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Research Article
- Association of cadmium with diabetes in middle-aged residents of abandoned metal mines: the first health effect surveillance for residents in abandoned metal mines
- Hee-seung Son, Soo-geun Kim, Byung-seong Suh, Dong-uk Park, Dae-seon Kim, Seung-do Yu, Yeong-seoub Hong, Jung-duck Park, Byung-kook Lee, Jai-dong Moon, Joon Sakong
- Ann Occup Environ Med 2015;27:20. Published online August 24, 2015
- DOI: https://doi.org/10.1186/s40557-015-0071-2
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Abstract
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ePub Objective The aim of this study was to determine the association between urinary cadmium (U-cd) concentration and diabetes in middle-aged Korean residents of abandoned mines using the first Health Effect Surveillance for Residents in Abandoned Metal mines (HESRAM).
Methods This study was cross-sectional study conducted on 719 residents between 40–70 years in 38 abandoned metal mines in Korea. Data was collected by HESRAM from 2008 to 2011. The correlation coefficient of U-cd and fasting blood glucose, odds ratio in urinary cadmium tertiles and diabetes prevalence was analyzed according to the sex category.
Results The correlation coefficient U-cd concentration and fasting blood glucose was 0.182 in male. Logistic regression analysis in male revealed a third tertile odds ratio of U-cd (2 μg/g creatinine < U-cd) while diabetes prevalence was 1.81 (95 % CI 1.05-3.12) with adjusted age, BMI, smoking and alcohol consumption, region, family income. On the other hand, the odds ratio for third tertile of U-cd (3 μg/g creatinine < U-cd) between diabetes prevalence in female was 1.39 (95 % CI 0.52-3.72) in addition to adjusted menopausal status.
Conclusions Environmental exposure to cadmium in abandoned mine residents was associated with diabetes in male. Closed monitoring and periodic evaluation of the health effects of chronic environmental exposure on abandoned mines residents will be needed.
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Citations
Citations to this article as recorded by
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Kai Li, Yisen Yang, Jiaxin Zhao, Quan Zhou, Yanbing Li, Ming Yang, Yaoyu Hu, Jing Xu, Meiduo Zhao, Qun Xu
Journal of Hazardous Materials.2024; 470: 134224. CrossRef - Is Environmental Cadmium Exposure Causally Related to Diabetes and Obesity?
Soisungwan Satarug
Cells.2023; 13(1): 83. CrossRef - Environmental Cadmium Exposure and Type 2 Diabetes Mellitus Risk: An Overview of Systematic Reviews
Julia Hildebrand, Swarni Thakar, Tonya-Leah Watts, Laura Banfield, Lehana Thabane, Joseph Macri, Stephen Hill, M. Constantine Samaan
Exposure and Health.2022; 14(3): 743. CrossRef - Effects of Environmental Exposure to Cadmium and Lead on the Risks of Diabetes and Kidney Dysfunction
Supabhorn Yimthiang, Phisit Pouyfung, Tanaporn Khamphaya, Saruda Kuraeiad, Paleeratana Wongrith, David A. Vesey, Glenda C. Gobe, Soisungwan Satarug
International Journal of Environmental Research and Public Health.2022; 19(4): 2259. CrossRef - Cadmium exposure and risk of diabetes and prediabetes: A systematic review and dose-response meta-analysis
Tommaso Filippini, Lauren A. Wise, Marco Vinceti
Environment International.2022; 158: 106920. CrossRef - Mitigation of Cadmium Toxicity through Modulation of the Frontline Cellular Stress Response
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Stresses.2022; 2(3): 355. CrossRef - A benchmark dose analysis for urinary cadmium and type 2 diabetes mellitus
Peng Shi, Huanchang Yan, Xingjun Fan, Shuhua Xi
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World Journal of Meta-Analysis.2021; 9(3): 234. CrossRef - Cadmium exposure, fasting blood glucose changes, and type 2 diabetes mellitus: A longitudinal prospective study in China
Lili Xiao, Wei Li, Chunmei Zhu, Shijie Yang, Min Zhou, Bin Wang, Xing Wang, Dongming Wang, Jixuan Ma, Yun Zhou, Weihong Chen
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Toxicology.2019; 425: 152252. CrossRef - Roles of C-reactive protein on the association between urinary cadmium and type 2 diabetes
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Environmental Pollution.2019; 255: 113341. CrossRef - Cadmium Body Burden and Gestational Diabetes Mellitus: A Prospective Study
Wenyu Liu, Bin Zhang, Zheng Huang, Xinyun Pan, Xiaomei Chen, Chen Hu, Hongxiu Liu, Yangqian Jiang, Xiaojie Sun, Yang Peng, Wei Xia, Shunqing Xu, Yuanyuan Li
Environmental Health Perspectives.2018;[Epub] CrossRef - Heavy Metal Exposure and Metabolic Syndrome: Evidence from Human and Model System Studies
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Endocrine.2018; 61(2): 258. CrossRef - Association of urinary cadmium with risk of diabetes: a meta-analysis
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Environmental Science and Pollution Research.2017; 24(11): 10083. CrossRef - Kidney Cadmium Toxicity, Diabetes and High Blood Pressure: The Perfect Storm
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The Tohoku Journal of Experimental Medicine.2017; 241(1): 65. CrossRef - Current health risk assessment practice for dietary cadmium: Data from different countries
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- Associations of metals and metal mixtures with glucose homeostasis: A combined bibliometric and epidemiological study
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Case Report
- Four Cases of Abnormal Neuropsychological Findings in Children with High Blood Methylmercury Concentrations
- Young-Seoub Hong, Dae-Seon Kim, Seung-Do Yu, Seong-Hwan Kim, Jong-Kuk Kim, Yu-Mi Kim, Jae-Ho Yu, Ji-Hyun Jung, Byoung-Gwon Kim
- Ann Occup Environ Med 2013;25:18-18. Published online September 24, 2013
- DOI: https://doi.org/10.1186/2052-4374-25-18
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Abstract
PDFPubReaderePub
Background Methylmercury (MeHg) easily crosses the blood–brain barrier and accumulates in the brain. Accumulated MeHg will cause neurological symptoms. We report four pediatric cases of neuropsychological findings with high blood MeHg concentrations.
Case presentation Four children were admitted for follow-up study because their total mercury (THg) concentration in the blood was found to be high during a national survey. Case 1 was a 9-year-old female with a 16.6
μ g/ℓ blood THg concentration in the survey. During admission, the blood THg, hair THg, and blood MeHg concentration(mercury indices) were 21.4μ g/ℓ, 7.2μ g/g, and 20.1μ g/ℓ, respectively. In our neuropsychological examination, cognitive impairment and attention deficit were observed. Her diet included fish intake 2–3 times per week, and she had been diagnosed with epilepsy at 3 years of age. Case 2 was a 12-year-old male with blood THg of 15.4μ g/ℓ in the survey and the mercury indices were 12.7μ g/ℓ, 5.7μ g/g, and 11.8μ g/ℓ, respectively, on admission. He was also observed to have attention-deficit/hyperactivity disorder. Case 3 was a 10-year-old male child with blood THg of 17.4μ g/ℓ in the survey, and the mercury indices on admission were 21.6μ g/ℓ, 7.5μ g/g and 21.5μ g/ℓ, respectively. In his case, mild attention deficit was observed. Case 4 was a 9-year-old male with blood THg of 20.6μ g/ℓ in the survey and the mercury indices were 18.9μ g/ℓ, 8.3μ g/g, and 14.4μ g/ℓ, respectively, on admission. Mild attention difficulty was observed.Conclusion We suggest that fish consumption may be the main source of MeHg exposure, and that MeHg may have been the cause of the neuropsychological deficits in these cases.
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Citations
Citations to this article as recorded by- Selenium Status: Its Interactions with Dietary Mercury Exposure and Implications in Human Health
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Nutrients.2022; 14(24): 5308. CrossRef - Characteristics, Treatment, and Prognosis of Elemental Mercury Intoxication in Children
Deniz Güven, İmran Özbek
Pediatric Emergency Care.2022; 38(10): 481. CrossRef - Oral methylmercury intoxication aggravates cardiovascular risk factors and accelerates atherosclerosis lesion development in ApoE knockout and C57BL/6 mice
Janayne L. Silva, Paola C. L. Leocádio, Jonas M. Reis, Gianne P. Campos, Luciano S. A. Capettini, Giselle Foureaux, Anderson J. Ferreira, Cláudia C. Windmöller, Flávia A. Santos, Reinaldo B. Oriá, Maria E. Crespo-López, Jacqueline I. Alvarez-Leite
Toxicological Research.2021; 37(3): 311. CrossRef - Mercury intoxication resembling pediatric rheumatic diseases: case series and literature review
Mehmet Yildiz, Amra Adrovic, Aybuke Gurup, Esra Karabag Yilmaz, Yavuz Ozer, Oya Koker, Sezgin Sahin, Ertugrul Kiykim, Nur Canpolat, Kenan Barut, Ozgur Kasapcopur
Rheumatology International.2020; 40(8): 1333. CrossRef
- Selenium Status: Its Interactions with Dietary Mercury Exposure and Implications in Human Health
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