Annals of Occupational and Environmental Medicine

Research Article

A study of relationship between blood mercury concentration and hypertension in residents living in old mine fields and related factors: Jeong Woo Kim, Byoung Gwon Kim, Jeong Woo Park, Jong Woo Yi, Jung Il Kim, Young Seoub Hong; Ann Occup Environ Med 2019;31:e6. Published online May 30, 2019; DOI: https://doi.org/10.35371/aoem.2019.31.e6

Background

In Korea, around the abandoned metal mines, heavy metals are being accumulating in the cultivated areas. Among exposed heavy metals, mercury is known to harm for cardiovascular system known to affect blood pressure. So, we studied the relationship between blood mercury level and hypertension in residents around abandoned metal mines.

Methods

From 2008 to 2011, we surveyed 7,055 residents in provinces affected by abandoned metal mines and collected data from 6 Hospitals. We conducted a personal questionnaire interview survey with residents on the basis of household questionnaires, sex, age, household income, smoking, and drinking items. Multiple logistic regression analysis was performed to investigate the association between blood mercury level and hypertension.

Results

We compared residents with low and high groups based on blood mercury level 5.8 μg/L, and higher group was significantly higher risk of hypertension than lower group (odds ratio [OR]: 1.277; 95% confidence interval [CI]: 1.135–1.436), also in adjusted model, higher group was significantly higher risk of hypertension than lower group (OR: 1.276; 95% CI: 1.117–1.457).

Conclusions

This study showed a significant correlation between mercury and hypertension in residents around abandoned metal mines. Therefore, we should continuously monitor people who are higher than the standard value and the hypertensive patients.

Citations

Citations to this article as recorded by

Environmental exposure to metal(loid)s and hypertensive disorders of pregnancy: A systematic review
Nayra Carla de Melo, Priscilla Cristovam Sampaio e Souza, Rejane Correa Marques, José Vicente Elias Bernardi, Wanderley Rodrigues Bastos, Mônica Pereira Lima Cunha
Environmental Research.2024; 257: 119391. CrossRef
Associations of fine particulate matter and its metal constituents with blood pressure: A panel study during the seventh World Military Games
Zhaoyuan Li, Shouxin Peng, Meijin Chen, Jinhui Sun, Feifei Liu, Huaiji Wang, Hao Xiang
Environmental Research.2023; 217: 114739. CrossRef
Evaluation of the Relationship between the Exposure Level to Mixed Hazardous Heavy Metals and Health Effects Using Factor Analysis
Eunseop Kim, Sun-In Moon, Dong-Hyuk Yim, Byung-Sun Choi, Jung-Duck Park, Sang-Yong Eom, Yong-Dae Kim, Heon Kim
Journal of Environmental Health Sciences.2022; 48(4): 236. CrossRef
Blood cadmium, lead, manganese, mercury, and selenium levels in American Indian populations: The Strong Heart Study
Zheng Li, Michael Lewin, Patricia Ruiz, Anne E. Nigra, Noelle B. Henderson, Jeffery M. Jarrett, Cynthia Ward, Jianhui Zhu, Jason G. Umans, Marcia O'Leary, Ying Zhang, Angela Ragin-Wilson, Ana Navas-Acien
Environmental Research.2022; 215: 114101. CrossRef
Co-exposure to Heavy Metals and Hypertension Among Adults in South Korea
Kisok Kim, Hyejin Park
Exposure and Health.2022; 14(1): 139. CrossRef
Effects of low-level mercury exposure on brain-derived neurotrophic factor in preschool children
Can-Can Zhou, Hui Fu, Guo-Yan Zhang, Jia-Wei Ma, Min Ni, Dong-Jie Li, Fu-Ming Shen, Fang Huang
Ecotoxicology and Environmental Safety.2021; 208: 111642. CrossRef
Hydrogen sulfide and cardiovascular disease: Doubts, clues, and interpretation difficulties from studies in geothermal areas
Francesca Gorini, Elisa Bustaffa, Kyriazoula Chatzianagnostou, Fabrizio Bianchi, Cristina Vassalle
Science of The Total Environment.2020; 743: 140818. CrossRef

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Research Article

Urinary arsenic species concentration in residents living near abandoned metal mines in South Korea: Jin-Yong Chung, Byoung-Gwon Kim, Byung-Kook Lee, Jai-Dong Moon, Joon Sakong, Man Joong Jeon, Jung-Duck Park, Byung-Sun Choi, Nam-Soo Kim, Seung-Do Yu, Jung-Wook Seo, Byeong-Jin Ye, Hyoun-Ju Lim, Young-Seoub Hong; Ann Occup Environ Med 2016;28:67. Published online November 22, 2016; DOI: https://doi.org/10.1186/s40557-016-0150-z

Abstract PDF PubReader ePub

Background

Arsenic is a carcinogenic heavy metal that has a species-dependent health effects and abandoned metal mines are a source of significant arsenic exposure. Therefore, the aims of this study were to analyze urinary arsenic species and their concentration in residents living near abandoned metal mines and to monitor the environmental health effects of abandoned metal mines in Korea.

Methods

This study was performed in 2014 to assess urinary arsenic excretion patterns of residents living near abandoned metal mines in South Korea. Demographic data such as gender, age, mine working history, period of residency, dietary patterns, smoking and alcohol use, and type of potable water consumed were obtaining using a questionnaire. Informed consent was also obtained from all study subjects (n = 119). Urinary arsenic species were quantified using high performance liquid chromatography (HPLC) and inductively coupled plasma mass spectrometry (ICP/MS).

Results

The geometric mean of urinary arsenic (sum of dimethylarsinic acid, monomethylarsonic acid, As³⁺, and As⁵⁺) concentration was determined to be 131.98 μg/L (geometric mean; 95% CI, 116.72–149.23) while urinary inorganic arsenic (As³⁺ and As⁵⁺) concentration was 0.81 μg/L (95% CI, 0.53–1.23). 66.3% (n = 79) and 21.8% (n = 26) of these samples exceeded ATSDR reference values for urinary arsenic (>100 μg/L) and inorganic arsenic (>10 μg/L), respectively. Mean urinary arsenic concentrations (geometric mean, GM) were higher in women then in men, and increased with age. Of the five regions evaluated, while four regions had inorganic arsenic concentrations less than 0.40 μg/L, one region showed a significantly higher concentration (GM 15.48 μg/L; 95% CI, 7.51–31.91) which investigates further studies to identify etiological factors.

Conclusion

We propose that the observed elevation in urinary arsenic concentration in residents living near abandoned metal mines may be due to environmental contamination from the abandoned metal mine.

Trial registration

Not Applicable (We do not have health care intervention on human participants).

Citations

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Assessing Acute and Chronic Risks of Human Exposure to Arsenic: A Cross-Sectional Study in Ethiopia Employing Body Biomarkers
Solomon Demissie, Seblework Mekonen, Tadesse Awoke, Bezatu Mengistie
Environmental Health Insights.2024;[Epub] CrossRef
Changes in arsenic accumulation and metabolic capacity after environmental management measures in mining area
Chen Zhao, Meng Du, Jun Yang, Guanghui Guo, Lingqing Wang, Yunxian Yan, Xuewen Li, Mei Lei, Tongbin Chen
Science of The Total Environment.2023; 855: 158652. CrossRef
Concentrations of blood and urinary arsenic species and their characteristics in general Korean population
Jeong Weon Choi, Yoon Chae Song, Nam-Yong Cheong, Kiyoung Lee, Sunmi Kim, Kyoung-Mu Lee, Kyunghee Ji, Mi-Yeon Shin, Sungkyoon Kim
Environmental Research.2022; 214: 113846. CrossRef
MTHFR, As3MT and GSTO1 Polymorphisms Influencing Arsenic Metabolism in Residents Near Abandoned Metal Mines in South Korea
Ulziikhishig Surenbaatar, Byoung-Gwon Kim, Hyun-Jin Son, Seong-Sik Cho, Gwon-Min Kim, Hyoun-Ju Lim, Jung-Yeon Kwon, Ki-Hwan Kim, Young-Seoub Hong
Journal of Environmental Health Sciences.2021; 47(6): 530. CrossRef

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Original Article

The Concentration of Cadmium in Urine, and Its Role in Health-risk Assessment of Residents in the Vicinity of Abandoned Mines in Gyeongsangbuk-do, Korea: Sung Ho Yun, Chang Yoon Kim, Tae Yoon Hwang, Kyu Chang Won, Jun Young Do, Se Jin Lee, Yeong Mog Park, Kwan Soo Jun, Gae Ho Lee, Do Young Lee, Kwang Seub Park, Joon Sakong; Korean Journal of Occupational and Environmental Medicine 2010;22(3):251-261. Published online September 30, 2010; DOI: https://doi.org/10.35371/kjoem.2010.22.3.251

Abstract PDF

OBJECTIVES
This study was conducted to assess the concentration of urine cadmium and health risks of residents in the vicinity of abandoned metal mines in Gyeongsangbuk-do.
METHODS
The concentration of cadmium in the soil, water, and agricultural crops was measured in Gyeongsangbuk-do, Butdeun and Suksan, which have abandoned metal mines. We measured the concentration of cadmium in the urine of residents from the following areas: 78 from village A, 99 from village C and 147 from control areas. Other health-risk assessments were performed on each resident, such as measuring the concentration of beta2-MG and a bone density test.
RESULTS
In abandoned mine areas, the mean concentration of cadmium was higher in agricultural soil and in the crops than in that of control areas. The concentration of cadmium in the stream exceeded the guideline level. In regard to provisional tolerable daily intake (PTDI) of cadmium, the actual intake rate through crops was 33.81%, 72.74% in abandoned mine areas and 5.03%, 6.16% in control areas. Residents in abandoned mine areas, A village and C village had a geometric mean of urine Cd of 1.90 microgram/g cr and 1.45 microgram/g cr. These measurements were significantly higher than those of residents in control areas, B village and D village, 0.59 microgram/g cr and 0.65 microgram/g cr (p<0.01). Following adjustments for age, sex, smoking habit, and occupational history, the concentration of urine cadmium of residents in the Butdeun abandoned meta mine was higher by 1.62 microgram/g cr as compared with the control group (p<0.01). Residents from the Suksan abandoned metal mine also had a higher concentration by 1.07 microgram/g cr (p<0.01). A multiple linear regression analysis was performed for the factors associated with T-score, and this showed that the concentration of urine cadmium was not an influential factor.
CONCLUSIONS
Based on these measurements, areas with abandoned metal mines contaminated streams, agricultural soil, and crops of the adjacent areas, with cadmium. Because residents in the adjacent areas intake contaminated crops, their urine cadmium was increased. Despite a lack of evidence demonstrating the detrimental effect of increased urine cadmium in residents, an additional study is needed to assess the health risks of residents in the vicinity of abandoned metal mines.

Citations

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Association between levels of exposure to heavy metals and renal function indicators of residents in environmentally vulnerable areas
Jung-Yeon Kwon, Seungho Lee, Ulziikhishig Surenbaatar, Hyoun-Ju Lim, Byoung-Gwon Kim, Sang-Yong Eom, Yong Min Cho, Woo Jin Kim, Byeng-Chul Yu, Kwan Lee, Young-Seoub Hong
Scientific Reports.2023;[Epub] CrossRef
Chronic Exposure to Lead and Cadmium in Residents Living near a Zinc Smelter
HyeJeong Jo, GeunBae Kim, JunYoung Chang, Kwan Lee, ChulWoo Lee, BoEun Lee
International Journal of Environmental Research and Public Health.2021; 18(4): 1731. CrossRef
A study on the correlation between upper airway diseases and urinary heavy metals concentration in household residents
Jihee Choi, Yujin Oh, Yunjae Kim, Munseob Ahn, Ji Young Im, Chung Soo Lee, Heejin Park, Moo-Kyun Park, Bu-Soon Son
Journal of Odor and Indoor Environment.2018; 17(1): 78. CrossRef
Comparative Analysis of Offensive Odorants in Urine Samples in Relation to Sample Treatment Conditions
Min-Hee Lee, Yong-Hyun Kim, Sang-Hee Jo, Si-On Choi, Inyoung Sa, Ki-Hyun Kim
Journal of Korean Society for Atmospheric Environment.2014; 30(5): 492. CrossRef

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Original Article

Blood and Urinary Cadmium Concentration of Residents around Abandoned Metal Mines in Busan and Gyeongsangnam-do: Hyo Jun Kim, Byoung Gwon Kim, Dae Seon Kim, Jeong Wook Seo, Byeng Chul Yu, Young Wook Kim, Young Seoub Hong; Korean Journal of Occupational and Environmental Medicine 2010;22(1):1-10. Published online March 31, 2010; DOI: https://doi.org/10.35371/kjoem.2010.22.1.1

Abstract PDF

OBJECTIVES
To evaluate the blood and urinary cadmium concentration levels of around abandoned metal mines in comparison with a control group.
METHODS
Blood and urinary cadmium concentration levels were analyzed through investigations of the dietary habits and dietary water of subjects living near abandoned metal mines (exposure group) (n=190) in comparison with those living in designated control areas (control group) (n=256).
RESULTS
The blood cadmium (1.93 microgram/l) and urinary cadmium (2.41 microgram/g cr) concentrations of the exposure group were significantly higher than those of the control group (blood cadmium: 1.19 microgram/l, urinary cadmium: 1.94 microgram/g cr). Both concentrations were significantly higher in vegetarians in both groups.
CONCLUSIONS
The exposure group had higher blood and urinary cadmium concentrations than the control group. We attributed the elevated blood and urine cadmium levels in the abandoned mine residents to the influence of the abandoned mine sites.

Citations

Citations to this article as recorded by

Association between levels of exposure to heavy metals and renal function indicators of residents in environmentally vulnerable areas
Jung-Yeon Kwon, Seungho Lee, Ulziikhishig Surenbaatar, Hyoun-Ju Lim, Byoung-Gwon Kim, Sang-Yong Eom, Yong Min Cho, Woo Jin Kim, Byeng-Chul Yu, Kwan Lee, Young-Seoub Hong
Scientific Reports.2023;[Epub] CrossRef
Health Effect and Blood Lead Concentration among Residents in Gwangyang and Yeosu
Heejin Park, Myung-Kyu Park, Tack-Shin Kang, Geun-Bae Kim, Jong-Wha Lee, Bong-Ki Jang, Bu-Soon Son
Korean Journal of Environmental Health Sciences.2016; 42(3): 205. CrossRef
Urinary Cadmium Concentration of Residents around Industrial Complex in Gwangyang and Yeosu
Heejin Park, Tack-Shin Kang, Jong-Dae Lee, Geun-Bae Kim, Seungdo Yu, Bong-Ki Jang, Jong-Wha Lee, Bu-Soon Son
Journal of Korean Society of Occupational and Environmental Hygiene.2015; 25(3): 338. CrossRef
Relationship between Urine Cadmium and Bone Mineral Density of Residents Around Abandoned Metal Mines
Kyung-Sick Jung, Nam-Soo Kim, Seung-Chul Ahn, Byung-Kook Lee
Korean Journal of Environmental Health Sciences.2012; 38(4): 323. CrossRef
Relationship between Heavy Metal Concentrations in the Soil with the Blood and Urine of Residents around Abandoned Metal Mines
Bong-Ki Jang, Sang-Il Park, Nam-Soo Kim, Kyung-Sick Jung, Byung-Kook Lee, Jong-Wha Lee
Korean Journal of Environmental Health Sciences.2011; 37(5): 348. CrossRef

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