The radiological finding, pulmonary ventilatory function test data, electrocardiography data were used for the study of relationship between these variables in cor pulmonale and normal group in coal Workers pneumoconiosis. The hospital records of 674 men who were diagnosed as coal workers pneumoconiosis were analysed. The ratio between interhilar distance and thoracic transverse diameter was used as a criterion in grouping of cor pulmonale. If. the ratio is greater than 0.36, it was classified, to cor pulmonale. The squared canonical correlation of pulmonary function variable to cor pulmonale grouping was less than 0.15. Logistic regression analysis with pulmonary function variable and electrocardiographic variable showed sensitivity 50.5%, specificity 72.2%, correctness 62.2%. Vital capacity and Forced vital capacity showed significantly decreased value in cor pulmonale group after adjustment of covariates( age, degree of dyspnea, pack-years of smoking, perfusion of small and large opacity).
This study was performed to investigate associations between serum alpha(1)-antitrypsin(AAT) concentration and radiological categories of coal workers' pneumoconlosis(CWP), between AAT concentration and pulmonary complications such as tuberculosis and emphysema, and to study associations between AAT concentration and FEV(1.0)% in CWP patients, We classified 254 CWP patients in D Hospital into categories of small opacity profusion. And we selected 86 subjects by with or without emphysematous finding in each categories by proportional stratified sampling method.
Semm AAT concentrations were quantkated by single radial immunodiffusion method, and the findings of chest radiographs were evaluated by radilogist.
The results were as follows: 1. Serum AAT concentrations were not significantly different among groups of radiological categories of small opacities.
2. Complication of emphysema was associated with smoking habits sigmficantlyl(chi square=12.16, p<0,01). And AAT concentraLion was higher in smokers and ex-smokers than in non-smokers. Serum AAT concentration was significantly higher in the cases with emphysema than in the cdses without emphybema{p<0.01).
3. Serum AAT concentration of the group with active pulmonary tuberculosis was significantly higher than with inactive or without: pulmonary tuberculosis group(p<0.1).
4. Serum AAT concentration of the group with low FEV(1.0)% was significantly higher than with high or normal group(p<0.05).