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The Brain Pathology on Recovery of Brain MRI after Manganese Administration in Rats
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Ji Hyeon Jung, Jung Il Kim, Se Young Kim, Min Ho Jung, Soon Sub Choi, Soo Jin Kim, Young Jin Park, Kap Yeol Jung
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Korean Journal of Occupational and Environmental Medicine 2010;22(4):371-377. Published online December 31, 2010
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DOI: https://doi.org/10.35371/kjoem.2010.22.4.371
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Abstract
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- OBJECTIVES
This study was carried out to investigate the effect on manganese on the brain of Sprague-Dawley rats, with particular focus on changes to anatomical pathology when brain MRI was recovered after manganese administration. METHODS There were 15 rats divided into 3 groups of 5 based on dose of manganese: control group, low dose group (10 mg/kg), and high dose group (40 mg/kg). Each dosing group received an injection of normal saline and manganese via the tail vein once a week for 4 weeks. And then, the rats were observed for 12 weeks after stopping manganese administration. Next, each rat underwent a brain MRI and then each was sacrificed. After the rats were killed, the concentrations of blood manganese were measured, and pathologic examinations of the brain were performed. RESULTS The signal intensity of basal ganglia on T1-weighted imaging of brain MRI did not differ between dosing groups. However, the ratio of neuron/glial cell in the basal ganglia was decreased in the low- and high-dose groups compared to the control group. CONCLUSIONS This study showed that the damage of neuron in basal ganglia might be permanent after signal intensity of basal ganglia on T1-weighted imaging of brain MRI was recovered.
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