Annals of Occupational and Environmental Medicine

Original Article

The Serum Copper and Zinc Concentration according to the Progression of Pneumoconiosis: Jung Rae Park, Jong Wook Park, Su Ill Lee, Cheol Ho Yi, Cha Jae O, Chang Won Kim, Byung Mann Cho, Don Kyoun Kim; Korean Journal of Occupational and Environmental Medicine 2000;12(3):384-394. Published online September 30, 2000; DOI: https://doi.org/10.35371/kjoem.2000.12.3.384

Abstract PDF: OBJECTIVES
Copper and Zinc, the trace elements of a living body, take a part in immunologic mechanism and induce the pulmonary fibrosis which is the pathologic progress of pneumoconiosis. This study was performed to assist the identification of the pathologic process of pulmonary fibrosis in pneumoconiosis.
METHODS
The subjects of this study was 200 diagnosed persons as pneumoconiosis, of whom 100 persons was the visitors in the outpatients departments of pneumoconiosis and 100 admissive pneumoconiosis patients. The serum copper and zinc are measured and com pared.
RESULTS
The mean serum copper concentration of visitor group was significantly higher than that of control group, and that of stage V3 subgroup of visitor group was highest because of their advanced fibrosis. But, there was not the difference of serum copper concentration between patient and control group. We thought that the reason was poor nutritional and health status of the patient. The mean of serum zinc concentration of visitor and patient control was lower than that of control group. As the degree of pulmonary fibrosis was more severe from stage Vl, V2, V3 of visitor to stage Pl, P2, P3 of patient, the mean of serum zinc concentration was lower. The ratio of serum copper/zinc of visitor and patient was higher than that of control, and that of patient was higher than that of visitor. Those results showed that the ratio of serum copper/zinc ratio more greatly expressed the degree of progression of pneumoconiosis than only copper or zinc concentration by adjustment of nutritional and health status of the patient.
CONCLUSIONS
As above study results, the degree of pulmonary fibrosis of pneumoconiosis could be estimated by means of serum copper/zinc ratio.

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Original Article

The Influence of Smoking, Alcohol Ingestion, and Physical Activity on Copper, Zinc and Ceruloplasmin in Blood of Male Adults: Jin Wan Park, Eun Yong Kang, In Cheol Shin, Byung Sun Choi, Jung Duck Park, Im Won Chang, Yeon Pyo Hong; Korean Journal of Occupational and Environmental Medicine 1999;11(4):569-578. Published online December 31, 1999; DOI: https://doi.org/10.35371/kjoem.1999.11.4.569

Objective : To investigate the influence of smoking, alcohol ingestion, and physical activity on copper and zinc in RBC and serum and serum ceruloplasmin, this study was performed in a cross-sectional study in 113 healthy men aged 20 to 40 years who had no symptomatic liver, heart, gastrointestinal, and other chronic diseases.
METHODS
At the men's entry into the study, blood samples were drawn from each subject and immediately centrifuged for analysis of copper, zinc, iron, ceruloplasmin, total cholesterol, and hematocrit. Each man completed a questionnaire that provided information on smoking, amount of alcohol intake, and physical activity. Partial regres sion analysis was performed on confounding variables such as age, body mass index, hematocrit, serum cholesterol, and serum iron.
RESULTS
In general linear models, adjustment for confounding variables did not show statistical differences, and there was only an increasing tendency in serum copper in heavy smoker (P=0.0678). There was no difference between high physical activity with mild smokers and lower physical activfty with, heavy smokers.
CONCLUSIONS
This study suggested that copper, zinc and eeruloplasmin were not good biomarker for early effect by smoking, alcohol intake and physical activity in young adult. However, selection bias should be considered in evaluation of this result, and a large prospective study will be needed in advance on usefulness of copper, zinc and ceruloplasmin as a marker for risk factors and early change of atherosclerosis.

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Assessment of reference ranges for blood Cu, Mn, Se and Zn in a selected Italian population
Beatrice Bocca, Roberto Madeddu, Yolande Asara, Paola Tolu, Juan A. Marchal, Giovanni Forte
Journal of Trace Elements in Medicine and Biology.2011; 25(1): 19. CrossRef

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