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Micronuclei in Peripheral Blood Lymphocytes of Chromate Workers
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Jung Ho Rah, Young Whan Kim, Jae Wook Choi, Hae Joon Kim
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Korean Journal of Occupational and Environmental Medicine 1999;11(3):393-406. Published online September 30, 1999
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DOI: https://doi.org/10.35371/kjoem.1999.11.3.393
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- No abstract available.
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Sister Chromatid Exchanges in Workers Occupationally Exposed to Ethylene Oxide
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Soung Hoon Chang, Won Jin Lee, Cheong Sik Kim, Cheong Hyun Hwang, Jong Tae Park, Dae Seong Kim, Young Whan Kim
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Korean Journal of Occupational and Environmental Medicine 1998;10(4):428-437. Published online December 31, 1998
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DOI: https://doi.org/10.35371/kjoem.1998.10.4.428
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- Operators of hospital sterilizers who use ethylene oxide (EtO) were studied to determine the exposure of EtO level and the frequency of sister chromatid exchanges (SCEs) from June 12 to July 20, 1997. To evaluate SCEs in the peripheral blood cells, we selected 22 workers at the central supply room of 4 university hospitals and 22 unexposed workers at the same hospitals according to match sex, age, and smoking habit and also did questionnaires. The mean air concentrations (8-hr TWA) of EtO at 4 university hospitals were less than 1 ppm. The SCE frequencies in exposed workers to EtO and controls were normally distributed. The SCE frequencies in exposed workers to EtO and controls were 6.42+/-.63, 5.86+/-.69, respectively and their differences were statistically significant (p=0.0093). But there were no statistically significant differences in smoking, alcohol intake, coffee drinking. Especially smokers who exposed to EtO were increased SCE statistically significant than the exposed group who did not smoke.
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Citations
Citations to this article as recorded by  - Analysis of Micronuclei and Its Association with Genetic Polymorphisms in Hospital Workers Exposed to Ethylene Oxide
Sun-Yeong Lee, Yang-Jee Kim, Young-Joo Choi, Joong-Won Lee, Young-Hyun Lee, Mi-Yeon Shin, Won Kim, Chung-Sik Yoon, Sung-Kyoon Kim, Hai-Won Chung
Korean Journal of Environmental Health Sciences.2011; 37(6): 429. CrossRef
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Mutagenicity Assay of Indoor Air Pollutants by Ames Test (Microsuspension assay) and Micro-nuclei of Lymphocyte
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Young Whan Kim, Young Chul Chang, In Jae Yoon, Young Ja Sung, Ji Young Ahn, Hae Joon Kim
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Korean Journal of Occupational and Environmental Medicine 1996;8(3):499-508. Published online December 31, 1996
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DOI: https://doi.org/10.35371/kjoem.1996.8.3.499
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- In order to evaluate the mutagenic effects of extractable indoor air pollutants (organic matters), we measured the mutagenic activities by sensitive microsuspension Ames test using new tester strains (YG 1024 and YG 1029). And additionally to evaluate the mutagenic effects on vital cell, we examined the frequencies of micronucleus appearing in lymphocytes from dye handling workers and controls. This study was conducted from Jan. toMay, 1995. The extractable indoor air pollutants were collected by low volume air sampler in a general office room and 3 of dye handling factories. And the environment of general office room divided into 3 different groups according to the type of room heaters. To determine the frequencies of micronucleus appearing in lymphocytes, we sampled peripheral venous blood from 20 of dye handling workers and 20 of controls, and cultured, and then examined the lymphocytes. The results obtained were as follows: 1. The indirect mutagenic activities of extractable organic matters from suspended particulates colleced in a general office room were higher than the direct one.
2. The strain YG 1024 was the most sensitive, and the increasing order of test strainsthat showed higher number of revertant were YG 1024, YG 1029, TA 100, and TA 98.
3. In the general office room, the room using kerosene heater showed the highest mutagenecity, and the next was buthan gas heater, and non-heating room in order.
4. The mutagenic effects of suspended particulates in::dye handling factories on the strain YG 1024 was 1.2 times higher than YG 1029.
5. The frequencies of micronucleus appearing in lymphocyte of the circulating blood of dye handling workers and the control were 5.65+/-2.97% and 4.65+/-0.97%, respectively. And the difference was statistically significant.
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