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Research Article
Association between prenatal polycyclic aromatic hydrocarbons and infantile allergic diseases modified by maternal glutathione S-transferase polymorphisms: results from the MOCEH birth cohort
Tai Kyung Koh, Hyesook Park, Yun-Chul Hong, Mina Ha, Yangho Kim, Bo-Eun Lee, Surabhi Shah, Eunhee Ha
Ann Occup Environ Med 2021;33:e12.   Published online April 23, 2021
DOI: https://doi.org/10.35371/aoem.2021.33.e12
AbstractAbstract PDFSupplementary MaterialPubReaderePub
Background

Prenatal exposure to polycyclic aromatic hydrocarbons (PAH) has been linked to allergic disease onset. Variations in the glutathione S-transferase (GST) gene family can impact the progression of allergic diseases. We sought to examine the association between prenatal PAH exposure and infantile allergic diseases in 6-month-old infants, and how maternal glutathione S-transferase M1 (GSTM1) or T1 (GSTT1) polymorphism affects the association between prenatal PAH exposure and allergic diseases in the Mothers and Children's Environmental Health (MOCEH) study.

Methods

The study sample comprised 349 infants and their mothers from the MOCEH study, for whom 1-hydroxypyrene (1-OHP) and 2-naphthol were measured in both the early period of pregnancy and late period of pregnancy. An infant was deemed to be affected by an allergic disease if diagnosed with or if developed at least one of the allergic diseases. A logistic regression analysis was performed to study the association between urinary 1-OHP and 2-naphthol levels during pregnancy and allergic diseases in 6-month-old infants. Furthermore, analyses stratified by maternal GSTM1 or GSTT1 present/null polymorphisms were performed.

Results

The risk of allergic diseases in 6-month-old infants was significantly increased in accordance with an increase in urinary 1-OHP during the early period of pregnancy (odds ratio [OR]: 1.84; 95% confidence interval [CI]: 1.05, 3.23; by one log-transformed unit of 1-OHP μg/g creatinine). The increased risk of infantile allergic diseases associated with urinary 1-OHP during the early period of pregnancy was limited to the maternal GSTT1 null type (OR: 2.69; 95% CI: 1.17, 6.21, by one log-transformed unit of 1-OHP μg/g creatinine); however, the Relative Excess Risk due to Interaction was not statistically significant.

Conclusions

The present study found that infantile allergic diseases could be affected by intrauterine PAH exposure, particularly in the early prenatal period and the risk was limited to the maternal GSTT1 null type.


Citations

Citations to this article as recorded by  
  • Infantile allergic diseases: a cohort study prenatal fish intake and mercury exposure context
    Surabhi Shah, Hae Soon Kim, Yun-Chul Hong, Hyesook Park, Mina Ha, Yangho Kim, Ji Hyen Lee, Eun-Hee Ha
    BMC Public Health.2024;[Epub]     CrossRef
  • Prenatal dietary exposure to mixtures of chemicals is associated with allergy or respiratory diseases in children in the ELFE nationwide cohort
    Manel Ghozal, Manik Kadawathagedara, Rosalie Delvert, Amandine Divaret-Chauveau, Chantal Raherison, Raphaëlle Varraso, Annabelle Bédard, Amélie Crépet, Véronique Sirot, Marie Aline Charles, Karine Adel-Patient, Blandine de Lauzon-Guillain
    Environmental Health.2024;[Epub]     CrossRef
  • Prenatal dietary exposure to chemicals and allergy or respiratory diseases in children in the EDEN mother–child cohort
    Manel Ghozal, Manik Kadawathagedara, Rosalie Delvert, Karine Adel-Patient, Muriel Tafflet, Isabella Annesi-Maesano, Amélie Crépet, Véronique Sirot, Marie Aline Charles, Barbara Heude, Blandine de Lauzon-Guillain
    Environment International.2023; 180: 108195.     CrossRef
  • Gene-environment interactions related to maternal exposure to environmental and lifestyle-related chemicals during pregnancy and the resulting adverse fetal growth: a review
    Sumitaka Kobayashi, Fumihiro Sata, Reiko Kishi
    Environmental Health and Preventive Medicine.2022; 27: 24.     CrossRef
  • Role of GSTM1 in Hypertension, CKD, and Related Diseases across the Life Span
    Rebecca Levy, Thu H. Le
    Kidney360.2022; 3(12): 2153.     CrossRef
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  • 5 Web of Science
  • 5 Crossref
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Research Article
Effect of maternal job strain during pregnancy on infant neurodevelopment by gender at 6 and 12 months: Mothers and Children’s Environmental Health (MOCEH) study
Eunjeong Kim, HyeSook Park, Yun-Chul Hong, Mina Ha, Yangho Kim, Bo-Eun Lee, Eun-Hee Ha
Ann Occup Environ Med 2015;27:8.   Published online March 20, 2015
DOI: https://doi.org/10.1186/s40557-015-0059-y
AbstractAbstract PDFPubReaderePub
Objectives

Limited evidence is available regarding the association between prenatal job strain and infant neurodevelopment. Most studies used stress indicators other than job strain to explain the relationship between prenatal maternal stress and child development. The objective of this study was to investigate the association between maternal job strain during pregnancy and neurodevelopment in infancy.

Methods

Mothers and Children’s Environmental Health (MOCEH) study, an on-going prospective birth cohort study, has been conducted in South Korea since 2006. Job strain during pregnancy was measured using Korean version of Job Content Questionnaire (JCQ). Infant neurodevelopment was assessed using Korean Bayley Scale of Infant Development II (K-BSID-II) at 6 and 12 months of age. A total of 343 mother-child pairs that completed JCQ and K-BSID-II more than once were included. Mental Developmental Index (MDI) and Psychomotor Developmental Index (PDI) defined in the K-BSID-II were used as outcome variables.

Results

Compared to infants from mothers with low job strain, significant (p < 0.05) decreases in PDI were found in infants from mothers with active and passive job at 6 months of age. After stratification by infant sex, boys in the high strain group had a lower MDI score than boys in the low job strain group at 12 months. On the other hand, girls in the high strain and active groups had higher MDI scores than girls in the low job strain group at 12 months. PDI at 12 months also showed different results by sex. Boys in the high strain and passive job groups had lower PDI scores than boys in the low job strain group. However, such difference was not observed in girls.

Conclusions

The findings of this study suggest that prenatal job strain affects infant neurodevelopment in a gender-dependent manner.


Citations

Citations to this article as recorded by  
  • Association between prenatal maternal anxiety and/or stress and offspring's cognitive functioning: A meta‐analysis
    Garance Delagneau, E. Sabrina Twilhaar, Renee Testa, Sarit van Veen, Peter Anderson
    Child Development.2023; 94(3): 779.     CrossRef
  • Sex-differences in the effects of indoor air pollutants and household environment on preschool child cognitive development
    Ming-Lun Zou, Hsiao-Chun Huang, Yi-Hua Chen, Chuen-Bin Jiang, Chih-Da Wu, Shih-Chun Candice Lung, Ling-Chu Chien, Yu-Chun Lo, Hsing Jasmine Chao
    Science of The Total Environment.2023; 860: 160365.     CrossRef
  • Low Job Control and Racial Disparities in Breastfeeding
    Margaret D. Whitley, Annie Ro, BongKyoo Choi
    Journal of Occupational & Environmental Medicine.2022; 64(8): e482.     CrossRef
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    Jorge Förster, Isabel López
    Revista Médica Clínica Las Condes.2022; 33(4): 338.     CrossRef
  • Maternal exposure to psychosocial job strain during pregnancy and behavioral problems in the 11-year-old children: a Danish cohort study
    Camilla Sandal Sejbaek, Janni Niclasen, Jens Peter E. Bonde, Petter Kristensen, Ann Dyreborg Larsen, Vivi Schlünssen, Karin Sørig Hougaard
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  • Pregnancy and workplace accidents: The impact of stereotype threat
    Lindsey M. Lavaysse, Tahira M. Probst
    Work & Stress.2021; 35(1): 93.     CrossRef
  • Environmental pollutants affecting children's growth and development: Collective results from the MOCEH study, a multi-centric prospective birth cohort in Korea
    Surabhi Shah, Kyoung Sook Jeong, Hyesook Park, Yun-Chul Hong, Yangho Kim, Byungmi Kim, Namsoo Chang, Suejin Kim, Yeni Kim, Bung-Nyun Kim, Hojang Kwon, Sanghyuk Bae, Hwan-Cheol Kim, Jong-Han Leem, Eun-Kyo Park, Hyunjoo Joo, Bohyun Park, Mina Ha, Eunhee Ha
    Environment International.2020; 137: 105547.     CrossRef
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  • 9 Web of Science
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Original Article
Association of Blood Mercury Level and Neurobehavioral Performance in Korean Elementary School Students
Joon Sakong, Man Joong Jeon, Sung Ho Yun, Yun Chul Hong, Chul Gab Lee, Young Ki Kim, Mina Ha, Ho Jang Kwon
Korean Journal of Occupational and Environmental Medicine 2010;22(4):324-330.   Published online December 31, 2010
DOI: https://doi.org/10.35371/kjoem.2010.22.4.324
AbstractAbstract PDF
OBJECTIVES
This study was conducted to examine the effect of blood mercury on neurobehavioral performance in Korean elementary school students.
METHODS
We measured the blood mercury concentration in 1,077 elementary school students from Seoul, Busan, Daegu and Gwangju, then the students underwent computerized neurobehavioral test.
RESULTS
The mean concentration of blood mercury of study subjects was 2.10 microg/L. An increased blood mercury was associated with an increased reaction time in digit addition and symbol digit.
CONCLUSIONS
The blood mercury concentration of study subjects was very high compared to findings in a foreign country. We found several associations between blood mercury level and neurobehavioral performance.

Citations

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  • Performance assessment on the Korean Computerized Neurobehavioral Test using a mobile device and a conventional computer: an experimental study
    Young Seok Byun, Sung Kyu Park, Joon Sakong, Man Joong Jeon
    Annals of Occupational and Environmental Medicine.2018;[Epub]     CrossRef
  • Evaluation of reliability of computerized neurobehavioral tests in Korean children
    Kyeong-Soo Lee, Man-Joong Jeon, Tae-Yoon Hwang, Chang-Yoon Kim, Joon Sakong
    NeuroToxicology.2012; 33(5): 1362.     CrossRef
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Original Article
Developing an Occupational Stress Scale for Korean Employees
Sei Jin Chang, Sang Baek Koh, Dongmug Kang, Seong Ah Kim, Myung Geun Kang, Chul Gab Lee, Jin Joo Chung, Jung Jin Cho, Mia Son, Chang Ho Chae, Jung Won Kim, Jung Il Kim, Hyeong Su Kim, Sang Chul Roh, Jae Beom Park, Jong Min Woo, Soo Young Kim, Jeong Youn Kim, Mina Ha, Jungsun Park, Kyung Yong Rhee, Hyoung Ryoul Kim, Jeong Ok Kong, In Ah Kim, Jeong Soo Kim, Jun Ho Park, Sook Jung Huyun, Dong Kook Son
Korean Journal of Occupational and Environmental Medicine 2005;17(4):297-317.   Published online December 31, 2005
DOI: https://doi.org/10.35371/kjoem.2005.17.4.297
AbstractAbstract PDF
BACKGROUND
AND PURPOSES: Over the past three decades, numerous studies performed in Korea have reported that job stress is a determinant risk factor for chronic diseases and work disability. Every society has its own culture and occupational climate particular to their organizations, and hence experiences different occupational stress. An occupational stress measurement tool therefore needs to be developed to estimate it objectively. The purpose of this study is to develop and standardize the Korean Occupational Stress Scale (KOSS) which is considered to be unique and specific occupational stressors in Korean employees. Subjects and METHODS: Data were obtained from the National Study for Development and Standardization of Occupational Stress (NSDSOS Project: 2002-2004). A total of 12,631 employees from a nationwide sample proportional to the Korean Standard Industrial Classification and the Korean Standard Occupational Classification were administered. The KOSS was developed for 2 years (2002- 2004). In the first year, we collected 255 items from the most popular job stress measurement tools such as JCQ, ERI, NIOSH and OSI, and 44 items derived from the a qualitative study (depth interview). Fortythree items of KOSS, in the second year, were retained for use in the final version of the KOSS by using Delphi and factor analysis. Items were scored using conventional 1-2-3-4 Likert scores for the response categories.
RESULTS
We developed eight subscales by using factor analysis and validation process: physical environment (3 items), job demand (8 items), insufficient job control (5 items), interpersonal conflict (4 items), job insecurity (6 items), organizational system (7 items), lack of reward (6 items), and occupational climate (4 items). Together they explained 50.0% of total variance. Internal consistency alpha scores were ranged from 0.51 to 0.82. Twenty-four items of the short form of the KOSS (KOSS-SF) were also developed to estimate job stress in the work setting. Because the levels of the subscales of occupational stress were gender dependent, gender-specific standard norms for both the 43-item full version and the 24-item short form using a quartile for the subscales of KOSS were presented.
CONCLUSION
The results of this study suggest that KOSS might be an appropriate measurement scale to estimate occupational stress of Korean employees. Further and more detailed study needs to be conducted to improve the validity of this scale.

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Original Article
Surveillance of work-related carpal tunnel syndrome in Korea
Woo Chul Jeong, Ho Jang Kwon, Mina Ha, Sang Chul Roh, Beom Seon Kwon, Jeong Gun Hyun, Seong Jae Lee, Jong Min Lee, Jeong Yi Kwon, Jun Seong Kim, Nam Jong Baek, Ho Lee, Kyng Woo Lee, Sam Kyu Lee
Korean Journal of Occupational and Environmental Medicine 2004;16(1):37-47.   Published online March 31, 2004
DOI: https://doi.org/10.35371/kjoem.2004.16.1.37
AbstractAbstract PDF
OBJECTIVES
Carpal tunnel syndrome (CTS) is one of the most important work related musculo-skeletal diseases in Korea. However, there are few epidemiologic studies on the work-related CTS (WR-CTS). This study aimed to investigate the epidemiologic characteristics of WR-CTS in Korea.
METHODS
Data obtained from the"CTS Surveillance System". Physician case-reports in the surveillance were used to document patterns of WR-CTS by age, gender, occupation, sign, symptom, working history.
RESULTS
Six hundred and seventy-two cases of WR-CTS were ascertained. of which 314 with complete information on occupational history were analyzed. It has been estimated that as many as 72% of all CTS cases are work-related. The highest proportion of WR-CTS was observed in 'elementary occupation workers', followed by 'skilled agricultural, forestry and fishery workers'. The distributions of WR-CTS cases were similar with respect to age, obesity, and past medical history. The proportion of WR-CTS was higher in females. There was no significant difference in physical examination findings between WR-CTS and non WR-CTS cases. Repetitive work and the inappropriate hand posture seemed to be the risks for WR-CTS.
CONCLUSION
WR-CTS is a significant public health problem. The CTS surveillance system is quite useful to elucidate the characteristics of WR-CTS, but it remains of limited use in targeting specific industries and occupations for intervention.

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    Won Jin Lee, Eun Shil Cha, Eun Kyeong Moon
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Original Article
The Effect of VDT Work on Work-related Musculoskeletal Disorder
Dorn Q Kim, Soo Hun Cho, Tai Ryoon Han, Ho Jang Kwon, Mina Ha, Nam Jong Paik
Korean Journal of Occupational and Environmental Medicine 1998;10(4):524-533.   Published online December 31, 1998
DOI: https://doi.org/10.35371/kjoem.1998.10.4.524
AbstractAbstract PDF
As use of the visual display terminal (VDT) is becoming more generalized as a result of office automation, the so-called 'VDT syndrome' which is often observed with the workers using VDT has emerged as a serious occupational health problem. However, few comparative study with control group using not only subjective symptom but also physical examination hag been conducted. We have conducted a study comparing prevalence rates of musculoskeletal disorder between 113 VDT operators of a telecommunication company and the control groups of housewives and office ladies through a review of subjective symptoms as well as physical examination by physiatrist to understand the magnitude of problem and relative risk of VDT worker. The symptom rates of upper extremity disability in VDT operators were higher than those of controls especially in neck and shoulder area. Fifty-four(47.8%) of 113 VDT operators met our case definition of upper extremity disorder by subjective symptom and physical examination. Myofascial pain syndrome of neck and shoulder muscles were the most common(46.9%). The odd ratio of using VDT operation for developing myofascial pain syndrome in the neck or shoulder area were 2.52(compared to controls of office ladies) and 2.64 (compared to controls of housewives). Other anatomical lesion such as elbow, hand and wrist shows slight higher prevalence rates of musculoskeletal disorder than control groups but not statistically significant.

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