Annals of Occupational and Environmental Medicine

Yong Tae Yum

10 Articles

Comparison of Blood Pre-treatment Methods for Determining Erythrocyte Pyrimidine 5'-Nucleotidase Activity: Byung Hean Kim, Hae Joon Kim, Jae Wook Choi, Eunil Lee, Yong Tae Yum; Korean Journal of Occupational and Environmental Medicine 1997;9(4):565-578. Published online December 31, 1997; DOI: https://doi.org/10.35371/kjoem.1997.9.4.565

Abstract PDF: Sakai's method has been known as the simplest one for determination of erythrocyte pyrimidine 5'-nucleotidase (P5N) activity using high performance liquid chromatography(HPLC). However the drawback of the method is that it is difficult to wash the erythrocyte for isolation. To search for the simpler method, we compared Sakai's method with other methods using whole blood treated with heparin and concanavalin A or whole blood treated with EDTA-2K instead of washing the erythrocyte. The mean concentrations of lead in blood samples collected from 44 male and 16 female workers who are healthy without any exposure to lead in their workplace were 4.30 +/- 1.31 microgram /dl (mean +/-standard deviation), which were measured by frameless atomic absorption spectrophotometer. Erythrocyte P5N activities were measured by 3 methods; Sakai's method(Method I), using whole blood treated with heparin and concanavalin A (Method II), and using whole blood treated with EDTA-2K (Method III). The results were obtained as follows ; 1. The mean of erythrocyte P5N activity by Sakai's method(Method I) were 12.7 +/-2.47 amole uridine/hr/gm of Hb. 2. The mean of erythrocyte P5N activity by the method using heparinized whole blood treated with concanavalin A(Method II) were 13.1 +/-2.41 micromole uridine/hr/gm of Hb. 3. The difference of mean erythrocyte P5N activity between Method I and Method was not significant. 4. The erythrocyte P5N activity by the method using whole blood treated with EDTA-2K (Method III) was significantly different from Method I. We thought that omission of incubation period which was required on Method III using EDTA-2K caused the difference between Method I and Method III. 5. Simple linear regression equation for erythrocyte P5N activity between Method I (Y) and Method II(X) was significant: Y = -0.012 + 0.9724 X. These results suggest that the method using whole blood treated with heparin and concanavalin A is simpler to examine the erythrocyte P5N activity as a biological indicator of lead intoxication than Sakai's method.

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Quantitative Sensory and Vascular Tests in the Assessment of Hand-Arm Vibration Syndrome: Seung Wan Kang, Eun Il Lee, Yong Tae Yum, Hae Joon Kim; Korean Journal of Occupational and Environmental Medicine 1996;8(2):210-222. Published online September 30, 1996; DOI: https://doi.org/10.35371/kjoem.1996.8.2.210

This study was conducted on 103 male workers exposed to local vibration (exposure workers) and 23 male clergical workers not exposed to local vibration (reference workers) to evaluate the effect of local vibration in a automobile industry workers who had used vibratory tools such as electric bolt impacter or grinder. The assessment methods of this study were some tests recommended by Wasserman and Taylor. None of reference workers complained sensorineural symptoms, but 43.7% of exposed workers complained over one of those symptoms. The proportion of non-recovery type, which means that there was no full recovery of temperature of finger tips, was from 0% to 31. 3% in reference workers and from 10.7% to 15.5% in exposure workers. There was statistically significant difference of recovery time of plethysmogram after cold provocation between mean recovery time of 0.44 minutes in reference workers and that of 3.05 minutes in exposure workers. The proportion of bad plethysmogram was from 0% to 4.4% in reference workers and from 3.9% to 7.8% in exposure workers. There was statistically significant difference of discrimination sense between mean length of 2.04 mm in reference workers and that of 2.9 mm in exposure workers. There were also statistically significant difference of pain sense between mean weights of from 5.02 g to 5.26 g in reference workers and those of from 6.81 g to 7.6 g in exposure workers. By the results of multiple stepwise regression analysis the statistically significant variable affecting discrimination and pain sense was exposure and those affecting vibration sense were exposure and age. We concluded that exposure of local vibration in automobile workers was significaritly associated with decrease of sensorineural sense regardless of age and other, possible related variables.

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Trans‐Cranial Doppler and Peripheral Sensory Threshold Tests for Carbon Disulfide Poisoning
Eunil Lee, Hun‐Jong Chung, Soon‐Duck Kim, Jong‐Tae Park, Donggeun Sul, Myung‐Hyun Kim
Journal of Occupational Health.2001; 43(6): 307. CrossRef

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Vibration Perception Threshold of Male Workers Exposed to Carbon Disulfide: Seung Hoi Park, Eun Il Lee, Byung Chul Chun, Yong Tae Yum, Jae Wook Chi; Korean Journal of Occupational and Environmental Medicine 1996;8(1):85-96. Published online February 29, 1996; DOI: https://doi.org/10.35371/kjoem.1996.8.1.85

Abstract PDF

This study was conducted on 367 male workers to evaluate the change of vibration perception threshold (VPT) according to exposure degree to carbon disulfide. VPT was measured on both metacarpal bones of index and little fingers and on fibular malleoli by Vibrometer (Rion, on 125Hz). The exposure degree was classified by the name of department. Workers in department 1 had been exposed to high concentration of carbon disulfide, those in. department 2 had been exposed to carbon disulfide moderately or intermittently, and those in department 3 had been exposed to undetectable concentration of carbon disulfide. The results were as follows: 1. The mean values of VPT of metacarpal(MC) bones showed dose-response pattern, i.e., the mean values of VPT at department 1 were highest, and those of VPT at department 3 were lowest with similar work duration or age. But the mean values of VPT of fibular malleoli (FM) showed dose-response pattern only in workers having above 5 years of work duration or whose age were above 30. 2. The mean values of VPT of MC bone of workers increased by age. 3. There were statistically significant difference in mean values of VPT of MC bone only in workers having 5-10 year work duration. And there were statistically significant difference of mean values of VPT of left 2nd and 5th MC bone in workers whose age was 30's, of right 2nd MC bone in those whose age was 40's, and of left 2nd MC bone in those whose age was 50's. 4. The variables affecting VPT significantly were department and age (or age group) both in multiple regression and general linear model. The department showed to have more effect to VPT than age in multiple regression, but age group showed to have more effect to VPT than department in general linear model. 5. The variables were transformed to indicator variable to do logistic regression analysis. Department 1, 2, 3 were classified into high exposure (spinning department) and low exposure (other department), age was classified into old (above 30) and young, and work duration was classified into long(above 10 years) and short. The exposure and age were significant variables by logistic regression analysis. Odds ratios of department and VPT on metacarpal bones or malleoli were 2.7-3.2 and those of age and VPT were 2.6 or 2.7. Odds ratio of age and abnormality of VPT on'any point was 3.3(1.59-6.;8), and that of department and VPT was 2.8(1.5-5.5). We concluded that exposure of carbon disulfied was significantly associated with reduction of VPT regardless of age; and that the test of VPT would be useful tool for screening and early detection in neuropathy by carbon disulfide or other neurotoxic chemicals,even though it is simple and cheap.

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Trans‐Cranial Doppler and Peripheral Sensory Threshold Tests for Carbon Disulfide Poisoning
Eunil Lee, Hun‐Jong Chung, Soon‐Duck Kim, Jong‐Tae Park, Donggeun Sul, Myung‐Hyun Kim
Journal of Occupational Health.2001; 43(6): 307. CrossRef
Carbon Disulfide Poisoning in Korea with Social and Historical Background
Eunil Lee, Soonduck Kim, Haejoon Kim, Kwangjong Kim, Yongtae Yum
Journal of Occupational Health.1996; 38(4): 155. CrossRef

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Evaluation of Mercury Concentration in Spot Urine for Biological Monitoring Among Metallic Mercury Exposed Workers: Durumee Hong, Soon Duck Kim, Yong Tae Yum, Jae Wook Choi; Korean Journal of Occupational and Environmental Medicine 1996;8(1):127-136. Published online February 29, 1996; DOI: https://doi.org/10.35371/kjoem.1996.8.1.127

Abstract PDF: Biological monitoring for exposures permits estimation of organ doses or body burdens from exposures through all relevant portals of entry. Biological monitoring data may be used to estimate environmental concentrations when the latter cannot be measured directly. Biological indices are usually surrogates for the concentration of a chemical or its metabolites or its effect at the true receptors. Mercury concentration in urine has-been most-coinmoialy-recommended as a biological exposure index of mercury. For data based on urine analysis, variation in urine volume is the most significant. The urinary concentration related to excretion of the solute provides some correction for fluctuation of urine output. Sampling time must be carefully observed because distribution and elimination of a chemical are kinetic events. This study has evaluated mercury concentration in spot urine compared to the results of 24 hour collected urine by the adjustment methods (specif ic gravity, creatinine) and sampling time. The subjects were 43 workers who had been exposed to the metallic mercury. The results were as follows: 1. The correlation coefficients between mercury concentration in 24 hour urine and that in spot urine were 0.639-0.715 and were not different by adjustment methods. 2. In the high exposure group who were over lOOug/1 of urinary mercury, the correlation coefficients between mercury concentration in 24 hour urine and that in spot urine were 0. 687-0.824 and were not different by adjustment methods. 3. Mercury concentration in spot urine were very variable by sampling time or exposure time. The correlation coefficients between mercury concentration in 24 hour urine and that in spot urine were most highest as 0.85-0.91 at first voiding urine in the morning, and were 0. 77-0.86 at urine collected within four hours before end of shift. In the biological monitoring to exposure of mercury, sampling of spot urine were most proper at first voiding urine in the morning, and then at urine collected within four hours before end of shift. But the adjustment methods of specific gravity and creatinine were no difference of the results.

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A Study on the Activity of Erythrocyte Pryrimidine 5'-Nucleotidase in Workers Exposed to Lead: Soung Hoon Chang, Yong Tae Yum; Korean Journal of Occupational and Environmental Medicine 1994;6(1):85-97. Published online February 28, 1994; DOI: https://doi.org/10.35371/kjoem.1994.6.1.85

Abstract PDF: In this study, we measured the activity of the erythrocyte pyrimidine 5'-nucleotidase(P5N) for 83 workers exposed to lead in their workplace, and analyzed the correlation of the activity with other biological exposure indices of lead. The measurement was performed by using a high performance liquid chromatography (HPLC) with a reverse phased ODS column. The results are as follows; 1. The correlation of the erythrocyte P5N activity with the concentration of blood lead(PbB) was shown to be statistically significant (r=-0.71, p=0.0001). 2. For a group of subjects whose PbB was less than 10microgram/dl, the erythrocyte P5N activity was 14.9+/-1.5 micromole uridine/h/g Hb. 3. For medical surveillance, this study suggests the erythrocyte P5N activity of 12 micromole uridine/h/g Hb is equivalent to 40 microgram/dl of PbB. 4. The correlation coefficients of the erythrocyte P5N activity with other biological exposure indices of lead such as PbB, ZPP, ALA-U, PBU, CP-U, ALAD, and log ALAD were -0.71, -0.64, -0.57, -0.51, -0.50, 0.46 and 0.64, respectively. 5. The correlation coefficients of the PbB with other biological exposure indices of lead for ALAD, P5N, ZPP, PBU, CP-U, and ALA-U were -0.76, -0.71, 0.68, 0.59, 0.42, and 0.41, respectively. The erythrocyte P5N activity can be used as a reliable biological exposure index of lead.

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Study on the states of occupational health management about the subcontract company among the medium and small scale companies: Jae Wook Choi, In Sung Oh, Yong Tae Yum; Korean Journal of Occupational and Environmental Medicine 1993;5(2):262-273. Published online September 30, 1993; DOI: https://doi.org/10.35371/kjoem.1993.5.2.262

Abstract PDF: No abstract available.

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A study on the mercury contamination sources and risk for occupational mercury poisoning of mercury exposed workers in Korea: Chul Whan Cha, Kwang Jong Kim, Yong Tae Yum; Korean Journal of Occupational and Environmental Medicine 1992;4(1):92-104. Published online February 29, 1992; DOI: https://doi.org/10.35371/kjoem.1992.4.1.92

Abstract PDF

No abstract available.

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Gun Il Park, Young Seok Byun, Man Joong Jeon, Joon Sakong
Annals of Occupational and Environmental Medicine.2017;[Epub] CrossRef
Population correlates of circulating mercury levels in Korean adults: the Korea National Health and Nutrition Examination Survey IV
Seongbeom Cho, David R Jacobs, Kyong Park
BMC Public Health.2014;[Epub] CrossRef
Occupational Diseases in Korea
Seong-Kyu Kang, Eun A Kim
Journal of Korean Medical Science.2010; 25(Suppl): S4. CrossRef

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Discussion on the health Care System for Industrial Workers in Korea In relation to Revision of Industrial Safety and Health Law: Yong Tae Yum; Korean Journal of Occupational and Environmental Medicine 1990;2(2):117-122. Published online August 31, 1990; DOI: https://doi.org/10.35371/kjoem.1990.2.2.117

Abstract PDF: No abstract available.

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Clinical Analysis of 8 Cases of Chronic Carbon Disulfide Poisoning in Workers Engaged in the Viscose Rayon Industry: Soon Duck Kim, Dong Bin Song, Yong Tae Yum; Korean Journal of Occupational and Environmental Medicine 1989;1(2):186-196. Published online November 30, 1989; DOI: https://doi.org/10.35371/kjoem.1989.1.2.186

Abstract PDF

The authors have experinced 8 cases of chronic carbon disulfide poisoning in workers engaged in the viacase rayon industry during the period between March 1987 and September 1988. Cases of carbon disulfide poisoning has not been reported in Korea till then. Carbon disulfide is primarily a neurotoxic poison, therefore those symptoms indicating central and peripheral nervous damage are very important. And it has toxic effects on the various organs such as skin, eye, ear, and respiratory, cardiovascular, gastrointestinal, hepatic, genitourinary, hematological, and endocrine system. Occupational histories were obtained, and clinical findings and laboratory findings were analysed on all cases. 1. Seven (7) cases had been exposed to carbon disulfide for more than 10 years, and 1 case has been exposed for 6 years. 2. Most common symptoms were neurological symptoms such as gait disturbance, extremity weakness, paresthesia, and speech disturbance. 3. Involvement of central nervous system was noted in 7 cases through abnormal findings of electroencephalography, brain computerized tomography, neurological signs, and psychological test. Needle electromyography and nerve conduction study showed polyneuropathy in all cases. Ophthalmological abnormalities were found in 7 cases, mainly retinal microaneurysms and peripheral constriction of the visual field. Renal damage appeared in 4 cases, increase of serum cholesterol and/or triglyceride level appeared in 3 cases, and dercrease of erythrocyte and hemoglobin appeared in 2 cases. And hypertenison appeared in 2 cases, and diabetes appeared in 1 case. One(1) case who has been exposed tn carbon disulfide for 6 years showed polyneuropathy and peripheral constriction of the visual field.

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Occupational Neurological Disorders in Korea
Eun-A Kim, Seong-Kyu Kang
Journal of Korean Medical Science.2010; 25(Suppl): S26. CrossRef
Work-related Cerebro-Cardiovascular Diseases in Korea
Dae-Seong Kim, Seong-Kyu Kang
Journal of Korean Medical Science.2010; 25(Suppl): S105. CrossRef
Carbon Disulfide Poisoning in Korea with Social and Historical Background
Eunil Lee, Soonduck Kim, Haejoon Kim, Kwangjong Kim, Yongtae Yum
Journal of Occupational Health.1996; 38(4): 155. CrossRef

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An Analytical Study on Work Environments and Occupational Diseases in Korea(1987): Yong Tae Yum; Korean Journal of Occupational and Environmental Medicine 1989;1(1):39-45. Published online February 28, 1989; DOI: https://doi.org/10.35371/kjoem.1989.1.1.39

Abstract PDF

Health care management for industrial workers in Korea in terms of occupational health launched in 1953 when the Labour Act was enacted. Nevertheless, negligence of government on reality of workers health was said to be inevitable under the cloak of urgent fast development in way of industrialization. Happily, however, since 1981 when Industrial Safety and Health Law was enacted, periodical evaluation of work environment and physical check-up of workers have been worked out by several professional organizations under the umbrella of Korean Industrial Health Association. In 1986, for about 5,700 industries, a total of 125,000 checks of work environment including the agents of dust, noise, lead, organic solvents, special chemicals, and of others were carried out, and on the other hand, a total of 340,000 physical check-ups were performed in accordance with exposed hazardous agents in the work-lines. The summarized results of the above achievements were as follows. 1. The case detection rates of occupational diseases among workers in industries of Korea has been revealed to be half of Japanese ones since 1975 decreasing from 2.3% in 1975 to 1.7% in 1987. However, it is too hard to believe that the above detection rate which is lower than that of Japan indicates the real prevalence rate of occupational diseases among industrial workers of Korea. It may be underestimated by defects in management of health care system for workers in Korea. 2. A total of 6,942 cases (1.65%) of occupational diseases were detected through 421,019 spells of check-up from 345,780 industrial workers in 1987. Detection rate by industry was highest among coal mines and secondly highest among mines other than coal ones. 3. Detection rate by hazardous agent was highest among workers in relation to dust, and secondly highest to noise. Case detection rate in relation to organic solvent, lead, special chemicals and others was less than 0.1% in total, which is very low comparing with that in Japan. There should be some modification in the check-up management. 4. A total of 32,035 (25.5%) work points was found to be improper showing higher level of hazardous agent than the TLV. Actually, a total of 125,721 work points was evaluated from 5,695 industries. The rate of detecting improper environment was highest among mines other than coal mines. Second highest was in textile manufacturing industries. 5. Noise and dust are the typical agents of which levels in workplace were high in most of industries. Levels of organic solvents, lead, and others were higher than TLV in 9.5-17.0% of samples tested. 6. In relation to noise, the rate of noise level exceeding TLV was higher in mines and textile industries. However, there were less workers of hearing loss in textile industries. 7. In relation to dust, the rate of dust concentration exceeding TLV was higher in non-metal manufacturing industries and mines. However, the majority(92.0%) of pneumoconiosis were detected from workers of mines. Rare cases of pneumoconiosis were detected from workers of textile industries.

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