Annals of Occupational and Environmental Medicine

Case Report

A case of chronic myeloid leukemia in a diagnostic radiographer: Chulyong Park, Sungyeul Choi, Dohyung Kim, Jaechan Park, Saerom Lee; Ann Occup Environ Med 2014;26:54. Published online November 28, 2014; DOI: https://doi.org/10.1186/s40557-014-0054-8

<bold>Background</bold>

Occupational radiation exposure causes certain types of cancer, specifically hematopoietic diseases like leukemia. In Korea, radiation exposure is monitored and recorded by law, and guidelines for compensation of radiation-related diseases were implemented in 2001. However, thus far, no occupation-related disease was approved for compensation under these guidelines. Here, we report the first case of radiation-related disease approved by the compensation committee of the Korea Workers’ Compensation and Welfare Service, based on the probability of causation.

<bold>Case presentation</bold>

A 45-year-old man complained of chronic fatigue and myalgia for several days. He was diagnosed with chronic myeloid leukemia. The patient was a diagnostic radiographer at a diagnostic radiation department and was exposed to ionizing radiation for 21 years before chronic myeloid leukemia was diagnosed. His job involved taking simple radiographs, computed tomography scans, and measuring bone marrow density.

<bold>Conclusion</bold>

To our knowledge, this is the first approved case report using quantitative assessment of radiation. More approved cases are expected based on objective radiation exposure data and the probability of causation. We need to find a resolution to the ongoing demands for appropriate compensation and improvements to the environment at radiation workplaces.

Citations

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Does occupational ionizing radiation exposure in healthcare workers affect their hematological parameters?
Nejdiye Güngördü, Seher Kurtul, Ayşenur Özdil, Mehmet Sarper Erdoğan
Archives of Environmental & Occupational Health.2023; 78(2): 80. CrossRef
Effects of exposure to low-dose ionizing radiation on changing platelets: a prospective cohort study
Ning Liu, Yang Peng, Xinguang Zhong, Zheng Ma, Suiping He, Ying Li, Wencui Zhang, Zijun Gong, Zhenjiang Yao
Environmental Health and Preventive Medicine.2021;[Epub] CrossRef

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Research Article

Subclinical interstitial lung damage in workers exposed to indium compounds: Sungyeul Choi, Yong-Lim Won, Dohyung Kim, Gwang-Yong Yi, Jai-Soung Park, Eun-A Kim; Ann Occup Environ Med 2013;25:24-24. Published online October 21, 2013; DOI: https://doi.org/10.1186/2052-4374-25-24

Abstract PDF PubReader ePub

Objectives

The present study was designed to determine whether there is a relationship between indium compound exposure and interstitial lung damage in workers employed at indium tin oxide manufacturing and reclaiming factories in Korea.

Methods

In 2012, we conducted a study for the prevention of indium induced lung damage in Korea and identified 78 workers who had serum indium or Krebs von den Lungen-6 (KL-6) levels that were higher than the reference values set in Japan (3 μg/L and 500 U/mL, respectively). Thirty-four of the 78 workers underwent chest high-resolution computed tomography (HRCT), and their data were used for statistical analysis.

Results

Geometric means (geometric standard deviations) for serum indium, KL-6, and surfactant protein D (SP-D) were 10.9 (6.65) μg/L, 859.0 (1.85) U/mL, and 179.27 (1.81) ng/mL, respectively. HRCT showed intralobular interstitial thickening in 9 workers. A dose–response trend was statistically significant for blood KL-6 levels. All workers who had indium levels ≥50 μg/L had KL-6 levels that exceeded the reference values. However, dose–response trends for blood SP-D levels, KL-6 levels, SP-D levels, and interstitial changes on the HRCT scans were not significantly different.

Conclusions

Our findings suggest that interstitial lung changes could be present in workers with indium exposure. Further studies are required and health risk information regarding indium exposure should be communicated to workers and employers in industries where indium compounds are used to prevent indium induced lung damage in Korea.

Citations

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Pulmonary effects of exposure to indium and its compounds: cross-sectional survey of exposed workers and experimental findings in rodents
Nan Liu, Yi Guan, Yan Yu, Gai Li, Ling Xue, Weikang Li, Xiaoyu Qu, Ning Li, Sanqiao Yao
Particle and Fibre Toxicology.2022;[Epub] CrossRef
Toxicokinetics and systematic responses of differently sized indium tin oxide (ITO) particles in mice via oropharyngeal aspiration exposure
Jing Qu, Jianli Wang, Haopeng Zhang, Jingying Wu, Xinmo Ma, Shile Wang, Yiteng Zang, Yuhui Huang, Ying Ma, Yuna Cao, Daming Wu, Ting Zhang
Environmental Pollution.2021; 290: 117993. CrossRef
Assessment of Occupational Exposure to Indium Dust for Indium-Tin-Oxide Manufacturing Workers
Boo Wook Kim, Wonseok Cha, Sungwon Choi, Jungah Shin, Byung-Soon Choi, Miyeon Kim
Biomolecules.2021; 11(3): 419. CrossRef
Biomonitorization of concentrations of 28 elements in serum and urine among workers exposed to indium compounds
Nan Liu, Yi Guan, Bin Li, Sanqiao Yao, Yi Hu
PLOS ONE.2021; 16(2): e0246943. CrossRef
The early onset and persistent worsening pulmonary alveolar proteinosis in rats by indium oxide nanoparticles
Sung-Hyun Kim, Soyeon Jeon, Dong-Keun Lee, Seonghan Lee, Jiyoung Jeong, Jong Sung Kim, Wan-Seob Cho
Nanotoxicology.2020; 14(4): 468. CrossRef
Effects of indium exposure on respiratory symptoms: a retrospective cohort study in Japanese workers using health checkup data
Toshiharu Mitsuhashi
PeerJ.2020; 8: e8413. CrossRef
Application of the ICRP respiratory tract model to estimate pulmonary retention of industrially sampled indium-containing dusts
Aleksandr B. Stefaniak, M. Abbas Virji, Melissa A. Badding, Kristin J. Cummings
Inhalation Toxicology.2017; 29(4): 169. CrossRef
Respirable indium exposures, plasma indium, and respiratory health among indium‐tin oxide (ITO) workers
Kristin J. Cummings, M. Abbas Virji, Ji Young Park, Marcia L. Stanton, Nicole T. Edwards, Bruce C. Trapnell, Brenna Carey, Aleksandr B. Stefaniak, Kathleen Kreiss
American Journal of Industrial Medicine.2016; 59(7): 522. CrossRef
Indium oxide (In2O3) nanoparticles induce progressive lung injury distinct from lung injuries by copper oxide (CuO) and nickel oxide (NiO) nanoparticles
Jiyoung Jeong, Jeongeun Kim, Seung Hyeok Seok, Wan-Seob Cho
Archives of Toxicology.2016; 90(4): 817. CrossRef
Interstitial lung disorders in the indium workers of Korea: An update study for the relationship with biological exposure indices
Sungyeul Choi, Yong Lim Won, Dohyung Kim, Mi‐Young Lee, Yoon jung Choi, Jai‐Soung Park, Hyoung‐Ryoul Kim, Jung Im Jung, Sang‐Gil Lee, Eun‐A Kim
American Journal of Industrial Medicine.2015; 58(1): 61. CrossRef
Tissue distribution of indium after repeated intratracheal instillations of indium‐tin oxide into the lungs of hamsters
Akiyo Tanaka, Miyuki Hirata, Nagisa Matsumura, Yutaka Kiyohara
Journal of Occupational Health.2015; 57(2): 189. CrossRef
Beryllium and other metal-induced lung disease
Annyce Mayer, Nabeel Hamzeh
Current Opinion in Pulmonary Medicine.2015; 21(2): 178. CrossRef
Investigating the potential exposure risk to indium compounds of target manufacturing workers through an analysis of biological specimens
Yong Lim Won, Yoon Jung Choi, Sungyeul Choi, Eun-A Kim
Journal of Korean Society of Occupational and Environmental Hygiene.2014; 24(3): 263. CrossRef
Early Changes in Clinical, Functional, and Laboratory Biomarkers in Workers at Risk of Indium Lung Disease
Kristin J. Cummings, M. Abbas Virji, Bruce C. Trapnell, Brenna Carey, Terrance Healey, Kathleen Kreiss
Annals of the American Thoracic Society.2014; 11(9): 1395. CrossRef

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Case Report

A Case of Tracheal Adenoid Cystic Carcinoma in a Worker Exposed to Rubber Fumes: Dohyung Kim, Yang-In Hwang, Sungyeul Choi, Chulyong Park, Naroo Lee, Eun-A Kim; Ann Occup Environ Med 2013;25:22-22. Published online October 17, 2013; DOI: https://doi.org/10.1186/2052-4374-25-22

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Background

Primary tracheal tumors occur infrequently, accounting for less than 0.1% of all tumors. Adenoid cystic carcinoma (ACC) is the second most common type of malignancy of the trachea after squamous cell carcinoma (SCC). Little has been reported on the risk factors for tracheal ACC. The purpose of this study is to describe a case of tracheal ACC in a patient who had been exposed to rubber fumes, and to review the relationship between tracheal ACC and rubber fumes.

Case report

A 48-year-old man who had been experiencing aggravation of dyspnea for several months was diagnosed as having ACC of the trachea on the basis of a pathologic examination of a biopsy specimen obtained via laser microscopy-guided resection. The patient had been exposed to rubber fumes for 10 years at a tire manufacturing factory where he worked until ACC was diagnosed. His job involved preheating and changing rubber molds during the curing process.

Conclusion

ACC of both the trachea and the salivary glands show very similar patterns with regard to histopathology and epidemiology and are therefore assumed to have a common etiology. Rubber manufacturing is an occupational risk factor for the development of salivary gland tumors. Further, rubber fumes have been reported to be mutagenic. The exposure level to rubber fumes during the curing process at the patient’s workplace was estimated to be close to or higher than British Occupational Exposure Limits. Therefore, tracheal ACC in this case might have been influenced by occupational exposure to rubber fumes.

Citations

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Trakea Yerleşimli Adenoid Kistik Karsinom: Olgu Sunumu
Deniz KÜTRİ, Alaattin ÖZEN, Suzan ŞAYLISOY
Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi.2021; 8(3): 227. CrossRef
Candida Infection Associated with Salivary Gland—A Narrative Review
Soo-Min Ok, Donald Ho, Tyler Lynd, Yong-Woo Ahn, Hye-Min Ju, Sung-Hee Jeong, Kyounga Cheon
Journal of Clinical Medicine.2020; 10(1): 97. CrossRef
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Virchows Archiv.2019; 475(5): 609. CrossRef
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Santhosh Kumar N, Elizabeth Mathew Iype, Shaji Thomas, Uma V. Sankar
Indian Journal of Surgical Oncology.2016; 7(1): 62. CrossRef

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