Annals of Occupational and Environmental Medicine

Research Article

Reticulocytosis in screen-printing workers exposed to 2-butoxyethanol and 2-ethoxyethanol: Seng-Ho Song, Seong-Kyu Kang, Won-Jun Choi, Kyeong Min Kwak, Dong-Hoon Lee, Dyuk-Yoon Kang, Sang-Ha Lee; Ann Occup Environ Med 2017;29:54. Published online November 7, 2017; DOI: https://doi.org/10.1186/s40557-017-0210-z

Background

Studies on the hematologic toxicity of ethylene glycol ethers in humans are limited. Therefore, the aim of this study was to examine the association between exposure to solvents (containing 2-butoxyethanol and 2-ethoxyethanol) and hematological effects.

Methods

Thirty-four screen-printing workers who were exposed to 2-butoxyethanol and 2-ethoxyethanol and 37 non-exposed clerical workers were selected using data from the health care facilities that provided regular health screening services. Student’s t-tests and Pearson’s chi-square tests were used to compare differences in hematological parameters between the exposed and the control groups. A multivariate analysis was performed using the multiple logistic regression models to adjust for other variables.

Results

The chi-square test showed the reticulocyte percentages and corrected reticulocyte counts to be significantly higher in the exposed group. The t-tests showed a significant increase in white blood cell counts, reticulocyte percentages, and corrected reticulocyte count (i.e., reticulocyte index) in the exposed group, with p-values of 0.002, 0.004, and 0.002, respectively. Multivariate analysis showed the odds ratio for the corrected reticulocyte counts to be 16.30 for the exposed group, when compared with that of the control group.

Conclusions

Exposure to 2-butoxyethanol and 2-ethoxyethanol was significantly associated with reticulocytosis, necessitating the implementation of preventive measures for workers prone to occupational exposure to ethylene glycol ethers.

Citations

Citations to this article as recorded by

Hepcidin is not essential for mediating testosterone's effects on erythropoiesis
W. Guo, P. J. Schmidt, M. D. Fleming, S. Bhasin
Andrology.2020; 8(1): 82. CrossRef
Cleaning workers’ exposure to volatile organic compounds and particulate matter during floor polish removal and reapplication
Joonas Ruokolainen, Marko Hyttinen
Journal of Occupational and Environmental Hygiene.2019; 16(10): 685. CrossRef

176 View
1 Download
3 Web of Science
2 Crossref

Review

Estimations of the lethal and exposure doses for representative methanol symptoms in humans: Chan-Seok Moon; Ann Occup Environ Med 2017;29:44. Published online October 2, 2017; DOI: https://doi.org/10.1186/s40557-017-0197-5

Abstract PDF PubReader ePub

Background

The aim of this review was to estimate the lethal and exposure doses of a representative symptom (blindness) of methanol exposure in humans by reviewing data from previous articles.

Methods

Available articles published from 1970 to 2016 that investigated the dose-response relationship for methanol exposure (i.e., the exposure concentration and the biological markers/clinical symptoms) were evaluated; the MEDLINE and RISS (Korean search engine) databases were searched. The available data from these articles were carefully selected to estimate the range and median of a lethal human dose. The regression equation and correlation coefficient (between the exposure level and urinary methanol concentration as a biological exposure marker) were assumed from the previous data.

Results

The lethal human dose of pure methanol was estimated at 15.8–474 g/person as a range and as 56.2 g/person as the median. The dose-response relationship between methanol vapor in ambient air and urinary methanol concentrations was thought to be correlated. An oral intake of 3.16–11.85 g/person of pure methanol could cause blindness. The lethal dose from respiratory intake was reported to be 4000–13,000 mg/l. The initial concentration of optic neuritis and blindness were shown to be 228.5 and 1103 mg/l, respectively, for a 12-h exposure.

Conclusion

The concentration of biological exposure indices and clinical symptoms for methanol exposure might have a dose-response relationship according to previous articles. Even a low dose of pure methanol through oral or respiratory exposure might be lethal or result in blindness as a clinical symptom.

Citations

Citations to this article as recorded by

Simultaneous Analysis of Formaldehyde and Methanol Emissions During Curing Reactions of Polyester-melamine Coatings
Elias Rippatha, Clemens Schwarzinger
Chromatographia.2024; 87(5): 275. CrossRef
Eco-efficient coatings for healthy indoors: Ozone deposition velocities, primary and secondary emissions
Alessandra Ranesi, Paulina Faria, M. Rosário Veiga, Elliott T. Gall
Building and Environment.2024; 254: 111306. CrossRef
The Experimental Investigation of the Effects on the Combustion, Performance, and Emission Characteristics of an RCCI Engine Using Methanol/Diesel Fuel
Mustafa Temur, Cenk Sayin, Ilker Turgut Yilmaz
Energies.2024; 17(6): 1436. CrossRef
Turkish validity and reliability study of the falsified hand sanitizer identification scale
Fatma Nur Karaçorlu, Edibe Pirinçci
Archives of Current Medical Research.2024; 5(2): 84. CrossRef
Detection of Ethanol and Methanol in Hand Sanitizers used in Public Places in Delhi during the COVID-19 Pandemic
Neha Afaria, Rohit Kanojia, A. K. Jaiswal, Sudhir K. Gupta, T. Millo
Toxicology International.2024; : 257. CrossRef
Substances of health concern in home-distilled and commercial alcohols from Texas
Coady Lapierre, Laura Weiser Erlandson, Randy Stoneroad II, Andrew Rhiner, Renae Gosnell, John Barber, Linh Pham
Heliyon.2024; 10(11): e32317. CrossRef
Is methanol a clean, efficient, healthy and safe cooking solution for Africa? Experiences of benefits, challenges and prospects for diffusion
David Kimemia, Ashley Van Niekerk
Energy for Sustainable Development.2024; 81: 101498. CrossRef
Male- and female-specific microRNA expression patterns in a mouse model of methanol poisoning
Nurullah Günay, Serpil Taheri, Mehmet Memiş, Zeynep Yilmaz Şükranli, Taner Şahin, Şeniz Demiryürek, Nahide Ekici Günay, Yusuf Ertugrul Aslan, Abdullah Tuncay Demiryürek
Food and Chemical Toxicology.2023; 174: 113666. CrossRef
Tertiary referral hospital experience of methanol poisoning in the COVID-19 era: a cross-sectional study in Northwestern Iran
Ali Jafarizadeh, Navid Sobhi, Mirsaeed Abdollahi, Zhila Khamnian, Farideh Mousavi, Saba Jabbari, Hossein Jabbari
Bulletin of the National Research Centre.2023;[Epub] CrossRef
Exploitations of Schiff’s test and iodoform test for an effective quality assessment of alcohol-based hand sanitizers
Chirapha Prakobdi, Duangjai Nacapricha, Thanthapatra Bunchuay, Phoonthawee Saetear
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy.2023; 302: 123076. CrossRef
Case Reports Study on Methanol Poisoning in King Abdul Aziz Specialist Hospital, Taif, Saudi Arabia
Ghadi I. Alqurashi, Fahad S. Alqurashi, Khalid M. Alhusayni, Alaa H. Falemban, Yosra Z. Alhindi, Safaa M. Alsanosi, Abdullah R. Alzahrani, Saeed S. Al-Ghamdi, Nahla Ayoub
Journal of Clinical Medicine.2023; 12(13): 4282. CrossRef
Metal–Phenolic Film Coated Quartz Crystal Microbalance as a Selective Sensor for Methanol Detection in Alcoholic Beverages
Karekin D. Esmeryan, Yuliyan Lazarov, Teodor Grakov, Yulian I. Fedchenko, Lazar G. Vergov, Stefan Staykov
Micromachines.2023; 14(6): 1274. CrossRef
Severe methanol intoxication with atypical symptoms and imaging changes: a fatal case report
Jiaqi Chen
British Journal of Neurosurgery.2023; 37(3): 370. CrossRef
Awareness raising and dealing with methanol poisoning based on effective strategies
Ali Jangjou, Mostafa Moqadas, Leila Mohsenian, Hesam Kamyab, Shreeshivadasan Chelliapan, Sultan Alshehery, Mohammed Azam Ali, Farbod Dehbozorgi, Krishna Kumar Yadav, Masoud Khorami, Najmeh Zarei Jelyani
Environmental Research.2023; 228: 115886. CrossRef
Setting limits for N-nitrosamines in drugs: A defined approach based on read-across and structure-activity relationship for N-nitrosopiperazine impurities
Carlos E. Matos dos Santos, Daniel Junqueira Dorta, Danielle Palma de Oliveira
Regulatory Toxicology and Pharmacology.2022; 136: 105288. CrossRef
The nature of gas production patterns associated with methanol degradation in natural aquifer sediments: A microcosm study
Cole J.C. Van De Ven, Laura Laurenzi, Ashley C. Arnold, Steven J. Hallam, K. Ulrich Mayer
Journal of Contaminant Hydrology.2022; 247: 103988. CrossRef
Toxic and Nutritional Optic Neuropathies—An Updated Mini-Review
Jacek Baj, Alicja Forma, Joanna Kobak, Magdalena Tyczyńska, Iga Dudek, Amr Maani, Grzegorz Teresiński, Grzegorz Buszewicz, Jacek Januszewski, Jolanta Flieger
International Journal of Environmental Research and Public Health.2022; 19(5): 3092. CrossRef
Biochemical mechanism underlying the pathogenesis of diabetic retinopathy and other diabetic complications in humans: the methanol-formaldehyde-formic acid hypothesis
Bao Ting Zhu
Acta Biochimica et Biophysica Sinica.2022; 54(4): 415. CrossRef
Inexpensive Portable Infrared Device to Detect and Quantify Alcohols in Hand Sanitizers for Public Health and Safety
Jee Kwan Ng, Feng Huai Tay, Patrick Steven Wray, Siti Syazana Mohd Saberi, Kenny Kai Ken Ting, Sook Mei Khor, Ka Lung Andrew Chan
Analytical Chemistry.2021; 93(45): 15015. CrossRef
Fluorometric trace methanol detection in ethanol and isopropanol in a water medium for application in alcoholic beverages and hand sanitizers
Snigdha Roy, Sanju Das, Ambarish Ray, Partha Pratim Parui
RSC Advances.2021; 11(48): 30093. CrossRef
Investigating the epidemiology of methanol poisoning outbreaks: a scoping review protocol
Mehrdad Askarian, Mahasti Khakpour, Mohammad Hossein Taghrir, Hossein Akbarialiabad, Roham Borazjani
JBI Evidence Synthesis.2021; 19(6): 1388. CrossRef
Effect of Different Drying Methods on the Nutritional Value of Hibiscus sabdariffa Calyces as Revealed by NMR Metabolomics
Sengnolotha Marak, Elena Shumilina, Nutan Kaushik, Eva Falch, Alexander Dikiy
Molecules.2021; 26(6): 1675. CrossRef
Manufacturing and characterization of craft beers with leaves from Ocimum selloi Benth
Raul Cremonezi Piva, Maria Helena Verdan, Maria do Socorro Mascarenhas Santos, Margareth Batistote, Claudia Andrea Lima Cardoso
Journal of Food Science and Technology.2021; 58(11): 4403. CrossRef
Biological Denitrification of Water Intended for Human Consumption
Alexandru Matei, Gabriel Racoviţeanu, Elena Vulpaşu
Modelling in Civil Environmental Engineering.2021; 16(4): 34. CrossRef
Evaporation of Methanol Solution for a Methanol Steam Reforming System
Ngoc Van Trinh, Younghyeon Kim, Hongjip Kim, Sangseok Yu
Energies.2021; 14(16): 4862. CrossRef
Sequential electrodeposition of Cu–Pt bimetallic nanocatalysts on boron-doped diamond electrodes for the simple and rapid detection of methanol
Surinya Traipop, Abdulhadee Yakoh, Sakda Jampasa, Sudkate Chaiyo, Yuttanant Boonyongmaneerat, Joongjai Panpranot, Piyasan Praserthdam, Orawon Chailapakul
Scientific Reports.2021;[Epub] CrossRef
Methanolintoxikation: ein Kollateralschaden der COVID-19-Pandemie
Bianca Wuchty, Julian Perneczky, Johann Sellner
psychopraxis. neuropraxis.2021; 24(4): 238. CrossRef
Diroximel Fumarate in the Treatment of Multiple Sclerosis
Elise Jonasson, Tobias Sejbaek
Neurodegenerative Disease Management.2020; 10(5): 267. CrossRef
Carcinogenic, ethanol, acetaldehyde and noncarcinogenic higher alcohols, esters, and methanol compounds found in traditional alcoholic beverages. A risk assessment approach
Manolis Kokkinakis, Ioannis Tsakiris, Manolis Tzatzarakis, Elena Vakonaki, Athanasios Alegakis, Stella Papachristou, Vasiliki Karzi, Aikaterini Kokkinaki, Marina Goumenou, Manolis Kallionakis, Alexandra Kalogeraki
Toxicology Reports.2020; 7: 1057. CrossRef
Photoluminescent properties of ZnO nanorods films used to detect methanol contamination in tequila
J.A. Maldonado-Arriola, R. Sánchez-Zeferino, M.E. Álvarez-Ramos
Sensors and Actuators A: Physical.2020; 312: 112142. CrossRef
Valorization of Zante currant side‐streams for the production of phenolic‐rich extract and bacterial cellulose: a novel biorefinery concept
Erminda Tsouko, Aikaterini Papadaki, Harris Papapostolou, Dimitris Ladakis, Aikaterini Natsia, Apostolis Koutinas, Adamantia Kampioti, Effimia Eriotou, Nikolaos Kopsahelis
Journal of Chemical Technology & Biotechnology.2020; 95(2): 427. CrossRef
Improving the Gastrointestinal Tolerability of Fumaric Acid Esters: Early Findings on Gastrointestinal Events with Diroximel Fumarate in Patients with Relapsing-Remitting Multiple Sclerosis from the Phase 3, Open-Label EVOLVE-MS-1 Study
Michael J. Palte, Angela Wehr, Mark Tawa, Kristopher Perkin, Richard Leigh-Pemberton, Jerome Hanna, Catherine Miller, Natasha Penner
Advances in Therapy.2019; 36(11): 3154. CrossRef
Redox titration on foldable paper-based analytical devices for the visual determination of alcohol content in whiskey samples
Sandro A. Nogueira, Adriano D. Lemes, Adriana C. Chagas, Maurício L. Vieira, Márcio Talhavini, Pedro A.O. Morais, Wendell K.T. Coltro
Talanta.2019; 194: 363. CrossRef

265 View
4 Download
36 Web of Science
33 Crossref

Original Article

The Application of Biological Monitoring and Effects of Ethanol and Phenobarbital on Plasma Protein Adducts Formed in Rats Exposed to Benzidine: Chi Nyon Kim, Se Hoon Lee, Jaehoon Roh; Korean Journal of Occupational and Environmental Medicine 2002;14(4):353-363. Published online December 31, 2002; DOI: https://doi.org/10.35371/kjoem.2002.14.4.353

Abstract PDF: OBJECTIVES
The effects of ethanol and phenobarbital,which are known to affect metabolism of xenobiotics, on the formation of benzidine-and its metabolites-plasma protein adducts in rats administered benzidine were evaluated.
METHODS
The experimental rats were divided into the control,ethanol and phenobar-bital groups. The experimental groups (ethanol and phenobarbital group)were pretreated with ethanol (1g/kg)or phenobarbital (80mg/kg)24 hours prior to the oral administration of benzidine (0.5mmol/kg). Blood samples were obtained from the vena cava from 5 rats in each group; and at 30 min,3 h,6 h,9 h,12 h,24 h,48 h,72 h,96 h,and 144 h after the administration of benzidine using heparin treated syringes.The plasma protein levels were separated immediately after taking blood samples. The adducts were underwent basic hydrolysis to convert them into aromatic amines. The hydrolyzed benzidine, monoacetylbenzidine, and 4-aminobiphenyl were analyzed by reverse-phased liquid chro-matography with an electrochemical detector. The quantitative amount of the metabolites was expressed by the plasma protein binding index(PBI).
RESULTS
Similar to the hemoglobin adducts,the levels of the plasma protein adducts of the ethanol and phenobarbital groups (benzidine-, monoacetylbenzidine-, and 4-amino-biphenyl-PBI)were higher than those of the control group. These results are attributable to the fact that ethanol and phenobarbital induced to the plasma protein adduct formation. The N-acetylation ratio in the control group was highest at 72 h with 2.34.In the ethanol group,it was highest at 72 h with a ratio of 2.46 and was highest in the phenobarbital group at 72 h with a ratio of 2.43. The N-acetylation ratio of the plasma protein adducts was relatively lower than that of the hemoglobin adducts.The level of the plasma protein adduct increased more rapidly than the hemoglobin adducts in all experimental groups regardless of the pretreatment,and decreased rapidly after reaching the maximum level.
CONCLUSION
The above results indicate that ethanol and phenobarbital increased the level of plasma protein adduct formation. The plasma protein adducts tended to decrease more rapidly than the hemoglobin adducts in the body after benzidine exposure. This results in this study result suggests that the effects of ethanol or phenobarbital need to be considered in the biochemical monitoring,and that the level of the plasma protein adducts be a more proper biomarker than the hemoglobin adducts for assessing the short term exposure to a benzidine and benzidine based dye.

50 View
0 Download

Original Article

A Study on the Hematologic Changes of Workers Exposed to Mixed Organic Solvents: Choong Ryeol Lee, Cheol In Ryu; Korean Journal of Occupational and Environmental Medicine 1997;9(4):549-564. Published online December 31, 1997; DOI: https://doi.org/10.35371/kjoem.1997.9.4.549

Abstract PDF: The purpose of this study is to evaluate the hematological changes of workers exposed to mixed organic solvents and to search the organic solvent that bring out these changes. The study participants were 1,605 workers, consisting 1,088 workers (male 989, female 99) exposed to mixed organic solvents and 517 non-exposed workers (male 431, female 86). The authors analyzed the results of complete blood count and differential count of leukocytes of all the workers and examined all of the material safety data sheets of substances with which they dealt and the results of their working environmental surveys during the last 3 years. The results were as follows: 1. The mean values of complete blood count in workers exposed to mixed organic solvents were lower than that of non-exposed workers in WBC, RBC, hemoglobin and hematocrit in cases of male and RBC, hemoglobin and hematocrit in cases of female, but the mean value of platelet count in male exposed workers and WBC count in female exposed workers were higher than those of non-exposed workers. 2. The distribution of differential count of leukocytes showed no difference between exposed workers and non-exposed workers. 3. The correlation coefficients between age and duration of employment and WBC showed statistically a positive value and that between age and duration of employment and RBC, hemoglobin, hematocrit showed a statistically negative value in cases of male exposed to mixed organic solvents. But in cases of female there was no statistical correlation between them. 4. In cases of male the proportions of workers with subnormal levels of WBC, RBC, hemoglobin, hematocrit and platelet according to the standard of classification were high or than those of non-exposed workers. The proportions of exposed workers were 3.6 %, 18.6 %, 5.3 %, 32.7 % and 1.4 % respectively and those of non-exposes workers were 2.8 %, 10.7 %, 2.1 %, 13.9 % and 0.2 % respectively. 5. In cased of female the proportion of workers with subnormal levels of RBC, hemoglobin and hematocrit according to the standard of classification were higher than those of non exposed workers. The proportion of exposed workers were 42.4 %, 55.6 % and 41.4 % respectively and those of non-exposed workers were 10.5 %, 11.6 % and 8.1 % respectively. 6. The number of substances with which workers exposed to mixed organic solvents dealt were about 500, and 22 organic solvents such as xylene, toluene, isopropyl alcohol, 2-ethoxyethanol and 2-ethoxy ethyl acetate were main components of substances according to the material safety data sheet and working environmental surveys during the last 3 years. The authors suspect 2-ethoxyethanol and 2-ethoxy ethyl acetate of the organic solvents, which bring out the hematological changes of workers exposed to mixed organic solvents. As a result of this study, the authors confirmed the hematological changes of workers exposed to mixed organic solvents and recommend : strict management of working environment, working time and the protective equipments of workers exposed to mixed organic solvents.

51 View
0 Download

First
Prev
Page of 1
Next
Last

Search