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Relationship of Biological Indices of Manganese with Pallidal Index on MRI in Liver Cirrhotics
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Younghee Choi, Neung Hwa Park, Jung Woo Shin, Hyo Kyung Kim, Sung Ryul Kim, Tae Heum Jeong, Ji Kang Park, Hun Lee, Cheol In Yoo, Choong Ryeol Lee, Ji Ho Lee, Yangho Kim
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Korean Journal of Occupational and Environmental Medicine 2004;16(2):129-138. Published online June 30, 2004
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DOI: https://doi.org/10.35371/kjoem.2004.16.2.129
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 Abstract
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- OBJECTIVES
The objectives of this study were to clarify which biological manganese exposure indices reflect the pallidal signal intensities in magnetic resonance imaging (MRI) in liver cirrhotics.
METHODS
We examined whole blood, plasma, RBC and urinary manganese concentrations, as well as, brain MRI in 22 cirrhotic patients and 10 healthy controls. From MRI scans we calculated the signal intensity of the globus pallidus using the pallidal index (PI), the ratio of the globus pallidus to subcortical frontal white-matter signal intensity in axial T1-weighted MRI planes multiplied by 100. In addition, we studied the relationships between PI and other measurements.
RESULTS
The high signal intensity in the globus pallidus on T1-weighted MRI was observed in 18 (81.8%) patients. There was a significant correlation between whole blood and RBC manganese concentration, and PI on MRI. According to multiple linear regression, whole blood and RBC manganese concentration reflected PI on MRI better the other indices did.
CONCLUSIONS
Whole blood and RBC manganese concentrations could be useful as biological manganese exposure indices that reflect PI on MRI.
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Renal Dysfunction Indicators in Lead Exposed Workers
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Sang Ju Lee, Young Seoub Hong, Sung Ryul Kim, Dong Il Kim, Joon Youn Kim, Kap Yeol Jung
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Korean Journal of Occupational and Environmental Medicine 1996;8(2):340-349. Published online September 30, 1996
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DOI: https://doi.org/10.35371/kjoem.1996.8.2.340
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Abstract
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- A range of indicators is available to assess renal dysfunction in lead exposure. This study was undertaken to find out which indicators were most valuable as markers of renal dysfunction. We selected 75 male workers from the secondary lead smelter, plastic stabilizer and radiator manufacturing industries (the "exposed" group) and 64 male office workers (the "control" group). Blood lead; blood zinc protoporphyrin; urine lead; urine coproporphyrin; delta-aminolevulinic acid dehydratase activity; and urine delta-aminolevulinic acid were chosen as indicators of lead exposure. Blood urea nitrogen; serum creatinine; serum uric acid; urine N-acetyl-beta-D-glucosaminidase; urine albumin; urine alpha1-microglobu-lin; and urine beta2-microglobulin were used as indicators of renal dysfunction. Urine alpha1-microglobulin level was significantly associated with, the lead exposure level. Blood urea nitrogen, urine N-acetyl-beta-D-glucosaminidase and urine alpha1-microglobulin levels were highly correlated with indicators of lead exposure. Urine alpha1-microglobulin had the highest correlation with other indicators of renal function. In addition, the proportion of subjects with high urine alpha1-microglobulin levels showed a gradient with lead exposure. Conclusively, Blood urea nitrogen, urine N-acetyl-beta-D-glucosaminidase and urine alpha1-microglobulin are useful indicators, but urine alpha1-microglobulin is ; the early 'and the most valuable indicator of renal dysfunction related to lead exposure.
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