Annals of Occupational and Environmental Medicine

Original Article

Early Objectified Detection Method of Sensorineural Component in Hand Arm Vibration Syndrome: Jae Kuk Yoon, Hun Lee, Nari Choy, Suk Hwan Kim, Hyoung Ouk Park, Ji Ho Lee, Cheol In Yoo; Korean Journal of Occupational and Environmental Medicine 2009;21(2):143-153. Published online June 30, 2009; DOI: https://doi.org/10.35371/kjoem.2009.21.2.143

OBJECTIVES
In order to determine find out the best methods for a more objective detection of neurologic abnormality in early hand arm vibration syndrome(HAVS), early with analyzing the validity of each of the detection methods was analyzed. We evaluated the relationships between the sensorineural stage of Stockholm-revised vibration syndrome classification and the results of several tests.
METHODS
497 workers were investigated for symptom, exposure duration, the types of tools used, and medical history from January 2000 to December 2007. Pain sense threshold, vibrotactile threshold, hand grasp force, finger grasp force, and a finger tapping frequency test were performed by the workers.
RESULTS
The grinder(67.3%) was the most commonly used tool and the mean exposure duration was 14.8 years. Although the pain sense and vibrotactile threshold level tended to increase according to sensorineural stage of the Stockholm classification, there was statistically significant difference in the vibrotactile threshold of 125, 250 Hz (p=0.006~0.038) but not in the pain sense threshold. Hand and finger grasp force tended to decrease according to the sensorineural stage of Stockholm classification and there was statistically significant difference(p=0.041,<0.001, 0.034) only on the right hand side. The tapping frequency also generally decreased according to the sensorineural stage of the Stockholm classification and there was statistically significant difference (p=0.002~0.019) only on the left hand side.
CONCLUSIONS
Although there is no single standardized method that can objectively diagnose the sensorineural component of early HAVS early, the combination of subjective symptoms, the sensorineural stage of Stockholm classification, the pain and vibrotactile threshold test, the hand and finger grasp force, and the finger agility (tapping) test can objectively detect sensorineural component of HAVS early.

Citations

Citations to this article as recorded by

Application of cold intolerance symptom severity questionnaire among vibration-exposed workers as a screening tool for the early detection of hand-arm vibration syndrome: a cross-sectional study
A Ram Kim, Dae Yun Kim, Ji Soo Kim, Heun Lee, Joo Hyun Sung, Cheolin Yoo
Annals of Occupational and Environmental Medicine.2019;[Epub] CrossRef
Trend of Human Vibration Research in Korea
Hee-Sok Park
Journal of the Ergonomics Society of Korea.2013; 32(4): 293. CrossRef

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Original Article

Mitochondrial DNA A3243G mutation in noise-induced sensorineural hearing loss: Dong Hoon Shin, Won Ki Baek, In Sung Chung; Korean Journal of Occupational and Environmental Medicine 2000;12(3):319-326. Published online September 30, 2000; DOI: https://doi.org/10.35371/kjoem.2000.12.3.319

Abstract PDF: OBJECTIVES
A different sequence change, in the mitochondrial tRNA gene, has been proposed as a candidate mutation in the sensorineurnal hearing loss. The purpose of current study is to identify the association between the noise-induced sensorineurnal hearing loss and the A to G mutation at nucleotide 3243 of mitochondrial DNA.
METHODS
Subjects were established by history and chart review, and audiological and clinical data were obtained. Blood was sampled from 101 controls, 50 noise-induced hearing loss, and 12 sensorineural deafness. The DNA of these individuals was extracted, and mitochondrial genome was analyzed by polymerase chain reaction. Subsequently, the coding sequence of mitochondrial genome was sequenced, and compared to the normal sequence, and all sequence variations were analyzed by restriction endonuclease ApaI.
RESULTS
Mitochondrial DNA mutation (3243A->G) was not detected by polymerase chain reaction (PCR) in any patients with noise-induced hearing loss, sensorineural hearing loss, and normal control without hearing loss in Koreans. The DNA sequencing of PCR products did not revealed an A to G substitution at nucleotide 3243 of mitochondrial DNA.
CONCLUSIONS
The noise-induced sensorineural hearing loss was not associated with mitochondrial DNA mutation (3243A->G)

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