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Association between urinary phthalate metabolites and obesity in adult Korean population: Korean National Environmental Health Survey (KoNEHS), 2012–2014
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Yangwon Kang, Juha Park, Kanwoo Youn
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Ann Occup Environ Med 2019;31:e23. Published online September 9, 2019
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DOI: https://doi.org/10.35371/aoem.2019.31.e23
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Abstract
PDFPubReaderePub
- Background
Phthalate is a chemical that is commonly used as a plasticizer in processing plastic products and as a solvent in personal care products. Although previous experimental studies have reported that phthalate metabolites are associated with obesity, epidemiological study results have been inconsistent and insufficient. The objective of the present study was to investigate the association between urinary phthalate metabolites and obesity in adult Korean population. MethodsThe present study selected 4,752 Korean adults aged 19 years or older from the 2012–2014 Korean National Environmental Health Survey data. The concentrations of urinary di-(2-ethyl-5-carboxypentyl) phthalate (DEHP) metabolites—i.e., mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) and mono-(2-ethyl-5-carboxypentyl) phthalate—mono-benzyl phthalate (MBzP) and mono-n-butyl phthalate (MnBP) were adjusted using the urinary creatinine. We used logistic regression analysis to investigate the association between urinary phthalate metabolite concentration and body mass index (BMI) with respect to sex and age. ResultsAmong women, urinary MEHHP and DEHP concentrations were found to have statistically significantly positive associations with obesity (Q4 versus Q1; odds ratio (OR): 1.72, 95% confidence interval (CI): 1.19–2.49 for MEHHP and OR: 1.52, 95% CI: 1.04–2.21 for DEHP). Among men, urinary MnBP concentration was found to have statistically significantly negative association with obesity (Q4 versus Q1; OR: 0.71, 95% CI: 0.50–0.99). In the analysis stratified by sex and age, women aged ≥ 50 years showed statistically significantly positive associations between the concentrations of urinary DEHP metabolites, DEHP, MBzP, and obesity (Q4 versus Q1; OR: 1.94, 95% CI: 1.28–2.94 for MEHHP, OR: 1.88, 95% CI: 1.21–2.94 for MEOHP, OR: 2.04, 95% CI: 1.31–3.18 for DEHP, and Q3 versus Q1; OR: 1.45, 95% CI: 1.02–2.05 for MBzP). Meanwhile, men aged ≥ 50 years showed no significant associations between urinary phthalate concentrations and obesity. ConclusionsIn the present study, we found differences in the associations between urinary phthalate metabolites and BMI according to sex and age. However, because the present study was cross-sectional in nature, additional support through prospective studies is needed to estimate the causal associations.
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Xiaoliu Shi, Wanyue Wang, Jiafan Feng, Xiaochun Ma, Mengting Xu, Cui Wang Environmental Pollution.2024; 349: 123959. CrossRef - Phthalates’ exposure leads to an increasing concern on cardiovascular health
Melissa Mariana, Miguel Castelo-Branco, Amadeu M. Soares, Elisa Cairrao Journal of Hazardous Materials.2023; 457: 131680. CrossRef - Association between phthalate exposure and obesity risk: A meta-analysis of observational studies
Qian Wu, Gang Li, Chen-Yang Zhao, Xiao-Lin Na, Yun-Bo Zhang Environmental Toxicology and Pharmacology.2023; 102: 104240. CrossRef - Risk of Nonalcoholic Fatty Liver Disease Is Associated with Urinary Phthalate Metabolites Levels in Adults with Subclinical Hypothyroidism: Korean National Environmental Health Survey (KoNEHS) 2012–2014
Eun-Jung Yang, Byung-Sun Choi, Yun-Jung Yang International Journal of Environmental Research and Public Health.2022; 19(6): 3267. CrossRef - The effects of chemical mixtures on lipid profiles in the Korean adult population: threshold and molecular mechanisms for dyslipidemia involved
Hai Duc Nguyen, Hojin Oh, Min-Sun Kim Environmental Science and Pollution Research.2022; 29(26): 39182. CrossRef - Association of Exposure to Phthalate Metabolites With Sex Hormones, Obesity, and Metabolic Syndrome in US Women
Pallavi Dubey, Sireesha Y. Reddy, Vishwajeet Singh, Ted Shi, Mallorie Coltharp, Deborah Clegg, Alok K. Dwivedi JAMA Network Open.2022; 5(9): e2233088. CrossRef - Mixtures modeling identifies heavy metals and pyrethroid insecticide metabolites associated with obesity
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Nayan Chandra Mohanto, Yuki Ito, Sayaka Kato, Michihiro Kamijima Frontiers in Endocrinology.2021;[Epub] CrossRef - Relationships between di-(2-ethylhexyl) phthalate exposure and lipid metabolism in adolescents: Human data and experimental rat model analyses
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Yun-Jung Yang, Taehyen Kim, Yeon-Pyo Hong International Journal of Environmental Research and Public Health.2021; 18(11): 6035. CrossRef - Benzyl Butyl Phthalate Induced Early lncRNA H19 Regulation in C3H10T1/2 Stem Cell Line
Jian Zhang, Mahua Choudhury Chemical Research in Toxicology.2021; 34(1): 54. CrossRef - Relationship between urinary phthalate metabolites and diabetes: Korean National Environmental Health Survey (KoNEHS) cycle 3 (2015–2017)
Do Jin Nam, Yeji Kim, Eun Hye Yang, Hyo Choon Lee, Jae-Hong Ryoo Annals of Occupational and Environmental Medicine.2020;[Epub] CrossRef - Urinary bisphenol A, phthalate metabolites, and obesity: do gender and menopausal status matter?
Jung-eun Lim, BongKyoo Choi, Sun Ha Jee Environmental Science and Pollution Research.2020; 27(27): 34300. CrossRef - Phthalate metabolites and biomarkers of oxidative stress in the follicular fluid of women undergoing in vitro fertilization
Xiao-Qiong Yuan, Yao-Yao Du, Chong Liu, Na Guo, Xue-Mei Teng, Xiang Hua, Yang-Cheng Yao, Yan-Ling Deng, Qiang Zeng, Tao-Ran Deng, Yu-Feng Li Science of The Total Environment.2020; 738: 139834. CrossRef
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Effect of night shift work on the control of hypertension and diabetes in workers taking medication
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Juha Park, Sang-Yeop Shin, Yangwon Kang, Jeongbae Rhie
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Ann Occup Environ Med 2019;31:e27. Published online October 10, 2019
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DOI: https://doi.org/10.35371/aoem.2019.31.e27
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Abstract
PDFPubReaderePub
- Background
Night shift work induces physiological and psychological stress by altering sleep and biological rhythms and is associated with hypertension, diabetes, obesity, and cardiovascular diseases. Few studies have been conducted on the control of hypertension and diabetes. This study aimed to examine the effect of night shift work on the control rate of hypertension and diabetes. MethodsSubjects comprised workers aged 20–65 years who underwent specific health examination at a single facility in seven different affiliated examination centers from 1 January to 31 December 2016. Workers were categorised into day workers and night shift workers. Demographic and medical history were taken, and physical examination was done. Blood pressure (BP) and fasting glucose were measured. The control rate of each disease was evaluated based on treatment goals presented in the treatment guidelines of the Korean Society of Hypertension and the Korean Diabetes Association (systolic BP < 140 mmHg and diastolic BP < 90 mmHg; fasting glucose ≤ 130 mg/dL). ResultsAmong 631,418 subjects, 11.2% (70,450) were night shift workers. Of whom 6.1% (4,319) were taking antihypertensive medication and 2.5% (1,775) were taking diabetes medication. Among patients taking antihypertensive medications, the proportion of those whose BP was controlled to suit treatment goals was 81.7% (26,635) of day workers and 77.4% (3,343) of night shift workers, which was significantly different (p < 0.001). Among patients taking diabetes medications, the proportion of those whose blood glucose was controlled to suit treatment goals was 37.4% (4,489) of day workers and 36.5% (647) of night shift workers, but the difference was not significant. The control rates for patients taking antihypertensive medications (odds ratio [OR]: 0.74, 95% confidence interval [CI]: 0.68–0.80) were lower among night shift workers than day workers with adjustment for age, sex, smoking history, alcohol consumption, exercise, and obesity. However, there were no differences in control rates for patients taking diabetes medications (OR: 0.99, 95% CI: 0.87–1.10) between day workers and night shift workers. ConclusionsNight shift work can have an effect on the uncontrolled BP in workers taking antihypertensive medications. Therefore, additional efforts for disease control are necessary for night shift workers with hypertension.
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Hyun-Jin Kim, Sang-Ho Jo The Korean Journal of Internal Medicine.2024; 39(2): 205. CrossRef - Workplace Hazards and Occupational Risk Assessment for Automotive Industry Workers
Elvira T. Valeeva, Rasima R. Galimova, Albina A. Distanova, Aleksandr S. Shastin, Anastasia F. Saitova ЗДОРОВЬЕ НАСЕЛЕНИЯ И СРЕДА ОБИТАНИЯ - ЗНиСО / PUBLIC HEALTH AND LIFE ENVIRONMENT.2024; : 58. CrossRef - Association between Shift Work and Metabolic Syndrome: A 4-Year Retrospective Cohort Study
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Vivian de Moraes Coelho, Camila Oliveira Sinhoroto, Patrícia Magnaboso, Maria Beatriz Guimarães Raponi, Maria Angélica Melo e Oliveira, Omar Pereira de Almeida, Valéria Nasser Figueiredo International Journal of Cardiovascular Sciences.2023;[Epub] CrossRef - Fatigue and its impact on performance and health
Ceri Sutherland, Aidan Smallwood, Tom Wootten, Nancy Redfern British Journal of Hospital Medicine.2023; 84(2): 1. CrossRef - Toward Precision Medicine: Circadian Rhythm of Blood Pressure and Chronotherapy for Hypertension - 2021 NHLBI Workshop Report
Michelle L. Gumz, Daichi Shimbo, Marwah Abdalla, Ravi C. Balijepalli, Christian Benedict, Yabing Chen, David J. Earnest, Karen L. Gamble, Scott R. Garrison, Ming C. Gong, John B. Hogenesch, Yuling Hong, Jessica R. Ivy, Bina Joe, Aaron D. Laposky, Mingyu L Hypertension.2023; 80(3): 503. CrossRef - Seeking Treatment Profile of Male Shift Workers With Hypertension and Diabetes
Nuri Purwito Adi, Tomohisa Nagata, Koji Mori, Tatsuhiko Kubo, Kenji Fujimoto, Makoto Ohtani, Kiminori Odagami, Masako Nagata, Shigeyuki Kajiki, Yoshihisa Fujino, Shinya Matsuda Journal of Occupational & Environmental Medicine.2023; 65(9): 783. CrossRef - Circadian Rhythms Disrupted by Light at Night and Mistimed Food Intake Alter Hormonal Rhythms and Metabolism
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Yinuo Cai Highlights in Science, Engineering and Technology.2023; 54: 314. CrossRef - Effect of night shift on development of metabolic syndrome among health care workers
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Relationship between occupational sunlight exposure and the incidence of renal cancer
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Hyun-Suk Jang, Jong-Han Leem, Seong Soo Jeon, Shin-Goo Park, Sangyoon Lee, Yangwon Kang, Go Choi, Hyung Doo Kim, Hyeonwoo Ju, Sung Wook Jang, Youna Won, Hwan-Cheol Kim
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Ann Occup Environ Med 2019;31:e32. Published online November 7, 2019
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DOI: https://doi.org/10.35371/aoem.2019.31.e32
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Abstract
PDFPubReaderePub
- Background
The risk factors for renal cancer include smoking, obesity, hypertension, and exposure to trichloroethylene. Recent studies have shown that low sunlight exposure increases the risk of developing a range of cancers, including renal cancer. Given that most of the daytime is spent at work, a lack of occupational sunlight exposure can be a risk factor for renal cancer. Therefore, this study examined the relationship between occupational sunlight exposure and the incidence of renal cancer. MethodsThis was a university hospital-based case-control study on renal cancer. Of the 706 newly diagnosed patients with renal cell carcinoma (RCC), 633 cases were selected; 73 who had no occupational history were excluded. In addition, 633 controls were selected from the general population after 1:1 matching with respect to sex, age (within 5 years), and residential area (constituency-level). Information on sunlight exposure by the occupational group was referred to data from France. To estimate the association between occupational sunlight exposure and the RCC risk, the odds ratios (ORs) were calculated using conditional logistic regression analysis. ResultsSunlight exposure was divided into quartiles and the risk of RCC was analyzed. The adjusted OR of RCC (OR: 0.664, 95% confidence interval: 0.449–0.983) was significantly lower for the Q4 group than Q1 group but the Q2 and Q3 groups did not show significant results. The risk of RCC tended to decrease with increasing exposure to sunlight (p for trend < 0.028). ConclusionsHigher occupational sunlight exposure reduces the risk of RCC.
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