Annals of Occupational and Environmental Medicine

Case Report

Acute liver injury in two workers exposed to chloroform in cleanrooms: a case report: Young Joong Kang, Jungho Ahn, Yang-In Hwang; Ann Occup Environ Med 2014;26:49. Published online November 4, 2014; DOI: https://doi.org/10.1186/s40557-014-0049-5

We report 2 cases of hepatotoxicity in cleanroom workers due to high retained chloroform air concentrations. The women, aged 34 and 41 years, who had been working in a medical endoscopic device manufacturer as cleanroom workers for approximately 40–45 days suffered severe liver damage. Two measured time-weighted averages of the chloroform concentration in the air in the cleanroom were 82.74 and 64.24 ppm, which are more than 6 times the legal occupational exposure limit in Korea. Only 7% of the cleanroom air was newly introduced from outside. The clinical courses of these cases and workplace inspection, led us to conclude that both cases of hepatotoxicity were caused by chloroform exposure.

Citations

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Cytotoxicity and genotoxicity evaluation of chloroform using Vicia faba roots
Xue Li, Ang Li, Ming Zhang, Tianpeng Gao
Toxicology and Industrial Health.2023; 39(10): 603. CrossRef
Acute liver injury in a non-alcoholic fatty liver disease patient with chloroform exposure: a case report
Yosuke Suehiro, Takuro Uchida, Masataka Tsuge, Eisuke Murakami, Daiki Miki, Tomokazu Kawaoka, Michio Imamura, Hiroshi Aikata, Koji Arihiro, Shiro Oka
Clinical Journal of Gastroenterology.2023;[Epub] CrossRef
A case report of toxic hepatitis caused by chloroform in automotive parts manufacturer coating process
Jong Hyun Hwang, Jung Il Kim
Annals of Occupational and Environmental Medicine.2022;[Epub] CrossRef
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Cristiano Brauner, Dvora Joveleviths, Mário R. Álvares-da-Silva, Norma Marroni, Silvia Bona, Elizângela Schemitt, Raissa Nardi
Journal of Environmental Science and Health, Part A.2020; 55(10): 1173. CrossRef
Chronic, Recreational Chloroform-Induced Liver Injury
Emily A. Minor, Mackenzie S. Newman, Justin T. Kupec
Case Reports in Hepatology.2018; 2018: 1. CrossRef
3-methyadenine attenuates chloroform-induced hepatotoxicity via autophagy activation
Lei WANG, Xiankui LI, Cai CHEN
Biomedical Research.2018; 39(2): 87. CrossRef
Chloroform ingestion causing severe gastrointestinal injury, hepatotoxicity and dermatitis confirmed with plasma chloroform concentrations
Dushan Jayaweera, Shawkat Islam, Naren Gunja, Chris Cowie, James Broska, Latesh Poojara, Michael S. Roberts, Geoffrey K. Isbister
Clinical Toxicology.2017; 55(2): 147. CrossRef

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Case Report

A Case of Tracheal Adenoid Cystic Carcinoma in a Worker Exposed to Rubber Fumes: Dohyung Kim, Yang-In Hwang, Sungyeul Choi, Chulyong Park, Naroo Lee, Eun-A Kim; Ann Occup Environ Med 2013;25:22-22. Published online October 17, 2013; DOI: https://doi.org/10.1186/2052-4374-25-22

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Background

Primary tracheal tumors occur infrequently, accounting for less than 0.1% of all tumors. Adenoid cystic carcinoma (ACC) is the second most common type of malignancy of the trachea after squamous cell carcinoma (SCC). Little has been reported on the risk factors for tracheal ACC. The purpose of this study is to describe a case of tracheal ACC in a patient who had been exposed to rubber fumes, and to review the relationship between tracheal ACC and rubber fumes.

Case report

A 48-year-old man who had been experiencing aggravation of dyspnea for several months was diagnosed as having ACC of the trachea on the basis of a pathologic examination of a biopsy specimen obtained via laser microscopy-guided resection. The patient had been exposed to rubber fumes for 10 years at a tire manufacturing factory where he worked until ACC was diagnosed. His job involved preheating and changing rubber molds during the curing process.

Conclusion

ACC of both the trachea and the salivary glands show very similar patterns with regard to histopathology and epidemiology and are therefore assumed to have a common etiology. Rubber manufacturing is an occupational risk factor for the development of salivary gland tumors. Further, rubber fumes have been reported to be mutagenic. The exposure level to rubber fumes during the curing process at the patient’s workplace was estimated to be close to or higher than British Occupational Exposure Limits. Therefore, tracheal ACC in this case might have been influenced by occupational exposure to rubber fumes.

Citations

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Trakea Yerleşimli Adenoid Kistik Karsinom: Olgu Sunumu
Deniz KÜTRİ, Alaattin ÖZEN, Suzan ŞAYLISOY
Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi.2021; 8(3): 227. CrossRef
Candida Infection Associated with Salivary Gland—A Narrative Review
Soo-Min Ok, Donald Ho, Tyler Lynd, Yong-Woo Ahn, Hye-Min Ju, Sung-Hee Jeong, Kyounga Cheon
Journal of Clinical Medicine.2020; 10(1): 97. CrossRef
Polyomavirus JCPyV infrequently detectable in adenoid cystic carcinoma of the oral cavity and the airways
Hanna Hämetoja, Jaana Hagström, Caj Haglund, Leif Bäck, Antti Mäkitie, Stina Syrjänen
Virchows Archiv.2019; 475(5): 609. CrossRef
Adenoid Cystic Carcinoma of the Trachea
Santhosh Kumar N, Elizabeth Mathew Iype, Shaji Thomas, Uma V. Sankar
Indian Journal of Surgical Oncology.2016; 7(1): 62. CrossRef

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