Annals of Occupational and Environmental Medicine

Original Article

Expression of IL-6 mRNA by Human Lung Fibroblast Cell Line Treated with Cadmium: Dong Hoon Shin; Korean Journal of Occupational and Environmental Medicine 1996;8(1):34-42. Published online February 29, 1996; DOI: https://doi.org/10.35371/kjoem.1996.8.1.34

Cadmium is a highly toxic element responsible for acute and chronic toxicity in man and induces pathophysiological effects by modulating components of immune system, Cytokines are being increasingly recognized as essential mediators of normal and pathologic immune response. The present study has been investigated the effect of cadmium cyto toxicity for lung fibroblast and expression of cytokine gene in unstimulated and cadmiurn-treated lung fibroblast using reverse transcription-polymerase chain reaction showed that cadmium inhibited the cell proliferation and expression of IL-6, TGF-b-mRNA in both unstimulated and cadmium-treated cell. The expression of IL-6 mRNA increased at 0.8mM and l.OmM cadmium treated for 2 hours and more increased a 0. ImM cadmium treated for 24 hours than for 2 hours. This results suggest that cadmium stimulates expression of D-i-6 mRNA in lung fibroblast.

Citations

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Predicting Respiratory Toxicity Using a Human 3D Airway (EpiAirway™) Model Combined with Multiple Parametric Analysis
Jamin A. Willoughby
Applied In Vitro Toxicology.2015; 1(1): 55. CrossRef

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Original Article

Expression of Interleukin-6 in Radiation Induced Lung Damage: Sung Sook Kirn, Eun Hee Ha, Duck Ja Han; Korean Journal of Occupational and Environmental Medicine 1996;8(1):119-126. Published online February 29, 1996; DOI: https://doi.org/10.35371/kjoem.1996.8.1.119

Abstract PDF: Ionizing radiation has proved to be most valuable in clinical diagnosis and radiotherapy. And also it is used very common in industries especially such as industrial radiography, atomic energy plant, inspectoring by gamma-ray, etc. However, inadvertent exposure to relatively high doses of ionizing radiation is capable of injuring and killing cells. The lungs, because of their rich vascularization, are vulnerable to radiation injury. It is now known that IL-6 is a pleiotrophic cytokine produced by various cells that regulates the immune reponses, acute phage reactions. We performed the immunohistochemical staining of IL-6 on radiation induced lung injury by duration, to clarify the role of IL-6 in tissue damage. IL-6 was strongly expressed in early phase of radiation from alveolar macrophages and damaged endothelial cells. These findings not only have important implications for increasing our understanding of mechanisms of radiation lung injury but they also have an impact on strategies for diagnosis and therapy of radiation damage.

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