Annals of Occupational and Environmental Medicine

Case Report

A Case of Peripheral Polyneuropathy Induced by Occupational 2,5-hexanedione Exposure: Seong Yong Cho, Yong Seok Jang, Eun Kyung Choi, Jin Seok Kim, Jay Young Yu, Kuck Hyun Woo, Tae Seong Choi; Korean Journal of Occupational and Environmental Medicine 2007;19(1):73-80. Published online March 31, 2007; DOI: https://doi.org/10.35371/kjoem.2007.19.1.73

OBJECTIVES
This study is a case report of 2,5-hexanedione induced occupational peripheral polyneuropathy. We also investigated the peripheral nerve function of all workers who had been exposed to 2,5-hexanedione in the same process.
METHODS
In June, 2006, a 2,5-hexanedione exposed worker complained of both hand numbness. He received neurologic, radiologic, laboratorial and electrophysiologic evaluation, including measurements of workplace environment. Five months after cessation of exposure to 2,5-hexanedione, a follow-up electrophysiologic examination was done. We evaluated the peripheral nerve function of 2,5-hexanedione exposed workers by comparing 13 male 2,5-hexanedione exposed workers who were in same company with the patient and 5 male workers who had not been exposed to 2,5-hexanedione.
RESULTS
Under electrophysiologic examination, there were abnormalities in sensory and motor nerve velocity, terminal latency, and F-latency of both median nerve and ulnar nerve. After 5 months, the patient symptoms and the results of follow-up electrophysiologic examinations were improved. Comparing the 2,5-hexanedione exposed group with the unexposed group, the sensory nerve velocity of the median and ulnar nerves in the exposed group was decreased. The motor nerve velocity of the peroneal nerve, and sensory nerve velocity of the median and sural nerves were decreased. Terminal latency of median, ulnar, peroneal, and tibial nerves in the exposed group were increased compared with the unexposed group(<0.05).
CONCLUSIONS
2.5-hexandione can induce peripheral polyneuropathy in male workers.

Citations

Citations to this article as recorded by

Occupational Neurological Disorders in Korea
Eun-A Kim, Seong-Kyu Kang
Journal of Korean Medical Science.2010; 25(Suppl): S26. CrossRef
The Association of Subjective Symptoms of Students and Indoor Air Quality in Private Academic Facilities
Kyung-Sick Jung, Nam-Soo Kim, Jong-Dae Lee, Young HwangBo, Bu-Soon Son, Byung-Kook Lee
Korean Journal of Environmental Health Sciences.2009; 35(6): 468. CrossRef
School Indoor Air Quality and Health Effects
Won-Ho Yang
Korean Journal of Environmental Health Sciences.2009; 35(3): 143. CrossRef

19 View
0 Download
3 Crossref

Case Report

Three Cases of Skin Pigmentation Caused by 2,5-Hexanedione: Seong Ah Kim, Sang Jae Jung, Chae Yong Lee, Sang Man Lee, Sang Woo Kim; Korean Journal of Occupational and Environmental Medicine 2002;14(2):199-203. Published online June 30, 2002; DOI: https://doi.org/10.35371/kjoem.2002.14.2.199

Abstract PDF

OBJECTIVES
To report on the skin discoloration experienced by three workers handling 2 , 5 -hexanedione METHODS: Three workers, who showed orange-brown discoloration of the palms during observation under the Kumi occupational disease surveillance system, had their history evaluated and underwent physical examination. A workplace survey was performed by an occupational physician and an industrial hygienist.
RESULTS
The three workers were determined to have been experiencing skin discoloration since the introduction of a new cleaning solvent. The new solvent contained 2,5-hexanedione, which is reported in the literature to be possibly capable of causing orangebrown discoloration of the skin. After discontinuation of solvent use, the workers recovered within a week.
CONCLUSIONS
These cases demonstrate that 2,5-hexanedione can produce skin pigmentation.

Citations

Citations to this article as recorded by

Occupational Diseases in Korea
Seong-Kyu Kang, Eun A Kim
Journal of Korean Medical Science.2010; 25(Suppl): S4. CrossRef

19 View
0 Download
1 Crossref

First
Prev
Page of 1
Next
Last

Search