Annals of Occupational and Environmental Medicine

Original Article

The effect of Smoking and Residential environment on Urinary 2-naphthol: Jee Na Lee, Jong Han Leem, Shin Goo Park, Joo Yeun Shin, Kwan Hee Lee, Yun Chul Hong, Hun Kim, Chul Ho Lee; Korean Journal of Occupational and Environmental Medicine 2004;16(1):82-91. Published online March 31, 2004; DOI: https://doi.org/10.35371/kjoem.2004.16.1.82

Abstract PDF: OBJECTIVES
To evaluate the association of urinary 2-naphthol level and air pollution caused by exposure to smoking, traffic and residential factors.
METHODS
The study subjects consisted of 300 university students in Incheon. The questionnaires concerning subject characteristics, smoking amount, traffic, distance between housing and main road, heating and cooking fuel including urinary cotinine levels were checked.
RESULTS
There was not any significant association between urinary 2-naphthol level and age, sex, body mass index, distance from mainroad, traffic, heating and cooking fuel. The urinary 2-naphthol level was higher in smokers or high urinary cotinine level group(p=0.0001)than in nonsmokers or low urinary cotinine group. After adjusting for age, sex, and body mass index in the basic model, the 2-naphthol level was also higher in the smokers or high urinary cotinine level group, too(p<0.0005). The model included both traffic and residential variables and it had a good fitness as compared to other models.
CONCLUSIONS
It has been known that as one of PAH metabolites, urinary 2-naphthol is a respiration-selective biological marker. We showed that tabacco smoking has a much stronger effects on urinary 2-naphthol levels than when subjects were exposed to air pollution, such as traffic, and other residential factors at the same time.

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Case Report

Lung Cancer Occurring in a Worker Exposed to Coke Oven Emissions: Hyun Sul Lim, Jung Keun Choi, Eun Hye Kwon, Heon Kim; Korean Journal of Occupational and Environmental Medicine 2002;14(1):97-106. Published online March 31, 2002; DOI: https://doi.org/10.35371/kjoem.2002.14.1.97

OBJECTIVES
We report a case of lung cancer (small cell carcinoma) occurring in a worker exposed to coke oven emissions.
METHODS
We examined the chest CT and pathologic findings of the patient. We reviewed previous environmental measurements for coke oven emissions at the workers place of employment. Also we measured the airborne concentrations for coke oven emissions and total polycyclic aromatic hydrocarbons in the work area. Finally, we analyzed the 1-hydroxypyrene and 2-naphthol concentrations in the subjects urine and compared this with student controls.
RESULTS
This case was a 56-year-old male who had worked in a coke oven plant within a steel manufacturing factory for 21 years (1977-1998). The airborne concentrations of coke oven emissions at the worksite were above the permissible exposure level (0.2 mg/m3) in 45 cases (33.1%) among 136 workers. The concentrations of 1-hydroxypyrene and 2-naphthol in the subjects urine were statistically significantly elevated as compared with those of controls (P<0.01).
CONCLUSIONS
We confirmed that the lung cancer occurring in this patient was as an occupational disease due to exposure to coke oven emissions. To prevent occupational cancer in coke oven plant workers, we must remodel the engineering procedure, begin comprehensive medical surveillance, educate workers on risks and the benefits of smoking cessation, and increase awareness of safety regulations in the workplace.

Citations

Citations to this article as recorded by

Occupational Cancers with Chemical Exposure and their Prevention in Korea: A Literature Review
Kyung-Taek Rim
Asian Pacific Journal of Cancer Prevention.2013; 14(6): 3379. CrossRef
Occupational Respiratory Cancer in Korea
Hye-Eun Lee, Hyoung Ryoul Kim
Journal of Korean Medical Science.2010; 25(Suppl): S94. CrossRef

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