Annals of Occupational and Environmental Medicine

Original Article

Two Cases of Convulsion Associated With Caprolactam: Kuck Hyeun Woo, Sang Je Jung, Wan Seup Park, Hea Ryeon Shin, Jin Seok Kim, Sang Woo Kim; Korean Journal of Occupational and Environmental Medicine 1998;10(1):116-120. Published online February 28, 1998; DOI: https://doi.org/10.35371/kjoem.1998.10.1.116

Abstract PDF: Two young men were seen with nausea, vomiting, dermatitis, seizure after two-four days of occupational exposure to caprolactam, a nylon fiber precursor. There were no significant results in laboratory test, brain CT, EEG except leukocytosis, hyperglycemia. Caprolactam has been shown to induce convulsive disorder in experimental animal studios and Tuma et al (1981) described that one worker acutely exposed to caprolactam developed generalized tonic-clonic seizure with leukocytosis. The coincidence of typical skin lesion with otherwise unexplained generalized tonic-clonic seizure in those young man strongly suggests that caprolactam was causal agent.

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