Annals of Occupational and Environmental Medicine

Minsang Yoo

1 Article

Association between urinary 3-phenoxybenzoic acid and body mass index in Korean adults: 1^st Korean National Environmental Health Survey: Minsang Yoo, Youn-Hee Lim, Taeshik Kim, Dongwook Lee, Yun-Chul Hong; Ann Occup Environ Med 2016;28:2. Published online January 13, 2016; DOI: https://doi.org/10.1186/s40557-015-0079-7

Background

According to US-EPA report, the use of pyrethrins and pyrethroids has increased during the past decade, and their area of use included not only in agricultural settings, but in commerce, and individual household. It is known that urinary 3-PBA, major metabolite of pyrethroid, have some associations with health effect in nervous and endocrine system, however, there’s no known evidence that urinary 3-PBA have associations with obesity.

Method

We used data of 3671 participants aged above 19 from the Korean National Environmental Health Survey in 2009–2011. In our analysis, multivariate piece-wise regression and logistic regression analysis were used to investigate the association between urinary 3-PBA (3-Phenoxybenzoic Acid) and BMI.

Result

Log-transformed level of urinary 3-PBA had significantly positive association with BMI at the low-level range of exposure (p < 0.0001), and opposite associations were observed at the high level exposure (p = 0.04) after adjusting covariates. In piece-wise regression analysis, the flexion point that changes direction of the associations was at around 4 ug/g creatinine of urinary 3-PBA. As quintiles based on concentration of urinary 3-PBA increased to Q4, the ORs for prevalence of overweight (BMI ≥ 23 kg/m²) were increased, and the OR of Q5 was lower than that of Q4 (OR = 1.810 for Q4; OR = 1.483 for Q5). In the analysis using obesity (BMI ≥ 25 kg/m²) as outcome variable, significant associations were observed between obesity and quintiles of 3-PBA, however, there were no differences between the OR of Q5 and that of Q4 (OR = 1.659 for Q4; OR = 1.666 for Q5).

Conclusion

Our analysis suggested that low-level of pyrethroid exposure has positive association with BMI, however, there is an inverse relationship above the urinary 3-PBA level at 4 ug/g creatinine.

Electronic supplementary material

The online version of this article (doi:10.1186/s40557-015-0079-7) contains supplementary material, which is available to authorized users.

Citations

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Efrizal, Chika Afrilia Ikbal, Robby Jannatan
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I. Martín-Carrasco, P. Carbonero-Aguilar, B. Dahiri, I.M. Moreno, M. Hinojosa
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Separations.2022; 9(3): 59. CrossRef
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Frontiers in Environmental Science.2022;[Epub] CrossRef
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Journal of Chromatography A.2020; 1613: 460660. CrossRef
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Chemosphere.2019; 220: 1179. CrossRef
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Environmental Research.2019; 172: 446. CrossRef
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Chemosphere.2018; 191: 990. CrossRef

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