OBJECTIVES The chrome-induced olfactory alterations is caused by inhalation of chromic acid, a highly corrossive and toxic materials. And nasal septum perforation(NSP) has been suspected with possible causative factor of olfactory alterations. To our knowledge, there has been no report of the detailed findings of the olfactory alterations in chrome exposed subjects without nasal septum perforation(NSP). So we present the results of olfactory function test measured by T&T olfactometer and olfactometer perception test among chromium exposed workers without NSP. METHODS We performed this study in 25 study subjects and 25 control subjects matched with age, alcohol and smoking.
All of subjects are man. We performed olfactory function test measured by T&T olfactometer and olfactometer perception test. RESULTS 1) The age distribution of the subjects involved in this study was from 20 to 54 years old (average 33.3 years old) and the mean duration exposed to chromium was from 64. 9 months. 2) The olfactory function was checked by detection and recognition thresholds in five odorants. The detection thresholds of exposed group dealing with chromium were significantly increased in A and B ordorants than nonexposed group. The recognition thresholds of exposed group were significantly increased in D ordorants than nonexposed group. 3) The mean threshold of olfactometer perception test of exposed group were more increased than nonexposed group.
But thresholds difference did not show statistical significance, 4) The detection thresholds of A and D ordorants, recognition threshold of C ordorants and thresholds of olfactometer perception test were increased in the relation with duration of chrome exposure. CONCLUSIONS There has been no remarkable alterations in olfactory sense (TkT olfactometer and Olfactometer Perception Test) in subjects without nasal septum perforation(NSP) exposed to chromic acid.
Chromic acid has widely been used for decorative chromium plating, hard chromium plating, and surface treatment of raw materials. However, its strong oxidizing action has been found to cause corrosion of mucous membranes and skin, such as the nasal septum, conjunctiva, face, and hand skin. Excessive exposure to chmmic acid has frequently caused ulceration and perforation of a nasal septum. These ulcerations are painless and confined to the cartilaginous portion at the lower anterior part of the septum known as Kisselbach's or Little's area. This study was undertaken to investigate the general characteristics, actual conditions of the working environment and the prevalence rate of nasal septal perforation due to inhalation of chromic acid mist in workers employed at plating industries. This study was conducted on 627 workers who were exposed to chromic acid from July to November 1988.
The results were summarized as follows: 1. The mean age of workers with septal perforation was 26 years and the mean working duration was 84 months.
2. The prevalence rates of nasal septal perforation and ulceration of mucosa of the plating workers were 31.7% and 10.5% respectively.
3. The significant variables related with occurrence of nasal septal perforation were age of workers, working duration, kinds of plating, efficiency of local ventilation and performance of health examinations.
From the above results, occurrences of nasal septal perforation in plating workers were affected by the duration of chromium exposed work and state of the working environment. Prevention of occupationsl diseases fri plating workers will be accomplished by implementation of an industrial health care system which includes thorough health checkups for workers and regular environmental monitoring.
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Occupational Diseases in Korea Seong-Kyu Kang, Eun A Kim Journal of Korean Medical Science.2010; 25(Suppl): S4. CrossRef