The purpose of this study was to compare the characteristics between chronic CS2 poisoning group and non-poisoning group, to find out major factors for decision of chronic CS2 poisoning, to describe the characteristics of cerebral infarctions, and to find out the related factors of cerebral infarctions. The study subjects were 220 ex-employees from W company and the study period was from August, 1993 to November, 1995. The proportion rate of chronic CS2 poisoning was higher in older age groups and longer work duration groups. The rate differed by cerebral infarction, microaneurysm, other retina lesions, polyneuropathy, psychiatric lesions, and sensorineural hearing loss. The cerebral infarction was found to be mainly multiple and the frequently occurred locations were periventricular white matter, frontal lobe and basal ganglia. The logistic regression for chronic CS2 poisoning showed that the major factors were microaneurysm, cerebral infarction, polyneuropathy, other retina lesions, diastolic blood pressure, and sensorineural hearing loss. Among the approved group 117 patients were followed up continuously at the outpatient clinic, 62.4% of the patients had hypertension, 61.5% had polyneuropathy, 52.1% had cerebral infarction, 35.0% had hyperlipidemia, 29.9% had liver disease, 15.4% had psychiatric diseases, 6.0% had angina, and 4.3% had anemia. For the hypertensive patients, 1.9 kinds of antihypertensive drugs were needed to control the blood pressure, and the BP decreased from 164/101 mmHg to 131/81 mmHg.
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The authors have experinced 8 cases of chronic carbon disulfide poisoning in workers engaged in the viacase rayon industry during the period between March 1987 and September 1988. Cases of carbon disulfide poisoning has not been reported in Korea till then. Carbon disulfide is primarily a neurotoxic poison, therefore those symptoms indicating central and peripheral nervous damage are very important. And it has toxic effects on the various organs such as skin, eye, ear, and respiratory, cardiovascular, gastrointestinal, hepatic, genitourinary, hematological, and endocrine system. Occupational histories were obtained, and clinical findings and laboratory findings were analysed on all cases.
1. Seven (7) cases had been exposed to carbon disulfide for more than 10 years, and 1 case has been exposed for 6 years.
2. Most common symptoms were neurological symptoms such as gait disturbance, extremity weakness, paresthesia, and speech disturbance.
3. Involvement of central nervous system was noted in 7 cases through abnormal findings of electroencephalography, brain computerized tomography, neurological signs, and psychological test. Needle electromyography and nerve conduction study showed polyneuropathy in all cases. Ophthalmological abnormalities were found in 7 cases, mainly retinal microaneurysms and peripheral constriction of the visual field. Renal damage appeared in 4 cases, increase of serum cholesterol and/or triglyceride level appeared in 3 cases, and dercrease of erythrocyte and hemoglobin appeared in 2 cases. And hypertenison appeared in 2 cases, and diabetes appeared in 1 case. One(1) case who has been exposed tn carbon disulfide for 6 years showed polyneuropathy and peripheral constriction of the visual field.
Citations
Citations to this article as recorded by
Occupational Neurological Disorders in Korea Eun-A Kim, Seong-Kyu Kang Journal of Korean Medical Science.2010; 25(Suppl): S26. CrossRef
Work-related Cerebro-Cardiovascular Diseases in Korea Dae-Seong Kim, Seong-Kyu Kang Journal of Korean Medical Science.2010; 25(Suppl): S105. CrossRef
Carbon Disulfide Poisoning in Korea with Social and Historical Background Eunil Lee, Soonduck Kim, Haejoon Kim, Kwangjong Kim, Yongtae Yum Journal of Occupational Health.1996; 38(4): 155. CrossRef