Annals of Occupational and Environmental Medicine

Original Article

Renal Dysfunction Indicators in Lead Exposed Workers: Sang Ju Lee, Young Seoub Hong, Sung Ryul Kim, Dong Il Kim, Joon Youn Kim, Kap Yeol Jung; Korean Journal of Occupational and Environmental Medicine 1996;8(2):340-349. Published online September 30, 1996; DOI: https://doi.org/10.35371/kjoem.1996.8.2.340

Abstract PDF: A range of indicators is available to assess renal dysfunction in lead exposure. This study was undertaken to find out which indicators were most valuable as markers of renal dysfunction. We selected 75 male workers from the secondary lead smelter, plastic stabilizer and radiator manufacturing industries (the "exposed" group) and 64 male office workers (the "control" group). Blood lead; blood zinc protoporphyrin; urine lead; urine coproporphyrin; delta-aminolevulinic acid dehydratase activity; and urine delta-aminolevulinic acid were chosen as indicators of lead exposure. Blood urea nitrogen; serum creatinine; serum uric acid; urine N-acetyl-beta-D-glucosaminidase; urine albumin; urine alpha1-microglobu-lin; and urine beta2-microglobulin were used as indicators of renal dysfunction. Urine alpha1-microglobulin level was significantly associated with, the lead exposure level. Blood urea nitrogen, urine N-acetyl-beta-D-glucosaminidase and urine alpha1-microglobulin levels were highly correlated with indicators of lead exposure. Urine alpha1-microglobulin had the highest correlation with other indicators of renal function. In addition, the proportion of subjects with high urine alpha1-microglobulin levels showed a gradient with lead exposure. Conclusively, Blood urea nitrogen, urine N-acetyl-beta-D-glucosaminidase and urine alpha1-microglobulin are useful indicators, but urine alpha1-microglobulin is ; the early 'and the most valuable indicator of renal dysfunction related to lead exposure.

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Original Article

Assessment of Cadmium in Blood and Urine of Occupationally Exposed Workers and Renal Dysfunction by Cumulative Exposure Estimate: Seong Kyu Kang, Jeong Sun Yang, Ki Woong Kim, Jae Yeon Jang, Ho Keum Chung; Korean Journal of Occupational and Environmental Medicine 1995;7(1):101-110. Published online February 28, 1995; DOI: https://doi.org/10.35371/kjoem.1995.7.1.101

88 workers exposed to cadmium were examined at the 12 factories using or producing cadmium in order to know the present state of cadmium exposure and renal dysfunction in 1992. Cadmium in blood and in urine were measured and compared by the 3 exposure level of cadmium in air. Cadmium in blood of low, moderate and high exposure group were 2.5, 3,8 and 7.6 microgram/L, respectively. Cadmium in urine were 1.8(1.3), 3.8(2,6) and 7.9 microgram/L(6.1 microgram/g creatinine) , resrectively. However, there was no relationship between Urinary cadmium and beta(2)-microglobulin. Cumulative exposure estimate (CEE) was calculated by multiplying the mean ambient cadmium level of the factory and working duration. CEE has a high correlation with cadmium in blood and urine, but no relation to beta(2)-microglobulin. Because working durations were relatively shorter than European workers', the highest CEE was just 300 microgram. year/m(3), which was not enough to induce renal tubular dysfunction. This study, however, suggested the possibility that renal tubular dysfunction caused by cadmium could be happened in Korea in the near future.

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Chronic Cadmium Intoxication and Renal Injury Among Workers of a Small-scale Silver Soldering Company
Won-Jun Choi, Seong-Kyu Kang, Seunghon Ham, Wookyung Chung, Ae Jin Kim, Myunghee Kang
Safety and Health at Work.2020; 11(2): 235. CrossRef

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