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Parkinson's disease in a worker exposed to insecticides at a greenhouse
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Yangwoo Kim, Inah Kim, Jung-Min Sung, Jaechul Song
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Ann Occup Environ Med 2021;33:e6. Published online February 5, 2021
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DOI: https://doi.org/10.35371/aoem.2021.33.e6
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Abstract
PDFPubReaderePub
- Background
Parkinson's disease (PD) is a rare, neurodegenerative disease with various occupational and environmental risk factors. Exposure to specific pesticides contributes significantly to the incidence of PD. However, it is difficult to measure the level of pesticide exposure in workers. This study presents the first case recognized the work-relatedness between PD and pesticide exposure. Case presentationA 68-year-old male was diagnosed with PD after working with pesticides at a tomato greenhouse for 12 years and 5 months. From the results of a field study, it was reasonable to assume that the patient had been exposed to a significant level of various insecticides. In the present report, we described the first accepted case of work-relatedness between PD and exposure to pesticides. The evaluation was conducted using the following steps: we ruled out other possible risk factors including additional occupational history and personal risk factors, we assessed the work environment, surveyed possible exposures, found proper epidemiological evidence, and calculated the probability of causation. The work-relatedness was determined through the review of epidemiological evidence and estimation of exposure situation and level, and biological plausibility. We also decided work-relatedness based on the exposure of PD related pesticides with identified biologically plausible and the presumption that the exposure level would be high due to the working process. ConclusionsIn this case, the field study and epidemiological results supported the work-relatedness of PD and exposure to pesticides. Moreover, the results of previous studies have confirmed a causal relationship between exposure to pesticides and PD.
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Citations
Citations to this article as recorded by
- Rotenone-Induced Model of Parkinson’s Disease: Beyond Mitochondrial Complex I Inhibition
María Teresa Ibarra-Gutiérrez, Norma Serrano-García, Marisol Orozco-Ibarra Molecular Neurobiology.2023; 60(4): 1929. CrossRef - Food Contamination: An Unexplored Possible Link between Dietary Habits and Parkinson’s Disease
Giulia Caioni, Annamaria Cimini, Elisabetta Benedetti Nutrients.2022; 14(7): 1467. CrossRef
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