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Relationship Between Urinary t, t-muconic Acid and Insulin Resistance in the Elderly
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Hyun Seung Park, Jeong Cheol Seo, Jin Hee Kim, Sang Hyuk Bae, Youn Hee Lim, Soo Hun Cho, Yun Chul Hong
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Korean Journal of Occupational and Environmental Medicine 2011;23(4):387-396. Published online December 31, 2011
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DOI: https://doi.org/10.35371/kjoem.2011.23.4.387
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Abstract
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- OBJECTIVES
To examine the associations between the urinary t, t-muconic acid (t, t-MA) concentration and three indices of insulin resistance; namely, the homeostasis assessment of insulin resistance (HOMA-IR) index, blood insulin level and fasting glucose level. METHODS A panel study was performed on the elderly at a public health care center population in the northern area of Seoul between 2008 and 2010. The participants were 560 elderly, over 60 years of age whose urinary t, t-MA and insulin resistance indices had been measured; questionnaires were completed by these participants. A generalized linear mixed (GLM) analysis was adjusted for age, sex, drinking, urinary cotinine, exercise, vitamin intake and body mass index, at a significance level of p<0.05. RESULTS A total of 411 participants were finally analyzed after excluding those with diabetes and only one visit to the public health care center. Higher urinary t, t-MA concentrations were linearly associated with the HOMA-IR index, blood insulin level and fasting glucose level in the simple and fully adjusted GLM models. Although there were few limitations, a portion of insulin resistance was proven to be explained by exposure to benzene using r-squared. A significant relationship was also observed between urinary t, t-MA and malondialdehyde (MDA) using the same GLM models. CONCLUSIONS Urinary t, t-MA is related to the development of insulin resistance which is a key factor for development of diabetes and its complications induced by oxidative stress.
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- Exploration of an Area with High Concentrations of Particulate Matter and Biomonitoring Survey of Volatile Organic Compounds among the Residents
Hyunji Ju, Seungho Lee, Jae-Hee Min, Yong-Sik Hwang, Young-Seoub Hong Journal of Environmental Health Sciences.2023; 49(6): 344. CrossRef - Association between urinary trans,trans-muconic acid and diabetes: a cross-sectional analysis of data from Korean National Environmental Health Survey (KoNEHS) cycle 3 (2015–2017)
Eun Hye Yang, Do Jin Nam, Hyo Choon Lee, Soon Su Shin, Jae-Hong Ryoo Annals of Occupational and Environmental Medicine.2021;[Epub] CrossRef
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Association between Cadmium and Cognitive Function in the Elderly
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Mo Yeol Kang, Soo Hun Cho, Youn Hee Leem, Jin Hee Kim, Sang Hyuk Bae, Yun Chul Hong
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Korean Journal of Occupational and Environmental Medicine 2011;23(3):309-316. Published online September 30, 2011
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DOI: https://doi.org/10.35371/kjoem.2011.23.3.309
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Abstract
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- OBJECTIVES
We conducted this study to investigate the relationship between the blood concentration of cadmium and cognitive function in elderly Koreans. METHODS This research is a part of the Korean Elderly Environmental Panel Study (KEEPS). A total of 403 subjects were enrolled and analyzed from August 2008 through August 2010. Demographic information and medical histories were obtained using a questionnaire. Blood concentration of cadmium and Mini-Mental State Examination (MMSE) with Functional Activities Questionnaire (FAQ) were evaluated for each subject. RESULTS The mean age of subjects was 70.67 (SD 5.18, n=403) and 72% were female. The mean blood cadmium level was 1.22 microg/dl (SD 0.56), mean MMSE score was 25.12 out of 30 and mean FAQ score was 2.03 out of 30. Using linear regression analysis to estimate the relationship between blood cadmium concentration and MMSE and FAQ, we observed a significant association between log transformed values of blood cadmium levels and MMSE (p<0.002) or FAQ (p=0.005) scores. After adjusting for age, sex, level of education, alcohol consumption and smoking habits, the relationship between blood cadmium concentration and MMSE and FAQ scores ramained statistically significant (p=0.033 and 0.029, respectively). CONCLUSIONS These results suggest that blood cadmium concentration is strongly associated with cognitive function and functional activity in the elderly.
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Citations
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- Association between heavy metals, high-sensitivity C-reaction protein and 10-year risk of cardiovascular diseases among adult Korean population
Hai Duc Nguyen, Hojin Oh, Ngoc Hong Minh Hoang, Min-Sun Kim Scientific Reports.2021;[Epub] CrossRef - Associations between Cadmium Exposure and Taste and Smell Dysfunction: Results from the National Health and Nutrition Examination Survey (NHANES), 2011–2014
Yi Zheng, Yun Shen, Zheng Zhu, Hui Hu International Journal of Environmental Research and Public Health.2020; 17(3): 943. CrossRef - The association between cadmium and lead exposure and blood pressure among workers of a smelting industry: a cross-sectional study
Hyun Chan An, Joo Hyun Sung, Jiho Lee, Chang Sun Sim, Sang Hoon Kim, Yangho Kim Annals of Occupational and Environmental Medicine.2017;[Epub] CrossRef - Does cadmium exposure contribute to depressive symptoms in the elderly population?
Changwoo Han, Youn-Hee Lim, Yun-Chul Hong Occupational and Environmental Medicine.2016; 73(4): 269. CrossRef
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