Annals of Occupational and Environmental Medicine

Research Article

Relationship between urinary phthalate metabolites and diabetes: Korean National Environmental Health Survey (KoNEHS) cycle 3 (2015–2017): Do Jin Nam, Yeji Kim, Eun Hye Yang, Hyo Choon Lee, Jae-Hong Ryoo; Ann Occup Environ Med 2020;32:e34. Published online September 18, 2020; DOI: https://doi.org/10.35371/aoem.2020.32.e34

Background

We aimed to determine relationship diabetes according to urinary phthalate metabolites using adult data from Korean National Environmental Health Survey cycle 3 (2015–2017).

Method

This study was conducted on 3,781 adults aged 19 years and older (1,648 men and 2,133 women) based on KoNEHS cycle 3. Participants' data were analyzed by gender; Relationship between phthalate metabolites in the urine and diabetes was analyzed by dividing the sociodemographic variables, health behavior-related variables, and urinary phthalate metabolite concentrations into quartiles. To determine the relationship between urinary phthalate metabolites and the prevalence of diabetes, the odds ratio (OR) was calculated using logistic regression analysis.

Results

Based on the 1st quartile of each metabolite, the ORs for di-2-ethylhexyl phthalate (DEHP) (4th quartile), mono-(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) (2nd quartile, 3rd quartile and 4th quartile), mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) (4th quartile), mono-(2-ethyl-5-carboxypentyl) phthalate (MECCP) (4th quartile), mono-n-butyl phthalate (MnBP) (3rd quartile and 4th quartile), mono-benzyl phthalate (MBzP) (2nd quartile) and 4th quartile), and mono (3-carboxypropyl) phthalate (MCPP) (3rd quartile and 4th quartile) were significantly higher after the adjustment in men. The ORs for DEHP (2nd quartile, 3rd quartile and 4th quartile), MEHHP (2nd quartile, 3rd quartile and 4th quartile), MEOHP (4th quartile), MECCP (4th quartile), MBzP (4th quartile), and MCPP (4th quartile) were significantly higher after the adjustment in women.

Conclusion

This study investigated relationship between urinary phthalate metabolites and diabetes. The higher urinary phthalate metabolites, the higher the prevalence of diabetes. Further regulation of phthalate may be needed, and further studies are warranted to confirm the association between phthalate concentration and other chronic diseases (such as hypertension, hyperlipidemia, and cardiovascular disease).

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Original Article

Environmental Monitoring of Occupational Exposure to Solvent Mixtures by Simultaneous Determination Using Gaschromatography: J T Lee, D W Moon, H Lee, M S Kwak, D W Kim, K T Pai, C U Lee; Korean Journal of Occupational and Environmental Medicine 1995;7(2):375-389. Published online October 31, 1995; DOI: https://doi.org/10.35371/kjoem.1995.7.2.375

Abstract PDF

Environmental monitoring by measuring the air, concentration of solvent mixtures should be the most useful method in the exposure assessment. But the solvent mixtures in air can be difficult to measure. In order to improve the method for air measurements of solvents, the author developed a simultaneous determination method for mixtures of 23 solvents using gaschromatography. And also for the purpose of assessing occupational exposure to solvent mixtures, the author applied this method to measure the air concentrations of solvent mixtures in industrial setting. The best condition of this method was 35degrees C-150degrees C for column temperature, 250degrees C for detector and injector temperature with capillary OV-1 column at 0.2 kg/cm2 if inlet pressure. And The recovery rates were 90% and over for 16 organic solvents including toluene and 70% and less for 4 organic solvents including ethanol. In raw materials (adhesives, diluents) of 3 industrial settings (paint manufacturing industry, chemical products industry & fishing products industry), the major components was aromatic hydrocarbons (toluene, o-, m-, p-xylene), and the number of detected items among 23 solvents were 4-16. The C(n)/N(n)-value (2.02) at one unit of adhesives developing department in chemical products industry exceeded permissible exposure limit (1), and C(n)/N(n)-values demonstrated a remarkable range (C(n)/N(n)-values were 0.04-2.02 for charcoal tube and 0.02-0.68 for passive sampler).

Citations

Citations to this article as recorded by

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Jun-Pyo Myong, Younmo Cho, Min Choi, Hyoung-Ryoul Kim
Annals of Occupational and Environmental Medicine.2018;[Epub] CrossRef

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