Annals of Occupational and Environmental Medicine

Research Article

Urinary arsenic species concentration in residents living near abandoned metal mines in South Korea: Jin-Yong Chung, Byoung-Gwon Kim, Byung-Kook Lee, Jai-Dong Moon, Joon Sakong, Man Joong Jeon, Jung-Duck Park, Byung-Sun Choi, Nam-Soo Kim, Seung-Do Yu, Jung-Wook Seo, Byeong-Jin Ye, Hyoun-Ju Lim, Young-Seoub Hong; Ann Occup Environ Med 2016;28:67. Published online November 22, 2016; DOI: https://doi.org/10.1186/s40557-016-0150-z

Background

Arsenic is a carcinogenic heavy metal that has a species-dependent health effects and abandoned metal mines are a source of significant arsenic exposure. Therefore, the aims of this study were to analyze urinary arsenic species and their concentration in residents living near abandoned metal mines and to monitor the environmental health effects of abandoned metal mines in Korea.

Methods

This study was performed in 2014 to assess urinary arsenic excretion patterns of residents living near abandoned metal mines in South Korea. Demographic data such as gender, age, mine working history, period of residency, dietary patterns, smoking and alcohol use, and type of potable water consumed were obtaining using a questionnaire. Informed consent was also obtained from all study subjects (n = 119). Urinary arsenic species were quantified using high performance liquid chromatography (HPLC) and inductively coupled plasma mass spectrometry (ICP/MS).

Results

The geometric mean of urinary arsenic (sum of dimethylarsinic acid, monomethylarsonic acid, As³⁺, and As⁵⁺) concentration was determined to be 131.98 μg/L (geometric mean; 95% CI, 116.72–149.23) while urinary inorganic arsenic (As³⁺ and As⁵⁺) concentration was 0.81 μg/L (95% CI, 0.53–1.23). 66.3% (n = 79) and 21.8% (n = 26) of these samples exceeded ATSDR reference values for urinary arsenic (>100 μg/L) and inorganic arsenic (>10 μg/L), respectively. Mean urinary arsenic concentrations (geometric mean, GM) were higher in women then in men, and increased with age. Of the five regions evaluated, while four regions had inorganic arsenic concentrations less than 0.40 μg/L, one region showed a significantly higher concentration (GM 15.48 μg/L; 95% CI, 7.51–31.91) which investigates further studies to identify etiological factors.

Conclusion

We propose that the observed elevation in urinary arsenic concentration in residents living near abandoned metal mines may be due to environmental contamination from the abandoned metal mine.

Trial registration

Not Applicable (We do not have health care intervention on human participants).

Citations

Citations to this article as recorded by

Assessing Acute and Chronic Risks of Human Exposure to Arsenic: A Cross-Sectional Study in Ethiopia Employing Body Biomarkers
Solomon Demissie, Seblework Mekonen, Tadesse Awoke, Bezatu Mengistie
Environmental Health Insights.2024;[Epub] CrossRef
Changes in arsenic accumulation and metabolic capacity after environmental management measures in mining area
Chen Zhao, Meng Du, Jun Yang, Guanghui Guo, Lingqing Wang, Yunxian Yan, Xuewen Li, Mei Lei, Tongbin Chen
Science of The Total Environment.2023; 855: 158652. CrossRef
Concentrations of blood and urinary arsenic species and their characteristics in general Korean population
Jeong Weon Choi, Yoon Chae Song, Nam-Yong Cheong, Kiyoung Lee, Sunmi Kim, Kyoung-Mu Lee, Kyunghee Ji, Mi-Yeon Shin, Sungkyoon Kim
Environmental Research.2022; 214: 113846. CrossRef
MTHFR, As3MT and GSTO1 Polymorphisms Influencing Arsenic Metabolism in Residents Near Abandoned Metal Mines in South Korea
Ulziikhishig Surenbaatar, Byoung-Gwon Kim, Hyun-Jin Son, Seong-Sik Cho, Gwon-Min Kim, Hyoun-Ju Lim, Jung-Yeon Kwon, Ki-Hwan Kim, Young-Seoub Hong
Journal of Environmental Health Sciences.2021; 47(6): 530. CrossRef

226 View
1 Download
4 Web of Science
4 Crossref

Research Article

Association of cadmium with diabetes in middle-aged residents of abandoned metal mines: the first health effect surveillance for residents in abandoned metal mines: Hee-seung Son, Soo-geun Kim, Byung-seong Suh, Dong-uk Park, Dae-seon Kim, Seung-do Yu, Yeong-seoub Hong, Jung-duck Park, Byung-kook Lee, Jai-dong Moon, Joon Sakong; Ann Occup Environ Med 2015;27:20. Published online August 24, 2015; DOI: https://doi.org/10.1186/s40557-015-0071-2

Abstract PDF PubReader ePub

Objective

The aim of this study was to determine the association between urinary cadmium (U-cd) concentration and diabetes in middle-aged Korean residents of abandoned mines using the first Health Effect Surveillance for Residents in Abandoned Metal mines (HESRAM).

Methods

This study was cross-sectional study conducted on 719 residents between 40–70 years in 38 abandoned metal mines in Korea. Data was collected by HESRAM from 2008 to 2011. The correlation coefficient of U-cd and fasting blood glucose, odds ratio in urinary cadmium tertiles and diabetes prevalence was analyzed according to the sex category.

Results

The correlation coefficient U-cd concentration and fasting blood glucose was 0.182 in male. Logistic regression analysis in male revealed a third tertile odds ratio of U-cd (2 μg/g creatinine < U-cd) while diabetes prevalence was 1.81 (95 % CI 1.05-3.12) with adjusted age, BMI, smoking and alcohol consumption, region, family income. On the other hand, the odds ratio for third tertile of U-cd (3 μg/g creatinine < U-cd) between diabetes prevalence in female was 1.39 (95 % CI 0.52-3.72) in addition to adjusted menopausal status.

Conclusions

Environmental exposure to cadmium in abandoned mine residents was associated with diabetes in male. Closed monitoring and periodic evaluation of the health effects of chronic environmental exposure on abandoned mines residents will be needed.

Citations

Citations to this article as recorded by

Associations of metals and metal mixtures with glucose homeostasis: A combined bibliometric and epidemiological study
Kai Li, Yisen Yang, Jiaxin Zhao, Quan Zhou, Yanbing Li, Ming Yang, Yaoyu Hu, Jing Xu, Meiduo Zhao, Qun Xu
Journal of Hazardous Materials.2024; 470: 134224. CrossRef
Is Environmental Cadmium Exposure Causally Related to Diabetes and Obesity?
Soisungwan Satarug
Cells.2023; 13(1): 83. CrossRef
Environmental Cadmium Exposure and Type 2 Diabetes Mellitus Risk: An Overview of Systematic Reviews
Julia Hildebrand, Swarni Thakar, Tonya-Leah Watts, Laura Banfield, Lehana Thabane, Joseph Macri, Stephen Hill, M. Constantine Samaan
Exposure and Health.2022; 14(3): 743. CrossRef
Effects of Environmental Exposure to Cadmium and Lead on the Risks of Diabetes and Kidney Dysfunction
Supabhorn Yimthiang, Phisit Pouyfung, Tanaporn Khamphaya, Saruda Kuraeiad, Paleeratana Wongrith, David A. Vesey, Glenda C. Gobe, Soisungwan Satarug
International Journal of Environmental Research and Public Health.2022; 19(4): 2259. CrossRef
Cadmium exposure and risk of diabetes and prediabetes: A systematic review and dose-response meta-analysis
Tommaso Filippini, Lauren A. Wise, Marco Vinceti
Environment International.2022; 158: 106920. CrossRef
Mitigation of Cadmium Toxicity through Modulation of the Frontline Cellular Stress Response
Soisungwan Satarug, David A. Vesey, Glenda C. Gobe
Stresses.2022; 2(3): 355. CrossRef
A benchmark dose analysis for urinary cadmium and type 2 diabetes mellitus
Peng Shi, Huanchang Yan, Xingjun Fan, Shuhua Xi
Environmental Pollution.2021; 273: 116519. CrossRef
Environmental pollution and diabetes mellitus
Amany El-Sikaily, Mohamed Helal
World Journal of Meta-Analysis.2021; 9(3): 234. CrossRef
Cadmium exposure, fasting blood glucose changes, and type 2 diabetes mellitus: A longitudinal prospective study in China
Lili Xiao, Wei Li, Chunmei Zhu, Shijie Yang, Min Zhou, Bin Wang, Xing Wang, Dongming Wang, Jixuan Ma, Yun Zhou, Weihong Chen
Environmental Research.2021; 192: 110259. CrossRef
Associations between metabolic syndrome and four heavy metals: A systematic review and meta-analysis
Ping Xu, Aiping Liu, Fengna Li, Alexey A. Tinkov, Longjian Liu, Ji-Chang Zhou
Environmental Pollution.2021; 273: 116480. CrossRef
Adipose tissue cadmium concentrations as a potential risk factor for insulin resistance and future type 2 diabetes mellitus in GraMo adult cohort
Inmaculada Salcedo-Bellido, Celia Gómez-Peña, Francisco M. Pérez-Carrascosa, Petra Vrhovnik, Vicente Mustieles, Ruth Echeverría, Željka Fiket, Celia Pérez-Díaz, Rocío Barrios-Rodríguez, José Juan Jiménez-Moleón, Juan Pedro Arrebola
Science of The Total Environment.2021; 780: 146359. CrossRef
Cadmium Is Associated with Type 2 Diabetes in a Superfund Site Lead Smelter Community in Dallas, Texas
Bert B. Little, Robert Reilly, Brad Walsh, Giang T. Vu
International Journal of Environmental Research and Public Health.2020; 17(12): 4558. CrossRef
Advancing Global Health through Environmental and Public Health Tracking
Paolo Lauriola, Helen Crabbe, Behrooz Behbod, Fuyuen Yip, Sylvia Medina, Jan C. Semenza, Sotiris Vardoulakis, Dan Kass, Ariana Zeka, Irma Khonelidze, Matthew Ashworth, Kees de Hoogh, Xiaoming Shi, Brigit Staatsen, Lisbeth E. Knudsen, Tony Fletcher, Danny
International Journal of Environmental Research and Public Health.2020; 17(6): 1976. CrossRef
Assessment of heavy metals by ICP‐OES and their impact on insulin stimulating hormone and carbohydrate metabolizing enzymes
Shakil Saba, Muhammad Sajid Hamid Akash, Kanwal Rehman, Uzma Saleem, Fareeha Fiayyaz, Tanvir Ahmad
Clinical and Experimental Pharmacology and Physiology.2020; 47(10): 1682. CrossRef
Evaluation of the association between urinary cadmium levels below threshold limits and the risk of diabetes mellitus: a dose-response meta-analysis
Fei-Fei Guo, Zhi-Yong Hu, Bing-Yan Li, Li-Qiang Qin, Chunling Fu, Huifang Yu, Zeng-Li Zhang
Environmental Science and Pollution Research.2019; 26(19): 19272. CrossRef
Cadmium exposure induces pancreatic β-cell death via a Ca2+-triggered JNK/CHOP-related apoptotic signaling pathway
Cheng-Chin Huang, Chun-Ying Kuo, Ching-Yao Yang, Jui-Ming Liu, Ren-Jun Hsu, Kuan-I Lee, Chin-Chuan Su, Chin-Ching Wu, Ching-Ting Lin, Shing-Hwa Liu, Chun-Fa Huang
Toxicology.2019; 425: 152252. CrossRef
Roles of C-reactive protein on the association between urinary cadmium and type 2 diabetes
Lili Xiao, Yun Zhou, Jixuan Ma, Limin Cao, Chunmei Zhu, Wei Li, Dongming Wang, Lieyang Fan, Zi Ye, Weihong Chen
Environmental Pollution.2019; 255: 113341. CrossRef
Cadmium Body Burden and Gestational Diabetes Mellitus: A Prospective Study
Wenyu Liu, Bin Zhang, Zheng Huang, Xinyun Pan, Xiaomei Chen, Chen Hu, Hongxiu Liu, Yangqian Jiang, Xiaojie Sun, Yang Peng, Wei Xia, Shunqing Xu, Yuanyuan Li
Environmental Health Perspectives.2018;[Epub] CrossRef
Heavy Metal Exposure and Metabolic Syndrome: Evidence from Human and Model System Studies
Antonio Planchart, Adrian Green, Cathrine Hoyo, Carolyn J. Mattingly
Current Environmental Health Reports.2018; 5(1): 110. CrossRef
Cadmium affects blood pressure and negatively interacts with obesity: Findings from NHANES 1999–2014
Qi Wang, Sheng Wei
Science of The Total Environment.2018; 643: 270. CrossRef
Dietary Cadmium Intake and Its Effects on Kidneys
Soisungwan Satarug
Toxics.2018; 6(1): 15. CrossRef
Gender-specific differences of interaction between cadmium exposure and obesity on prediabetes in the NHANES 2007–2012 population
Fei Jiang, Xueyuan Zhi, Miao Xu, Bingyan Li, Zengli Zhang
Endocrine.2018; 61(2): 258. CrossRef
Association of urinary cadmium with risk of diabetes: a meta-analysis
Yujie Li, Yun Zhang, Weijing Wang, Yili Wu
Environmental Science and Pollution Research.2017; 24(11): 10083. CrossRef
Kidney Cadmium Toxicity, Diabetes and High Blood Pressure: The Perfect Storm
Soisungwan Satarug, David A. Vesey, Glenda C. Gobe
The Tohoku Journal of Experimental Medicine.2017; 241(1): 65. CrossRef
Current health risk assessment practice for dietary cadmium: Data from different countries
Soisungwan Satarug, David A. Vesey, Glenda C. Gobe
Food and Chemical Toxicology.2017; 106: 430. CrossRef
The role of cadmium in obesity and diabetes
Alexey A. Tinkov, Tommaso Filippini, Olga P. Ajsuvakova, Jan Aaseth, Yordanka G. Gluhcheva, Juliana M. Ivanova, Geir Bjørklund, Margarita G. Skalnaya, Eugenia R. Gatiatulina, Elizaveta V. Popova, Olga N. Nemereshina, Marco Vinceti, Anatoly V. Skalny
Science of The Total Environment.2017; 601-602: 741. CrossRef
Association between cadmium exposure and diabetes mellitus risk: a prisma-compliant systematic review and meta-analysis
Ming Wu, Jukun Song, Chen Zhu, Yadong Wang, Xinhai Yin, Guanglei Huang, Ke Zhao, Jianguo Zhu, Zhuhui Duan, Lingkai Su
Oncotarget.2017; 8(68): 113129. CrossRef

239 View
1 Download
26 Web of Science
27 Crossref

Research Article

Association of Diabetes Mellitus with a Combination of Vitamin D Deficiency and Arsenic Exposure in the Korean General Population: Analysis of 2008–2009 Korean National Health and Nutrition Examination Survey Data: Byung-Kook Lee, Yangho Kim; Ann Occup Environ Med 2013;25:7-7. Published online May 21, 2013; DOI: https://doi.org/10.1186/2052-4374-25-7

Abstract PDF PubReader ePub

Objectives

We present data from the Korean National Health and Nutritional Examination Survey (KNHANES) 2008–2009 on the combination of vitamin D deficiency and arsenic exposure on diabetes mellitus (DM) in a representative sample of the adult Korean population.

Methods

This study was based on data obtained from the KNHANES 2008–2009, which was conducted for 3 years (2007–2009) using a rolling sampling design that involved a complex, stratified, multistage, probability-cluster survey of a representative sample of the non-institutionalized civilian population in South Korea.

Results

Data analysis revealed that subjects who showed both vitamin D levels in the 1^st quartile (Q) and urinary arsenic levels in the 4^th Q, had a 302% increased risk of having DM, as compared with those whose vitamin D and urinary arsenic levels were in the 4^th Q and 1^st Q, respectively.

Conclusion

The present study reconfirmed an association of DM with low vitamin D levels and arsenic exposure, and further showed a combination of vitamin D deficiency and arsenic exposure on DM in the general Korean population. To the best of our knowledge, this is the first report describing a combination of vitamin D deficiency and arsenic exposure on DM. The present findings have important public health implications.

Citations

Citations to this article as recorded by

Potential association between arsenic and vitamin D
Mythri Chittilla, Chantal Uzoma, Desiree Brewer, Mohammed S. Razzaque
Frontiers in Endocrinology.2024;[Epub] CrossRef
Arsenic and type 2 diabetes: Revealing the environmental exposure relationship through effective factors - A systematic review
Samaneh Abolli, Samaneh Dehghani, Rasha Atlasi, Zahra Maleki, Masud Yunesian, Ozra Tabatabaei-Malazy, Maryam Saraei, Mina Khosravifar, Zahra Soleimani
Results in Engineering.2024; 22: 102054. CrossRef
Association between urinary arsenic species and vitamin D deficiency: a cross-sectional study in Chinese pregnant women
Jingran Zhang, Yuxuan Bai, Xi Chen, Shuying Li, Xiangmin Meng, Aifeng Jia, Xueli Yang, Fenglei Huang, Xumei Zhang, Qiang Zhang
Frontiers in Public Health.2024;[Epub] CrossRef
An updated systematic review and dose-response meta-analysis on the relation between exposure to arsenic and risk of type 2 diabetes
Nader Rahimi Kakavandi, Taraneh Mousavi, Tayebeh Asadi, Ayda Moradi, Mahta Esmaeili, Ahmad Habibian Sezavar, Shekoufeh Nikfar, Mohammad Abdollahi
Toxicology Letters.2023; 384: 115. CrossRef
Dietary Selenium Deficiency Partially Mimics the Metabolic Effects of Arsenic
Christopher M. Carmean, Mizuho Mimoto, Michael Landeche, Daniel Ruiz, Bijoy Chellan, Lidan Zhao, Margaret C. Schulz, Alexandra M. Dumitrescu, Robert M. Sargis
Nutrients.2021; 13(8): 2894. CrossRef
Arsenic Exposure Decreases Adiposity During High‐Fat Feeding
Christopher M. Carmean, Andrew G. Kirkley, Michael Landeche, Honggang Ye, Bijoy Chellan, Hani Aldirawi, Austin A. Roberts, Patrick J. Parsons, Robert M. Sargis
Obesity.2020; 28(5): 932. CrossRef
The health effects of exposure to arsenic-contaminated drinking water: a review by global geographical distribution
Lei Huang, Haiyun Wu, Tsering Jan van der Kuijp
International Journal of Environmental Health Research.2015; 25(4): 432. CrossRef
Association between Arsenic Exposure and Diabetes: A Meta-Analysis
Tzu-Ching Sung, Jhih-Wei Huang, How-Ran Guo
BioMed Research International.2015; 2015: 1. CrossRef
Can Exposure to Environmental Chemicals Increase the Risk of Diabetes Type 1 Development?
Johanna Bodin, Lars Christian Stene, Unni Cecilie Nygaard
BioMed Research International.2015; 2015: 1. CrossRef

120 View
0 Download
9 Web of Science
9 Crossref

First
Prev
Page of 1
Next
Last

Search