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The Risk Factors of Metabolic Syndrome and its Relation with gamma-GTP in Steel-mill Workers
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Je Hyeok Mun, Sang Jun Lee, Jung Duck Park
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Korean Journal of Occupational and Environmental Medicine 2007;19(1):17-25. Published online March 31, 2007
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DOI: https://doi.org/10.35371/kjoem.2007.19.1.17
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 Abstract
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- OBJECTIVES
This study was performed to estimate the prevalence and possible risk factors of the metabolic syndrome in steel-mill workers, and to evaluate the relation between gamma-glutamyltransferase (gamma-GTP) and the metabolic syndrome.
METHODS
The study subjects comprised 1,604 male steel-mill workers. The indices of metabolic syndrome, such as BMI, triglyceride, HDL-cholesterol, blood pressure, fasting glucose, and gamma-GTP were analyzed in each subject. We collected information about demographic characteristics, behavioral patterns, such as alcohol drinking, smoking, and exercise, and family medical history through a self-administered questionnaire. Statistical analysis was done by using the chi-square test, Mantel-Haenszel trend test and logistic regression model.
RESULTS
The crude and age-adjusted prevalences of the metabolic syndrome were 21.3% and 15.5%, respectively, in the steel-mill workers. Age (OR: 1.063, 95% CI: 1.033-1.094), alcohol drinking (OR: 1.657, 95% CI: 1.175-2.337) and smoking (OR: 1.359, 95% CI: 1.017-1.816) were risk factors for the metabolic syndrome. Meanwhile, shift work showed a significant relation with hypertension (OR: 1.329, 95% CI: 1.038-1.700), but not with other metabolic syndrome components. However, tenure, exercise and family medical history were not significant factors for the metabolic syndrome in this study. The risk ratio of the metabolic syndrome (OR: 3.345, 95 % CI: 2.534-4.416) and its components, such as obesity, hypertriglyceridemia, hypertension and hyperglycemia, were higher in the high gamma-GTP group (> or =63 IU/ liter) than in the controls (<63 IU/liter).
CONCLUSIONS
These results confirm the need for health education to control the metabolic syndrome by improving behavioral patterns, such as alcohol drinking and smoking, in factory workers. In addition, it is suggested that gamma-GTP might be a useful candidate in screening for the metabolic syndrome.
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Citations
Citations to this article as recorded by  - Association of total dietary antioxidant capacity with oxidative stress and metabolic markers among patients with metabolic syndrome
Dongwoo Ham, Shinyoung Jun, Minji Kang, Sangah Shin, Gyung-Ah Wie, Hyun Wook Baik, Hyojee Joung
Journal of Nutrition and Health.2017; 50(3): 246. CrossRef - A Study on the Prevalence and Influencing Factors of Metabolic Syndrome among Police Officers
Ju Hee Hong, Sa-Woo Lee
Journal of Korean Society of Occupational and Environmental Hygiene.2014; 24(4): 566. CrossRef - The Factors related to Dyslipidemia and Hypertension among Male Office Workers
Eun Kyung Lee, Ok Soo Kim
Korean Journal of Adult Nursing.2013; 25(4): 432. CrossRef - An Investigation on the Metabolic Syndromes and Health-Related Risk Factors among Male Workers
Sun-Young Choi, Na-Eun Kang, Sung-Hee Kim
The Korean Journal of Food And Nutrition.2013; 26(4): 975. CrossRef - Effects of Providing Health Education to Workers for the Management of Liver Disease Screened by Periodic Health Surveys
Mee-Ra Lee, Jin-Seok Kim
Korean Journal of Occupational Health Nursing.2013; 22(4): 324. CrossRef - Relation of Health Promotion Behaviors and Metabolic Syndrome in Daytime Workers
Dae-Sik Ko, Bu-Yeon Park, Gyeong-Hyu Seok
The Journal of the Korea institute of electronic communication sciences.2013; 8(12): 1941. CrossRef - Factors associated with the Patterns of Alcohol Use in Korean Adults
Sung Suk Chung, Kyoung Hwa Joung
Korean Journal of Adult Nursing.2012; 24(5): 441. CrossRef - Lifestyle and Metabolic Syndrome among Male Workers in an Electronics Research and Development Company
Jun Pyo Myong, Hyoung Ryoul Kim, Yong Kyu Kim, Jung-Wan Koo, Chung Yill Park
Journal of Preventive Medicine and Public Health.2009; 42(5): 331. CrossRef
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The Role of TNFalpha Gene Promoter Polymorphism in the Development of Coal Workers' Pneumoconiosis
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Byoung Yong Ahn, Kyoung Ah Kim, Hae Yun Nam, Je Hyeok Mun, Jin Sook Jeoung, Young Lim
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Korean Journal of Occupational and Environmental Medicine 2002;14(2):117-123. Published online June 30, 2002
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DOI: https://doi.org/10.35371/kjoem.2002.14.2.117
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Abstract
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- OBJECTIVES
This study was performed in order to investigate the frequency of the TNF2 allele in patients with coal workers pneumoconiosis (CWP).
METHODS
We compared the genotype distribution of TNFalpha gene promoter polymorphism between 80 CWP patients and 54 healthy controls.
RESULTS
The results were as follows : 1. The rare allele TNF2 was significantly more frequent in CWP patients (20.6 %) than in controls (10.2 %). 2. The spontaneous or LPS-induced release of TNFalpha from the peripheral monocytes was slightly increased in the TNF2 group, but these values were not significantly different between groups. 3. In the CWP TNF2 group, the increase of LPS-induced TNFalpha release was significant in comparison with that of the controls.
CONCLUSIONS
From the above results, we suggest that the TNF2 allele is strongly associated with susceptibility to CWP development.
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Autoregulation of Quartz-induced iNOS by iNOS-derived Hydrogen Peroxide in Rat2 Fibroblast
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Kyoung Ah Kim, Hae Yun Nam, Je Hyeok Mun, Jin Sook Jeong, Young Lim, Chee Kyung Chung
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Korean Journal of Occupational and Environmental Medicine 2001;13(4):385-392. Published online December 31, 2001
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DOI: https://doi.org/10.35371/kjoem.2001.13.4.385
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Abstract
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- OBJECTIVES
This study was performed in order to investigate the molecular mechanism regulating nitric oxide synthase(NOS) induced by alpha-quartz in Rat2 fibroblast.
METHODS
alpha-quartz-induced nitric oxide(NO) and H2O2 formation and alpha- quartz-induced iNOS protein expression in Rat2 fibroblast were monitored. With iNOS inhibitor(L-N6- (1-iminoethyl)lysine hydrochloride, L-NIL) or antioxidant(catalase), we observed NO and H2O2 formation and iNOS protein expression in Rat2 fibroblast stimulated with alpha-quartz.
RESULTS
alpha-quartz stimulated iNOS-induced NO and H2O2 formation in Rat2 fibroblast. L-NIL inhibited H2O2 formation and iNOS protein expression by alpha-quartz in Rat2 fibroblast. Pretreatment with catalase blocked the autoinhibitory pathway of iNOS by iNOSinduced H2O2, therefore H2O2 and NO production and iNOS protein expression were increased in Rat2 fibrobalst stimulated with alpha-quartz CONCLUSIONS: alpha-quartz-induced iNOS stimulated H2O2 formation in Rat2 fibroblast. INOS-induced H2O2 by alpha-quartz plays an important role in the autoinhibition pathway for regulating the iNOS function in Rat2 fibroblast
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Autoproliferation of Fibroblast by Exposure to Crystalline Silica - Evaluation by H2O2 and PDGF-AA and TGF beta
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Byoung Young Ahn, Kyoung Ah Kim, Je Hyeok Mun, Jin Sook Jeong, Eun Kyung Kim, Young Lim
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Korean Journal of Occupational and Environmental Medicine 2000;12(2):209-217. Published online June 30, 2000
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DOI: https://doi.org/10.35371/kjoem.2000.12.2.209
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Abstract
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- OBJECTIVES
The aim of this study is to find out the activity of autoproliferation of ratfibroblast exposed to crystalline silica and the role of mediators secreted from rat fibroblast.
METHODS
The effect of alpha-quartz on production of growth factor (platelet-derived growth factor-AA and transforming growth factor beta)from rat fibroblasts were evaluated by ELISA and immunocytochemical analysis.
Gene expression of these growth factors in rat fibrobast exposed to crystalline silica was evaluated by RT-PCR.
Furthermore, fibroblast proliferation by culture supernatant of rat fibroblast was assayed by the neutral red test.
RESULTS
The amounts of H2O2 and growth factors synthesized in rat fibroblasts were significantly increased by the stimulation of crystalline silica(alpha-quartz), which showed the dose-dependent manner to the concentration of alpha-quartz with the maximum response at the dosage of 100 microgram/cm2. The result of RT-PCR demonstrated that alpha-quartz induced gene expression of PDGF-AA and TGFbeta in rat fibroblast. We also found that supernatant of alpha-quartz-cocultured rat fibroblast induced a significant proliferation of fibroblast.
CONCLUSION
Crystalline silica directly induce functional change in fibroblast such as increased release of reactive oxygen species and growth factors. The products of these functional change promote fibroblast proliferation via autocrine loop.
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