Annals of Occupational and Environmental Medicine

Review

Silica exposure and work-relatedness evaluation for occupational cancer in Korea: Hyoung-Ryoul Kim, Boowook Kim, Bum Seak Jo, Ji-Won Lee; Ann Occup Environ Med 2018;30:4. Published online January 31, 2018; DOI: https://doi.org/10.1186/s40557-018-0216-1

Crystalline silica has been classified as a definite carcinogen (Group 1) causing lung cancer by the International Agency for Research on Cancer (IARC). In Korea, crystalline silica has been the most common causal agent for workers to apply to the Korea Workers’ Compensation and Welfare Service (KWCWS). We used KWCWS data to evaluate workers’ crystalline silica exposure levels according to their occupations and industries, and reviewed research papers describing the dose-response relationship between cumulative exposure levels and lung cancer incidence. In addition, we reviewed lung cancer cases accepted by the KWCWS, and suggest new criteria for defining occupational cancer caused by crystalline silica in Korea. Rather than confining to miners, we propose recognizing occupational lung cancer whenever workers with pneumoconiosis develop lung cancer, regardless of their industry. Simultaneous exposure and lag time should also be considered in evaluations of work-relatedness.

Citations

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The association between lung cancer and silicosis: from theory to practice in occupational medicine
Marina Ruxandra Oțelea
Romanian Journal of Occupational Medicine.2022; 73(1): 45. CrossRef
Occupational exposure to respirable crystalline silica in municipal household waste collection and road cleaning workers
Boowook Kim, Eunyoung Kim, Wonseok Cha, Jungah Shin, Byung-Soon Choi, Daeho Kim, Miyeon Kim, Wonyang Kang, Sungwon Choi
Scientific Reports.2021;[Epub] CrossRef
Neuroprotective effects of sonochemical- synthesized SiO2 nanoparticles in vivo models of ischemic/reperfusion injury in stroke
Chengcheng Cui, Dayong Shen, Dandan Zuo, Xinchun Ye
Arabian Journal of Chemistry.2021; 14(11): 103416. CrossRef
Break-even Analysis of Respirable Crystalline Silica (RCS) Exposure Interventions in the Construction Sector
Emile Tompa, Amirabbas Mofidi, Chaojie Song, Victoria Arrandale, Katherine J. Jardine, Hugh Davies, Thomas Tenkate, Paul A. Demers
Journal of Occupational & Environmental Medicine.2021; 63(11): e792. CrossRef
Subradiological silicosis
Rodney Ehrlich, Jill Murray, David Rees
American Journal of Industrial Medicine.2018; 61(11): 877. CrossRef

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Case Report

Diagnosis of perinuclear anti-neutrophil cytoplasmic antibody-associated microscopic polyangiitis in silicotics: case report: Ji-Won Lee, Jun-Pyo Myong, Yeong-Jin Choi, Seyoung Lee, Bum Seak Jo, Jung-Wan Koo; Ann Occup Environ Med 2016;28:21. Published online May 14, 2016; DOI: https://doi.org/10.1186/s40557-016-0108-1

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Background

An association between silica exposure and autoimmune diseases including rheumatoid arthritis, systemic sclerosis, systemic lupus erythematosus, and anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis has been made.

Case presentation

A 56-year-old male presented with silicosis and had an occupational history of precious metal processing for 30 years and a 30 pack-year smoking history. The patient was diagnosed with pneumoconiosis and received compensation. No other complications were reported for pneumoconiosis. The patient suddenly presented with a non-specific headache for several days and microscopic hematuria was identified upon examination in the outpatient clinic. Following several weeks, the patient presented with aggravated dyspnea and hemoptysis, and his Modification of Diet in Renal Disease estimated glomerular filtration rate indicated acute kidney injury. Diagnostic analysis revealed perinuclear ANCA-associated microscopic polyangiitis (p-ANCA-associated MPA).

Conclusion

Exposure to silica dust was likely one of the cause of p-ANCA-associated MPA. Possible pathogenic mechanisms of autoimmune diseases in silicotics and emphasis of the necessity for early diagnosis are discussed.

Citations

Citations to this article as recorded by

Occupational Silica Exposure as a Potential Risk for Microscopic Polyangiitis
Alper Alp, Melike Ersoy, İbrahim Meteoğlu, Nesibe Kahraman Çetin, Hakan Akdam, Yavuz Yeniçerioğlu
Wilderness & Environmental Medicine.2023; 34(4): 543. CrossRef
Renal involvement in a silicosis patient – case report and literature review
Fei-Fei Chen, Hai-Yan Tang, Feng Yu, Cheng-Li Que, Fu-de Zhou, Su-Xia Wang, Guang-Fa Wang, Ming-Hui Zhao
Renal Failure.2019; 41(1): 1045. CrossRef
IL-10-Producing B Cells Suppress Effector T Cells Activation and Promote Regulatory T Cells in Crystalline Silica-Induced Inflammatory Response In Vitro
Yiping Lu, Fangwei Liu, Chao Li, Ying Chen, Dong Weng, Jie Chen
Mediators of Inflammation.2017; 2017: 1. CrossRef

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Research Article

Risk factors associated with mortality from pneumonia among patients with pneumoconiosis: Bum Seak Jo, Jongin Lee, YounMo Cho, Junsu Byun, Hyoung Ryoul Kim, Jung Wan Koo, Jun Pyo Myong; Ann Occup Environ Med 2016;28:19. Published online April 7, 2016; DOI: https://doi.org/10.1186/s40557-016-0103-6

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Background

The aim of this study was to evaluate factors associated with increased risk of mortality from pneumonia among patients with pneumoconiosis.

Methods

Medical records of 103 pneumoconiosis patients hospitalized for pneumonia were investigated. Seven patients who had lung cancer or other malignancy and 13 patients with insufficient medical record were excluded. Two female patients were excluded due to small number to analyze. The subjects were divided into two groups by clinical outcome of pneumonia, the deceased group and the survival group. The two groups were compared in terms of age, smoking history, episode of recent pneumonia, concomitancy of interstitial fibrosis or fungal ball infection, extent of small opacities, grade of large opacities and results of spirometry. Multiple logistic regression was applied to determine the association between these variables and mortality from pneumonia.

Results

The deceased group showed more frequent history of recent pneumonia (p = 0.006), higher prevalence of interstitial fibrosis (p = 0.007) and longer hospitalization period (p = 0.044). The proportion of subjects who had decreased FVC, less than 70 % of predicted value, was higher in the deceased group (p < 0.001). In multiple logistic regression, after adjusting age, smoking history, recent pneumonia, fungal ball, large opacity, profusion and FVC (or FEV₁) less than 70 % of predicted value, history of recent pneumonia, concomitancy of interstitial fibrosis, type of pneumoconiosis and fungal ball presented statistically significant association with mortality from pneumonia.

Conclusions

The concomitancy of fungal ball or interstitial fibrosis, history of recent pneumonia within last 90 days, type of pneumoconiosis, FVC less than 70 % of predicted value, FEV₁ less than 70 % of predicted value presented statistically significant association with mortality from pneumonia. More attention should be given to patients who have such factors when treating pneumonia with pneumoconiosis.

Citations

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ЗДОРОВЬЕ НАСЕЛЕНИЯ И СРЕДА ОБИТАНИЯ - ЗНиСО / PUBLIC HEALTH AND LIFE ENVIRONMENT.2021; : 78. CrossRef
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ЗДОРОВЬЕ НАСЕЛЕНИЯ И СРЕДА ОБИТАНИЯ - ЗНиСО / PUBLIC HEALTH AND LIFE ENVIRONMENT.2020; : 79. CrossRef
Association between Occupational and Radiological Factors and Nontuberculous Mycobacteria Lung Infection in Workers with Prior Dust Exposure
Ji-Won Lee, Jun-Pyo Myong
International Journal of Environmental Research and Public Health.2019; 16(11): 1966. CrossRef

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