related olfactory disorder: a case series and review: Soon Woo Park, Young Joong Kang, Huisu Eom, Hyun-Jin Cho, Jungho Ahn, Sang-Gil Lee; Ann Occup Environ Med 2018;30:18. Published online March 12, 2018; DOI: https://doi.org/10.1186/s40557-018-0230-3

Abstract PDF PubReader ePub

Background

The olfactory bulb is anatomically exposed and thus can be directly damaged by external stimulation. This can occur as an occupational injury owing to contact with organic solvents or other causes. We present cases of eight patients who sustained occupation-related exposure to potentially toxic substances and later presented with signs and symptoms of anosmia. We examined the occupational and medical characteristics of the patients and evaluated their work-relatedness.

Case presentation

Case 1: A 50-year-old man performed high-frequency heat treatments for approximately 11 years. He experienced decreased senses for olfaction and taste during the later years culminating in the diagnosis of anosmia after 3 years (high work-relatedness). Case 2: A 54-year-old man whose work involved exposure to various organic solvents, such as spray painting and application of paint and thinners for approximately 4 years, was subsequently diagnosed with anosmia based on rhinorrhea, headache, and loss of olfaction (high work-relatedness). Case 3: A 44-year-old-man who performed spray painting for approximately 17 years developed anosmia (high work-relatedness). Case 4: A 44-year-old man was involved in ship engine cleaning once a month, for approximately 7 h per cleaning session; he was diagnosed with anosmia based on loss of olfaction (low work-relatedness). Case 5: A 41-year-old man worked in ship building block construction for approximately 13 years; anosmia diagnosis was based on loss of olfaction (low work-relatedness). Case 6: A 47-year-old woman performed product inspection and labeling at a plant manufacturing automobile parts; anosmia diagnosis was based on decreased olfaction and taste (low work-relatedness). Case 7: A 50-year-old woman performed epoxy coating in a plant manufacturing automobile parts; anosmia diagnosis was based on diminishing olfaction (low work-relatedness). Case 8: A 57-year-old woman performed cleaning of the area where mobile phone parts were manufactured; anosmia diagnosis was based on diminishing olfaction (low work-relatedness).

Conclusion

The study results confirmed work-relatedness when the subject was young, and the duration of exposure was long without any other cause of anosmia. Regarding compensation for occupational diseases, work-relatedness can be recognized as a relative concept.

Citations

Citations to this article as recorded by

Predictors of Olfactory Decline in Aging: A Longitudinal Population-Based Study
Ingrid Ekström, Maria Larsson, Debora Rizzuto, Johan Fastbom, Lars Bäckman, Erika J Laukka, Anne B Newman
The Journals of Gerontology: Series A.2020; 75(12): 2441. CrossRef

59 View
0 Download
1 Web of Science
1 Crossref

Review

Evaluation of mercury exposure level, clinical diagnosis and treatment for mercury intoxication: Byeong-Jin Ye, Byoung-Gwon Kim, Man-Joong Jeon, Se-Yeong Kim, Hawn-Cheol Kim, Tae-Won Jang, Hong-Jae Chae, Won-Jun Choi, Mi-Na Ha, Young-Seoub Hong; Ann Occup Environ Med 2016;28:5. Published online January 22, 2016; DOI: https://doi.org/10.1186/s40557-015-0086-8

Abstract PDF PubReader ePub

Mercury occurs in various chemical forms, and it is different to health effects according to chemical forms. In consideration of the point, the evaluation of the mercury exposure to human distinguished from occupational and environmental exposure.

With strict to manage occupational exposure in factory, it is declined mercury intoxication cases by metallic and inorganic mercury inhalation to occupational exposure. It is increasing to importance in environmental exposure and public health.

The focus on the health impact of exposure to mercury is more on chronic, low or moderate grade exposure—albeit a topic of great controversy—, not high concentration exposure by methylmercury, which caused Minamata disease.

Recently, the issue of mercury toxicity according to the mercury exposure level, health effects as well as the determination of what mercury levels affect health are in the spotlight and under active discussion. Evaluating the health effects and Biomarker of mercury exposure and establishing diagnosis and treatment standards are very difficult.

It can implement that evaluating mercury exposure level for diagnosis by a provocation test uses chelating agent and conducting to appropriate therapy according to the result. but, indications for the therapy of chelating agents with mercury exposure have not yet been fully established.

The therapy to symptomatic patients with mercury poisoning is chelating agents, combination therapy with chelating agents, plasma exchange, hemodialysis, plasmapheresis. But the further evaluations are necessary for the effects and side effects with each therapy.

Citations

Citations to this article as recorded by

Ameliorative impacts of sinapic acid against mercuric chloride-induced renal toxicity: role of antioxidants and inflammatory cytokines
Arshad Mehmood, Mohamed Mohamed Soliman, Daklallah A Almalki, Khalid S Alotaibi, Gehan Basiony Ahmed Youssef, Saed Althobaiti
Toxicology Research.2024;[Epub] CrossRef
Health and environmental risk assessment of mercury in outdoor and indoor dust in artisanal and small-scale gold mining area in Amansie-west district in the Ashanti Region of Ghana
Patrick Adu Poku, Sylvester Addai-Arhin, Collins Nimako, Syafran Arrazy, Tia Agustiani, Huiho Jeong, Tetsuro Agusa, Yasuhiro Ishibashi, Jun Kobayashi
Environmental Geochemistry and Health.2024;[Epub] CrossRef
Ion-Selective Electrodes in the Food Industry: Development Trends in the Potentiometric Determination of Ionic Pollutants
Antonio Ruiz-Gonzalez
Electrochem.2024; 5(2): 178. CrossRef
Anthropogenic short-lived halogens increase human exposure to mercury contamination due to enhanced mercury oxidation over continents
Xiao Fu, Xianyi Sun, Oleg Travnikov, Qinyi Li, Chuang Qin, Carlos A. Cuevas, Rafael P. Fernandez, Anoop S. Mahajan, Shuxiao Wang, Tao Wang, Alfonso Saiz-Lopez
Proceedings of the National Academy of Sciences.2024;[Epub] CrossRef
Toxicological and bioremediation profiling of nonessential heavy metals (mercury, chromium, cadmium, aluminium) and their impact on human health: A review
Harsh Sable, Vandana Singh, Vaishali Kumar, Arpita Roy, Soumya Pandit, Kirtanjot Kaur, Sarvesh Rustagi, Sumira Malik
Toxicologie Analytique et Clinique.2024; 36(3): 205. CrossRef
Mercury risk assessment scenarios: exposure from fish dietary behaviors of Katingan River Basin community
Fika R. Mufakhir, Gunawan P. Yoga, Taryono Darusman, Dwi P. Lestari, Desra Arriyadi, Rosetyati R. Utami, Slamet Sumardi, Widi Astuti, Hendra Prasetia
International Journal of Environmental Health Research.2024; 34(9): 3317. CrossRef
Review and assessment of mercury contamination and risk in sediment and food chain near a chlor-alkali plant
Sedigheh Mohamadi, Mohsen Saeedi
Emerging Contaminants.2024; 10(4): 100384. CrossRef
Maternal exposure to bisphenols, phthalates, perfluoroalkyl acids, and trace elements and their associations with gestational diabetes mellitus in the APrON cohort
Munawar Hussain Soomro, Gillian England-Mason, Anthony J.F. Reardon, Jiaying Liu, Amy M. MacDonald, David W. Kinniburgh, Jonathan W. Martin, Deborah Dewey
Reproductive Toxicology.2024; 127: 108612. CrossRef
Baseline characteristics including blood and urine metal levels in the Trial to Assess Chelation Therapy 2 (TACT2)
Ana Navas-Acien, Regina M. Santella, Bonnie R. Joubert, Zhen Huang, Yuliya Lokhnygina, Francisco Ujueta, Irina Gurvich, Nancy J. LoIacono, Filippo Ravalli, Cynthia D. Ward, Jeffery M. Jarrett, Alfonsina De Leon Salazar, Robin Boineau, Teresa L.Z. Jones, D
American Heart Journal.2024; 273: 72. CrossRef
Seasonal and age-dependent differences in mercury concentrations in Apodemus sp. in the north-western region of Slovakia
Lenka Zábojníková
Environmental Science and Pollution Research.2024; 31(7): 10521. CrossRef
Complementary and Alternative Medicine Use and Glomerular Disease: A Contemporary Case Series
Prem Kumar Devaraju, Jayalakshmi Seshadri, Chelvamalai Muthukumaran Balasubramanian, Anila Abraham Kurien, Guhan Senthilkumaran, Vaishanavi Devi Rajarathinam, Vijayakumar Stanlybai Jibia, Vinoj Murugesan, Tanuj Moses Lamech, Dineshkumar Thanigachalam, Sak
Kidney Medicine.2024; 6(6): 100827. CrossRef
Surgical Management of Iatrogenic Mercury Poisoning From Subcutaneous Injection Into the Arm
Evan C. Bowen, Katherine C. Benedict, John M. Sullivan, Katherine E. Baker, Morgan E. Schock, Marc E. Walker
Annals of Plastic Surgery.2024; 93(2): 205. CrossRef
Acute onset parkinsonism after consumption of traditional Chinese medicine: A cause for vigilance
Ko-Ying Kuo, Ying-Sheng Li, Poyin Huang
Heliyon.2024; 10(11): e31628. CrossRef
Should ebselen be considered for the treatment of mercury intoxication? A minireview
Nilda V. Barbosa, Michael Aschner, Alexey A. Tinkov, Marcelo Farina, João Batista Teixeira da Rocha
Toxicology Mechanisms and Methods.2024; 34(1): 1. CrossRef
Public health assessment of Kenyan ASGM communities using multi-element biomonitoring, dietary and environmental evaluation
Maureene Auma Ondayo, Michael J. Watts, Olivier S. Humphrey, Odipo Osano
Ecotoxicology and Environmental Safety.2024; 277: 116323. CrossRef
MEASUREMENT OF PERSISTENT ORGANIC POLLUTANTS, PERFLUORINATED COMPOUNDS, AND TOXIC METALS IN THE BLOOD OF HUMBOLDT PENGUINS (SPHENISCUS HUMBOLDTI) AT PUNTA SAN JUAN, PERU USING DRIED BLOOD SPOTS
Michael J. Adkesson, Alan Shlosberg, Andreas F. Lehner, Wilson K. Rumbeiha, Susana Cárdenas-Alayza, Marco Cardeña-Mormontoy, Kurunthachalam Kannan
Journal of Zoo and Wildlife Medicine.2024;[Epub] CrossRef
Exposure to heavy metals and neurocognitive function in adults: a systematic review
Raed H. Althomali, Manal A. Abbood, Ebraheem Abdu Musad Saleh, Laylo Djuraeva, Barno Sayfutdinovna Abdullaeva, Ruqayah Taher Habash, Muataz S. Alhassan, Ahmed Hussien Radie Alawady, Ali Hashiem Alsaalamy, Moslem Lari Najafi
Environmental Sciences Europe.2024;[Epub] CrossRef
A photoluminescent and electrochemiluminescent probe based on an iridium(iii) complex with a boronic acid-functionalised ancillary ligand for the selective detection of mercury(ii) ions
Kyoung-Rok Kim, Jinrok Oh, Jong-In Hong
The Analyst.2023; 148(22): 5619. CrossRef
Report of the Scientific Committee of the Spanish Agency for Food Safety and Nutrition (AESAN) on the available evidence in relation to the potential obesogenic activity of certain chemical compounds that may be present in foods
Ana María Rivas Velasco, Irene Bretón Lesmes, Araceli Díaz Perales, Ángel Gil Izquierdo, María José González Muñoz, Victoria Moreno Arribas, María del Puy Portillo Baquedano, Silvia Pichardo Sánchez
Food Risk Assess Europe.2023;[Epub] CrossRef
Colorimetric detection of mercury (Hg2+) using UV–vis spectroscopy and digital image analysis based on gold nanoparticles functionalized with bromelain enzyme
Nurul Azreen Suhaidi, Mohd Izuan Effendi Halmi, Asraf Alif Rashidi, Mohd Firdaus Mohd Anuar, Khairil Mahmud, Norzila Kusnin, Siti Salwa Abd Gani, Mohd Yunus Abd Shukor
3 Biotech.2023;[Epub] CrossRef
The switchable fluorescent detection of mercury, copper, and iodine in real water samples using bola-amphiphilic-tetraphenylethene
Sinan Bayindir, Abdullah Saleh Hussein, Ferruh Lafzi, Mahmut Toprak
Journal of Molecular Liquids.2023; 382: 121939. CrossRef
Human biomonitoring of environmental contaminants in Gulf Countries – current status and future directions
Raghad Khaled, Shahd Elabed, Asmaa Masarani, Anfal Almulla, Shamsa Almheiri, Rinsha Koniyath, Lucy Semerjian, Khaled Abass
Environmental Research.2023; 236: 116650. CrossRef
Antioxidant Supplementation Alleviates Mercury-Induced Cytotoxicity and Restores the Implantation-Related Functions of Primary Human Endometrial Cells
Andrea Palomar, Alicia Quiñonero, Yassmin Medina-Laver, Roberto Gonzalez-Martin, Silvia Pérez-Debén, Pilar Alama, Francisco Domínguez
International Journal of Molecular Sciences.2023; 24(10): 8799. CrossRef
Hg Content in EU and Non-EU Processed Meat and Fish Foods
Vincenzo Nava, Giuseppa Di Bella, Francesco Fazio, Angela Giorgia Potortì, Vincenzo Lo Turco, Patrizia Licata
Applied Sciences.2023; 13(2): 793. CrossRef
Gingerol extract-stabilized silver nanoparticles and their applications: colorimetric and machine learning-based sensing of Hg(ii) and antibacterial properties
Kittiya Plaeyao, Ratchaneekorn Kampangta, Yuparat Korkokklang, Chanon Talodthaisong, Apichart Saenchoopa, Saengrawee Thammawithan, Krailikhit Latpala, Rina Patramanon, Navaphun Kayunkid, Sirinan Kulchat
RSC Advances.2023; 13(29): 19789. CrossRef
A method for reliable quantification of mercury in occupational and environmental medical urine samples by inductively coupled plasma mass spectrometry
Martin Winter, Frederik Lessmann, Volker Harth
Analytical Methods.2023; 15(16): 2030. CrossRef
A brief study on the role of cerium oxide nanoparticles in growth and alleviation of mercury-induced stress in Vigna radiata and soil bacteria Bacillus coagulans
Sampurna Mukherjee, Suresh Babu Krishnamoorthy, Rengaraj Subrayan, Arunava Goswami, Sutanuka Mitra
Environmental Science and Pollution Research.2023; 30(29): 73952. CrossRef
Assessing the Correlation between Blood Trace Element Concentrations, Picky Eating Habits, and Intelligence Quotient in School-Aged Children
Abdullah A. Saati, Heba M. Adly
Children.2023; 10(7): 1249. CrossRef
Blood and Urinary Metal Levels among Exclusive Marijuana Users in NHANES (2005–2018)
Katlyn E. McGraw, Anne E. Nigra, Joshua Klett, Marisa Sobel, Elizabeth C. Oelsner, Ana Navas-Acien, Xin Hu, Tiffany R. Sanchez
Environmental Health Perspectives.2023;[Epub] CrossRef
Genome-Wide Association Study of Blood Mercury in European Pregnant Women and Children
Kyle Dack, Mariona Bustamante, Caroline M. Taylor, Sabrina Llop, Manuel Lozano, Paul Yousefi, Regina Gražulevičienė, Kristine Bjerve Gutzkow, Anne Lise Brantsæter, Dan Mason, Georgia Escaramís, Sarah J. Lewis
Genes.2023; 14(12): 2123. CrossRef
Acute Mercury Poisoning in Young Children: When to Treat?
Sudha Chandelia, Viresh Vohra, Shankar Prasad, Mithlesh Kumar Tiwari, Karthi Nallasamy, Suresh Kumar Angurana
Indian Journal of Pediatrics.2023; 90(6): 629. CrossRef
Electrochemical separation and purification of no-carrier-added 177Lu for radiopharmaceutical preparation: Translation from bench to bed
Sourav Patra, Rubel Chakravarty, Khajan Singh, K.V. Vimalnath, Sudipta Chakraborty
Chemical Engineering Journal Advances.2023; 14: 100444. CrossRef
Suicidal intoxication with mercury chloride
Sławomir Majdanik, Barbara Potocka-Banaś, Sebastian Glowinski, Sylwester Luzny
Forensic Toxicology.2023; 41(2): 304. CrossRef
Biomonitoring of firefighting forces: a review on biomarkers of exposure to health-relevant pollutants released from fires
Bela Barros, Marta Oliveira, Simone Morais
Journal of Toxicology and Environmental Health, Part B.2023; 26(3): 127. CrossRef
Barbituric acid appended fluorescent sensor for the detection of Cu2+/Hg2+ ions along with real-life utility in recognition of malathionin food samples and fingerprint imaging
Gitanjali Jindal, Navneet Kaur
Journal of Photochemistry and Photobiology A: Chemistry.2023; 434: 114238. CrossRef
A methionine biomolecule-modified chromenylium-cyanine fluorescent probe for the analysis of Hg2+ in the environment and living cells
Yusuf Alcay, Emre Ozdemir, Mustafa Semih Yildirim, Utku Ertugral, Ozgur Yavuz, Hulya Aribuga, Yilmaz Ozkilic, Nurcan Şenyurt Tuzun, Ayse Buse Ozdabak Sert, Fatma Nese Kok, Ismail Yilmaz
Talanta.2023; 259: 124471. CrossRef
Associations between exposure to cadmium, lead, mercury and mixtures and women’s infertility and long-term amenorrhea
Maria McClam, Jihong Liu, Yihan Fan, Tingjie Zhan, Qiang Zhang, Dwayne E. Porter, Geoffrey I. Scott, Shuo Xiao
Archives of Public Health.2023;[Epub] CrossRef
Spots in Dermatology
Swathy Prasannan, AS Savitha, TS Nagesh
Clinical Dermatology Review.2022; 6(1): 59. CrossRef
Domestic water and accumulating mercury toxicity in the kidney
Raafat Abdeldayem
Applied Water Science.2022;[Epub] CrossRef
Effects of Low-Level Organic Mercury Exposure on Oxidative Stress Profile
Radu Ciprian Tincu, Cristian Cobilinschi, Iulia Alexandra Florea, Ana-Maria Cotae, Alexandru Emil Băetu, Sebastian Isac, Raluca Ungureanu, Gabriela Droc, Ioana Marina Grintescu, Liliana Mirea
Processes.2022; 10(11): 2388. CrossRef
Renaissance mercurial therapy in the mummies of Saint Domenico Maggiore in Naples: a palaeopathological and palaeotoxicological approach
Antonio Fornaciari, Silvio Chericoni, Fabio Stefanelli, Gino Fornaciari, Valentina Giuffra
Archaeological and Anthropological Sciences.2022;[Epub] CrossRef
A Systematic Review of Mercury Exposures from Skin-Lightening Products
Ashley Bastiansz, Jessica Ewald, Verónica Rodríguez Saldaña, Andrea Santa-Rios, Niladri Basu
Environmental Health Perspectives.2022;[Epub] CrossRef
Recurrent Rash in an 11-Year-Old Boy With Pericardial and Pleural Effusions
Allison M. Weisnicht, Ryan Byrne, Erin B. Henkel, Stephen A. Harding, Stefan P. Kostelyna, Deborah Schady, Jamie Lai, Leigh A. Stubbs
Pediatrics.2022;[Epub] CrossRef
Prenatal Mercury Exposure and Infant Weight Trajectories in a UK Observational Birth Cohort
Kyle Dack, Robyn E. Wootton, Caroline M. Taylor, Sarah J. Lewis
Toxics.2022; 11(1): 10. CrossRef
Colorimetric screening of elevated urinary mercury levels by a novel Hg2+-selective probe of resorufin phosphinothioate
Myung Gil Choi, Byung Hoon Yun, Hyeong Min Kim, Sangdoo Ahn, Suk-Kyu Chang
RSC Advances.2022; 12(37): 24107. CrossRef
Heavy metal-induced lipogenic gene aberration, lipid dysregulation and obesogenic effect: a review
Yang Zhou, Frank Peprah Addai, Xinshuang Zhang, Yuelin Liu, Yinfeng Wang, Feng Lin, Alex Tuffour, Jie Gu, Guangxiang Liu, Haifeng Shi
Environmental Chemistry Letters.2022; 20(3): 1611. CrossRef
Functional consequences of lead and mercury exposomes in the heart
Gonzalo Ferreira, Axel Santander, Luisina Chavarría, Romina Cardozo, Florencia Savio, Luis Sobrevia, Garth L. Nicolson
Molecular Aspects of Medicine.2022; 87: 101048. CrossRef
Sensitive fluorescent chemosensor for Hg(II) in aqueous solution using 4’-dimethylaminochalcone
Marco Mellado, Nicole Roldán, Rodrigo Miranda, Luis F. Aguilar, Manuel A. Bravo, Waldo Quiroz
Journal of Fluorescence.2022; 32(4): 1449. CrossRef
Beyond efficiency fever: Preventing lead leakage for perovskite solar cells
Pengfei Wu, Shirong Wang, Xianggao Li, Fei Zhang
Matter.2022; 5(4): 1137. CrossRef
A Reversible Optical Sensor Film for Mercury Ions Discrimination Based on Isoxazolidine Derivative and Exhibiting pH Sensing
Reham Ali, Siwar Ghannay, Sabri Messaoudi, Fahad M. Alminderej, Kaïss Aouadi, Sayed M. Saleh
Biosensors.2022; 12(11): 1028. CrossRef
Mercury pollution in Peru: geographic distribution, health hazards, and sustainable removal technologies
Fernando G. Torres, Gabriel E. De-la-Torre
Environmental Science and Pollution Research.2022; 29(36): 54045. CrossRef
Occupational exposure to mercury from cinnabar enriched sand in workers of Grado Beach, Gulf of Trieste (North-eastern Italy, upper Adriatic Sea)
Luca Cegolon, Giuseppe Mastrangelo, Stefano Covelli, Elisa Petranich, Elena Pavoni, Francesca Larese Filon
Marine Pollution Bulletin.2022; 184: 114057. CrossRef
Mercury and Movement Disorders: The Toxic Legacy Continues
Jacky Ganguly, Dinkar Kulshreshtha, Mandar Jog
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.2022; 49(4): 493. CrossRef
SNS donors as mimic to enzymes, chemosensors, and imaging agents
Poonam Kaswan, Preeti Oswal, Arun Kumar, Chandra Mohan Srivastava, Dipti Vaya, Varun Rawat, Kamal Nayan Sharma, Gyandshwar Kumar Rao
Inorganic Chemistry Communications.2022; 136: 109140. CrossRef
Aptasensors for full body health checkup
Tanu Bhardwaj, Tarun Kumar Sharma
Biosensors and Bioelectronics: X.2022; 11: 100199. CrossRef
Concentration of mercury in human hair and associated factors in residents of the Gulf of Trieste (North-Eastern Italy)
Luca Cegolon, Elisa Petranich, Elena Pavoni, Federico Floreani, Nicolò Barago, Elisa Papassissa, Francesca Larese Filon, Stefano Covelli
Environmental Science and Pollution Research.2022; 30(8): 21425. CrossRef
Ziziphus spina-christi Leaf Extract Mitigates Mercuric Chloride-induced Cortical Damage in Rats
Rafa S. Almeer, Saad Alkahtani, Saud Alarifi, Ahmed E. Abdel Moneim, Saba Abdi, Gadah Albasher
Combinatorial Chemistry & High Throughput Screening.2021; 25(1): 103. CrossRef
Maternal Urinary Metal and Metalloid Concentrations in Association with Oxidative Stress Biomarkers
Pahriya Ashrap, Deborah J. Watkins, Ginger L. Milne, Kelly K. Ferguson, Rita Loch-Caruso, Jennifer Fernandez, Zaira Rosario, Carmen M. Vélez-Vega, Akram Alshawabkeh, José F. Cordero, John D. Meeker
Antioxidants.2021; 10(1): 114. CrossRef
Changes in the renal function after acute mercuric chloride exposure in the rat are associated with renal vascular endothelial dysfunction and proximal tubule NHE3 inhibition
João Vitor dos Anjos Vieira, Vinicius Bermond Marques, Luiza Valli Vieira, Renato de Oliveira Crajoinas, Maria Heloisa Massola Shimizu, Antonio Carlos Seguro, Maria Tereza Weitzel Dias Carneiro, Adriana Castello Costa Girardi, Dalton Valentim Vassallo, Le
Toxicology Letters.2021; 341: 23. CrossRef
Children with Amalgam Dental Restorations Have Significantly Elevated Blood and Urine Mercury Levels
Lei Yin, Simon Lin, Anne O Summers, Van Roper, Matthew J Campen, Xiaozhong Yu
Toxicological Sciences.2021; 184(1): 104. CrossRef
Speciation analysis of mercury employing volatile species generation: Approaches to reliable determination in blood and hair
Inga Petry-Podgórska, Věra Schrenková, Michaela Migašová, Tomáš Matoušek, Jan Kratzer
Microchemical Journal.2021; 170: 106606. CrossRef
Assessment of radioactivity and heavy metals in water sources from Artisanal mining areas of Anka, Northwest Nigeria
Mbet Amos Akpanowo, Nasiru Adebayo Bello, Ibrahim Umaru, Shekwonyadu Iyakwari, Emmanuel Joshua, Samson Yusuf, Godwin Bassey Ekong
Scientific African.2021; 12: e00761. CrossRef
Metals and Metal-Nanoparticles in Human Pathologies: From Exposure to Therapy
Joanna Izabela Lachowicz, Luigi Isaia Lecca, Federico Meloni, Marcello Campagna
Molecules.2021; 26(21): 6639. CrossRef
Functionalized magnetic nanoparticles Fe3O4@SiO2@PTA (PTA = (2-pyrimidylthio)acetic acid) for efficient removal of mercury from water
Gaurav Vyas, Shreya Bhatt, Parimal Paul
Colloids and Surfaces A: Physicochemical and Engineering Aspects.2021; 611: 125861. CrossRef
Identification of metal binding motifs in protein frameworks to develop novel remediation strategies for Hg2+ and Cr(VI)
J. Sreeshma, C. Sudandiradoss
BioMetals.2021; 34(3): 621. CrossRef
Comparison of Ultrastructural Features Between Patients with Mercury-associated Membranous Nephropathy and Idiopathic Membranous Nephropathy
Ai-bo Qin, Zi-shan Lin, Su-xia Wang, Hui Wang, Zhao Cui, Fu-de Zhou, Ming-hui Zhao
The American Journal of the Medical Sciences.2021; 361(3): 327. CrossRef
Recent Advances on the Development of Chemosensors for the Detection of Mercury Toxicity: A Review
Shiva Prasad Kollur, Chandan Shivamallu, Shashanka K. Prasad, Ravindra Veerapur, Sharanagouda S. Patil, Charley A. Cull, Johann F. Coetzee, Raghavendra G. Amachawadi
Separations.2021; 8(10): 192. CrossRef
Heavy Metals in Indian Traditional Systems of Medicine: A Systematic Scoping Review and Recommendations for Integrative Medicine Practice
Sanchari Mukhopadhyay, Shalu Elizabeth Abraham, Bharath Holla, Kishore Kr Ramakrishna, Kamala Lakshmi Gopalakrishna, Akhila Soman, Umesh C. Chikkanna, Muchukunte Mukunda Srinivas Bharath, Hemant Bhargav, Shivarama Varambally, Bangalore Nanjundaiah Gangadh
The Journal of Alternative and Complementary Medicine.2021; 27(11): 915. CrossRef
Characteristics and treatment of elemental mercury intoxication: A case series
Kelly Johnson‐Arbor, Eshetu Tefera, John Farrell
Health Science Reports.2021;[Epub] CrossRef
Imaging Microstructural Damage and Alveolar Bone Loss in Rats Systemically Exposed to Methylmercury: First Experimental Evidence
Géssica de Oliveira Lopes, Walessa Alana Bragança Aragão, Leonardo Oliveira Bittencourt, Bruna Puty, Armando Pereira Lopes, Sávio Monteiro dos Santos, Marta Chagas Monteiro, Edivaldo Herculano Corrêa de Oliveira, Márcia Cristina Freitas da Silva, Rafael R
Biological Trace Element Research.2021; 199(10): 3707. CrossRef
Analysis of Cadmium, Mercury, and Lead Concentrations in Erythrocytes of Renal Transplant Recipients from Northwestern Poland
Aleksandra Wilk, Maciej Romanowski, Barbara Wiszniewska
Biology.2021; 10(1): 62. CrossRef
The Aging Kidney—As Influenced by Heavy Metal Exposure and Selenium Supplementation
Jan Aaseth, Jan Alexander, Urban Alehagen, Alexey Tinkov, Anatoly Skalny, Anders Larsson, Guido Crisponi, Valeria Marina Nurchi
Biomolecules.2021; 11(8): 1078. CrossRef
Adsorption and Removal of Hazardous Metallic Elements Hg ⁰, Ni ⁰ and Pb ⁰: A DFT Study on g-C ₃N ₄ Monolayer Modified with Pt _n (n=1 - 7) Clusters
Siying Zhong, Shao-Yi Wu, Gao-Jun Zhang, Jia-Xing Guo, Li Yan
SSRN Electronic Journal .2021;[Epub] CrossRef
Cellular and Molecular Mechanisms Mediating Methylmercury Neurotoxicity and Neuroinflammation
João P. Novo, Beatriz Martins, Ramon S. Raposo, Frederico C. Pereira, Reinaldo B. Oriá, João O. Malva, Carlos Fontes-Ribeiro
International Journal of Molecular Sciences.2021; 22(6): 3101. CrossRef
Methylmercury plus Ethanol Exposure: How Much Does This Combination Affect Emotionality?
Diandra Araújo Luz, Sabrina de Carvalho Cartágenes, Cinthia Cristina Sousa de Menezes da Silveira, Bruno Gonçalves Pinheiro, Kissila Márvia Matias Machado Ferraro, Luanna de Melo Pereira Fernandes, Enéas Andrade Fontes-Júnior, Cristiane do Socorro Ferraz
International Journal of Molecular Sciences.2021; 22(23): 13131. CrossRef
Unveiling the Features of Mercury-Associated Minimal Change Disease: Comparison with Primary Minimal Change Disease
Ai-bo Qin, Xiao-juan Yu, Su-xia Wang, Fu-de Zhou, Ming-hui Zhao
Kidney Diseases.2021; 7(2): 156. CrossRef
Mercury and Prenatal Growth: A Systematic Review
Kyle Dack, Matthew Fell, Caroline M. Taylor, Alexandra Havdahl, Sarah J. Lewis
International Journal of Environmental Research and Public Health.2021; 18(13): 7140. CrossRef
The “wing-heeled” traveler
Taylor Kain, Jordan Weinstein, Aaron Thompson, Andrea K. Boggild
Tropical Diseases, Travel Medicine and Vaccines.2020;[Epub] CrossRef
Mercury exposure and nonmelanoma skin cancer: what're the odds?
N. Taylor
British Journal of Dermatology.2020; 183(3): 413. CrossRef
Mercury intoxication resembling pediatric rheumatic diseases: case series and literature review
Mehmet Yildiz, Amra Adrovic, Aybuke Gurup, Esra Karabag Yilmaz, Yavuz Ozer, Oya Koker, Sezgin Sahin, Ertugrul Kiykim, Nur Canpolat, Kenan Barut, Ozgur Kasapcopur
Rheumatology International.2020; 40(8): 1333. CrossRef
Comparing the Neuroprotective Effects of Aqueous and Methanolic Extracts of Vernonia Amygdalina on the Cerebellum of Adult Male Wistar Rats
Ugochukwu Samuel Aguwa, Somadina M Okeke, Chijioke M Okeke, Chinyere E Eze, Benedict Nzube Obinwa, Morris Izuogu, Felix Ogbo Ovie, Darlington Nnamdi Onyejike, Doris Kasarachi Ogbuokiri, Damian N Ezejindu
International Annals of Science.2020; 9(1): 145. CrossRef
Broken thermometer in foot: a source of mercury poisoning
Peyman Erfantalab, Nasim Zamani, Hossein Hassanian-Moghaddam
Tropical Doctor.2020; 50(1): 83. CrossRef
Status of mercury accumulation in agricultural soils across China (1976–2016)
Xingyuan Li, Jingru Zhang, Yiwei Gong, Shuhui Yang, Mai Ye, Xuan Yu, Jin Ma
Ecotoxicology and Environmental Safety.2020; 197: 110564. CrossRef
In Situ Doping-Enabled Metal and Nonmetal Codoping in Graphene Quantum Dots: Synthesis and Application for Contaminant Sensing
Aruna N. Nair, Venkata S.N. Chava, Saptasree Bose, Ting Zheng, Srikanth Pilla, Sreeprasad T. Sreenivasan
ACS Sustainable Chemistry & Engineering.2020; 8(44): 16565. CrossRef
A review on nanostructure-based mercury (II) detection and monitoring focusing on aptamer and oligonucleotide biosensors
Samet Şahin, Mustafa Oguzhan Caglayan, Zafer Üstündağ
Talanta.2020; 220: 121437. CrossRef
Blood Mercury Levels in Children with Kawasaki Disease and Disease Outcome
Ling-Sai Chang, Jia-Huei Yan, Jin-Yu Li, Deniz Des Yeter, Ying-Hsien Huang, Mindy Ming-Huey Guo, Mao-Hung Lo, Ho-Chang Kuo
International Journal of Environmental Research and Public Health.2020; 17(10): 3726. CrossRef
Elevated Hair Mercury Levels Are Associated With Neurodevelopmental Deficits in Children Living Near Artisanal and Small‐Scale Gold Mining in Peru
Aaron Reuben, Helena Frischtak, Axel Berky, Ernesto J. Ortiz, Ana Maria Morales, Heileen Hsu‐Kim, Laura L. Pendergast, William K. Pan
GeoHealth.2020;[Epub] CrossRef
Current issues of environmental mercury pollution (review)
V. N. Rakitskii, T. A. Synitskaya, Sergeii V. Skupnevskii
Hygiene and sanitation.2020; 99(5): 460. CrossRef
Evaluation of kidney function and oxidative stress biomarkers in prolonged occupational exposure with mercury in dentists
Mohsen Yazdanian, Ghader Ghanizadeh, Shirin Rastgoo, Sayyed Morteza Hosseini Shokouh
Gene Reports.2020; 19: 100627. CrossRef
Is there evidence of weathering among women seeking fertility treatments?: Evidence and insights
Katherine Tierney
Social Science & Medicine.2020; 247: 112816. CrossRef
An unusual cause of nephrotic syndrome in a 10-year-old girl: Answers
Yu Bao, Huijun Shen
Pediatric Nephrology.2020; 35(7): 1219. CrossRef
Mercury Exposure Among Artisanal and Small-Scale Gold Miners in Four Regions in Uganda
Mercy Wendy Wanyana, Friday E. Agaba, Deogratias K. Sekimpi, Victoria N. Mukasa, Geoffrey N. Kamese, Nkonge Douglas, John C. Ssempebwa
Journal of Health and Pollution.2020;[Epub] CrossRef
Blood Response to Mercury Exposure in Athletic Horse From Messina, Italy
Francesco Fazio, Nicola Cicero, Giuseppe Piccione, Claudia Giannetto, Patrizia Licata
Journal of Equine Veterinary Science.2020; 84: 102837. CrossRef
Current issues of environmental mercury pollution (review)
V. N. Rakitskii, T. A. Synitskaya, Sergeii V. Skupnevskii
Hygiene and sanitation.2020; 99(5): 460. CrossRef
Regulation of Single-Channel Conductance of Voltage-Dependent Anion Channel by Mercuric Chloride in a Planar Lipid Bilayer
Chetan Malik, Subhendu Ghosh
The Journal of Membrane Biology.2020; 253(4): 357. CrossRef
Lead and Mercury Exposure and Related Health Problems in Metal Artisan Workplaces and High-Risk Household Contacts in Thimphu, Bhutan
Adeep Monger, Karma Wangdi
The Scientific World Journal.2020; 2020: 1. CrossRef
The interrelation of neurophysiological, psychological, and biochemical indicators in patients with occupational chronic mercury intoxication suffering from insomnia
Elena V. Katamanova, Elena N. Korchuganova, Natalia V. Slivnitsyna, Irina V. Kudaeva, Oleg L. Lakhman
Russian Journal of Occupational Health and Industrial Ecology.2020; 60(12): 904. CrossRef
Toxic Metals Depuration Profiles from a Population Adjacent to a Military Target Range (Vieques) and Main Island Puerto Rico
Héctor Jirau-Colón, Ashley Cosme, Víctor Marcial-Vega, Braulio Jiménez-Vélez
International Journal of Environmental Research and Public Health.2019; 17(1): 264. CrossRef
A Case of Accidental Mercury Intoxication
Olivia L. Kamensky, Destiny Horton, Donald P. Kingsley, Christy C. Bridges
The Journal of Emergency Medicine.2019; 56(3): 275. CrossRef
Endoplasmic reticulum stress participates in the pathophysiology of mercury-caused acute kidney injury
Plácido Rojas-Franco, Margarita Franco-Colín, Alejandra Paola Torres-Manzo, Vanessa Blas-Valdivia, María del Rocio Thompson-Bonilla, Sinan Kandir, Edgar Cano-Europa
Renal Failure.2019; 41(1): 1001. CrossRef
Lethal concentrations of mercury or lead do not affect coagulation kinetics in human plasma
Vance G. Nielsen
Journal of Thrombosis and Thrombolysis.2019; 48(4): 697. CrossRef
The Clinical Importance of the Mercury Problem in Artisanal Small-Scale Gold Mining
Justice Afrifa, Yeboah Kwaku Opoku, Eric Ofori Gyamerah, George Ashiagbor, Rosemary Doe Sorkpor
Frontiers in Public Health.2019;[Epub] CrossRef
Ziziphus spina-christi Leaf Extract Suppressed Mercury Chloride-Induced Nephrotoxicity via Nrf2-Antioxidant Pathway Activation and Inhibition of Inflammatory and Apoptotic Signaling
Rafa S. Almeer, Gadah Albasher, Fatimah Alotibi, Saud Alarifi, Daoud Ali, Saad Alkahtani
Oxidative Medicine and Cellular Longevity.2019; 2019: 1. CrossRef
Genetically encoded FRET-based optical sensor for Hg2+ detection and intracellular imaging in living cells
Neha Soleja, Mohamad Aman Jairajpuri, Aarfa Queen, Mohd Mohsin
Journal of Industrial Microbiology and Biotechnology.2019; 46(12): 1669. CrossRef
Impaired participation of potassium channels and Na+/K+‐ATPase in vasodilatation due to reduced nitric oxide bioavailability in rats exposed to mercury
Tatiani Botelho, Vinícius B. Marques, Maylla R. Simões, Patricia R. do Val Lima, Fabiana V. Simões, Dalton V. Vassallo, Leonardo dos Santos
Basic & Clinical Pharmacology & Toxicology.2019; 124(2): 190. CrossRef
Mercury-associated glomerulonephritis: a retrospective study of 35 cases in a single Chinese center
Ai-bo Qin, Tao Su, Su-xia Wang, Fan Zhang, Fu-de Zhou, Ming-hui Zhao
BMC Nephrology.2019;[Epub] CrossRef
The life-threatening rash of poisoning
Michael Joseph Lavery, Ronni Wolf
Clinics in Dermatology.2019; 37(2): 136. CrossRef
Mercury levels in human population from a mining district in Western Colombia
Harry Gutiérrez-Mosquera, S.B. Sujitha, M.P. Jonathan, S.K. Sarkar, Fairy Medina-Mosquera, Helcias Ayala-Mosquera, Gladis Morales-Mira, Laura Arreola-Mendoza
Journal of Environmental Sciences.2018; 68: 83. CrossRef
Mercury poisoning in a fisherman working on a pelagic fishing vessel due to excessive tuna consumption
Ji-Sung Ahn, Kyung Wook Kang, Won-Yang Kang, Hyeong-Min Lim, Seunghyeon Cho, Jai-Dong Moon, Won-Ju Park
Journal of Occupational Health.2018; 60(1): 89. CrossRef
The Content of Mercury in Herbal Dietary Supplements
Barbara Brodziak-Dopierała, Agnieszka Fischer, Wioletta Szczelina, Jerzy Stojko
Biological Trace Element Research.2018; 185(1): 236. CrossRef
The associations between blood mercury levels and shark meat intake among workers in Gyeongsangbuk-do
Gun Il Park, Young Seok Byun, Man Joong Jeon, Joon Sakong
Annals of Occupational and Environmental Medicine.2017;[Epub] CrossRef
A review: Aptamer-based analytical strategies using the nanomaterials for environmental and human monitoring of toxic heavy metals
Leila Farzin, Mojtaba Shamsipur, Shahab Sheibani
Talanta.2017; 174: 619. CrossRef
Metal Ion Toxins and Brain Aquaporin-4 Expression: An Overview
Adriana Ximenes-da-Silva
Frontiers in Neuroscience.2016;[Epub] CrossRef
Regulation of Sirt1/Nrf2/TNF-α signaling pathway by luteolin is critical to attenuate acute mercuric chloride exposure induced hepatotoxicity
Daqian Yang, Xiao Tan, Zhanjun Lv, Biying Liu, Ruiqi Baiyun, Jingjing Lu, Zhigang Zhang
Scientific Reports.2016;[Epub] CrossRef
Assessment of the Cardiac Autonomic Nervous System in Mercury-Exposed Individuals via Post-Exercise Heart Rate Recovery
Omer Hinc Yilmaz, Ugur Nadir Karakulak, Engin Tutkun, Ceylan Bal, Meside Gunduzoz, Emine Ercan Onay, Mehmet Ayturk, Mujgan Tek Ozturk, Mehmet Erdem Alaguney
Medical Principles and Practice.2016; 25(4): 343. CrossRef

183 View
2 Download
132 Web of Science
115 Crossref

Case Report

A case of chronic myeloid leukemia in a diagnostic radiographer: Chulyong Park, Sungyeul Choi, Dohyung Kim, Jaechan Park, Saerom Lee; Ann Occup Environ Med 2014;26:54. Published online November 28, 2014; DOI: https://doi.org/10.1186/s40557-014-0054-8

Abstract PDF PubReader ePub

<bold>Background</bold>

Occupational radiation exposure causes certain types of cancer, specifically hematopoietic diseases like leukemia. In Korea, radiation exposure is monitored and recorded by law, and guidelines for compensation of radiation-related diseases were implemented in 2001. However, thus far, no occupation-related disease was approved for compensation under these guidelines. Here, we report the first case of radiation-related disease approved by the compensation committee of the Korea Workers’ Compensation and Welfare Service, based on the probability of causation.

<bold>Case presentation</bold>

A 45-year-old man complained of chronic fatigue and myalgia for several days. He was diagnosed with chronic myeloid leukemia. The patient was a diagnostic radiographer at a diagnostic radiation department and was exposed to ionizing radiation for 21 years before chronic myeloid leukemia was diagnosed. His job involved taking simple radiographs, computed tomography scans, and measuring bone marrow density.

<bold>Conclusion</bold>

To our knowledge, this is the first approved case report using quantitative assessment of radiation. More approved cases are expected based on objective radiation exposure data and the probability of causation. We need to find a resolution to the ongoing demands for appropriate compensation and improvements to the environment at radiation workplaces.

Citations

Citations to this article as recorded by

Does occupational ionizing radiation exposure in healthcare workers affect their hematological parameters?
Nejdiye Güngördü, Seher Kurtul, Ayşenur Özdil, Mehmet Sarper Erdoğan
Archives of Environmental & Occupational Health.2023; 78(2): 80. CrossRef
Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study
Ning Liu, Yang Peng, Xinguang Zhong, Zheng Ma, Suiping He, Ying Li, Wencui Zhang, Zijun Gong, Zhenjiang Yao
Environmental Health and Preventive Medicine.2021;[Epub] CrossRef

70 View
0 Download
2 Web of Science
2 Crossref

Research Article

Musculoskeletal Disorders of the Upper Extremities Due to Extensive Usage of Hand Held Devices: Deepak Sharan, Mathankumar Mohandoss, Rameshkumar Ranganathan, Jeena Jose; Ann Occup Environ Med 2014;26:22-22. Published online August 6, 2014; DOI: https://doi.org/10.1186/s40557-014-0022-3

Abstract PDF PubReader ePub

Objective

The use of hand held devices (HHD) such as mobile phones, game controls, tablets, portable media players and personal digital assistants have increased dramatically in past decade. While sending a text message or using the controls of the HHD the users need to use their thumb and other palm muscles extensively. The objective of this study was to describe the risk factors and clinical features of the musculoskeletal disorders (MSDs) arising due to usage of hand held devices and to evaluate the effectiveness of a sequenced rehabilitation protocol.

Methods

A retrospective report analysis of 70 subjects, who were diagnosed to have a MSD affecting the upper extremities, was conducted. Medical charts from a tertiary level rehabilitation centre from 2005–2013 were analysed. All the subjects reported pain in their upper extremities following extensive usage of HHD and were examined and diagnosed to have a MSD by an orthopaedic and rehabilitation physician. After the assessment and diagnosis, all the patients underwent rehabilitation using a sequenced protocol.

Results

All the subjects reported pain in the thumb and forearm with associated burning, numbness and tingling around the thenar aspect of the hand, and stiffness of wrist and hand. 43 subjects had symptoms on the right side; 9 on left and 18 had bilateral symptoms. Correlation was found between hand dominance and MSD. 33 subjects complained of onset of symptoms following extensive text messaging. All the subjects were diagnosed to have tendinosis of Extensor Pollicis Longus and Myofascial Pain Syndrome affecting the 1st interossei, thenar group of muscles and Extensor Digitorum Communis. 23 of the subjects were senior executives, among these 7 were CEO’s of major multinational companies in India. All the subjects recovered completely following the rehabilitation.

Conclusions

The study concluded that mobile phones and gadgets that promoted the predominant usage of thumb or only one finger while texting or using the controls were associated with a higher prevalence of MSDs. Treatment using a sequenced rehabilitation protocol was found to be effective.

Citations

Citations to this article as recorded by

Optimizing learning comfort: ergonomic influences on children’s transition to online education
Mohammed Said Obeidat, Dalia Saaydeh
Ergonomics.2024; : 1. CrossRef
The Prevalence of Nomophobia in Medical Undergraduate Students of Central India
Mahek R Mohani, Pratik Phansopkar, Nikita H Seth, Pranali S Fokmare
Cureus.2024;[Epub] CrossRef
A multi-dimensional assessment of internet gaming disorder in children and adolescents: A case-control study
Caner Mutlu, Tansu Birinci, Aybike Senel, Rustem Mustafaoglu, Esra Bulanık Koc, Gul Karacetin, Ebru Kaya Mutlu
Work.2024; 77(4): 1089. CrossRef
The impact of smartphone use duration and posture on the prevalence of hand pain among college students
Faeze Dehghan Banadaki, Benyamin Rahimian, Fatemeh Moraveji, Sakineh Varmazyar
BMC Musculoskeletal Disorders.2024;[Epub] CrossRef
Effectiveness of Tailor-Made Physiotherapy Protocol in Smartphone-Addicted Individuals With Text Neck Syndrome and Short Message Service (SMS) Thumb
Harsh R Nathani, Pratik Phansopkar
Cureus.2024;[Epub] CrossRef
Comparison of musculoskeletal pain and upper extremity disability in smartphone addicts and smartphone non-addicts among university students: A cross-sectional study
Mehmet Kurtaran
Journal of Bodywork and Movement Therapies.2024; 40: 279. CrossRef
The relationship between smartphone usage position, pain, smartphone addiction, and hand function
Ozde Depreli, Ender Angin
Journal of Back and Musculoskeletal Rehabilitation.2024; : 1. CrossRef
Prevalence of Thumb and Wrist Pain Among Smartphone Users in the Saudi Arabian General Population: A Cross-Sectional Study
Mahmoud Mohammed Hassaan, Mohammad A Jareebi, Hanan A AlKaabi , Alhassan H Hobani, Yazeed M Alfuhigi, Norah K Albahli , Hatim Alrashed, Sami K Alotaibi, Abdulaziz S Almadi, Othman A Iskander, Khalid Alyahyawi, Jamaludeen A Othman , Waseem S Borik, Mohamm
Cureus.2024;[Epub] CrossRef
Prevalence and Awareness of Musculoskeletal Injuries Associated With Competitive Video Gaming in Saudi Arabia
Anas Fathuldeen, Mohammed F Alshammiri, Abdullah Abdulmohsen
Cureus.2023;[Epub] CrossRef
Orthopedic Problems due to Overuse of Smartphones
Saurabh Agarwal, Rahul Bharti
Journal of Orthopaedic Diseases and Traumatology.2023; 6(3): 201. CrossRef
The association between mobile phone use and neuromusculoskeletal complaints
Jumana Ma’touq, Nasim Alnuman, Ibrahim Abuzer, Bara’a AbdelGader
Work.2023; 76(2): 759. CrossRef
Comparing the Mediating Effect of Adolescent Lifestyle Profiles on the Relationship between Smartphone Addiction and Health-related Quality of Life Among Male and Female Senior High School Students in the Philippines
Danilo B. Buctot, Nami Kim, Sun Hee Kim
International Journal of Mental Health and Addiction.2023; 21(1): 511. CrossRef
The Relationship between Smartphone Addiction and Functional Neck Disability among University Students during COVID-19 Pandemic
Amr ABDEL-AZİEM, Ibrahim DEWİR, Mosab ALOTİBİ, Hamzh MORSHED, Ziyad ALKHAMMASH, Muqren ALSHAHRANİ
Clinical and Experimental Health Sciences.2023; 13(3): 562. CrossRef
Exploring the Relation of Smartphone Addiction and Musculoskeletal Pain in the Neck, Trunk, and Upper Limbs: A Cross-sectional Study
Yixin Wang, Ye-Jin Kim, Kyeong-Ah Moon, Joo-Hee Park, Hye-Seon Jeon
Physical Therapy Korea.2023; 30(3): 211. CrossRef
Uso de smartphones como fator de risco para o desenvolvimento de morbidades no punho e nos dedos
Ana Mariza dos Santos Gonçalves, Vinícius José Guimarães do Carmo, Letycia Monteiro Cavalcanti Araújo, Taciane Machado de Melo Pereira
Revista Brasileira de Ortopedia.2023; 58(03): 457. CrossRef
21st century medicine and emerging biotechnological syndromes: a cross-disciplinary systematic review of novel patient presentations in the age of technology
Isabel Straw, Geraint Rees, Parashkev Nachev
BMC Digital Health.2023;[Epub] CrossRef
Prevalence of mobile device-related lower extremity discomfort: a systematic review
Maša Legan, Klementina Zupan
International Journal of Occupational Safety and Ergonomics.2022; 28(2): 1091. CrossRef
Mobile phone usage among Nigerians: Risk factors for musculoskeletal injuries and preventive strategies
SundayRufus Akinbo, AyoolaIbifubara Aiyegbusi, UdokaArinze Okafor, OluwaseyiJessy Balogun
Nigerian Postgraduate Medical Journal.2022; 29(3): 221. CrossRef
Musculoskeletal disorders in video gamers – a systematic review
Chuck Tholl, Peter Bickmann, Konstantin Wechsler, Ingo Froböse, Christopher Grieben
BMC Musculoskeletal Disorders.2022;[Epub] CrossRef
Spine Posture, Mobility, and Stability of Top Mobile Esports Athletes: A Case Series
Wing-Kai Lam, Bob Chen, Rui-Tan Liu, James Chung-Wai Cheung, Duo Wai-Chi Wong
Biology.2022; 11(5): 737. CrossRef
Smartphone addiction and its impact on musculoskeletal pain in neck, shoulder, elbow, and hand among college going students: a cross-sectional study
Sohel Ahmed, Arushi Mishra, Rahemun Akter, Md. Hasanuzzaman Shah, Asima Akter Sadia
Bulletin of Faculty of Physical Therapy.2022;[Epub] CrossRef
The Impact of Smartphone Addiction on Chinese University Students’ Physical Activity: Exploring the Role of Motivation and Self-Efficacy
Bo Lin, Eng Wah Teo, Tingting Yan
Psychology Research and Behavior Management.2022; Volume 15: 2273. CrossRef
Akıllı Telefon Kullanımının Sağlık Üzerine Etkileri: Genel Bir Bakış
Ali CEYLAN
Ankara Sağlık Bilimleri Dergisi.2022; 11(2): 266. CrossRef
Prevalence of mobile device-related musculoskeletal pain among working university students: a cross-sectional study
Maša Legan, Klementina Zupan
International Journal of Occupational Safety and Ergonomics.2022; 28(2): 734. CrossRef
Assessment of the Effect of Smartphone Usage on the Range of Motion and Fatigability of the Joints and Muscles of the Thumb Among Users: A Cross-Sectional Study in Central India
Ananyan Sampath, Avani Kulkarni, Revadi G, Manmohan Patel, Bertha A Rathinam
Cureus.2022;[Epub] CrossRef
AOASM Position Statement on Esports, Active Video Gaming, and the Role of the Sports Medicine Physician
R. Robert Franks, Dominic King, Warren Bodine, Emanuele Chisari, Alan Heller, Faraz Jamal, John Luksch, Kate Quinn, Raunak Singh, Mary Solomon
Clinical Journal of Sport Medicine.2022; 32(3): e221. CrossRef
MUSCULOSKELETAL DISORDERS OF HAND IN HEALTHCARE WORKERS: A CROSS-SECTIONAL STUDY
İbrahim EYİ, Banu Yeşim BÜYÜKAKINCI
Ergonomi.2022; 5(3): 144. CrossRef
ASSOCIATION BETWEEN CELL PHONE USAGE AND MUSCULOSKELETAL DISORDERS IN SCHOOL GOING CHILDREN
Sujata Mandhwani, Sadaf Zia, Emad Salman Shaikh, Dante Duarte, Erum Tanveer
Journal of Musculoskeletal Research.2022;[Epub] CrossRef
Microvascular blood flow changes of the abductor pollicis brevis muscle during sustained static exercise
Martina Giovannella, Evelina Urtane, Marta Zanoletti, Umut Karadeniz, Uldis Rubins, Udo M. Weigel, Zbignevs Marcinkevics, Turgut Durduran
Biomedical Optics Express.2021; 12(7): 4235. CrossRef
Response to “letter to editor: Symptoms and absence of symptoms while using a telephone: The paradox of thoracic outlet syndrome”
Emrah Zirek, Rustem Mustafaoglu, Zeynal Yasaci, Mark D. Griffiths
Musculoskeletal Science and Practice.2021; 51: 102264. CrossRef
Musculoskeletal Pain and Risk Factors Associated with Smartphone Use in University Students
Prachita P. Walankar, Manasi Kemkar, Aniket Govekar, Agasthya Dhanwada
Indian Journal of Occupational and Environmental Medicine.2021; 25(4): 220. CrossRef
Investigating the effect of smartphone addiction on musculoskeletal system problems and cognitive flexibility in university students
Özgü İnal, Selen Serel Arslan
Work.2021; 68(1): 107. CrossRef
The relationship between smartphone addiction and musculoskeletal pain prevalence among young population: a cross-sectional study
Rustem Mustafaoglu, Zeynal Yasaci, Emrah Zirek, Mark D. Griffiths, Arzu Razak Ozdincler
The Korean Journal of Pain.2021; 34(1): 72. CrossRef
Smartphone addiction and its association with upper body musculoskeletal symptoms among university students classified by age and gender
Panida Hanphitakphong, Orawan Keeratisiroj, Nuanlaor Thawinchai
Journal of Physical Therapy Science.2021; 33(5): 394. CrossRef
The impact of cell phone texting on superficial blood flow, touch threshold, and symptoms for individuals with carpal tunnel syndrome
Mike Szekeres, Derek Cheung, Joy Macdermid
Work.2021; 69(3): 839. CrossRef
A scope of mobile health solutions in COVID-19 pandemics
Afsoon Asadzadeh, Leila R. Kalankesh
Informatics in Medicine Unlocked.2021; 23: 100558. CrossRef
Prevalence of text neck syndrome and SMS thumb among smartphone users in college-going students: a cross-sectional survey study
Sohel Ahmed, Rahemun Akter, Nikita Pokhrel, Asir John Samuel
Journal of Public Health.2021; 29(2): 411. CrossRef
Symptoms and absence of symptoms while using a telephone: The paradox of thoracic outlet syndrome
Pierre Abraham, Samir Henni
Musculoskeletal Science and Practice.2021; 51: 102266. CrossRef
A systematic review of musculoskeletal complaints, symptoms, and pathologies related to mobile phone usage
Emrah Zirek, Rustem Mustafaoglu, Zeynal Yasaci, Mark D. Griffiths
Musculoskeletal Science and Practice.2020; 49: 102196. CrossRef
Evaluating hand performance and strength in children with high rates of smartphone usage: an observational study
Nadia L. Radwan, Marwa M. Ibrahim, Waleed Salah El-Din Mahmoud
Journal of Physical Therapy Science.2020; 32(1): 65. CrossRef
COVID-19 Pandemic- A Curse to the Physical Well-Being of Every Individual in Lock-Down
Pratik Arun Phansopkar, Waqar Mohsin Naqvi, Arti Isherkumar Sahu
Journal of Evolution of Medical and Dental Sciences.2020; 9(35): 2561. CrossRef
Head forward flexion, lateral bending and viewing distance in smartphone users: A comparison between sitting and standing postures
Zahra Vahedi, Adel Mazloumi, Ali Sharifnezhad, Zeinab Kazemi, Ehsan Garosi
Work.2020; 67(4): 837. CrossRef
Mobile technology and cumulative trauma symptomology among millennials
Nathan Short, Madison Blair, Chloe Crowell, Abby Loewenstein, Annie Lynch, Ravina Nakum, Allyson Warner
Hand Therapy.2020; 25(1): 11. CrossRef
Work-related musculoskeletal disorders amongst undergraduate nursing students at the University of Johannesburg
Malany Moodley, Fatima Ismail, Armand Kriel
Health SA Gesondheid.2020;[Epub] CrossRef
Quarantine Exercises in the Time of Covid-19- A Review
Arti Sahu, Waqar M. Naqvi
Journal of Evolution of Medical and Dental Sciences.2020; 9(26): 1922. CrossRef
Factors associated with smartphone addiction prevalence and its predictive capacity for health-related quality of life among Filipino adolescents
Danilo B. Buctot, Nami Kim, Jinsoo Jason Kim
Children and Youth Services Review.2020; 110: 104758. CrossRef
The association between smartphone addiction and thumb/wrist pain
Ayman Baabdullah, Diyaa Bokhary, Yousof Kabli, Omar Saggaf, Motaz Daiwali, Amre Hamdi
Medicine.2020; 99(10): e19124. CrossRef
A trend of cumulative trauma disorders in indian computer users: A comparison of surveys of the year 2009 versus 2019
PoojaPankaj Mehta, ChandanbalaOjas Maru
The Indian Journal of Occupational Therapy.2020; 52(2): 50. CrossRef
COVID-19 and applications of smartphone technology in the current pandemic
Karthikeyan Iyengar, Gaurav K. Upadhyaya, Raju Vaishya, Vijay Jain
Diabetes & Metabolic Syndrome: Clinical Research & Reviews.2020; 14(5): 733. CrossRef
Influence of hand and smartphone anthropometric measurements on hand pain and discomfort
Dalia M. Kamel, Christine Al Hakeem, Sayed A. Tantawy
Medicine.2020; 99(11): e19513. CrossRef
In Vivo Measurement of Thumb Joint Reaction Forces During Smartphone Manipulation: A Biomechanical Analysis
Wanlim Kim, Yusung Kim, Hyung‐Soon Park
Journal of Orthopaedic Research.2019; 37(11): 2437. CrossRef
The Head Down Generation: Musculoskeletal Symptoms and the Use of Smartphones Among Young University Students
Glaukus Regiani Bueno, Lucas França Garcia, Sonia Maria Marques Gomes Bertolini, Tiago Franklin Rodrigues Lucena
Telemedicine and e-Health.2019; 25(11): 1049. CrossRef
THE IMPACT OF MOBILE TOUCH SCREEN DEVICE USE ON MUSCULOSKELETAL SYSTEM: A LITERATURE REVIEW
Orhan KORHAN, Ali ELGHOMATİ
Ergonomi.2019; 2(3): 137. CrossRef
Examining the Effect of Smartphone on Musculoskeletal Disorders and Neck Kinematic Among Smartphone Users in Different Postures and Tasks
Zahra Vahedi, Adel Mazlomi, Ali Sharifnezhad, Kamal Azam
Journal of Ergonomics.2019; 6(4): 58. CrossRef
A Wrist-Worn Piezoelectric Sensor Array for Gesture Input
Riley Booth, Peter Goldsmith
Journal of Medical and Biological Engineering.2018; 38(2): 284. CrossRef
A scoping review on smart mobile devices and physical strain
Patricia Tegtmeier
Work.2018; 59(2): 273. CrossRef
The effect of smartphone usage on the upper extremity performance among Saudi Youth, KSA
Mohammed Khalid Alruzayhi, Muath Salman Almuhaini, Akrm Ibrahem Alwassel, Osama Mansour Alateeq
Romanian Journal of Rhinology.2018; 8(29): 47. CrossRef
The associations of mobile touch screen device use with musculoskeletal symptoms and exposures: A systematic review
Siao Hui Toh, Pieter Coenen, Erin K. Howie, Leon M. Straker, Heiner Baur
PLOS ONE.2017; 12(8): e0181220. CrossRef
Accessing physical activity among young adults attending a university: the role of sex, race/ethnicity, technology use, and sleep
Samuel D. Towne, Marcia G. Ory, Matthew Lee Smith, S. Camille Peres, Adam W. Pickens, Ranjana K. Mehta, Mark Benden
BMC Public Health.2017;[Epub] CrossRef
Exercise training and postural correction improve upper extremity symptoms among touchscreen smartphone users
Abeer Ahmed Abdelhameed, Amr Almaz Abdel-aziem
Hong Kong Physiotherapy Journal.2016; 35: 37. CrossRef

125 View
0 Download
46 Web of Science
60 Crossref

Original Article

Health Effect Assessment on Volunteers Involved in the Cleanup Operation Following the Hebei Spirit Oil Spill Along the Taean Coast, Korea: Chul Ho Lee, Kyung Hwa Park, Min Jung Lee, Wook Hee Choi, Heon Kim, Choong Hee Park, Dae Seon Kim, Seung Do Yu; Korean Journal of Occupational and Environmental Medicine 2010;22(1):11-19. Published online March 31, 2010; DOI: https://doi.org/10.35371/kjoem.2010.22.1.11

Abstract PDF

OBJECTIVE: The objetive of this study is to assess the level of oxidative stress by the exposure to volatile organic compounds (VOCs) and polycyclic aromatic hydrocarbons (PAHs) in volunteers who cleaned up the crude oil spilled from the Hebei Spirit on the Coast of Taean County, Korea.
METHODS
The study subjects were 46 volunteers and 37 controls from the National Institute of Environmental Research. A self-administered questionnaire was used for volunteers to examine their working environment and health effects. Urinary concentrations of hippuric acid, 1-hydroxypyrene, and 2-naphthol were measured as exposure markers for VOCs and PAHs, and urinary thiobarbituric acid reactive substances (TBARS) and 8-hydroxydeoxyguanosine (8-OHdG) levels were measured as oxidative stress markers.
RESULTS
Sixty-four percent of the respondents presented a variety of symptoms, including sore eyes and throat, nausea, dizziness, headache, low back pain, and leg pain after participating in the cleanup operation. Urinary 2-naphthol and TBARS concentrations appeared higher in the volunteers. Univariate and multivariate analyses showed that urinary TBARS and 8-OHdG levels were positively correlated with urinary 2-naphthol and 1-hydroxypyrene concentrations respectively, especially among the volunteers.
CONCLUSIONS
The result implies that participating in cleanup work of oil spills may have a possibility to induce oxidative damage by exposure to PAHs in crude oil.

Citations

Citations to this article as recorded by

Evaluation of performance of hybrid fiber-reinforced self-compacting concrete using non-destructive testing techniques
Shailja Bawa, Pravez Alam, Shivam Saini
Innovative Infrastructure Solutions.2023;[Epub] CrossRef
Survey of airborne organic compounds in residential communities near a natural gas compressor station: Response to community concern
Kaitlin A. Vollet Martin, Elizabeth Z. Lin, Timothy J. Hilbert, Krystal J. Godri Pollitt, Erin N. Haynes
Environmental Advances.2021; 5: 100076. CrossRef
Human health and ecological assessment programs for Hebei Spirit oil spill accident of 2007: Status, lessons, and future challenges
Dawoon Jung, Jung-Ah Kim, Myung-Sook Park, Un Hyuk Yim, Kyungho Choi
Chemosphere.2017; 173: 180. CrossRef
Health Effect Assessment on Cleanup Workers of an Oil Spill in Yeosu
Geunbae Kim, Tack Shin Kang, Mira Yoon, Hyejung Jo, Youngkyung Joo, Seung Do Yu, Bo Eun Lee
Korean Journal of Environmental Health Sciences.2016; 42(6): 385. CrossRef
Association between Metabolic Syndrome and Participation in Clean-up Work at the Hebei Spirit Oil Spill
Ik-Jin Lee, Bong-Ki Jang, Jong-Wha Lee, Bu-Soon Son, Hae-Kwan Cheong, Mina Ha, Young-Hyun Choi, Myungsook Park
Korean Journal of Environmental Health Sciences.2015; 41(5): 335. CrossRef
Changes of Eating Habits of the Residents of Taean, Korea after the Herbei Oil Spill Accident Based on Focus Group Interviews
Ji Hyun Park, Sung Ok Kwon, Woo Cheol Jeong, Jong Il Huh, Se-Young Oh
Korean Journal of Community Nutrition.2011; 16(4): 466. CrossRef

26 View
0 Download
6 Crossref

Original Article

Blood Lead Level as a Predictor of Coronary Artery Disease: Ryoung Jin Park, Seung Hyun Kim, Ji Ung Park, Yang Hyun Kim, Myoung Bo Kim, Won Ju Park, Jai Dong Moon; Korean Journal of Occupational and Environmental Medicine 2009;21(1):38-45. Published online March 31, 2009; DOI: https://doi.org/10.35371/kjoem.2009.21.1.38

Abstract PDF

OBJECTIVES
Lead exposure is known to be associated with high blood pressure, hypertension, coronary artery disease, peripheral arterial disease, left ventricular hypertropy, and electrocardiographic abnormalities. We investigated the association between blood lead and coronary artery calcification and stenosis.
METHODS
Between April 2006 and July 2007, 502 adults (345 males and 157 females), who had no history of cardiovascular disease or occupational exposure to lead, were recruited as study subjects. All subjects underwent coronary CT angiography and blood lead measurement.
RESULTS
Blood lead levels were distributed from 0.43 to 11.30 (microgram/dL with a geometric mean blood lead level of 2.98+/-1.5 (microgram/dL. The geometric mean blood lead levels were higher in men than women (3.31+/-1.5 (microgram/dL vs. 2.36+/-1.5 (microgram/dL, P < 0.01). Based on a multivariate analysis, a 1 unit ((microgram/dL) increase in blood lead level was associated with a 1.09 (95% confidence interval, 0.92~1.29) and a 1.01 fold (95% confidence interval, 0.63~1.63) greater risk for coronary artery calcification in men and women, respectively. Similarly, a 1 unit (microgram/dL) increase in blood lead level was associated with a 1.25 (95% confidence interval, 1.03~1.51) and a 1.42 fold (95% confidence interval, 0.73~2.75) greater risk for coronary artery stenosis in men and women, respectively.
CONCLUSIONS
The results suggest that increased blood lead levels are associated with an increased risk of coronary artery stenosis.

Citations

Citations to this article as recorded by

Blood Lead Levels and Cardiovascular Disease Risk: Results from the Korean National Health and Nutrition Examination Survey
Yoonjin Park, Jungjin Han
International Journal of Environmental Research and Public Health.2021; 18(19): 10315. CrossRef
Blood lead concentration and related factors in Korea from the 2008 National Survey for Environmental Pollutants in the Human Body
Seong Wook Jeong, Chae Kwan Lee, Chun Hui Suh, Kun Hyung Kim, Byung Chul Son, Jeong Ho Kim, Jong Tae Lee, Soo Woong Lee, Yeong Beom Park, Jong Wha Lee, Seung-Do Yu, Chan Seok Moon, Dae Hwan Kim, Sang Yoon Lee
International Journal of Hygiene and Environmental Health.2014; 217(8): 871. CrossRef
The Effects of Blood Lead on Blood Pressure Among Non-smokers
Yun-Suk Pak, Sang-Sin Park, Tae-Hun Kim, Sang-Yoon Lee, Young-Lim Kho, Eun-Hee Lee
Korean Journal of Environmental Health Sciences.2012; 38(4): 311. CrossRef
National estimates of blood lead, cadmium, and mercury levels in the Korean general adult population
Nam-Soo Kim, Byung-Kook Lee
International Archives of Occupational and Environmental Health.2011; 84(1): 53. CrossRef

20 View
0 Download
4 Crossref

Original Article

Effect of Genetic Polymorphisms of CYP2E1 and ALDH2 on the Relationship between the Levels of Urinary 8-Hydroxydeoxyguanosine and t,t-Muconic Acid: Yong Dae Kim, Jong Won Kang, Sang Yong Eom, Yan Wei Zhang, Sung Hoon Kim, Eun Young Kim, Chul Ho Lee, Jai Dong Moon, Heon Kim; Korean Journal of Occupational and Environmental Medicine 2007;19(2):164-170. Published online June 30, 2007; DOI: https://doi.org/10.35371/kjoem.2007.19.2.164

Abstract PDF: OBJECTIVES
This study was performed to investigate the effect of genetic polymorphisms on the oxidative genetic damage caused by benzene exposure in workers.
METHODS
We measured urinary t,t-muconic acid levels as a biomarker for benzene exposure and measured the level of urinary 8-OHdG to assess oxidative DNA damage in benzene-exposed healthy male workers. Genetic polymorphisms of ALDH2 and CYP2E1 were determined by TaqMan assay. We estimated Pearson correlation coefficients between urinary t,t-muconic acid and 8-OHdG according to the genetic polymorphisms of CYP2E1 and ALDH2.
RESULTS
There was a significant relationship between urinary t,t-muconic acid and 8-OHdG concentrations in overall subjects (R=0.532, p<0.001). Smokers showed a higher correlation coefficient between the markers than nonsmokers did (R=0.520 vs. 0.010). Individuals with CYP2E1 c1/c1 genotype also showed a higher correlation coefficient between them than those with CYP2E1 c1/c2 or c2/c2 genotypes (R=0.670 vs. -0.145). In multiple linear regression analysis including smoking status, sorbic acid intake, age and genetic polymorphisms of CYP2E1 and ALDH2 as the independent variables, urinary t,t-muconic acid showed a significant association with urinary 8-OHdG.
CONCLUSIONS
There was a significant correlation between urinary 8-OHdG and urinary t,t-muconic acid in benzene-exposed workers. This relationship was affected by genetic polymorphisms of CYP2E1and ALDH2.

23 View
0 Download

Case Report

Two cases of anosmia suspected to be caused by chronic chlorine exposure in cleansing works: Sung mo Ku, Hyun joo Kim; Korean Journal of Occupational and Environmental Medicine 2005;17(2):155-159. Published online June 30, 2005; DOI: https://doi.org/10.35371/kjoem.2005.17.2.155

Abstract PDF

OBJECTIVES
We report two cases of anosmia that were suspected to be caused by chronic chlorine exposure in cleansing works METHODS: We examined the cases in order to assess the work-relatedness of their anosmia. We conducted olfactory threshold test and olfactory perception test repeatedly at one-month intervals. Using ion chromatography, we analyzed the detergent that the workers had been using for several years before their olfactory function decreased.
RESULTS
A 59-year-old male who had worked in a cleansing process for 10 years (1983-1993) and a 58-year-old female who had worked in the same process for 8 years (1987-1995) were diagnosed with anosmia. The cause of the anosmia was presumed to have been the chlorine gas that was generated from the process of heating the detergent-dissolved water, in which chloride was detected.
CONCLUSIONS
This is the first report on anosmia due to chronic chlorine exposure. Greater attention needs to be focused on the prevention of anosmia because there are many workers who have been exposed to chlorine gas in chlorine treating and generating processes.

Citations

Citations to this article as recorded by

Occupational Neurological Disorders in Korea
Eun-A Kim, Seong-Kyu Kang
Journal of Korean Medical Science.2010; 25(Suppl): S26. CrossRef

21 View
0 Download
1 Crossref

Original Article

Autoregulation of Quartz-induced iNOS by iNOS-derived Hydrogen Peroxide in Rat2 Fibroblast: Kyoung Ah Kim, Hae Yun Nam, Je Hyeok Mun, Jin Sook Jeong, Young Lim, Chee Kyung Chung; Korean Journal of Occupational and Environmental Medicine 2001;13(4):385-392. Published online December 31, 2001; DOI: https://doi.org/10.35371/kjoem.2001.13.4.385

Abstract PDF: OBJECTIVES
This study was performed in order to investigate the molecular mechanism regulating nitric oxide synthase(NOS) induced by alpha-quartz in Rat2 fibroblast.
METHODS
alpha-quartz-induced nitric oxide(NO) and H2O2 formation and alpha- quartz-induced iNOS protein expression in Rat2 fibroblast were monitored. With iNOS inhibitor(L-N6- (1-iminoethyl)lysine hydrochloride, L-NIL) or antioxidant(catalase), we observed NO and H2O2 formation and iNOS protein expression in Rat2 fibroblast stimulated with alpha-quartz.
RESULTS
alpha-quartz stimulated iNOS-induced NO and H2O2 formation in Rat2 fibroblast. L-NIL inhibited H2O2 formation and iNOS protein expression by alpha-quartz in Rat2 fibroblast. Pretreatment with catalase blocked the autoinhibitory pathway of iNOS by iNOSinduced H2O2, therefore H2O2 and NO production and iNOS protein expression were increased in Rat2 fibrobalst stimulated with alpha-quartz CONCLUSIONS: alpha-quartz-induced iNOS stimulated H2O2 formation in Rat2 fibroblast. INOS-induced H2O2 by alpha-quartz plays an important role in the autoinhibition pathway for regulating the iNOS function in Rat2 fibroblast

17 View
0 Download

Original Article

Effects of Chromium Exposure on the Level of Urinary 8-Hydroxydeoxyguanosine: Seong Joon Kim, Byung Chul Yu, Sang Hwa Ohm, Ki Won Jeong, Luck Hee Sung, Won Chang Shin, Jong Rae Cho, Jin Ho Chun; Korean Journal of Occupational and Environmental Medicine 2001;13(3):253-261. Published online September 30, 2001; DOI: https://doi.org/10.35371/kjoem.2001.13.3.253

Abstract PDF

OBJECTIVES
To investigate the possibility of utilizing DNA adduct as a carcinogenic biological marker for workers exposed to chromium, and the effect of chromium exposure on the formation of urinary 8-hydroxydeoxyguanosine(8-OH-dG) was also evaluated.
METHODS
The chromium concentrations of venous blood and urine were measured in 20 chromium exposed workers(exposure group) and in 11 chromium workers(control group) who were not exposed. The concentration of 8-OH-dG in their urine was determined using high performance liquid chromatography with electrochemical detection.
RESULTS
The blood chromium concentration was significantly higher in the exposure group ( 0.46+/-0.18 microgram/100 ml) than in control group(0.27+/-0.15 microgram/100 ml), but the urinary chromium concentration was not significantly higher in the exposure group. The urinary 8-OH-dG was higher in the exposure group(1.71+/-1.82 micromol/mol creatinine) than that in the control group(0.45+/-0.46 micromol/mol creatinine) and was significantly correlated with the blood chromium concentration(r=0.49). Results of multiple regression analysis revealed that the level of urinary 8-OH-dG depended upon the level of the blood chromium conc entration ( r2= 0.21).
CONCLUSIONS
Urinary 8-OH-dG was significantly related to chromium exposure and this finding suggests the possibility that urinary 8-OH-dG could be used as a biological index of chromium induced DNA damage.

Citations

Citations to this article as recorded by

Association of serum and hair antioxidant minerals with an oxidative stress marker in relation with characteristics of healthy adults: a cross-sectional study
Yoo-Ree Kang, Mi-Kyung Sung, Hyun-Wook Baik, Mi-Kyeong Choi
Scientific Reports.2024;[Epub] CrossRef

30 View
0 Download
1 Crossref

Original Article

Analysis of Claimed Cases as an Occupational Disease at Korea Occupational Safety and Health Agency from 1992 to 1999: Seong Kyu Kang, Kyoo Sang Kim, Yangho Kim, Jung Keun Choi, Yeon Soon Ahn, Yeong Woo Jin, Byong Soon Choi, Jeong Sun Yang, Euna Kim, Chang Ho Chae, Yong Hue Choi, Dae Seong Kim, Jung Sun Park, Ho Keun Chung; Korean Journal of Occupational and Environmental Medicine 2000;12(2):292-301. Published online June 30, 2000; DOI: https://doi.org/10.35371/kjoem.2000.12.2.292

Abstract PDF

OBJECTIVES
Pneumoconisis and noise-induced hearing loss(NIHL) have been reported as main occupational diseases by the Special Health Examination. The Industrial Accident Compensation Insurance has reported various work-related diseases, however, these two diseases occupied almost a half of compensated cases. Therefore, it was not well known about the status of occupational diseases other than pneumoconiosis, NIHL, and cardiocerebrovascular accident(CVA). This study was conducted to analyze claimed cases as an occupational disease, that was requested to the Korea Industrial Safety and Health Agency (KOSHA).
METHODS
The local office of the Korea Labor Welfare Corporation(KLWC) has asked the KOSHA for confirmation of claimed cases as an occupational disease. We analyzed 379 cases requested from KLWC, the Ministry of Labor, employers, unions and occupational health agencies from 1992 to 1999.
RESULTS
Male was 80. 7 % of the requested cases. Their mean age was 42 years old and 75. 5 % of them were more than 35 years old. The requested cases were increased rapidly from 25 cases in 1992 to 108 cases in 1999 and the accept rate was 50. 7 %. The majority of requested cases were respiratory diseases(22.4 %), cancers(18.5 %), Neuropsychiatric problems (14. 5 %), and musculoskeletal problems (13. 5 %). The accept rate was high in reproductive, respiratory, musculoskeletal and digestive disorders and low in neuropsychiatric, renal and otologic problems and occupational cancers. 73. 6 % of them were caused by chemical agents, especially 28. 5 % were by organic solvents. 67 % of them were clinically confirmed at university hospitals. A half of the cases were from KyongIn area, even the request came from the whole country.
CONCLUSIONS
A claim was common in workers whose age was over 35 years old and exposure history was over 10 years. The respiratory diseases and neuropsychiatric disorders were still main problems in occupational health and occupational cancers was increasing even though its accept rate was not high yet.

Citations

Citations to this article as recorded by

Gastric and rectal cancers in workers exposed to asbestos: a case series
Byeong Ju Choi, Saerom Lee, Iu Jin Lee, Soon Woo Park, Sanggil Lee
Annals of Occupational and Environmental Medicine.2020;[Epub] CrossRef
Systemic sclerosis due to crystalline silica exposure among jewelry workers in Korea: two case reports
Jae Yoon Kim, Sang Yoon Do, Young Hoon Moon, Chul Gab Lee, Yun Sung Kim, Byung Soon Choi, Eun-A Kim, Han Soo Song
Annals of Occupational and Environmental Medicine.2017;[Epub] CrossRef
Characteristics and Influencing Factors on Recuperators with Work-related Musculoskeletal Disorders
Kyoo-Sang Kim, Hee-Gyeong Jeon, Day-Sung Kim
Journal of the Ergonomics Society of Korea.2012; 31(5): 671. CrossRef
Work-related Cerebro-Cardiovascular Diseases in Korea
Dae-Seong Kim, Seong-Kyu Kang
Journal of Korean Medical Science.2010; 25(Suppl): S105. CrossRef
Occupational Neurological Disorders in Korea
Eun-A Kim, Seong-Kyu Kang
Journal of Korean Medical Science.2010; 25(Suppl): S26. CrossRef
Occupational Diseases in Korea
Seong-Kyu Kang, Eun A Kim
Journal of Korean Medical Science.2010; 25(Suppl): S4. CrossRef
Occupational Lymphohematopoietic Cancer in Korea
Eun-A Kim, Won Jin Lee, Mia Son, Seong-Kyu Kang
Journal of Korean Medical Science.2010; 25(Suppl): S99. CrossRef
Occupational exposure to benzene in South Korea
Seong-Kyu Kang, Mi-Young Lee, Tae-Kyun Kim, Jeong-Oh Lee, Yeon Soon Ahn
Chemico-Biological Interactions.2005; 153-154: 65. CrossRef

32 View
1 Download
8 Crossref

Original Article

Health Hazards and Diagnostic Methods of Glass Fiber Workers: Hyun Sul Lim, Hae Kwan Jun, Soo Keun Kim, Jung Ran Kim; Korean Journal of Occupational and Environmental Medicine 1999;11(2):181-195. Published online June 30, 1999; DOI: https://doi.org/10.35371/kjoem.1999.11.2.181

Abstract PDF: This study was conducted to evaluate the health hazards and to develop diagnostic methods of glass fiber workers. We examined 40 male glass fiber workers (exposure group) and 57 male non-glass fiber workers (reference group) with a questionnaire, physical examination, chest x-ray and pathological examination in Mar, 1997. Also we examined 65 male glass fiber workers (exposure group) and 42 male non-glass fiber workers (reference group) with the same methods also we did some energy-dispersive x-ray analyses with a scanning electron microscopic examination in Sep. 1997. Most of the clinical symptoms were significantly more frequent among the exposure group than the reference group. Coughing (32.5%), itching of the nose (30.0%), irritation of eyes (27.5%), irritation of the nose (25.0%) and sputum (22.5%) were the major symptoms among the exposure group in Mar. 1997. Only itching of the nose was significantly more frequent in Sep. 1997. No cases of pneumoconiosis were observed among the groups and there were no differences in chest abnormalities between the exposure group with the reference group on both examinations. The prevalence of dermatosis among the exposure group was 20.0% (8 cases) and the cumulative prevalence was 72.5% (29 cases) in Mar. 1997. The prevalence of dermatosis among the exposure group was 23.1% (15 cases) and the cumulative prevalence was 58.5% (38 cases) in Sep. 1997. Onset of dermatosis among the exposure group was most frequent within one month after handling. The frequent sites of skin lesions were the hands and arms on both examinations. Glass fiber induced skin lesions can be diagnosed by the scotch tape method or KOH mount and then can be examined under the light, polarizing and phase-contrast microcopies. Glass fibers can be identified by some energy-dispersive x-ray analyses with a scanning electron microscopic examination.

23 View
0 Download

Original Article

Polyneuropathy by Occupational Exposure to Acrylamide: Hae Kwan Cheong, Yong Wook Kwon, Kyung Yun Uh, Byung Joon Kim, Jeong Sun Yang, Cheol Jung, Youngwoo Jin, Mi Young Lee, Seong Kyu Kang; Korean Journal of Occupational and Environmental Medicine 1998;10(3):388-403. Published online August 31, 1998; DOI: https://doi.org/10.35371/kjoem.1998.10.3.388

Abstract PDF

Authors report a first Korean case of polyneuropathy in an acrylamide producing factory together with an environmental and epidemiologic survey for the ten workers of the same workplace and 46 workers in the production and manufacturing acrylamide in Ulsan, Korea. The case is 30 years old man who worked in the prcduction of the acrylamide for two years. In August, 1997, he had a weakness of the lower extremity with loss of body weight of 15 Kg which progressed to paresthesia of the limbs, the loss of vibration sense, difficulty in walking, speech disturbance, dysuria, constipation, difficulty in erection and swallowing difficulty. Neurologic examination showed a complete loss of vibration and position sense, and loss of deep tendon reflex in all the limbs. There was a contact dermatitis-like skin lesion on the feet. Electrodiagnostic test showed a generalized polyneuropathy of moderate degree involving motor and sensory component of peripheral and cranial nerves. After 8 months' cessation from exposure and supportive care, his symptoms were completely resolved, but abnormality in electrodiagnostic test and vibrotactile perception threshold still persisted, although much improved than before. There were 11 workers in the same workplace of the case, producing acrylamide by microorganism as a catalyst. Environmental monitoring of the workplace revealed air-borne concentration of the acrylamide to be from 0.05 to 0.23 mg/m(3) by personal sampling and from 7.65 to 11.65 mg/m(3) by area sampling during filter exchanging process, which far exceeds TLV-TWA of 0.03 mg/m(3). However acrylamide was not detected from the plasma of the workers. Symptom questionnaire showed a markedly higher complain of neurologic symptoms, compared to the workers of the other acrylamide producing companies. Electrodiagnostic test showed a several workers are in the lower normal range without definite abnormality. Vibrotactile perception threshold by Vibratron II showed a significantly increased threshold in the workers of the same workplace compared to the other acrylamide workers and significantly decreased test score of color vision compared to normal controls. After improvement of the production process and strict wearing of the protective device, most workers reported the improvement of clinical symptoms, but vibrotactile perception threshold was not improved. These result suggests the need for the effective environmental monitoring together with a periodic biological monitoring. Development of effective screening test is urgently needed to control and assess the skin absorption of acrylamide.

Citations

Citations to this article as recorded by

Dermal and neural toxicity caused by acrylamide exposure in two Korean grouting workers: a case report
Heeyun Kim, Sang Gil Lee, Jeongbae Rhie
Annals of Occupational and Environmental Medicine.2017;[Epub] CrossRef
Occupational Neurologic Disorders in Korea
Yangho Kim, Kyoung Sook Jeong, Yong-Hun Yun, Myoung-Soon Oh
Journal of Clinical Neurology.2010; 6(2): 64. CrossRef
Occupational Neurological Disorders in Korea
Eun-A Kim, Seong-Kyu Kang
Journal of Korean Medical Science.2010; 25(Suppl): S26. CrossRef
Occupational Diseases in Korea
Seong-Kyu Kang, Eun A Kim
Journal of Korean Medical Science.2010; 25(Suppl): S4. CrossRef

21 View
0 Download
4 Crossref

Original Article

The Measurement of IL-1, 8, TNF for the Diagnosis of Pneumoconiosis: Young Lim, Kyoung Ah Kim, Im Goung Yun; Korean Journal of Occupational and Environmental Medicine 1997;9(1):17-25. Published online February 28, 1997; DOI: https://doi.org/10.35371/kjoem.1997.9.1.17

Abstract PDF

Many acute and chronic lung diseased including pneumoconiosis are characterized by the presence of increased numbers of activated macrophages. These macrophages generate several inflammatory cell chemoattractants, by which neutrophil migrate from vascular compartment to the alveolar space. Recruited neutrophils secrete toxic oxygen radicals or proteolytic enzymes and induce inflammatory response. Continuing inflammatory response results in alteration of the pulmonary structure and irreversible fibrosis. Recently, a polypeptide with specific neutrophil chemotactic activity, interleukin-8 (IL-8), has been cloned and isolated from a number of cells such as: monocytes, macrophages and fibroblasts. IL-1 and/or TNF-alpha preceded for the synthesis of IL-8, and we already observed high level of IL-1 and TNF-alpha in vivo experiments. So we hypothesized that IL-8 might play a central role in the pathogenesis of pneumoconiosis. In order to evaluate the clinical utility of IL-1, IL-8, TNF as a biomarker in the early diagnosis of pneumoconiosis, we investigated the increase of IL-1, 8, TNF in the pneumoconiotic patient and the significant (p<0.05) correlation between IL-8 level and progression of pneumoconiosis.

Citations

Citations to this article as recorded by

The Effects of Air-borne Particulate Matters on the Alveolar Macrophages for the TNF-α and IL-1β Secretion
Tian Zhu Li, Soo-Jin Lee, Se-Jong Park, Byung-Joon Chang, Jong-Hwan Lee, Kil-Soo Kim, Myoung-Heon Lee, Nong-Hoon Choe
Tuberculosis and Respiratory Diseases.2006; 60(5): 554. CrossRef

58 View
0 Download
1 Crossref

First
Prev
Page of 1
Next
Last

Search