Annals of Occupational and Environmental Medicine

Research Article

Review of carcinogenicity of hexavalent chrome and proposal of revising approval standards for an occupational cancers in Korea: Jungwon Kim, Sangyun Seo, Yangho Kim, Dae Hwan Kim; Ann Occup Environ Med 2018;30:7. Published online January 31, 2018; DOI: https://doi.org/10.1186/s40557-018-0215-2

Background

The objective of this study is to suggest revised recognition standards for occupational disease due to chromium (VI) by reflecting recent domestic and international research works and considering domestic exposure status with respect to target organs, exposure period, and cumulative exposure dose in relation to the chromium (VI)-induced occupational disease compensation.

Methods

In this study, the reports published by major international institutions such as World Health Organization (WHO) International Agency for Research on Cancer (IARC) (2012), Occupational Safety and Health Administration (OSHA) (2006), National Institute for Occupational Safety and Health (NIOSH) (2013), American Conference of Governmental Industrial Hygienists (ACGIH) (2004), National Toxicology Program (NTP) (2014), and Agency for Toxic Substances and Disease Registry (ASTDR) (2012) were reviewed and the recent research works searched by PubMed were summarized.

Results

Considering the recent research works and the domestic situation, only lung cancer is conserved in the legislative bill in relation to chromium (VI), and the exposure period is not included in the bill. Nasal and paranasal sinus cancer was excluded from the list of cancers that are compensated as the chromium (VI)- induced occupational disease, while lung cancer remains in the list. In the view of legislative unity, considering the fact that only the cancers having sufficient evidence are included in the conventional list of cancers compensated as occupational disease, nasal and paranasal sinus cancer having limited evidence were excluded from the list.

The exposure period was also removed from the legislative bill due to the insufficient evidence. Recent advices in connection with cumulative exposure dose were proposed, and other considerable points were provided with respect to individual occupational relevance.

Conclusions

It is suggested that the current recognition standard which is “Lung cancer or nasal and paranasal sinus cancer caused by exposure to chromium (VI) or compounds thereof (exposure for two years or longer), or nickel compounds” should be changed to “Lung cancer caused by exposure to chromium (VI) or compounds thereof, and lung cancer or nasal and paranasal sinus cancer caused by exposure to nickel compounds”.

Citations

Citations to this article as recorded by

Echinacea purpurea root extract mitigates hepatotoxicity, genotoxicity, and ultrastructural changes induced by hexavalent chromium via oxidative stress suppression
Fatma M. El-Demerdash, Mustafa M. Karhib, Nora F. Ghanem, Mohamed M. Abdel-Daim, Raghda A. El-Sayed
Environmental Science and Pollution Research.2024; 31(18): 26760. CrossRef
Esophageal and Head and Neck Cancer Patients Attending Ocean Road Cancer Institute in Tanzania from 2019 to 2021: An Observational Study
Luco P. Mwelange, Simon H. D. Mamuya, Julius Mwaiselage, Magne Bråtveit, Bente E. Moen
International Journal of Environmental Research and Public Health.2023; 20(4): 3305. CrossRef
Ecological risk assessment of metal and hydrocarbon pollution in sediments from an urban tropical estuary: Tijuca lagoon (Rio de Janeiro, Brazil)
Matheus Teixeira, Ricardo Cesar, Denis Abessa, Celeste Siqueira, Rodrigo Lourenço, Mariana Vezzone, Yan Fernandes, Gustavo Koifman, Fernando Cesar Perina, Roberto Meigikos dos Anjos, Helena Polivanov, Zuleica Castilhos
Environmental Science and Pollution Research.2023; 30(1): 184. CrossRef
A Comparative Research on Corrosion Behavior of Electroplated and Magnetron Sputtered Chromium Coatings
Stefano Mauro Martinuzzi, Lorenzo Donati, Walter Giurlani, Federico Pizzetti, Emanuele Galvanetto, Nicola Calisi, Massimo Innocenti, Stefano Caporali
Coatings.2022; 12(2): 257. CrossRef
On the Determination of Cr(VI) in Cr(III)-Rich Particulates: From the Failure of Official Methods to the Development of an Alternative Protocol
Andrea Spinazzè, Davide Spanu, Pietro Della Bella, Cristina Corti, Francesca Borghi, Giacomo Fanti, Andrea Cattaneo, William Robert Wise, Stefan John Davis, Domenico Maria Cavallo, Sandro Recchia
International Journal of Environmental Research and Public Health.2022; 19(19): 12111. CrossRef
Hexavalent chromium: Regulation and health effects
Carla Cedillo Alvarez, María Elena Bravo Gómez, Araceli Hernández Zavala
Journal of Trace Elements in Medicine and Biology.2021; 65: 126729. CrossRef
Hepatoprotective potential of Rosmarinus officinalis essential oil against hexavalent chromium-induced hematotoxicity, biochemical, histological, and immunohistochemical changes in male rats
Fatma M. El-Demerdash, Raghda A. El-Sayed, Mohamed M. Abdel-Daim
Environmental Science and Pollution Research.2021; 28(14): 17445. CrossRef
PM2.5-bound heavy metals from the major cities in China: Spatiotemporal distribution, fuzzy exposure assessment and health risk management
Fei Li, Jingjing Yan, Yongchang Wei, Jingjing Zeng, Xiaoying Wang, Xiyao Chen, Chuanrong Zhang, Weidong Li, Min Chen, Guonian Lü
Journal of Cleaner Production.2021; 286: 124967. CrossRef
Biomonitoring of Trace Elements in Subjects Living Near a Hazardous Waste Incinerator: Concentrations in Autopsy Tissues
Francisco García, Montse Marquès, Eneko Barbería, Pilar Torralba, Inés Landin, Carlos Laguna, José L. Domingo, Martí Nadal
Toxics.2020; 8(1): 11. CrossRef
Protective Effect of Curcuma Against Chromium Hepatotoxicity in Rats
M. Saidi, O. Aouacheri, S. Saka
Phytothérapie.2020; 18(3-4): 148. CrossRef
The Effect of Hexavalent Chromium on the Incidence and Mortality of Human Cancers: A Meta-Analysis Based on Published Epidemiological Cohort Studies
Yujiao Deng, Meng Wang, Tian Tian, Shuai Lin, Peng Xu, Linghui Zhou, Cong Dai, Qian Hao, Ying Wu, Zhen Zhai, Yue Zhu, Guihua Zhuang, Zhijun Dai
Frontiers in Oncology.2019;[Epub] CrossRef
Chromium Monitoring in Water by Colorimetry Using Optimised 1,5-Diphenylcarbazide Method
Annija Lace, David Ryan, Mark Bowkett, John Cleary
International Journal of Environmental Research and Public Health.2019; 16(10): 1803. CrossRef

66 View
0 Download
13 Web of Science
12 Crossref

Review

Systematic Review of the Effects of Asbestos Exposure on the Risk of Cancer between Children and Adults: Dongmug Kang, Min-Seung Myung, Young-Ki Kim, Jong-Eun Kim; Ann Occup Environ Med 2013;25:10-10. Published online July 8, 2013; DOI: https://doi.org/10.1186/2052-4374-25-10

Abstract PDF PubReader ePub

Children are considerably more susceptible to enviro006Emental hazards than adults. This study was conducted to investigate whether the first asbestos exposure in childhood increases the risk of asbestos-related cancer including mesothelioma and lung cancer. MEDLINE (PubMed), Embase, and Google Scholar were searched to find relevant studies published up to July 2012. Six studies reported the relationship between age, including age during childhood, at the first asbestos exposure and mesothelioma. Among them, 4 indicated that people exposed to asbestos in childhood have a higher risk of mesothelioma than those exposed in adulthood. Meanwhile, the other 2 studies showed that asbestos exposure later in life increases the risk of mesothelioma. The results of the 2 studies including non-occupational early childhood exposure report conflicting results. There were 3 studies regarding the relationship between age at first asbestos exposure and lung cancer. However, none of them reported an association between age at first asbestos exposure and the risk of lung cancer. All studies have limitations including small numbers of subjects, the validity of the standardized mortality ratio, and different age categories at first asbestos exposure. There are only a few studies on the harmful effects of asbestos in children in the literature. Therefore, the effect of asbestos exposure during childhood remains unclear and requires further study.

Citations

Citations to this article as recorded by

Characterisation of asbestos-containing wastes by thermal analysis
Robert Kusiorowski, Anna Gerle, Magdalena Kujawa, Andrzej Śliwa, Jakub Adamek
Journal of Thermal Analysis and Calorimetry.2024;[Epub] CrossRef
Problem of asbestos-containing wastes in Poland
Robert Kusiorowski, Barbara Lipowska, Magdalena Kujawa, Anna Gerle
Cleaner Waste Systems.2023; 4: 100085. CrossRef
Cancer Incidence and Risk of Multiple Cancers after Environmental Asbestos Exposure in Childhood—A Long-Term Register-Based Cohort Study
Sofie Bünemann Dalsgaard, Else Toft Würtz, Johnni Hansen, Oluf Dimitri Røe, Øyvind Omland
International Journal of Environmental Research and Public Health.2021; 19(1): 268. CrossRef
Risk assessment of asbestos containing materials in a deteriorated dwelling area using four different methods
Yuan-Long Zhang, Hwi-Seok Byeon, Won-Hwa Hong, Gi-Wook Cha, Yoon-Ha Lee, Young-Chan Kim
Journal of Hazardous Materials.2021; 410: 124645. CrossRef
Measurement of asbestos emissions associated with demolition of abandoned residential dwellings
Richard L. Neitzel, Stephanie K. Sayler, Avery H. Demond, Hannah d'Arcy, David H. Garabrant, Alfred Franzblau
Science of The Total Environment.2020; 722: 137891. CrossRef
Environmental asbestos exposure in childhood and risk of mesothelioma later in life: a long-term follow-up register-based cohort study
Sofie Bünemann Dalsgaard, Else Toft Würtz, Johnni Hansen, Oluf Dimitri Røe, Øyvind Omland
Occupational and Environmental Medicine.2019; 76(6): 407. CrossRef
Are children more vulnerable to mesothelioma than adults? A comparison of mesothelioma risk among children and adults exposed non-occupationally to blue asbestos at Wittenoom
Alison Reid, Peter Franklin, Geoffrey Berry, Susan Peters, Nita Sodhi-Berry, Fraser Brims, Arthur William Musk, Nicholas H de Klerk
Occupational and Environmental Medicine.2018; 75(12): 898. CrossRef
Time-dependent effect of intensity of smoking and of occupational exposure to asbestos on the risk of lung cancer: results from the ICARE case–control study
Emilie Lévêque, Aude Lacourt, Danièle Luce, Marie-Pierre Sylvestre, Pascal Guénel, Isabelle Stücker, Karen Leffondré
Occupational and Environmental Medicine.2018; 75(8): 586. CrossRef
Environmental health centers for asbestos and their health impact surveys and activities
Dong-Mug Kang, Jong-Eun Kim, Yong-Jin Lee, Hyun-Hee Lee, Chang-yeol Lee, Seong-Jae Moon, Min-Sung Kang
Annals of Occupational and Environmental Medicine.2016;[Epub] CrossRef
Environmental asbestos exposure sources in Korea
Dong-Mug Kang, Jong-Eun Kim, Ju-Young Kim, Hyun-Hee Lee, Young-Sik Hwang, Young-Ki Kim, Yong-Jin Lee
International Journal of Occupational and Environmental Health.2016; 22(4): 307. CrossRef
Risk assessment of gastric cancer associated with asbestosis: a case report
Soo-Hong Park, Dong-Mug Kang, Bon-Hak Koo, Young-Ki Kim, Jong-Eun Kim
Annals of Occupational and Environmental Medicine.2015;[Epub] CrossRef
Biological effects of argentine asbestos: mineralogical and morphological characterisation
Leticia Lescano, Norberto A. Gandini, Silvina A. Marfil, Pedro J. Maiza
Environmental Earth Sciences.2015; 73(7): 3433. CrossRef

77 View
0 Download
14 Web of Science
12 Crossref

Original Article

A Study of the Results of Sputum Cytology as a Special Health Examination: Jun Hoo Lee, Chang Ho Chae, Young Wook Kim, Jun Seok Son, Ja Hyeon Kim, Seung Hyun Park, Ho Seong Cho; Korean Journal of Occupational and Environmental Medicine 2011;23(2):122-129. Published online June 30, 2011; DOI: https://doi.org/10.35371/kjoem.2011.23.2.122

Abstract PDF: OBJECTIVES
This study aims investigate the results of sputum cytology, which began its test period from 2009 as a special health examination for individuals whose lungs have been exposed to carcinogens.
METHODS
22,215 cases of sputum results were classified into six categories through Papanicolau classification. The sputum results were analyzed according to age, exposure degree to welding fumes and smoking status. Chi-square tests and logistic regression analysis were used to compare and analyze the associations between sputum results and smoking status, exposure degree and age classifications.
RESULTS
The number of class I cases was 20,784 with a frequency of (93.6%), class II had 1,076 cases (4.8%), class III had 69 cases (0.3%), and the inadequate class had 286 cases (1.3%) and there were no cases in class VI and V. Patients in class III received CT scans of their chest for further evaluation, but no cancer patients were found from that. There were 2.48 times (95% CI 1.12~5.53) more smokers than non-smokers in class III and 1.70 times (95% CI 1.43~2.02) more in class II. The number of ex-smokers was 2.46 times (95% CI 1.01~5.99) larger than the number of non-smokers in class III and 1.28 times (95% CI 1.03~1.60) larger than the number of non-smokers in class II. There were 1.54 times (95% CI 1.28~1.85) more patients from the mid-exposure group than the low exposure group in class II. There were 1.62 times (95% CI 1.31~1.99) more patients from the high-exposure group than the low-exposure group in class II.
CONCLUSIONS
As a screening test for lung cancer, the usefulness of sputum cytology is limited. However, the precancerous cells (class II, class III) varied according to welding fume exposure degree and smoking status.

22 View
0 Download

Case Report

Lung Cancer Occurring in a Worker Exposed to Coke Oven Emissions: Hyun Sul Lim, Jung Keun Choi, Eun Hye Kwon, Heon Kim; Korean Journal of Occupational and Environmental Medicine 2002;14(1):97-106. Published online March 31, 2002; DOI: https://doi.org/10.35371/kjoem.2002.14.1.97

Abstract PDF

OBJECTIVES
We report a case of lung cancer (small cell carcinoma) occurring in a worker exposed to coke oven emissions.
METHODS
We examined the chest CT and pathologic findings of the patient. We reviewed previous environmental measurements for coke oven emissions at the workers place of employment. Also we measured the airborne concentrations for coke oven emissions and total polycyclic aromatic hydrocarbons in the work area. Finally, we analyzed the 1-hydroxypyrene and 2-naphthol concentrations in the subjects urine and compared this with student controls.
RESULTS
This case was a 56-year-old male who had worked in a coke oven plant within a steel manufacturing factory for 21 years (1977-1998). The airborne concentrations of coke oven emissions at the worksite were above the permissible exposure level (0.2 mg/m3) in 45 cases (33.1%) among 136 workers. The concentrations of 1-hydroxypyrene and 2-naphthol in the subjects urine were statistically significantly elevated as compared with those of controls (P<0.01).
CONCLUSIONS
We confirmed that the lung cancer occurring in this patient was as an occupational disease due to exposure to coke oven emissions. To prevent occupational cancer in coke oven plant workers, we must remodel the engineering procedure, begin comprehensive medical surveillance, educate workers on risks and the benefits of smoking cessation, and increase awareness of safety regulations in the workplace.

Citations

Citations to this article as recorded by

Occupational Cancers with Chemical Exposure and their Prevention in Korea: A Literature Review
Kyung-Taek Rim
Asian Pacific Journal of Cancer Prevention.2013; 14(6): 3379. CrossRef
Occupational Respiratory Cancer in Korea
Hye-Eun Lee, Hyoung Ryoul Kim
Journal of Korean Medical Science.2010; 25(Suppl): S94. CrossRef

32 View
1 Download
2 Crossref

First
Prev
Page of 1
Next
Last

Search