Annals of Occupational and Environmental Medicine

Case Report

Dermal and neural toxicity caused by acrylamide exposure in two Korean grouting workers: a case report: Heeyun Kim, Sang Gil Lee, Jeongbae Rhie; Ann Occup Environ Med 2017;29:50. Published online October 9, 2017; DOI: https://doi.org/10.1186/s40557-017-0207-7

Background

Peripheral neuritis caused by acrylamide is well-known, and many Korean grouting workers are frequently exposed to acrylamide in grouting agents that are injected into cracked concrete. We recently encountered two cases of dermal and neural toxicity in Korean grouting workers with exposure to grouting agents that contained a high concentration of acrylamide.

Case presentation

The first case involved a 44-year-old man with 8 years of waterproofing experience. The patient developed peeling skin on both hands while grouting, which progressed to systemic neurological symptoms, such as reduced sensory function and strength. The patient was diagnosed with peripheral neuropathy caused by acrylamide exposure, and fully recovered after conservative treatment and withdrawal of exposure to the grouting agent. The second case involved a 34-year-old man with 10 years of grouting experience. The patient initially experienced weakness in both legs, which progressed to weakness in his arms and uncontrolled phonation. After being hospitalized, he was diagnosed with cerebellar ataxia and peripheral neuropathy caused by acrylamide exposure, and was discharged after conservative treatment. Our follow-up investigation revealed that both workers were recently exposed to grouting agents that contained higher concentrations of acrylamide, compared to the agents that they had previously been using.

Conclusions

Both workers had workplace acrylamide exposure through dermal contact plus inhalation of dust and vapor, which led to the neural toxicity and dermatitis. Therefore, government studies are needed to investigate the current status of workplace acrylamide use, and to protect workers from the hazardous effects of using acrylamide-containing grouting agents.

Citations

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Internal exposure to heat-induced food contaminants in omnivores, vegans and strict raw food eaters: biomarkers of exposure to acrylamide (hemoglobin adducts, urinary mercapturic acids) and new insights on its endogenous formation
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Archives of Toxicology.2024; 98(9): 2889. CrossRef
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Acrylamide induces neurotoxicity in zebrafish (Danio rerio) via NLRP3-mediated pyroptosis
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Science of The Total Environment.2023; 896: 165208. CrossRef
Seepage behavior and mechanical properties of two kinds of polyurethane/water glass in combined grouting experiment
Pengcheng Wang, Shuchen Li, Jinglong Li, Huiying Zhou, Pengfei Ma, Ye Tian, Chao Yuan, Xianda Feng
Tunnelling and Underground Space Technology.2023; 136: 105092. CrossRef
Effect of long-term exposure to acrylamide on endoplasmic reticulum stress and autophagy in rat cerebellum
Yiqi Wang, Lian Duan, Xing Zhang, Yang Jiao, Ying Liu, Lingling Dai, Hong Yan
Ecotoxicology and Environmental Safety.2021; 224: 112691. CrossRef
A Review on Acrylamide in Food: Occurrence, Toxicity, and Mitigation Strategies
Lubna Rifai, Fatima A. Saleh
International Journal of Toxicology.2020; 39(2): 93. CrossRef
Risk of exposure to acrylamide
Milena Bušová, Vladimír Bencko, Katarína Veszelits Laktičová, Ivana Holcátová, Mária Vargová
Central European Journal of Public Health.2020; 28(Supplement): S43. CrossRef
A new formulation of polymer gel dosimeter with reduced toxicity: Dosimetric characteristics and radiological properties
Abdulrahman Rashidi, Seyed Mohammad Mahdi Abtahi, Elham Saeedzadeh, Mohammad Esmaeil Akbari
Zeitschrift für Medizinische Physik.2020; 30(3): 185. CrossRef
Learning, memory deficits, and impaired neuronal maturation attributed to acrylamide
Seulah Lee, Hee Ra Park, Joo Yeon Lee, Jung-Hyun Cho, Hye Min Song, Ah Hyun Kim, Wonjong Lee, Yujeong Lee, Seung-Cheol Chang, Hyung Sik Kim, Jaewon Lee
Journal of Toxicology and Environmental Health, Part A.2018; 81(9): 254. CrossRef

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Case Report

A Case of Cerebellar Dysfunction After Acute Organotin Poisoning: Suk Hwan Kim, Cheol In Yoo, Jee Hyun Kwon, Jin Ho Bae, Young Cheol Weon, Yangho Kim; Korean Journal of Occupational and Environmental Medicine 2009;21(3):289-292. Published online September 30, 2009; DOI: https://doi.org/10.35371/kjoem.2009.21.3.289

Abstract PDF

BACKGROUND
We performed a follow-up study of an acute organotin poisoning case on the neurological sequelae that remained after 3 years since diagnosis.
CASE
In the previous study, a 43-year-old male was reported for acute organotin poisoning. After 3 years, the neurological sequelae were studied using neurological examination, cognitive tests, neurobehavioral tests (by CAYSYS 2000(TM)), brain magnetic resonance imaging (MRI), and 18F-fluorodeoxyglucose (18F-FDG) PET/CT. Upon neurological examination and other tests, orientation was improved compared to that 3 years before, but cerebellar ataxia, dysmetria and dysdiadochokinesia remained the same, with little change. Brain MRI showed cerebellar atrophy. 18F-FDG PET/CT revealed mildly decreased metabolic activity in the pons and in both cerebellar hemispheres.
DISCUSSION
This is the first brain MRI study on cerebellar atrophy caused by organotin poisoning. Cerebellar ataxia was confirmed by decreased metabolic activity in 18F-FDG PET/CT.

Citations

Citations to this article as recorded by

Magnetic resonance imaging of leukoencephalopathy in amnestic workers exposed to organotin
Eunmi Lee, Ji Eun Park, Mayu Iida, Tomoya Fujie, Toshiyuki Kaji, Gaku Ichihara, Young Cheol Weon, Yangho Kim
NeuroToxicology.2016; 57: 128. CrossRef
Toxic Encephalopathy
Yangho Kim, Jae Woo Kim
Safety and Health at Work.2012; 3(4): 243. CrossRef
Occupational Neurological Disorders in Korea
Eun-A Kim, Seong-Kyu Kang
Journal of Korean Medical Science.2010; 25(Suppl): S26. CrossRef
Occupational Neurologic Disorders in Korea
Yangho Kim, Kyoung Sook Jeong, Yong-Hun Yun, Myoung-Soon Oh
Journal of Clinical Neurology.2010; 6(2): 64. CrossRef

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