Annals of Occupational and Environmental Medicine

Original Article

Health Effect Assessment on Volunteers Involved in the Cleanup Operation Following the Hebei Spirit Oil Spill Along the Taean Coast, Korea: Chul Ho Lee, Kyung Hwa Park, Min Jung Lee, Wook Hee Choi, Heon Kim, Choong Hee Park, Dae Seon Kim, Seung Do Yu; Korean Journal of Occupational and Environmental Medicine 2010;22(1):11-19. Published online March 31, 2010; DOI: https://doi.org/10.35371/kjoem.2010.22.1.11

OBJECTIVE: The objetive of this study is to assess the level of oxidative stress by the exposure to volatile organic compounds (VOCs) and polycyclic aromatic hydrocarbons (PAHs) in volunteers who cleaned up the crude oil spilled from the Hebei Spirit on the Coast of Taean County, Korea.
METHODS
The study subjects were 46 volunteers and 37 controls from the National Institute of Environmental Research. A self-administered questionnaire was used for volunteers to examine their working environment and health effects. Urinary concentrations of hippuric acid, 1-hydroxypyrene, and 2-naphthol were measured as exposure markers for VOCs and PAHs, and urinary thiobarbituric acid reactive substances (TBARS) and 8-hydroxydeoxyguanosine (8-OHdG) levels were measured as oxidative stress markers.
RESULTS
Sixty-four percent of the respondents presented a variety of symptoms, including sore eyes and throat, nausea, dizziness, headache, low back pain, and leg pain after participating in the cleanup operation. Urinary 2-naphthol and TBARS concentrations appeared higher in the volunteers. Univariate and multivariate analyses showed that urinary TBARS and 8-OHdG levels were positively correlated with urinary 2-naphthol and 1-hydroxypyrene concentrations respectively, especially among the volunteers.
CONCLUSIONS
The result implies that participating in cleanup work of oil spills may have a possibility to induce oxidative damage by exposure to PAHs in crude oil.

Citations

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Evaluation of performance of hybrid fiber-reinforced self-compacting concrete using non-destructive testing techniques
Shailja Bawa, Pravez Alam, Shivam Saini
Innovative Infrastructure Solutions.2023;[Epub] CrossRef
Survey of airborne organic compounds in residential communities near a natural gas compressor station: Response to community concern
Kaitlin A. Vollet Martin, Elizabeth Z. Lin, Timothy J. Hilbert, Krystal J. Godri Pollitt, Erin N. Haynes
Environmental Advances.2021; 5: 100076. CrossRef
Human health and ecological assessment programs for Hebei Spirit oil spill accident of 2007: Status, lessons, and future challenges
Dawoon Jung, Jung-Ah Kim, Myung-Sook Park, Un Hyuk Yim, Kyungho Choi
Chemosphere.2017; 173: 180. CrossRef
Health Effect Assessment on Cleanup Workers of an Oil Spill in Yeosu
Geunbae Kim, Tack Shin Kang, Mira Yoon, Hyejung Jo, Youngkyung Joo, Seung Do Yu, Bo Eun Lee
Korean Journal of Environmental Health Sciences.2016; 42(6): 385. CrossRef
Association between Metabolic Syndrome and Participation in Clean-up Work at the Hebei Spirit Oil Spill
Ik-Jin Lee, Bong-Ki Jang, Jong-Wha Lee, Bu-Soon Son, Hae-Kwan Cheong, Mina Ha, Young-Hyun Choi, Myungsook Park
Korean Journal of Environmental Health Sciences.2015; 41(5): 335. CrossRef
Changes of Eating Habits of the Residents of Taean, Korea after the Herbei Oil Spill Accident Based on Focus Group Interviews
Ji Hyun Park, Sung Ok Kwon, Woo Cheol Jeong, Jong Il Huh, Se-Young Oh
Korean Journal of Community Nutrition.2011; 16(4): 466. CrossRef

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Original Article

Effect of Genetic Polymorphisms of CYP2E1 and ALDH2 on the Relationship between the Levels of Urinary 8-Hydroxydeoxyguanosine and t,t-Muconic Acid: Yong Dae Kim, Jong Won Kang, Sang Yong Eom, Yan Wei Zhang, Sung Hoon Kim, Eun Young Kim, Chul Ho Lee, Jai Dong Moon, Heon Kim; Korean Journal of Occupational and Environmental Medicine 2007;19(2):164-170. Published online June 30, 2007; DOI: https://doi.org/10.35371/kjoem.2007.19.2.164

Abstract PDF: OBJECTIVES
This study was performed to investigate the effect of genetic polymorphisms on the oxidative genetic damage caused by benzene exposure in workers.
METHODS
We measured urinary t,t-muconic acid levels as a biomarker for benzene exposure and measured the level of urinary 8-OHdG to assess oxidative DNA damage in benzene-exposed healthy male workers. Genetic polymorphisms of ALDH2 and CYP2E1 were determined by TaqMan assay. We estimated Pearson correlation coefficients between urinary t,t-muconic acid and 8-OHdG according to the genetic polymorphisms of CYP2E1 and ALDH2.
RESULTS
There was a significant relationship between urinary t,t-muconic acid and 8-OHdG concentrations in overall subjects (R=0.532, p<0.001). Smokers showed a higher correlation coefficient between the markers than nonsmokers did (R=0.520 vs. 0.010). Individuals with CYP2E1 c1/c1 genotype also showed a higher correlation coefficient between them than those with CYP2E1 c1/c2 or c2/c2 genotypes (R=0.670 vs. -0.145). In multiple linear regression analysis including smoking status, sorbic acid intake, age and genetic polymorphisms of CYP2E1 and ALDH2 as the independent variables, urinary t,t-muconic acid showed a significant association with urinary 8-OHdG.
CONCLUSIONS
There was a significant correlation between urinary 8-OHdG and urinary t,t-muconic acid in benzene-exposed workers. This relationship was affected by genetic polymorphisms of CYP2E1and ALDH2.

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Original Article

Effects of Chromium Exposure on the Level of Urinary 8-Hydroxydeoxyguanosine: Seong Joon Kim, Byung Chul Yu, Sang Hwa Ohm, Ki Won Jeong, Luck Hee Sung, Won Chang Shin, Jong Rae Cho, Jin Ho Chun; Korean Journal of Occupational and Environmental Medicine 2001;13(3):253-261. Published online September 30, 2001; DOI: https://doi.org/10.35371/kjoem.2001.13.3.253

Abstract PDF

OBJECTIVES
To investigate the possibility of utilizing DNA adduct as a carcinogenic biological marker for workers exposed to chromium, and the effect of chromium exposure on the formation of urinary 8-hydroxydeoxyguanosine(8-OH-dG) was also evaluated.
METHODS
The chromium concentrations of venous blood and urine were measured in 20 chromium exposed workers(exposure group) and in 11 chromium workers(control group) who were not exposed. The concentration of 8-OH-dG in their urine was determined using high performance liquid chromatography with electrochemical detection.
RESULTS
The blood chromium concentration was significantly higher in the exposure group ( 0.46+/-0.18 microgram/100 ml) than in control group(0.27+/-0.15 microgram/100 ml), but the urinary chromium concentration was not significantly higher in the exposure group. The urinary 8-OH-dG was higher in the exposure group(1.71+/-1.82 micromol/mol creatinine) than that in the control group(0.45+/-0.46 micromol/mol creatinine) and was significantly correlated with the blood chromium concentration(r=0.49). Results of multiple regression analysis revealed that the level of urinary 8-OH-dG depended upon the level of the blood chromium conc entration ( r2= 0.21).
CONCLUSIONS
Urinary 8-OH-dG was significantly related to chromium exposure and this finding suggests the possibility that urinary 8-OH-dG could be used as a biological index of chromium induced DNA damage.

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Association of serum and hair antioxidant minerals with an oxidative stress marker in relation with characteristics of healthy adults: a cross-sectional study
Yoo-Ree Kang, Mi-Kyung Sung, Hyun-Wook Baik, Mi-Kyeong Choi
Scientific Reports.2024;[Epub] CrossRef

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