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Case Report
Severe chemical burns related to dermal exposure to herbicide containing glyphosate and glufosinate with surfactant in Korea
Jihyun Shin, Namkyu Lim, Sangchul Roh
Ann Occup Environ Med 2020;32:e28.   Published online July 20, 2020
DOI: https://doi.org/10.35371/aoem.2020.32.e28
AbstractAbstract PDFPubReaderePub
Background

Glyphosate and glufosinate use widely used as herbicide ingredients. There have been several reported cases of chemical burns caused by dermal exposure to glyphosate-containing herbicide, and patients in these cases were discharged without fatal complications. There were no cases of severe symptoms due to non-oral exposure of glufosinate-containing herbicides. Here, we report a case of fatality accompanied with severe chemical burns in an 81-year-old man who did not wash his skin for more than 48 hours after dermal exposure to herbicide containing glyphosate and glufosinate with surfactant (HGlyGluS).

Case presentation

An 81-year-old male with no underlying disease was admitted to the emergency department (ED). He had sprayed HGlyGluS with a manual knapsack sprayer 3 days ago and had not wash away the herbicide. On arrival, he was drowsy and had multiple severe corrosive skin lesions. Skin necrosis (10 × 15 cm) on the right shoulder and skin lesions with subcutaneous fat exposure (15 × 20 cm) on the right thigh were observed. Although he was treated including continuous renal replacement therapy, antibiotic apply, debridement operations, and so on, he was unable to recover and expired.

Conclusions

We suggest that prolonged dermal exposure to HGlyGluS induces fatality. Further studies including prolonged dermal exposure and ingredients of surfactants should be carried out. Also, it is necessary to educate farmers that it is very important to wash immediately after dermal exposure to pesticide.


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  • Prospective applications of chitosan and chitosan-based nanoparticles formulations in sustainable agricultural practices
    Bhoomika M. Karamchandani, Sunil G. Dalvi, Mahima Bagayatkar, Ibrahim M. Banat, Surekha K. Satpute
    Biocatalysis and Agricultural Biotechnology.2024; 58: 103210.     CrossRef
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Case Report
Hydrofluoric Acid Burns: A Case Report
Jieun Lee, Byung Seong Suh, Chanho Jo, Won Cheol Lee
Korean Journal of Occupational and Environmental Medicine 2011;23(2):225-233.   Published online June 30, 2011
DOI: https://doi.org/10.35371/kjoem.2011.23.2.225
AbstractAbstract PDF
BACKGROUND
Hydrofluoric acid_(HF) is widely used in many industrial and domestic settings such as etching glass, and polishing metals. HF is one of the most corrosive inorganic acids and can produce progressive and serious tissue necrosis with severe pain. Since HF chemical burns can be asymptomatic for the first few hours, it is crucial to understand its toxicity and the early use of antidote.
CASE
A 37-year-old man presented with erythematous lesion and pain on his face, anterior neck, both forearms, both thighs, and left ankle after injury resulting from a chemical burn caused by HF. He showed normal vital signs and dyspnea, but complained of a sore throat. Liquid form of HF had splashed on his face and anterior neck first and run down his forearms and thighs while working at HF supply tanks. Some of the HF was splashed into his mouth. He immediately removed his clothes and showered with abundant water. A 4.5% calcium gluconate jel was applied to the involved area. He was given subcutaneous injection of 10% calcium gluconate solution. During 17 days of admission he didn't show any signs of systemic intoxication or deep tissue defects.
CONCLUSIONS
Immediate cleansing of the affected area with running cold water is the first critical treatment for a chemical burn due to HF. Applying calcium gluconate gel within one hour was very effective for preventing further damage to the injured area as well as systemic injury. In order to reduce the risk of accident and perform first-aid treatment quickly, it is imperative to provide workers with safety education and establish safety facilities.

Citations

Citations to this article as recorded by  
  • Analysis of Trend of Studies on Microneedle Treatment System (MTS)
    Hea-Sun Chun, Ho-Seub Song
    Journal of Pharmacopuncture.2021; 24(4): 182.     CrossRef
  • Dermal absorption and skin damage following hydrofluoric acid exposure in an ex vivo human skin model
    Kathrin Dennerlein, Franklin Kiesewetter, Sonja Kilo, Thomas Jäger, Thomas Göen, Gintautas Korinth, Hans Drexler
    Toxicology Letters.2016; 248: 25.     CrossRef
  • Characteristics of composition and surface morphology of soil particles influenced by inorganic acids with different acidity
    Dong-Sung Lee, Kyo-suk Lee, Ji-Soo Shin, Jae-Bong Lee, Ri-Na Joo, Myong-Youn Lee, Se-Won Min, Doug-Young Chung
    Korean Journal of Agricultural Science.2015; 42(3): 191.     CrossRef
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