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Sang-Yoo Park 1 Article
Pesticide metabolite and oxidative stress in male farmers exposed to pesticide
Kang Myoung Lee, Sang-Yoo Park, Kyungsuk Lee, Sung-Soo Oh, Sang Baek Ko
Ann Occup Environ Med 2017;29:5.   Published online February 28, 2017
DOI: https://doi.org/10.1186/s40557-017-0162-3
AbstractAbstract PDFPubReaderePub
Background

The objective of this study was to measure malondialdehyde (MDA) and isoprostane which has been used as an index of lipid injury, 8-hydroxy-2′-deoxyguanosine (8-OHdG), which has been used as an index of DNA damage, and dialkyl-phosphate (DAP), which has been used to quantify pesticide exposure, and to investigate the relationship between pesticide exposure and oxidative stress.

Methods

This study was a cross-sectional study that evaluated 84 male farmers exposure to pesticide. In this study, 8-OHdG, isoprostane, and MDA were measured as oxidative stress indices, and dialkyl-phosphate (dimethylphosphate(DMP), diethylphosphate(DEP), dimethylthiophosphate(DMTP), and diethylthiophosphate (DETP)) excreted in the urine was also measured to evaluate pesticide exposure. A linear regression analysis was performed to investigate the relationship between pesticide metabolites, and oxidative stress biomarkers.

Results

A Correlation analysis was performed for pesticide exposure month (PEI), cumulative exposure index (CEI), and DAP as well as the concentration of the oxidative stress biomarkers. The PEM significantly and positively correlated to the levels of 8-OHdG, isoprostane, CEI, and DMP. CEI showed a correlation to 8-OHdG and PEM. DMP, DEP, and DETP showed a positive correlation to 8-OHdG, isoprostane, and MDA. A correlation analysis was adjusted some demographic characteristics, such as age, smoking, drinking, and exercise to determine the relationship between pesticide exposure and oxidative stress. The 8-OHdG, isoprostane, and MDA levels were significantly related to the DMP (ß = 0.320), DEP (ß = 0.390), and DETP (ß = 0.082); DMP (ß = 0.396), DEP (ß = 0.508), and DETP (ß = 0.504); and DMP (ß = 0.432), DEP (ß = 0.508), and DETP (ß = 0.329) levels, respectively.

Conclusions

The concentration between oxidative stress biomarkers and the pesticide metabolite were a positive correlation. Indicators of oxidative stress was associated with a pesticide metabolite DMP, DEP, and DETP. Therefore, Pesticide exposure and oxidative stress were relevant.


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    Food and Chemical Toxicology.2023; 179: 113977.     CrossRef
  • Exposure to Low Concentrations of AMPA Influences Morphology and Decreases Survival During Larval Development in a Widespread Amphibian Species
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    International Journal of Molecular Sciences.2023; 24(4): 3488.     CrossRef
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  • Occupational exposure to pesticides in farmworkers and the oxidative markers
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    Toxicology and Industrial Health.2022; 38(8): 455.     CrossRef
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    Science of The Total Environment.2022; 814: 152832.     CrossRef
  • Exposure to organophosphate insecticides, inappropriate personal protective equipment use, and cognitive performance among pesticide applicators
    Jiraporn Chittrakul, Ratana Sapbamrer, Surat Hongsibsong
    Frontiers in Public Health.2022;[Epub]     CrossRef
  • Use of metabolomics in refining the effect of an organic food intervention on biomarkers of exposure to pesticides and biomarkers of oxidative damage in primary school children in Cyprus: A cluster-randomized cross-over trial
    Corina Konstantinou, Stephanie Gaengler, Stavros Oikonomou, Thibaut Delplancke, Pantelis Charisiadis, Konstantinos C. Makris
    Environment International.2022; 158: 107008.     CrossRef
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    Journal of Cellular Neuroscience and Oxidative Stress.2022;[Epub]     CrossRef
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    Frontiers in Medicine.2022;[Epub]     CrossRef
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    International Journal of Environmental Research and Public Health.2022; 19(12): 7550.     CrossRef
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    Reproductive Toxicology.2021; 103: 124.     CrossRef
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    Biologia.2021; 76(6): 1849.     CrossRef
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    Environmental Toxicology and Pharmacology.2021; 87: 103703.     CrossRef
  • Commentary: Novel strategies and new tools to curtail the health effects of pesticides
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    Environmental Health.2021;[Epub]     CrossRef
  • A critical review of different factors governing the fate of pesticides in soil under biochar application
    Sana Khalid, Muhammad Shahid, Behzad Murtaza, Irshad Bibi, Natasha, Muhammad Asif Naeem, Nabeel Khan Niazi
    Science of The Total Environment.2020; 711: 134645.     CrossRef
  • Increased risk of atherosclerosis associated with pesticide exposure in rural areas in Korea
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    PLOS ONE.2020; 15(5): e0232531.     CrossRef
  • The association between PON1 and GSTM1 genetic variation with methylation of p16 gene promoter among Javanese farmers exposed to pesticides at Magelang Regency, Central Java, Indonesia
    Maya G. Ratna, Dwi A.A. Nugrahaningsih, Eti N. Sholikhah, Ery K. Dwianingsih, Rusdy G. Malueka
    Heliyon.2020; 6(5): e03993.     CrossRef
  • Pesticide exposure and related health problems among family members of farmworkers in southeast Iran. A case-control study
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