KSOEM
Articles
- Page Path
- HOME > Ann Occup Environ Med > Volume 31; 2019 > Article
- Research Article The effect of diabetes on 4-year changes of hearing thresholds in male workers exposed to noise in a single company: a longitudinal study
-
Dae Yun Kim1
, A Ram Kim1, Joo Hyun Sung2, Choong Ryeol Lee1, Jiho Lee1 -
Annals of Occupational and Environmental Medicine 2019;31:e11.
DOI: https://doi.org/10.35371/aoem.2019.31.e11
Published online: June 28, 2019
1Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
2Department of Occupational and Environmental Medicine, Institute of Health Sciences, Gyeongsang National University Changwon Hospital, Gyeongsang National University College of Medicine, Jinju, Korea.
- Correspondence: Jiho Lee. Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, 877 Bangeojinsunhwando-ro, Dong-gu, Ulsan 44033, Korea. oemdoc@naver.com
• Received: January 8, 2019 • Accepted: June 12, 2019
Copyright © 2019 Korean Society of Occupational & Environmental Medicine
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
- 142 Views
- 0 Download
- 2 Scopus
Abstract
-
Background Recently, several studies have assessed the association between diabetes and hearing impairment. However, the effect of diabetes on hearing impairment is not well known in diabetic patients exposed to noise, a typical cause of hearing impairment. The aim of this study is to longitudinally analyze the effect of diabetes on hearing impairment in workers exposed to similar noise levels from 2013 to 2017 who had experienced little change in their working conditions.
-
Methods The study subjects included 2,087 male workers exposed to noise in a single company and who underwent health examinations at the same hospital in Ulsan city in 2013 and 2017. Hearing impairment was defined that a pure-tone average of pure-tone audiometry (PTA) thresholds at 1,000, 2,000, 3,000, and 4,000 Hz was 25 dB and over in both ears. Statistical analyses were conducted using χ2 tests, ANOVA, and Cox proportional hazard models. We analyzed covariates that might affect hearing impairment, including age; working period; levels of total cholesterol, triglyceride, and serum creatinine; smoking and alcohol history; and noise level.
-
Results The average PTA thresholds and their average changes between 2013 and 2017 were significant in the diabetes mellitus (DM) group than those in the normal and impaired fasting glucose group. Among the subjects with the same status of fasting glucose group in 2013 and 2017, the adjusted hazard ratios for incident hearing impairment among those in the DM group compared to normal group were 3.35 (95% confidence interval [CI], 1.54–7.29) in the left ear and 5.66 (95% CI, 2.01–15.98) in the right ear.
-
Conclusions This study suggested that the risk of hearing impairment in the DM group was significantly higher than that in the normal group in both ears, even when exposed to similar noise levels.
BACKGROUND
Among the well-known causes of hearing impairment, including age, noise, genetic factors, toxic drugs, virus infections, and harmful substances [1,2,3,4,5], noise affects workers most significantly. In Korea, workplace environmental noise levels above 8-hour time-weighted average of 80 dB are subject to workplace environmental measurement [6] and the legal standard of noise exposure is above 90 dB (A) for 8 hours a day [7]. However, the meta-analysis of environmental noise for the general population showed that noise levels in the living areas of nearby airports, roads, and railways, which are considered to be relatively loud, was rarely above 80 dB [8]. As such, unlike the general population, manufacturing workers are exposed to significant noise levels, which are considered the main cause of hearing impairment among them [4].
Diabetes mellitus (DM) is a common systemic metabolic disease worldwide [9] and diabetic complications are major problems affecting patients' quality of life [10,11]. The results of studies on hearing impairment in patients with diabetes have been controversial, some suggesting that diabetes is not related to hearing impairment [12,13,14]; however, several recent studies, including a meta-analysis, have reported significant associations [15,16,17,18,19,20]. Therefore, if workers with diabetes are exposed to noise, this may have more negative effect on hearing. However, to our knowledge, there have been few studies on this topic.
Individuals with diabetes among workers exposed to noise require special care and management. Classification of several factors affecting hearing, such as workplace noise level, age, etc., according to fasting glucose level over several years may reveal the effects of diabetes on hearing impairment. To assess the relationship between hearing impairment and diabetes among workers exposed to noise, we think that longitudinal data analysis is necessary. Also, since noise and age are powerful influencing factors for hearing impairment, follow-up of the same individuals is necessary in order to control for variations in these factors. With this research design, we can determine the effect of hearing impairment due to diabetes, which has a relatively small effect. Therefore, we analyzed the effect of diabetes on hearing impairment in workers exposed to similar noise levels from 2013 to 2017 with little change in their working conditions, longitudinally.
METHODS
The study subjects were male workers at a single company who underwent health examinations at the same hospital in Ulsan city in both 2013 and 2017. Of 7,173 individuals with screening data in 2013 and 2017, we excluded 2,970 workers whose status of fasting blood glucose group changed between 2013 and 2017. A total of 4,203 subjects were categorized into 3 groups such as normal, impaired fasting glucose (IFG), and DM group by fasting glucose level and subjects of each group in 2013 remained in the same group in 2017.
Among them, we excluded 1,221 workers for a lack of data on the noise level in their work environments, 95 workers with abnormal otoscopic examination findings or history of ear diseases, 64 workers with missing data for on examination results. Of 2,823 eligible study subjects, we excluded 736 workers whose pure-tone audiometry (PTA) threshold improved by more than 10 dB in 2017 compared to that in 2013. Without abnormal otoscopic examination findings or history of ear diseases, PTA threshold of workers would worsen as time goes on. Based on our result, the observed changes of hearing thresholds between 2013 and 2017 did not exceed 10 dB, so we considered that PTA thresholds improved more than 10 dB were considered as a type of pure-tone audiometric testing error. Thus, a total of 2,087 subjects were eventually included. According to their fasting glucose levels, the analysis included 1,474 subjects in the normal group, 497 in the IFG group, and 116 in the DM group. Furthermore, we selected 1,545 normal hearing subjects (pure-tone average ≤ 25 dB) in both ears in 2013 and we analyzed them by using the Cox proportional hazards models for hearing impairment subjects (pure-tone average > 25 dB) in both ears in 2017 (Fig. 1).
Data from health examinations performed in 2013 and 2017 were collected. Age; working period; systolic and diastolic blood pressures; serum levels of total cholesterol, triglycerides, and creatinine; smoking status; alcohol consumption; and fasting blood glucose level were obtained from the data. The hearing evaluation included measurements of PTA thresholds at frequencies of 1,000, 2,000, 3,000, and 4,000 Hz in both ears, otoscopic examinations, and history taking of ear diseases in 2013 and 2017. We calculated the pure-tone average of PTA thresholds at 1,000, 2,000, 3,000, and 4,000 Hz (= thresholds at 1,000 Hz + 2,000 Hz + 3,000 Hz + 4,000 Hz 4 
) and defined pure-tone average > 25 dB as hearing impairment and ≤ 25 dB as normal hearing [21]. Fasting blood samples were collected after at least 8 hours of fasting. Subjects with fasting blood glucose below 100 mg/dL were defined as the normal group, while subjects with fasting blood glucose between 100 and 125 mg/dL were defined as the IFG group. Subjects with fasting blood glucose over 125 mg/dL and those taking anti-diabetic medications and with a self-reported history of diabetes were defined as the DM group [15,18]. Blood pressure was analyzed as a continuous variable by calculating the mean arterial pressure (M A P = s y s t o l i c b l o o d p r e s s u r e + 2 × d i a s t o l i c b l o o d p r e s s u r e 3 
) which reflects the average effective pressure [22]. Smoking history was classified as smokers or non-smokers, in which smokers were defined as those participants who had smoked more than 100 cigarettes and those who currently smoked cigarettes [23]. Drinking history was classified as high-risk alcohol intake or non-alcohol intake, in which high-risk alcohol intake was defined as a minimum of 7 shots on average in 1 seating with a minimum of 2 drinking sessions per week for men [23].
) and defined pure-tone average > 25 dB as hearing impairment and ≤ 25 dB as normal hearing [21]. Fasting blood samples were collected after at least 8 hours of fasting. Subjects with fasting blood glucose below 100 mg/dL were defined as the normal group, while subjects with fasting blood glucose between 100 and 125 mg/dL were defined as the IFG group. Subjects with fasting blood glucose over 125 mg/dL and those taking anti-diabetic medications and with a self-reported history of diabetes were defined as the DM group [15,18]. Blood pressure was analyzed as a continuous variable by calculating the mean arterial pressure () which reflects the average effective pressure [22]. Smoking history was classified as smokers or non-smokers, in which smokers were defined as those participants who had smoked more than 100 cigarettes and those who currently smoked cigarettes [23]. Drinking history was classified as high-risk alcohol intake or non-alcohol intake, in which high-risk alcohol intake was defined as a minimum of 7 shots on average in 1 seating with a minimum of 2 drinking sessions per week for men [23].Pure-tone audiometric testing was performed in 2013 and 2017 by trained audiometric technicians in sound-attenuating booths in accordance with the Korea Occupational Safety and Health Agency standards using AC40 (Interacoustics Co., Middelfart, Denmark) and HARP BASIC (Inventis Co., Padova, Italy) audiometers equipped with TDH-39P supra-aural earphones (Telephonics Co., New York, NY, USA) with sound calibration performed annually.
The workplace environmental noise levels were evaluated with a noise dosimeter for a maximum of 20 persons in the same work department, including at least 2 of the highest-exposed workers per workplace unit. The noise dosimeter was attached to the ear and the sound equivalent levels were measured using it with A-frequency weighting. We calculated the workplace noise levels as the average of the noise measurements of the selected workers in each unit workplace.
To analyze the variables according to the fasting blood glucose groups in 2013, ANOVA was performed for age; working period; noise level; mean arterial pressure; fasting blood glucose; and levels of total cholesterol, triglyceride, and serum creatinine. The χ2 tests were performed to compare the work environmental noise levels (≤ 79.9 dB, 80.0–84.9 dB, and ≥ 85.0 dB), working period (≤ 14.9, 15.0–29.9, or ≥ 30.0 years), smoking, and high-risk alcohol intake among the normal, IFG, and DM groups. The PTA thresholds in 2013 and 2017 and the changes in these thresholds between 2013 and 2017 were analyzed by ANOVA. Post-hoc comparison was performed using Bonferroni's method. Cox proportional hazards models were used to adjust the factors affecting hearing changes among normal hearing subjects (pure-tone average ≤ 25 dB) in 2013 with hearing impairment (pure-tone average > 25 dB) in 2017. Model 1 was adjusted for age and working period; model 2 was further adjusted for noise level; and model 3 was further adjusted for MAP and levels of total cholesterol, triglycerides, and serum creatinine, smoking, and high-risk alcohol intake. We used the covariates of 2013 in 3 models. IBM SPSS Statistics for Windows, version 21.0 (IBM Corp., Armonk, NY, USA) was used for the analysis and p-values lower than 0.05 were considered to indicate a statistical significance.
This study was approved by the Institutional Review Board (IRB) of Ulsan University Hospital (IRB No. 2018-11-019), which waived the requirement for informed consent, as we used only deidentified data obtained during regular health check-up.
RESULTS
Table 1 shows general characteristics of the study subjects according to the fasting blood glucose groups in 2013. The 2,087 total subjects were classified into 3 groups according to fasting blood glucose level, with 1,474 (70.6%) in the normal group, 497 (23.8%) in the IFG group, and 116 (5.6%) in the DM group. Age; working period; noise level; MAP, and fasting blood glucose, total cholesterol, triglyceride, serum creatinine levels differed significantly among the 3 groups. In particular, age, working period, and fasting blood glucose levels were highest in the DM group, followed by the IFG and normal groups. The noise level in the work environment was higher in the normal group than the DM group after post-hoc comparison. After categorizing the workplace noise levels (≤ 79.9 dB, 80.0–84.9 dB, and ≥ 85.0 dB), the proportion of noise levels 80.0–84.9 dB was high in the normal and IFG groups, while levels ≤ 79.9 dB were high in the DM group. However, the differences among 3 groups were not significant. When the working period was classified as ≤ 14.9, 15.0–29.9, or ≥ 30.0 years, significantly higher proportion was observed for ≤ 14.9 years in the normal group and 15.0–29.9 years in the IFG and DM groups. The proportion of current smoker in normal group was highest and lowest in DM group, whereas high-risk alcohol intake did not differ significantly among the 3 groups.
Table 1
General characteristics of study subjects according to fasting blood glucose groups in 2013
Table 2 shows the average PTA thresholds in 2013 and 2017 and their average changes between both years for 1,000, 2,000, 3,000, and 4,000 Hz in both ears on individual subjects according to the same fasting glucose groups. The average PTA thresholds in the left and right ears in 2017 were higher than those in 2013 in all 3 fasting blood glucose groups. The average changes in PTA thresholds between the 2 years on individual subjects were largest in the DM group, followed by the IFG and normal groups. Post-hoc comparison analysis showed that average PTA thresholds in each year and the average changes in these pure thresholds between both years on individual subjects were significantly greater in the DM group than those in the normal group.
Table 2
Pure-tone audiometry thresholds changes on individual subjects according to the same fasting glucose groups in 2013 and 2017
Table 3 shows the results of Cox proportional hazards models for hearing impairment (pure-tone average > 25 dB) in 2017 after adjusting for covariates affecting hearing impairment in each fasting glucose group. To analyze 4-year changes for the events of hearing impairment (pure-tone average > 25 dB) in 2017, covariates of 2013 were used in the analysis. In the left ear, among 1,145 normal hearing subjects in the normal group in 2013, 32 experienced hearing impairment in 2017. Similarly, 19 out of 341 in the IFG group and 10 out of 59 in the DM group experienced hearing impairment. In the right ear, 17 out of 1,145, 10 out of 341, and 6 out of 59 subjects in the normal, IFG, and DM groups, respectively, had experienced hearing impairment. In the left ear, the adjusted hazard ratios (HRs) for incident hearing impairment for subjects in the DM group were 2.76 (95% confidence interval [CI], 1.33–5.72) in model 1, 2.80 (95% CI, 1.35–5.80) in model 2, and 3.35 (95% CI, 1.54–7.29) in model 3 when normal group was reference. In the right ear, those were 3.19 (95% CI, 1.23–8.29), 3.24 (95% CI, 1.25–8.41), and 5.66 (95% CI, 2.01–15.98), respectively. All adjusted HRs in the DM group were statistically significant. In all models, the HRs for incident hearing impairment for subjects in the DM group was higher than those in the IFG group.
Table 3
Adjusted HRs of hearing impairment by pure-tone average compared to normal fasting glucose group
Data are shown as HR (95% confidence interval).
IFG: impaired fasting glucose; DM: diabetes mellitus; HR: hazard ratio.
*Model 1, adjusted for age, working period; †Model 2, further adjusted for noise level; ‡Model 3, further adjusted for mean arterial pressure, total cholesterol, triglyceride, serum creatinine, smoking, high-risk alcohol intake.
DISCUSSION
In this study, we investigated the effect of diabetes on hearing impairment in workers exposed to similar noise levels with little change in their working conditions during the 4-year follow-up period. PTA thresholds according to fasting blood glucose groups were higher in all frequencies in 2013 and 2017 in the order of the DM, IFG, and normal groups in both ears. The average PTA thresholds of the DM group were significantly higher than those of the normal group. The average changes in PTA thresholds on individual subjects during the study were also statistically significantly higher in the DM group than those in the normal group. In the Cox proportional hazards analysis, which calculated the HRs after adjusting for various covariates affecting hearing, in which a pure-tone average > 25 dB was defined as hearing impairment, the HRs of the DM group were significantly higher compared to those in the normal group (2.76–3.35 in the left ears and 3.19–5.66 in the right ears). The HRs in the present study were higher than those of other studies [12,15], this is estimated to be due to the calculation of pure-tone average including the pure-tone threshold at 4,000 Hz. Our results indicate that diabetes affect hearing impairment based on the average changes in PTA thresholds between 2013 and 2017 and the higher HRs from 2013 to 2017 in the DM group compared to the normal group despite similar noise exposure levels.
Few studies have assessed the association between diabetes and PTA thresholds among subjects exposed to high noise levels. We identified an association between diabetes and changes in PTA thresholds at 1,000, 2,000, 3,000, and 4,000 Hz. Recent studies have reported that diabetes has significant associations with hearing impairment. In a cohort study between 2002 and 2014 that defined incident hearing loss as a pure-tone average of thresholds at 0.5, 1.0 and 2.0 kHz > 25 dB in both right and left ears, Kim et al. [15] reported multivariable-adjusted HRs of subjects with pre-diabetes and diabetes of 1.04 (95% CI, 0.95–1.14) and 1.36 (95% CI, 1.19–1.56), respectively. In the cross-sectional Busselton Health Ageing Survey by Sommer et al. [24], which defined hearing loss as the 4-frequency average (4FA) of pure-tone thresholds at 500, 1,000, 2,000, and 4,000 Hz and the high-frequency average of pure-tone thresholds at 4,000 and 8,000 Hz > 25 dB in the better ear, the prevalence of 4FA hearing loss increased from 2.3% (95% CI, 1.5–3.4) in participants with normoglycemia to 5.7% (95% CI, 3.0–10.6) in those with prediabetes and 10.2% (4.2–21.5) in those with diabetes among 1,286 participants aged < 60 years. In multivariable analysis with normoglycemia as the reference, the odds ratios (ORs) for 4FA hearing loss were 2.84 (95% CI, 1.29–6.27) for prediabetes and 5.93 (95% CI, 1.67–21.05) for diabetes in the < 60-year age group [24]. In contrast to prior studies, some studies have reported a weak association between diabetes and hearing loss. In a cross-sectional study, Samelli et al. [12] defined hearing loss as average low-middle range frequencies at 250, 500, 1,000 and 2,000 Hz, and high range frequencies at 3,000, 4,000, 6,000, and 8,000 Hz > 25 dB, reporting ORs of participants with diabetes after adjusting for covariates of 1.03 (95% CI, 0.56–1.92) at low-middle range frequencies and 1.18 (95% CI, 0.78–1.78) at high range frequencies. In addition, there were no significant differences when the ORs were analyzed for each frequency. In a cross-sectional study of cardiovascular risk factors and hearing loss, Engdahl et al. [13] found a weak positive association with diabetes in multivariate regression analysis when they calculated pure-tone average thresholds of low (0.25 and 0.5 kHz), middle (1 and 2 kHz), and high (3, 6, and 8 kHz) after excluding the cardiovascular risk factors presented in this study. In addition, multivariate regression analysis including the cardiovascular risk factors revealed no significant association with diabetes. Among other major factors that affect hearing, triglyceride has been associated with a higher risk of noise-induced hearing loss among subjects with hypertriglyceridemia [25,26], hypertension is associated with hearing loss [27,28], and serum creatinine was used as an indicator of the degree and management of DM in relation to microvascular diseases [29].
Several studies have proposed hypotheses regarding the mechanism of hearing loss caused by diabetes. These are cochlear injury due to microangiopathy [30,31,32], damage to the auditory nerve caused by diabetic peripheral neuropathy [33,34] and mitochondrial damage caused by diabetes [35,36,37]. Also, mechanism of noise-induced hearing loss is that the noise causes mechanical and metabolic damage to the internal structure of the cochlea, which causes cell death in the cochlea, apoptosis through the metabolic damage process culminating in the accumulation of reactive oxygen species due to oxidative stress, cochlear ischemia followed by reperfusion injury, and excitotoxicity to the auditory neuron induced by the excessive release of glutamate, the cochlear afferent neurotransmitter [38]. In general, the first signs of the effects of noise on hearing begin as a dip or notch at 3,000–6,000 Hz in audiograms, leading to gradual deterioration at the high frequencies due to increased noise exposure [39,40]. Genetic and complicating factors, including diabetes, are more likely to cause hearing loss at both high and low frequencies [41]. In conclusion, diabetes alone is likely to cause hearing loss, which is worsened if both diabetes and noise exposure is present.
This study has several strengths. First, this is a large-scale study including 2,087 subjects who were similarly exposed to high noise levels and who had little change in working conditions. Also, we performed a longitudinal analysis of subjects with the same fasting blood glucose levels during a 4-year study period. Second, in analyzing the HR of the DM group compared to that of the normal group, we could adjust and evaluate many factors through various models to confirm similar tendencies. Finally, the observation that diabetes can contribute more to hearing impairment among workers exposed to high noise levels in our study may impact the hearing management of diabetic patients.
This study also has some limitations. As a limitation inherent to the cross-sectional design, we considered noise exposure in the work environment but it was difficult to determine the actual noise exposure time and noise characteristics of individual people and only the average noise level was considered in each department. In addition, the data on high frequencies including 6,000 and 8,000 Hz were insufficient in the health examination data; thus, the effect of high-frequency noise could not be analyzed. Lastly, there was a possibility of misclassification error due to a lack of information on the duration of diabetes and actual diabetes management of individuals.
CONCLUSIONS
This study investigated the effect of diabetes on hearing impairment in occupational noise exposed workers without changes in working conditions including noise level. We found that the HRs of hearing impairment (pure-tone average > 25 dB) was higher in the DM group than those in the normal group and IFG group for both ears during the 4-year follow-up period after adjusting covariates. These findings indicate the need for special care and precautions in the hearing management of workers with diabetes exposed to noise.
Acknowledgements
The authors would like to thank occupational & environmental medical center, Ulsan University Hospital and the participants of study.
-
Competing interests: The authors declare that they have no competing interests.
-
Availability of data and materials: Please contact author for data request.
-
Author Contributions:
Conceptualization: Lee JH, Lee CR, Kim DY.
Data curation: Kim DY.
Formal analysis: Kim DY.
Investigation: Kim DY, Kim AR.
Methodology: Lee JH, Lee CR, Sung JH, Kim DY.
Project administration: Lee JH, Lee CR.
Resources: Sung JH, Kim DY, Kim AR.
Software: Kim DY, Kim AR.
Supervision: Lee JH, Lee CR.
Validation: Lee JH, Lee CR, Kim DY.
Visualization: Kim DY.
Writing - original draft: Kim DY.
Writing - review & editing: Lee JH, Lee CR, Sung JH.
Abbreviations
PTA
pure-tone audiometry
DM
diabetes mellitus
CI
confidence interval
IFG
impaired fasting glucose
MAP
mean arterial pressure
HR
hazard ratio
4FA
4-frequency average
OR
odds ratio
- 1. Verhoeff M, van der Veen EL, Rovers MM, Sanders EA, Schilder AG. Chronic suppurative otitis media: a review. Int J Pediatr Otorhinolaryngol 2006;70(1):1–12. 16198004.ArticlePubMed
- 2. Palomar García V, Abdulghani Martínez F, Bodet Agustí E, Andreu Mencía L, Palomar Asenjo V. Drug-induced otoxicity: current status. Acta Otolaryngol 2001;121(5):569–572. 11583387.ArticlePubMed
- 3. Konigsmark BW. Genetic hearing loss with no associated abnormalities: a review. J Speech Hear Disord 1972;37(1):89–99. 4559857.ArticlePubMed
- 4. Sliwinska-Kowalska M, Davis A. Noise-induced hearing loss. Noise Health 2012;14(61):274–280. 23257577.ArticlePubMed
- 5. Kidd Iii AR, Bao J. Recent advances in the study of age-related hearing loss: a mini-review. Gerontology 2012;58(6):490–496. 22710288.ArticlePubMedPMCPDF
- 6. National Law Information Center. Occupational safety and health act enforcement rule (attached Table 11-5). Sejong: National Law Information Center; 2017, Accessed 14 May 2019]. http://www.law.go.kr/법령/산업안전보건법시행규칙.
- 7. Ministry of Employment and Labor. Ministry of Labor and Employment amended by notice No. 2018-62. Sejong: Ministry of Employment and Labor; 2018.
- 8. Guski R, Schreckenberg D, Schuemer R. WHO environmental noise guidelines for the European region: a systematic review on environmental noise and annoyance. Int J Environ Res Public Health 2017;14(12):E1539. 29292769.ArticlePubMedPMC
- 9. World Health Organization. Diabetes. Geneva: World Health Organization; 2018, Accessed 21 Dec 2018]. http://www.who.int/mediacentre/factsheets/fs312/en/.
- 10. Vijan S. In the clinic. Type 2 diabetes. Ann Intern Med 2010;152(5):ITC31–ITC15. 20194231.PubMed
- 11. Kaźmierczak H, Doroszewska G. Metabolic disorders in vertigo, tinnitus, and hearing loss. Int Tinnitus J 2001;7(1):54–58. 14964957.PubMed
- 12. Samelli AG, Santos IS, Moreira RR, Rabelo CM, Rolim LP, Bensenõr IJ, et al. Diabetes mellitus and sensorineural hearing loss: is there an association? Baseline of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Clinics (Sao Paulo) 2017;72(1):5–10. 28226026.ArticlePubMedPMC
- 13. Engdahl B, Aarhus L, Lie A, Tambs K. Cardiovascular risk factors and hearing loss: the HUNT study. Int J Audiol 2015;54(12):958–966. 26642893.ArticlePubMed
- 14. Hodgson MJ, Talbott E, Helmkamp JC, Kuller LH. Diabetes, noise exposure, and hearing loss. J Occup Med 1987;29(7):576–579. 3612333.PubMed
- 15. Kim MB, Zhang Y, Chang Y, Ryu S, Choi Y, Kwon MJ, et al. Diabetes mellitus and the incidence of hearing loss: a cohort study. Int J Epidemiol 2017;46(2):717–726. 27818377.ArticlePubMedPMCPDF
- 16. Akinpelu OV, Mujica-Mota M, Daniel SJ. Is type 2 diabetes mellitus associated with alterations in hearing? A systematic review and meta-analysis. Laryngoscope 2014;124(3):767–776. 23945844.ArticlePubMedPDF
- 17. Horikawa C, Kodama S, Tanaka S, Fujihara K, Hirasawa R, Yachi Y, et al. Diabetes and risk of hearing impairment in adults: a meta-analysis. J Clin Endocrinol Metab 2013;98(1):51–58. 23150692.ArticlePubMed
- 18. Jang TW, Kim BG, Kwon YJ, Im HJ. The association between impaired fasting glucose and noise-induced hearing loss. J Occup Health 2011;53(4):274–279. 21670562.ArticlePubMedPDF
- 19. Mitchell P, Gopinath B, McMahon CM, Rochtchina E, Wang JJ, Boyages SC, et al. Relationship of type 2 diabetes to the prevalence, incidence and progression of age-related hearing loss. Diabet Med 2009;26(5):483–488. 19646187.ArticlePubMed
- 20. Botelho CT, Carvalho SA, Silva IN. Increased prevalence of early cochlear damage in young patients with type 1 diabetes detected by distortion product otoacoustic emissions. Int J Audiol 2014;53(6):402–408. 24564623.ArticlePubMed
- 21. Cheng YJ, Gregg EW, Saaddine JB, Imperatore G, Zhang X, Albright AL. Three decade change in the prevalence of hearing impairment and its association with diabetes in the United States. Prev Med 2009;49(5):360–364. 19664652.ArticlePubMed
- 22. Jung SJ, Woo KH, Park WD, Yu JY, Choi TS, Kim SW, et al. Related factors of high frequency hearing loss in the noise-exposed male workers. Korean J Occup Environ Med 2000;12(2):187–197.ArticlePDF
- 23. Korea Centers for Disease Control and Prevention. The Sixth Korea National Health and Nutrition Examination Survey (KNHANES VI-2). Cheongju: Korea Centers for Disease Control and Prevention; 2015.
- 24. Sommer J, Brennan-Jones CG, Eikelboom RH, Hunter M, Davis WA, Atlas MD, et al. A population-based study of the association between dysglycaemia and hearing loss in middle age. Diabet Med 2017;34(5):683–690. 28135010.ArticlePubMedPDF
- 25. Doosti A, Lotfi Y, Bakhshi E. Effects of hyperlipidemia on noise induced hearing loss (NIHL). Indian J Otolaryngol Head Neck Surg 2016;68(2):211–213. 27340639.ArticlePubMedPMCPDF
- 26. Chang NC, Yu ML, Ho KY, Ho CK. Hyperlipidemia in noise-induced hearing loss. Otolaryngol Head Neck Surg 2007;137(4):603–606. 17903577.ArticlePubMedPDF
- 27. Bener A, Al-Hamaq AO, Abdulhadi K, Salahaldin AH, Gansan L. Interaction between diabetes mellitus and hypertension on risk of hearing loss in highly endogamous population. Diabetes Metab Syndr 2017;11(Suppl 1):S45–S51. 27614865.ArticlePubMed
- 28. Lin BM, Curhan SG, Wang M, Eavey R, Stankovic KM, Curhan GC. Hypertension, diuretic use, and risk of hearing loss. Am J Med 2016;129(4):416–422. 26656761.ArticlePubMedPMC
- 29. Kakarlapudi V, Sawyer R, Staecker H. The effect of diabetes on sensorineural hearing loss. Otol Neurotol 2003;24(3):382–386. 12806288.ArticlePubMed
- 30. Fukushima H, Cureoglu S, Schachern PA, Paparella MM, Harada T, Oktay MF. Effects of type 2 diabetes mellitus on cochlear structure in humans. Arch Otolaryngol Head Neck Surg 2006;132(9):934–938. 16982969.ArticlePubMed
- 31. Guerci B, Kearney-Schwartz A, Böhme P, Zannad F, Drouin P. Endothelial dysfunction and type 2 diabetes. Part 1: physiology and methods for exploring the endothelial function. Diabetes Metab 2001;27(4 Pt 1):425–434. 11547216.PubMed
- 32. Taslipinar A, Yaman H, Yilmaz MI, Demirbas S, Saglam M, Taslipinar MY, et al. The relationship between inflammation, endothelial dysfunction and proteinuria in patients with diabetic nephropathy. Scand J Clin Lab Invest 2011;71(7):606–612. 21864054.ArticlePubMed
- 33. Sonneville R, den Hertog HM, Güiza F, Gunst J, Derese I, Wouters PJ, et al. Impact of hyperglycemia on neuropathological alterations during critical illness. J Clin Endocrinol Metab 2012;97(6):2113–2123. 22442271.ArticlePubMed
- 34. Vaughan N, James K, McDermott D, Griest S, Fausti S. Auditory brainstem response differences in diabetic and non-diabetic veterans. J Am Acad Audiol 2007;18(10):863–871. 18496995.ArticlePubMed
- 35. Yamasoba T, Oka Y, Tsukuda K, Nakamura M, Kaga K. Auditory findings in patients with maternally inherited diabetes and deafness harboring a point mutation in the mitochondrial transfer RNA(Leu) (UUR) gene. Laryngoscope 1996;106(1 Pt 1):49–53. 8544627.ArticlePubMed
- 36. Newkirk JE, Taylor RW, Howell N, Bindoff LA, Chinnery PF, Alberti KG, et al. Maternally inherited diabetes and deafness: prevalence in a hospital diabetic population. Diabet Med 1997;14(6):457–460. 9212310.ArticlePubMed
- 37. Khardori R, Stephens JW, Page OC, Dow RS. Diabetes mellitus and optic atrophy in two siblings: a report on a new association and a review of the literature. Diabetes Care 1983;6(1):67–70. 6839924.ArticlePubMedPDF
- 38. Shim HJ. Noise-induced hearing loss. Hanyang Med Rev 2015;35(2):84–91.Article
- 39. McBride DI, Williams S. Audiometric notch as a sign of noise induced hearing loss. Occup Environ Med 2001;58(1):46–51. 11119634.ArticlePubMedPMC
- 40. Sellick PM, Patuzzi R, Johnstone BM. Measurement of basilar membrane motion in the guinea pig using the Mössbauer technique. J Acoust Soc Am 1982;72(1):131–141. 7108035.ArticlePubMedPDF
- 41. Yamasoba T, Lin FR, Someya S, Kashio A, Sakamoto T, Kondo K. Current concepts in age-related hearing loss: epidemiology and mechanistic pathways. Hear Res 2013;303:30–38. 23422312.ArticlePubMedPMC
References
Figure & Data
REFERENCES
Citations
Citations to this article as recorded by 
PubReader
ePub Link
Cite
XML DownloadThe effect of diabetes on 4-year changes of hearing thresholds in male workers exposed to noise in a single company: a longitudinal study
Fig. 1 Flow chart of study design.IFG: impaired fasting glucose; DM: diabetes mellitus.
Fig. 1
The effect of diabetes on 4-year changes of hearing thresholds in male workers exposed to noise in a single company: a longitudinal study
| Classification variables | Normala (n=1,474) | IFGb (n=497) | DMc (n=116) | Total (n=2,087) | p-value* | Post-hoc comparison | |
|---|---|---|---|---|---|---|---|
| Age (years) | 41.5 ± 9.5 | 44.5 ± 9.9 | 49.3 ± 7.9 | 42.6 ± 9.7 | < 0.001 | a < b < c | |
| Working period (years) | 15.9 ± 11.3 | 19.2 ± 11.4 | 24.4 ± 8.6 | 17.2 ± 11.4 | < 0.001 | a < b < c | |
| Noise level (decibel) | 83.1 ± 5.5 | 82.8 ± 5.3 | 81.8 ± 5.3 | 83.0 ± 5.4 | 0.036 | c < a | |
| Mean arterial pressure (mmHg) | 91.8 ± 8.6 | 93.9 ± 8.1 | 95.5 ± 8.2 | 92.5 ± 8.5 | < 0.001 | a < b, c | |
| Fasting blood glucose (mg/dL) | 92.1 ± 5.7 | 109.7 ± 6.6 | 132.2 ± 28.8 | 98.5 ± 14.2 | < 0.001 | a < b < c | |
| Total cholesterol (mg/dL) | 200.6 ± 32.0 | 204.3 ± 31.5 | 183.0 ± 39.2 | 200.5 ± 32.6 | < 0.001 | c < a, b | |
| Triglyceride (mg/dL) | 120.0 ± 76.9 | 140.5 ± 109.7 | 134.5 ± 91.4 | 125.7 ± 87.0 | < 0.001 | a < b | |
| Serum creatinine (mg/dL) | 1.0 ± 0.1 | 1.0 ± 0.1 | 1.0 ± 0.3 | 1.0 ± 0.1 | 0.035 | a, b < c | |
| Noise level (dB) | 0.103 | ||||||
| ≤ 79.9 | 384 (26.1) | 139 (28.0) | 43 (37.1) | 566 (27.1) | |||
| 80.0–84.9 | 563 (38.2) | 188 (37.8) | 42 (36.2) | 793 (38.0) | |||
| ≥ 85.0 | 527 (35.8) | 170 (34.2) | 31 (26.7) | 728 (34.9) | |||
| Working period (years) | < 0.001 | ||||||
| ≤ 14.9 | 738 (50.1) | 193 (38.8) | 23 (19.8) | 954 (45.7) | |||
| 15.0–29.9 | 528 (35.8) | 197 (39.6) | 66 (56.9) | 791 (37.9) | |||
| ≥ 30.0 | 208 (14.1) | 107 (21.5) | 27 (23.3) | 342 (16.4) | |||
| Smoking | 0.006 | ||||||
| No | 736 (49.9) | 274 (55.1) | 70 (60.3) | 1,080 (51.7) | |||
| Yes | 738 (50.1) | 223 (44.9) | 46 (39.7) | 1,007 (48.3) | |||
| High-risk alcohol intake | 0.954 | ||||||
| No | 1,104 (74.9) | 343 (69.0) | 98 (84.5) | 1,545 (74.0) | |||
| Yes | 370 (25.1) | 154 (31.0) | 18 (15.5) | 542 (26.0) | |||
| Frequencies | Normala (n=1,474) | IFGb (n=497) | DMc (n=116) | Total (n=2,087) | p-value* | Post-hoc comparison | ||
|---|---|---|---|---|---|---|---|---|
| Left ear (dB) | ||||||||
| 1,000 Hz | ||||||||
| 2013 | 13.2 ± 9.5 | 14.0 ± 8.9 | 17.0 ± 13.9 | 13.6 ± 9.7 | < 0.001 | a, b < c | ||
| 2017 | 13.9 ± 11.4 | 15.3 ± 11.3 | 19.3 ± 15.4 | 14.5 ± 11.7 | < 0.001 | a, b < c | ||
| Changes | 0.7 ± 4.8 | 1.3 ± 4.6 | 2.2 ± 6.0 | 0.9 ± 4.8 | < 0.001 | a, b < c | ||
| 2,000 Hz | ||||||||
| 2013 | 15.0 ± 12.1 | 16.1 ± 11.9 | 20.6 ± 16.3 | 15.6 ± 12.4 | < 0.001 | a, b < c | ||
| 2017 | 16.2 ± 14.3 | 18.2 ± 14.2 | 24.2 ± 17.9 | 17.1 ± 14.6 | < 0.001 | a, b < c | ||
| Changes | 1.2 ± 5.1 | 2.1 ± 5.5 | 3.6 ± 5.7 | 1.5 ± 5.2 | < 0.001 | a, b < c | ||
| 3,000 Hz | ||||||||
| 2013 | 19.6 ± 16.6 | 22.8 ± 18.0 | 30.0 ± 20.2 | 21.0 ± 17.3 | < 0.001 | a, b < c | ||
| 2017 | 20.8 ± 18.4 | 24.2 ± 19.0 | 32.3 ± 21.0 | 22.2 ± 18.9 | < 0.001 | a, b < c | ||
| Changes | 1.1 ± 5.2 | 1.4 ± 4.7 | 2.2 ± 4.9 | 1.3 ± 5.0 | 0.059 | a, b < c | ||
| 4,000 Hz | ||||||||
| 2013 | 24.9 ± 19.7 | 28.6 ± 20.4 | 37.1 ± 21.3 | 26.5 ± 20.2 | < 0.001 | a, b < c | ||
| 2017 | 27.1 ± 21.1 | 30.7 ± 21.4 | 40.4 ± 22.2 | 28.7 ± 21.5 | < 0.001 | a, b < c | ||
| Changes | 2.2 ± 5.6 | 2.2 ± 5.3 | 3.3 ± 5.8 | 2.2 ± 5.5 | 0.091 | a, b < c | ||
| Right ear (dB) | ||||||||
| 1,000 Hz | ||||||||
| 2013 | 13.1 ± 8.5 | 14.5 ± 12.1 | 16.7 ± 14.6 | 13.7 ± 9.9 | < 0.001 | a, b < c | ||
| 2017 | 13.7 ± 10.6 | 16.2 ± 13.9 | 19.0 ± 16.3 | 14.6 ± 11.9 | < 0.001 | a < b < c | ||
| Changes | 0.6 ± 4.6 | 1.7 ± 5.2 | 2.2 ± 5.2 | 0.9 ± 4.9 | 0.004 | a < b, c | ||
| 2,000 Hz | ||||||||
| 2013 | 14.5 ± 11.4 | 16.2 ± 14.3 | 19.8 ± 16.6 | 15.2 ± 12.5 | < 0.001 | a, b < c | ||
| 2017 | 15.4 ± 13.5 | 18.3 ± 16.3 | 22.6 ± 17.8 | 16.5 ± 14.6 | < 0.001 | a, b < c | ||
| Changes | 0.9 ± 4.7 | 2.1 ± 5.3 | 2.8 ± 5.3 | 1.3 ± 5.0 | 0.002 | a < b, c | ||
| 3,000 Hz | ||||||||
| 2013 | 18.6 ± 16.1 | 22.5 ± 19.4 | 28.0 ± 19.3 | 20.1 ± 17.3 | < 0.001 | a < b < c | ||
| 2017 | 19.5 ± 17.8 | 24.2 ± 20.6 | 30.3 ± 20.5 | 21.2 ± 18.9 | < 0.001 | a < b < c | ||
| Changes | 0.9 ± 4.6 | 1.7 ± 4.6 | 2.3 ± 5.1 | 1.2 ± 4.6 | < 0.001 | a < c | ||
| 4,000 Hz | ||||||||
| 2013 | 23.9 ± 19.6 | 28.8 ± 22.1 | 35.2 ± 20.3 | 25.7 ± 20.5 | < 0.001 | a < b < c | ||
| 2017 | 25.2 ± 20.6 | 30.6 ± 22.5 | 38.0 ± 21.8 | 27.2 ± 21.4 | < 0.001 | a < b < c | ||
| Changes | 1.3 ± 5.1 | 1.8 ± 4.8 | 2.8 ± 6.2 | 1.5 ± 5.1 | 0.003 | a, b < c | ||
| Fasting blood glucose group | Events/No. of subjects | Model 1* | Model 2† | Model 3‡ | |
|---|---|---|---|---|---|
| Left ear | |||||
| Normal | 32/1,145 | Reference | Reference | Reference | |
| IFG | 19/341 | 1.29 (0.73–2.29) | 1.31 (0.74–2.32) | 1.35 (0.76–2.41) | |
| DM | 10/59 | 2.76 (1.33–5.72) | 2.80 (1.35–5.80) | 3.35 (1.54–7.29) | |
| Right ear | |||||
| Normal | 17/1,145 | Reference | Reference | Reference | |
| IFG | 10/341 | 1.30 (0.59–2.85) | 1.32 (0.60–2.89) | 1.54 (0.69–3.44) | |
| DM | 6/59 | 3.19 (1.23–8.29) | 3.24 (1.25–8.41) | 5.66 (2.01–15.98) | |
Table 1 General characteristics of study subjects according to fasting blood glucose groups in 2013
Data are shown as mean ± standard deviation or number (%).
IFG: impaired fasting glucose; DM: diabetes mellitus.
*
Table 2 Pure-tone audiometry thresholds changes on individual subjects according to the same fasting glucose groups in 2013 and 2017
Data are shown as mean ± standard deviation or number (%).
IFG: impaired fasting glucose; DM: diabetes mellitus.
*
Table 3 Adjusted HRs of hearing impairment by pure-tone average compared to normal fasting glucose group
Data are shown as HR (95% confidence interval).
IFG: impaired fasting glucose; DM: diabetes mellitus; HR: hazard ratio.
*Model 1, adjusted for age, working period; †Model 2, further adjusted for noise level; ‡Model 3, further adjusted for mean arterial pressure, total cholesterol, triglyceride, serum creatinine, smoking, high-risk alcohol intake.
