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Case Reports
Work-related olfactory disorder: a case series and review
Soon Woo Park, Young Joong Kang, Huisu Eom, Hyun-Jin Cho, Jungho Ahn, Sang-Gil Lee
Ann Occup Environ Med 2018;30:18.   Published online March 12, 2018
DOI: https://doi.org/10.1186/s40557-018-0230-3
AbstractAbstract PDFPubReaderePub
Background

The olfactory bulb is anatomically exposed and thus can be directly damaged by external stimulation. This can occur as an occupational injury owing to contact with organic solvents or other causes. We present cases of eight patients who sustained occupation-related exposure to potentially toxic substances and later presented with signs and symptoms of anosmia. We examined the occupational and medical characteristics of the patients and evaluated their work-relatedness.

Case presentation

Case 1: A 50-year-old man performed high-frequency heat treatments for approximately 11 years. He experienced decreased senses for olfaction and taste during the later years culminating in the diagnosis of anosmia after 3 years (high work-relatedness). Case 2: A 54-year-old man whose work involved exposure to various organic solvents, such as spray painting and application of paint and thinners for approximately 4 years, was subsequently diagnosed with anosmia based on rhinorrhea, headache, and loss of olfaction (high work-relatedness). Case 3: A 44-year-old-man who performed spray painting for approximately 17 years developed anosmia (high work-relatedness). Case 4: A 44-year-old man was involved in ship engine cleaning once a month, for approximately 7 h per cleaning session; he was diagnosed with anosmia based on loss of olfaction (low work-relatedness). Case 5: A 41-year-old man worked in ship building block construction for approximately 13 years; anosmia diagnosis was based on loss of olfaction (low work-relatedness). Case 6: A 47-year-old woman performed product inspection and labeling at a plant manufacturing automobile parts; anosmia diagnosis was based on decreased olfaction and taste (low work-relatedness). Case 7: A 50-year-old woman performed epoxy coating in a plant manufacturing automobile parts; anosmia diagnosis was based on diminishing olfaction (low work-relatedness). Case 8: A 57-year-old woman performed cleaning of the area where mobile phone parts were manufactured; anosmia diagnosis was based on diminishing olfaction (low work-relatedness).

Conclusion

The study results confirmed work-relatedness when the subject was young, and the duration of exposure was long without any other cause of anosmia. Regarding compensation for occupational diseases, work-relatedness can be recognized as a relative concept.


Citations

Citations to this article as recorded by  
  • Predictors of Olfactory Decline in Aging: A Longitudinal Population-Based Study
    Ingrid Ekström, Maria Larsson, Debora Rizzuto, Johan Fastbom, Lars Bäckman, Erika J Laukka, Anne B Newman
    The Journals of Gerontology: Series A.2020; 75(12): 2441.     CrossRef
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The work-relatedness at a case of acute lymphoblastic leukemia in a radiation oncologist
Bong Hyun Kim, Young-Jun Kwon, Young-Su Ju, Bong Kyu Kim, Hyun Seok Lee, Sang-gil Lee, Yun Kyung Chung
Ann Occup Environ Med 2017;29:28.   Published online June 27, 2017
DOI: https://doi.org/10.1186/s40557-017-0186-8
AbstractAbstract PDFPubReaderePub
Background

Clinicians who perform radiation therapy (RT) are exposed to radiation, which may negatively affect their health. The present study reports a case of acute lymphoblastic leukemia in a healthcare provider who was exposed to radiation at work; we also present a literature review of this topic.

Case presentation

A 45-year-old patient, who had been a radiation oncologist and had been exposed to radiation while performing brachytherapy 10 years ago, complained of chest pain and was suspected of having leukemia based on the results of a blood test in an outpatient clinic. He was diagnosed with acute lymphoblastic leukemia, and subsequently underwent chemotherapy. However, the case died during treatment. Through epidemiological investigation, it was found that the case’s cumulative exposure dose based on personal exposure and spatial dose measured during the work period was in the range of 6.08–12.15 mSv.

Conclusions

Based on the following considerations, acute lymphoblastic leukemia was highly correlated with the level of radiation to which the case was exposed while performing brachytherapy on patients with cancer. Firstly, the latent period of acute lymphoblastic leukemia in the case closely matched the latency time reported in previous published studies (5–10 years). In addition, numerous studies have reported significantly higher relative risks of cancer among clinicians who perform RT compared with the general population. The case was also atypically exposed to radiation through his hands, despite wearing protective equipment. Lastly, the case’s coworkers were also found to have been exposed to high levels of radiation. Investigation into the influence of radiation exposure through atypical routes during RT on the health of clinicians is recommended.


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Research Articles
Work-relatedness of lung cancer by smoking and histologic type in Korea
Young-Il Lee, Sang-Gil Lee, Dong-Mug Kang, Jong-Eun Kim, Young-Ki Kim, Jong-Han Leem, Hwan-Cheol Kim
Ann Occup Environ Med 2014;26:43.   Published online December 1, 2014
DOI: https://doi.org/10.1186/s40557-014-0043-y
AbstractAbstract PDFPubReaderePub
Objectives

This study investigated the distribution of causative agents related to occupational lung cancer, their relationships with work, and associations between work-relatedness and the histologic type of lung cancer.

Methods

We used data from the occupational surveillance system in Korea in 2013. In addition, data from 1,404 participants diagnosed with lung cancer were collected through interviews. We included the patients’ longest-held job in the analysis. Work-relatedness was categorized as “definite,” “probable,” “possible,” “suspicious,” “none,” or “undetermined.”

Results

Among the subjects, 69.3% were men and 30.7% were women. Regarding smoking status, current smokers were the most prevalent (35.5%), followed by non-smokers (32.3%), ex-smokers (32.2%). Regarding the causative agents of lung cancer, asbestos (1.0%) and crystalline silica (0.9%) were the most common in definite work-related cases, while non-arsenical insecticide (2.8%) was the most common in probable cases followed by diesel engine exhaust (1.9%) and asbestos (1.0%). Regarding histologic type, adenocarcinoma was the most common (41.7%), followed by squamous cell carcinoma (21.2%). Among current smokers, squamous cell carcinoma was the most common among definite and probable cases (13.4%), while non-small cell lung cancer was the least common (7.1%). Among non-smokers, squamous cell carcinoma was the most common (21.4%), while the least common was adenocarcinoma (1.6%).

Conclusions

Approximately, 9.5% of all lung cancer cases in Korea are occupational-related lung cancer. Well-known substances associated with lung cancer, such as crystalline silica, asbestos, and diesel engine exhaust, are of particular concern. However, the histologic types of lung cancer related to smoking were inconsistent with previous studies when work-relatedness was taken into account. Future studies are required to clarify the incidence of occupational lung cancer in agricultural workers exposed to non-arsenical insecticides and the associations between work-relatedness and the histologic type of lung cancer.


Citations

Citations to this article as recorded by  
  • KL-6 in Obstructive Sleep Apnea: A Potential Biomarker of Subclinical Lung Injury
    Sei Won Kim, Hwan Hee Kim, Heayon Lee, In Kyoung Kim, Sang Haak Lee, Hyeon Hui Kang
    Chronobiology in Medicine.2021; 3(2): 64.     CrossRef
  • Development of a Protein Biomarker Panel to Detect Non–Small-Cell Lung Cancer in Korea
    Young Ju Jung, Evaldas Katilius, Rachel M. Ostroff, Youndong Kim, Minkyoung Seok, Sujin Lee, Seongsoo Jang, Woo Sung Kim, Chang-Min Choi
    Clinical Lung Cancer.2017; 18(2): e99.     CrossRef
  • Smoking habits and nicotine dependence of North Korean male defectors
    Sei Won Kim, Jong Min Lee, Woo Ho Ban, Chan Kwon Park, Hyoung Kyu Yoon, Sang Haak Lee
    The Korean Journal of Internal Medicine.2016; 31(4): 685.     CrossRef
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Blood lead levels of Korean lead workers in 2003–2011
Ji-Hye Kim, Eun-A Kim, Dong-Hee Koh, Kiwhan Byun, Hyang-Woo Ryu, Sang-Gil Lee
Ann Occup Environ Med 2014;26:30-30.   Published online October 1, 2014
DOI: https://doi.org/10.1186/s40557-014-0030-3
AbstractAbstract PDFPubReaderePub
Objectives

This study aimed to document the trend in blood lead levels in Korean lead workers from 2003 until 2011 and blood lead levels within each of the main industries.

Methods

Nine years (2003–2011) of blood lead level data measured during a special health examination of Korean lead workers and collected by the Korea Occupational Safety and Health Agency were analyzed. Blood lead levels were determined by year, and a geometric mean (GM) was calculated for each industry division.

Results

The overall GM blood lead level for all years combined (n = 365,331) was 4.35 μg/dL. The GM blood lead level decreased from 5.89 μg/dL in 2003 to 3.53 μg/dL in 2011. The proportion of the results ≥30 μg/dL decreased from 4.3% in 2003 to 0.8% in 2011. In the “Manufacture of Electrical Equipment” division, the GM blood lead level was 7.80 μg/dL, which was the highest among the industry divisions. The GM blood lead levels were 7.35 μg/dL and 6.77 μg/dL in the “Manufacturers of Rubber and Plastic Products” and the “Manufacture of Basic Metal Products” division, respectively.

Conclusions

The blood lead levels in Korean lead workers decreased from 2003 to 2011 and were similar to those in the US and UK. Moreover, workers in industries conventionally considered to have a high risk of lead exposure also tended to have relatively high blood lead levels compared to those in other industries.


Citations

Citations to this article as recorded by  
  • Evaluation of Temporal Trends of Lead Exposure in Korean Workers Using Workplace Monitoring Data
    Dong-Hee Koh, Sangjun Choi, Ju-Hyun Park, Sang-Gil Lee, Hwan-Cheol Kim, Inah Kim, Jong-Uk Won, Dae Sung Lim, Hoekyeong Seo, Dong-Uk Park
    Journal of Korean Medical Science.2023;[Epub]     CrossRef
  • The lead burden of occupational lead-exposed workers in Guangzhou, China: 2006–2019
    Jiabin Liang, Jieyan Cai, Jiaming Guo, Jianping Mai, Liping Zhou, Jinwei Zhang, Yimin Liu, Zhi Wang
    Archives of Environmental & Occupational Health.2022; 77(5): 403.     CrossRef
  • Does Exposure of Lead and Cadmium Affect the Endometriosis?
    Min-Gi Kim, Young-Sun Min, Yeon-Soon Ahn
    International Journal of Environmental Research and Public Health.2021; 18(17): 9077.     CrossRef
  • Chronic Stress and Cardiovascular Disease among Individuals Exposed to Lead: A Pilot Study
    Emmanuel Obeng-Gyasi, Barnabas Obeng-Gyasi
    Diseases.2020; 8(1): 7.     CrossRef
  • Joint Toxicity of a Multi-Heavy Metal Mixture and Chemoprevention in Sprague Dawley Rats
    Yafei Wang, Yuqing Tang, Zhou Li, Qihang Hua, Li Wang, Xin Song, Baobo Zou, Min Ding, Jinshun Zhao, Chunlan Tang
    International Journal of Environmental Research and Public Health.2020; 17(4): 1451.     CrossRef
  • Collective exposure to lead from an approved natural product-derived drug in Korea
    Dae-Young Lim, Won-Yang Kang, Ji-Sung Ahn, Seunghyeon Cho, Suwhan Kim, Jai-Dong Moon, Byung-Chan Lee, Won-Ju Park
    Annals of Occupational and Environmental Medicine.2019;[Epub]     CrossRef
  • Estimation of Lead Exposure Prevalence in Korean Population through Combining Multiple Experts’ Judgment based on Objective Data Sources
    Dong-Hee Koh, Ju-Hyun Park, Sang-Gil Lee, Hwan-Cheol Kim, Sangjun Choi, Hyejung Jung, Jae-Oh Park, Dong-Uk Park
    Annals of Work Exposures and Health.2018; 62(2): 210.     CrossRef
  • Mean Blood Lead Level in Iranian Workers: A Systematic and Meta-Analysis
    Milad Azami, Zainab Tardeh, Akram Mansouri, Ali Soleymani, Kourosh Sayehmiri
    Iranian Red Crescent Medical Journal.2018;[Epub]     CrossRef
  • Lead Poisoning at an Indoor Firing Range
    Kyung Wook Kang, Won-Ju Park
    Journal of Korean Medical Science.2017; 32(10): 1713.     CrossRef
  • Occupational Lead Exposure from Indoor Firing Ranges in Korea
    Won-Ju Park, Suk-Ho Lee, Se-Ho Lee, Hye-Sik Yoon, Jai-Dong Moon
    Journal of Korean Medical Science.2016; 31(4): 497.     CrossRef
  • Blood Lead Levels and Cause-Specific Mortality of Inorganic Lead-Exposed Workers in South Korea
    Min-Gi Kim, Jae-Hong Ryoo, Se-Jin Chang, Chun-Bae Kim, Jong-Ku Park, Sang-Baek Koh, Yeon-Soon Ahn, Max Costa
    PLOS ONE.2015; 10(10): e0140360.     CrossRef
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Long Working Hours and Emotional Well-Being in Korean Manufacturing Industry Employees
Kyoung-Hye Lee, Jong-Eun Kim, Young-Ki Kim, Dong-Mug Kang, Myeong-Ja Yun, Shin-Goo Park, Jae-Seok Song, Sang-Gil Lee
Ann Occup Environ Med 2013;25:38-38.   Published online December 5, 2013
DOI: https://doi.org/10.1186/2052-4374-25-38
AbstractAbstract PDFPubReaderePub
Objectives

Korea is well known for its long work hours amongst employees. Because workers of the manufacturing industry are constantly exposed to extended work hours, this study was based on how long work hours affect their emotional well-being.

Methods

The analysis was done using the secondary Korean Working Condition Survey (KWCS). Long work hours were defined to be more than 48 hours, and they were subcategorized into units of 52 hours and 60 hours. Based on the WHO (five) well-being index, emotional state was subdivided into three groups - reference group, low-mood group, and possible depression group- where 28 points and 50 points were division points, and two groups were compared at a time. Association between long work hours and emotional state was analyzed using binary and multinomial logistic regression analysis.

Results

Working for extended working hours in the manufacturing industry showed a statistically significant increase (t test p < 0.001) in trend among the possible depression group when compared to the reference group and the low-mood group. When demographical characteristics, health behaviors, socioeconomic state, and work-related characteristics were fixed as controlled variables, as work hours increased the odds ratio of the possible depression group increased compared to the reference group, and especially the odds ratio was 2.73 times increased for work hours between 48–52 and 4.09 times increased for 60 hours or more and both were statistically significant. In comparing the low-mood group and possible depression group, as work hours increased the odds ratio increased to 1.73, 2.39, and 4.16 times, and all work hours from working 48–52 hours, 53–60 hours, and 60 hours or more were statistically significant. Multinomial logistic regression analysis also showed that among the reference group and possible group, the possible depression group was statistically significant as odds ratio increased to 2.94 times in working 53–60 hours, and 4.35 times in 60 hours or more.

Conclusions

Long work hours have an adverse effect on emotional well-being. A more diversified research towards variables that affect long work hours and emotional well-being and how they interact with each other and their relationship to overall health is imperative.


Citations

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  • The Influence of Workplace Violence, Psychosocial Working Conditions on Depressive Symptoms Among Female Workers in South Korea
    Jee-Seon Yi, Eun-Ok Im
    Asia Pacific Journal of Public Health.2024; 36(2-3): 232.     CrossRef
  • Working hours and life satisfaction: finding blind spots from Korean panel data
    Hayoung Lee
    International Review of Public Administration.2021; 26(1): 92.     CrossRef
  • Impacts of heavy smoking and alcohol consumption on workplace presenteeism
    So Young Lee, Jinhwa Lee, Min Kwon
    Medicine.2021; 100(47): e27751.     CrossRef
  • The Relationship between Sweet Taste Perception and Obesity of Workers in Some Industrial Area
    Sanghee Lee, Juhyung Lee, Seonhee Yang, Mi-Young Lee
    Keimyung Medical Journal.2020; 39(1): 43.     CrossRef
  • The negative impact of long working hours on mental health in young Korean workers
    Sungjin Park, Hyungdon Kook, Hongdeok Seok, Jae Hyoung Lee, Daeun Lim, Dong-Hyuk Cho, Suk-Kyu Oh, Sergio A. Useche
    PLOS ONE.2020; 15(8): e0236931.     CrossRef
  • Associations among working hours, sleep duration, self-rated health, and health-related quality of life in Korean men
    Darae Woo, Yeonjin Lee, Sangshin Park
    Health and Quality of Life Outcomes.2020;[Epub]     CrossRef
  • Association Between Presenteeism/Absenteeism and Well-being Among Korean Workers
    Wonjeong Jeong, Yun Kyung Kim, Sarah Soyeon Oh, Jin-Ha Yoon, Eun-Cheol Park
    Journal of Occupational & Environmental Medicine.2020; 62(8): 574.     CrossRef
  • The Effect of Yoga on Quality of Life in Women with Metabolic Syndrome: An Exploratory Pilot Study
    Ju-Youn An, Youngmi Eun, Ha-Na Kim, Sang-Wook Song, Yun-A Lee, Sung-Goo Kang
    Korean Journal of Clinical Geriatrics.2020; 21(1): 32.     CrossRef
  • Effect of Long Working Hours on Depression and Mental Well-Being among Employees in Shanghai: The Role of Having Leisure Hobbies
    Zan Li, Junming Dai, Ning Wu, Yingnan Jia, Junling Gao, Hua Fu
    International Journal of Environmental Research and Public Health.2019; 16(24): 4980.     CrossRef
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    Hye‐Jin Kim, Jin‐Young Min, Kyoung‐Bok Min
    American Journal of Industrial Medicine.2019; 62(9): 783.     CrossRef
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    Journal of Occupational Health.2019; 61(4): 288.     CrossRef
  • Working hours and depressive symptoms over 7 years: evidence from a Korean panel study
    Seoyeon Ahn
    International Archives of Occupational and Environmental Health.2018; 91(3): 273.     CrossRef
  • Associations between working environment and weight control efforts among workers with obesity in Korea
    Hye Sun Hyun, Yunyoung Kim
    Journal of International Medical Research.2018; 46(6): 2307.     CrossRef
  • Working hours and depressive symptoms: the role of job stress factors
    Yeogyeong Yoon, Jia Ryu, Hyunjoo Kim, Chung won Kang, Kyunghee Jung-Choi
    Annals of Occupational and Environmental Medicine.2018;[Epub]     CrossRef
  • Long working hours, job satisfaction, and depressive symptoms: a community-based cross-sectional study among Japanese employees in small- and medium-scale businesses
    Akinori Nakata
    Oncotarget.2017; 8(32): 53041.     CrossRef
  • Association between second-hand smoke and psychological well-being amongst non-smoking wageworkers in Republic of Korea
    Seong-Jin Kim, Dirga Kumar Lamichhane, Shin-Goo Park, Bum-Joon Lee, So-Hyun Moon, Sung-Min Park, Hyun-Suk Jang, Hwan-Cheol Kim
    Annals of Occupational and Environmental Medicine.2016;[Epub]     CrossRef
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    Nien-Chih Hu, Jong-Dar Chen, Tsun-Jen Cheng
    Journal of Occupational & Environmental Medicine.2016; 58(5): 514.     CrossRef
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    Woorim Kim, Eun-Cheol Park, Tae-Hoon Lee, Tae Hyun Kim
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    Bokim Lee
    Workplace Health & Safety.2016; 64(5): 187.     CrossRef
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